ライフサイエンスコーパス: origin recognition complex

1 spacing, are bent by EBNA1, and recruit the origin recognition complex.

2 nature and the characteristics of the human origin recognition complex.

3 in multiple, redundant binding sites for the origin recognition complex.

4 t with it being a part of the putative human origin recognition complex.

5 chromatin requires Xorc2, a component of the origin recognition complex.

6 the genome with the highest affinity for the origin recognition complex.

7 ied histone acetyltransferase binding to the origin recognition complex 1 (Hbo1) as a potential Plk1

8 information regulator 1 protein (Sir1p) and origin recognition complex 1 protein (Orc1p), the larges

9 rocesses including genome replication (ORC1 [origin recognition complex 1], ORC4, ORC6, CDT1, and CDC

10 munoprecipitation assay performed using anti-origin recognition complex 2 (alpha-ORC2) and alpha-LANA

11 cribe the mechanistic roles of two proteins--origin recognition complex 2 (Orc2) and heterochromatin

12 We have identified origin recognition complex 2 (Orc2), a member of the DNA

13 iP replication activity and increases EBNA1, origin recognition complex 2 (ORC2), and minichromosome

14 odomain-containing protein 2 (BRD2), and the origin recognition complex 2 protein (ORC2) and was enri

15 In the first phase, the origin recognition complex and Cdc6 prereplication prote

16 mutations in other pre-RC proteins (such as Origin Recognition Complex and Cdc6), but not to mutatio

17 ing minichromosome maintenance proteins, the origin recognition complex and DNA polymerase alpha.

18 ractions between MUM2 and a component of the origin recognition complex and polymerase alpha-primase

19 in to become functionally licensed: ORC (the origin recognition complex) and Cdc6, plus the two compo

20 pull-down assays demonstrate that ORCA-ORC (Origin Recognition Complex) and multiple H3K9 KMTs exist

21 CE3 and Ori-beta, are directly bound by Orc (origin recognition complex), and two-dimensional gel ana

22 Bromodeoxyuridine, origin recognition complex, and the elongation factors m

23 l connection between wild-type Sum1p and the origin recognition complex, and this relationship also c

24 Human cells that lack a subunit in their origin recognition complex are viable, which suggests th

25 The pre-replication complex protein, origin recognition complex-associated (ORCA/LRWD1), pref

26 We find heterochromatin protein 1/origin recognition complex-associated protein (HOAP) to

27 ing by PCNA and CDC45 mutations required the origin recognition complex binding site of the HMR-E sil

28 lication (OBR), which mapped adjacent to the origin recognition complex binding site.

29 The association of origin recognition complex-binding sites with selected p

30 yeast, the eukaryotic initiator protein ORC (origin recognition complex) binds to a bipartite sequenc

31 mutations in ORC1, encoding a subunit of the origin recognition complex, cause microcephalic primordi

32 Three additional factors--the origin recognition complex, Cdc6 and Cdt1--are required

33 The origin recognition complex, Cdc6 and the minichromosome

34 ed onto chromatin by the concerted action of origin recognition complex, Cdc6, and Cdt1.

35 A replication, the Orc1 subunit of the human origin recognition complex controls centriole and centro

36 This atypical ACS binds the origin recognition complex efficiently and is required f

37 SWI/SNF-related complexes co-localizes with origin recognition complexes, GINS complexes, and prolif

38 the six subunits of Saccharomyces cerevisiae origin recognition complex have been reported so far.

39 Histone acetyltransferase binding to origin recognition complex (HBO1) plays a crucial role i

40 and B1 elements, which are known to bind the origin recognition complex; however, the ARS1 A element

41 We report that a highly purified human origin recognition complex (HsORC) has intrinsic DNA-bin

42 n of an initial complex containing the human origin recognition complex (HsORC), HsCdt1, HsCdc6, and

43 Orc5p is a subunit of the origin recognition complex in the budding yeast Saccharo

44 s with two Orc1-like proteins in the unusual origin recognition complex in trypanosomes.

45 ORC2 is a subunit of the origin recognition complex in yeast and has been implica

46 eins we identified is identical to the human origin recognition complex-interacting protein termed HB

47 tional silencing, and ORC is the six-subunit origin recognition complex involved in the initiation of

48 The Xenopus origin recognition complex is essential for chromosomal

49 S1 association of Mcm2p, but not that of the origin recognition complex, is diminished by disruption

50 an evolutionarily conserved component of the origin recognition complex, is essential for deoxyribonu

51 hromatin-bound B-subunit in association with origin recognition complex mediates recruiting Polalpha-

52 o early G1 phase through an interaction with Origin Recognition Complex or another origin-associated

53 The origin recognition complex or ORC is a six-subunit prote

54 is chromatin is perturbed in mutants for the origin recognition complex (ORC) 2 subunit.

55 c cells at the onset of S phase requires the origin recognition complex (ORC) [1].

56 in transcriptional silencing mediated by the origin recognition complex (ORC) and a heterochromatin s

57 eucine enabled Sum1-1p to associate with the origin recognition complex (ORC) and accumulate near ORC

58 the association of the Cdc6 protein with the Origin Recognition Complex (ORC) and appears concomitant

59 y reveal a functional connection between the origin recognition complex (ORC) and Cdc45p but also ext

60 expected to recruit initiation proteins like origin recognition complex (ORC) and Cdc6 in eukaryotes

61 We show that origin recognition complex (ORC) and Cdc6 recruit multip

62 In contrast, both subunits of origin recognition complex (ORC) and Cdc6, which are req

63 An interaction between the origin recognition complex (ORC) and Cdc6p is the first

64 t1 onto origins bound by the heterohexameric origin recognition complex (ORC) and functions as a repl

65 is determined by the interaction between the origin recognition complex (ORC) and genomic DNA.

66 ts DUE sequence, despite the presence of the origin recognition complex (ORC) and MCM proteins at the

67 Origin Recognition Complex (ORC) and minichromosome main

68 f DNA replication in eukaryotes requires the origin recognition complex (ORC) and other proteins that

69 inhibits MCM loading by phosphorylating the origin recognition complex (ORC) and promotes CMG format

70 were reduced in their ability to recruit the origin recognition complex (ORC) and stimulate OriP repl

71 The origin recognition complex (ORC) and the minichromosome

72 alyzed the developmental localization of the origin recognition complex (ORC) and the minichromosome

73 tiate DNA replication and interacts with the origin recognition complex (ORC) and the p34cdc2 CDK.

74 ental stage-specific binding regions for the Origin Recognition Complex (ORC) and the replicative hel

75 Cdc6p and the origin recognition complex (ORC) are essential for assem

76 ion assay, we have measured the stability of origin recognition complex (ORC) associated with sperm c

77 itory sequence positioned 3' to the sites of origin recognition complex (ORC) binding and pre-RC asse

78 It begins with the origin recognition complex (ORC) binding DNA sites calle

79 , which flank the silenced loci, includes an origin recognition complex (ORC) binding site (ACS).

80 The origin recognition complex (ORC) binds origins of replic

81 The origin recognition complex (ORC) binds sites from which

82 genome duplication begins when a six-subunit origin recognition complex (ORC) binds to DNA.

83 Although the origin recognition complex (ORC) binds to origins of DNA

84 The origin recognition complex (ORC) binds to the specific p

85 architecture of the Saccharomyces cerevisiae origin recognition complex (ORC) bound to yeast origins

86 The Tetrahymena thermophila origin recognition complex (ORC) contains an integral RN

87 The origin recognition complex (ORC) coordinates bidirection

88 The origin recognition complex (ORC) defines origins of repl

89 In this system, the origin recognition complex (ORC) did not become stoichio

90 The lack of sequence specificity in origin recognition complex (ORC) DNA binding complicates

91 In a Xenopus egg replication system, the origin recognition complex (ORC) does not bind to CpG me

92 cle-dependent changes in the affinity of the origin recognition complex (ORC) for chromatin are invol

93 Immunoprecipitation of the origin recognition complex (ORC) from yeast extracts ide

94 The eukaryotic six-subunit origin recognition complex (ORC) governs the initiation

95 The origin recognition complex (ORC) has an important functi

96 A new member of human origin recognition complex (ORC) has been cloned and ide

97 ARS consensus sequence (ACS) that binds the origin recognition complex (ORC) has been experimentally

98 plicative helicase and between one and three origin recognition complex (ORC) homologues involved in

99 first genome-wide analysis of binding of the origin recognition complex (ORC) in a differentiated met

100 tificial locus results in recruitment of the origin recognition complex (ORC) in a manner dependent o

101 The origin recognition complex (ORC) in yeast is a complex o

102 Purified human origin recognition complex (ORC) induces similar topolog

103 The origin recognition complex (ORC) initiates the assembly

104 The origin recognition complex (ORC) is a 6-subunit complex

105 The Origin Recognition Complex (ORC) is a critical component

106 The six-subunit origin recognition complex (ORC) is a DNA replication in

107 The origin recognition complex (ORC) is a DNA replication in

108 The origin recognition complex (ORC) is a six subunit comple

109 Origin recognition complex (ORC) is a six subunit comple

110 The Origin Recognition Complex (ORC) is a six-protein assemb

111 The origin recognition complex (ORC) is a six-subunit, ATP-r

112 The origin recognition complex (ORC) is an essential compone

113 The origin recognition complex (ORC) is an essential DNA rep

114 The origin recognition complex (ORC) is an initiator protein

115 The six-subunit Origin Recognition Complex (ORC) is believed to be an es

116 The Saccharomyces cerevisiae origin recognition complex (ORC) is bound to origins of

117 The Saccharomyces cerevisiae origin recognition complex (ORC) is composed of six subu

118 The origin recognition complex (ORC) is conserved in all euk

119 le of Saccharomyces cerevisiae, the level of origin recognition complex (ORC) is constant and ORCs ar

120 In eukaryotes, the heterohexameric origin recognition complex (ORC) is essential for coordi

121 The six-subunit origin recognition complex (ORC) is essential for the in

122 The origin recognition complex (ORC) is involved in formatio

123 e location analysis, we demonstrate that the origin recognition complex (ORC) is localized to specifi

124 The origin recognition complex (ORC) is required to initiate

125 visiae, sequence-specific DNA binding by the origin recognition complex (ORC) is responsible for sele

126 The origin recognition complex (ORC) is the DNA replication

127 In eukaryotic cells, the origin recognition complex (ORC) is the initiator protei

128 ORC1, the Origin Recognition Complex (ORC) large subunit, is inher

129 Drosophila origin recognition complex (ORC) localizes to defined po

130 The origin recognition complex (ORC) marks chromosomal posit

131 The origin recognition complex (ORC) nucleates DNA replicati

132 cetylation of nucleosomes and binding of the origin recognition complex (ORC) occur in a broad domain

133 Mutations in genes encoding the origin recognition complex (ORC) of Saccharomyces cerevi

134 The origin recognition complex (ORC) of Saccharomyces cerevi

135 of a pre-replication complex facilitated by Origin Recognition Complex (ORC) onto the chromatin duri

136 The origin recognition complex (ORC) plays a central role in

137 The origin recognition complex (ORC) plays a central role in

138 The origin recognition complex (ORC) plays a key role during

139 Origin recognition complex (ORC) plays critical roles in

140 c7p kinase activity, or interaction with the origin recognition complex (ORC) postulated to recruit C

141 aintenance (MCM) proteins, together with the origin recognition complex (ORC) proteins and Cdc6, play

142 Origin recognition complex (ORC) proteins serve as a lan

143 Before initiation of DNA replication, origin recognition complex (ORC) proteins, cdc6, and min

144 Budding yeast (Saccharomyces cerevisiae) origin recognition complex (ORC) requires ATP to bind sp

145 The eukaryotic origin recognition complex (ORC) selects the genomic sit

146 The origin recognition complex (ORC) specifies replication o

147 ins by chromatin immunoprecipitation against origin recognition complex (ORC) subunits 2 and 3 showed

148 protein complex of HP1 containing Drosophila origin recognition complex (ORC) subunits in the early D

149 e cyclin-dependent kinases (CDKs) target two origin recognition complex (ORC) subunits, Orc2 and Orc6

150 ure-sensitive mutation in a component of the origin recognition complex (ORC) that also causes a defe

151 role for the Orc1 protein, a subunit of the origin recognition complex (ORC) that is a key component

152 s of binding sites for Abf1p, Rap1p, and the origin recognition complex (ORC) that serve to recruit t

153 emonstrated that EBNA1 recruits the cellular origin recognition complex (ORC) through an RNA-dependen

154 myces cerevisiae requires the binding of the origin recognition complex (ORC) to autonomously replica

155 CM loading is orchestrated by binding of the origin recognition complex (ORC) to DNA, but how ORC coo

156 ion begins with the binding of a six subunit origin recognition complex (ORC) to DNA.

157 ined in part by the binding of a heteromeric origin recognition complex (ORC) to DNA.

158 EBNA1 recruits the origin recognition complex (ORC) to establish a replicat

159 Binding of the Origin Recognition Complex (ORC) to origins of replicati

160 Binding of the Origin Recognition Complex (ORC) to replication origins

161 s solely responsible for in vitro binding of origin recognition complex (ORC) to specific AT-rich sit

162 otein complex (Mcm), topoisomerases, and the origin recognition complex (ORC) using an in vitro assay

163 A new member of the human origin recognition complex (ORC) was cloned and identifi

164 replication initiation and silencing by the origin recognition complex (ORC) was examined.

165 The origin recognition complex (ORC) was initially discovere

166 The six-subunit origin recognition complex (ORC) was originally identifi

167 The origin recognition complex (ORC) was originally identifi

168 The origin recognition complex (ORC) was required for Sum1-1

169 s the silencer through interactions with the origin recognition complex (ORC), a protein complex that

170 In eukaryotes, DNA replication requires the origin recognition complex (ORC), a six-subunit assembly

171 The origin recognition complex (ORC), a six-subunit protein,

172 sequence (ACS) element, presumed to bind the origin recognition complex (ORC), and a broad 3'-flankin

173 meters of transcription, localization of the origin recognition complex (ORC), and histone acetylatio

174 These loci are identified and bound by the origin recognition complex (ORC), and subsequently activ

175 g the role of the prereplication complex and origin recognition complex (ORC), and uncovering regulat

176 he ACS is the binding site for the initiator origin recognition complex (ORC), but the selected seque

177 he prereplicative complex (pre-RC) proteins: origin recognition complex (ORC), CDC-6, and CDT-1.

178 The origin recognition complex (ORC), Cdc6 and Cdt1 load Mcm

179 tions of a variety of proteins including the origin recognition complex (ORC), Cdc6 and the Mcm2-7 he

180 Origin recognition complex (ORC), Cdc6, and Cdt1 assembl

181 The loading of Mcm2-7 onto DNA requires the origin recognition complex (ORC), Cdc6, and Cdt1, and de

182 It is recruited to chromatin by the origin recognition complex (ORC), Cdc6, and Cdt1, and it

183 replicative complexes (pre-RCs) requires the Origin Recognition Complex (ORC), Cdc6, and Cdt1.

184 The sequential binding of the origin recognition complex (ORC), Cdc6, and the minichro

185 lex (pre-RC), and its formation requires the origin recognition complex (ORC), Cdc6, Cdt1, and ATP.

186 ins of replication through the action of the origin recognition complex (ORC), Cdc6, Cdt1, and the Mc

187 ential binding to replication origins of the origin recognition complex (ORC), Cdc6/Cdc18, Cdt1, and

188 The origin recognition complex (ORC), Cdc6p, and minichromos

189 The origin recognition complex (ORC), Cdc6p, and the MCM pro

190 re-RCs) as an inactive double hexamer by the origin recognition complex (ORC), Cdt1 and Cdc6; the hel

191 CM)2-7 recruitment to origins in G1 requires origin recognition complex (ORC), Cdt1, and Cdc6, and ac

192 la Orc6 protein, the smallest subunit of the origin recognition complex (ORC), directly binds to sept

193 mechanisms, including phosphorylation of the origin recognition complex (ORC), downregulation of Cdc6

194 The origin recognition complex (ORC), first identified in Sa

195 ctors 1 (TRF1) and 2 (TRF2), subunits of the origin recognition complex (ORC), heterochromatin protei

196 We identify the origin recognition complex (ORC), including LRWD1 as a s

197 ction with Orc1p, the largest subunit of the origin recognition complex (ORC), is critical for Sir1p'

198 we demonstrate that the yeast initiator, the origin recognition complex (ORC), is required to maintai

199 to DNA replication, including a role for the origin recognition complex (ORC), the DNA replication in

200 t sites of DNA replication are marked by the origin recognition complex (ORC), which coordinates Mcm2

201 esemble those generated in vitro by purified origin recognition complex (ORC), which is essential for

202 interaction between origin sequences and the origin recognition complex (ORC), which is highly conser

203 teraction between an origin sequence and the origin recognition complex (ORC), which is highly conser

204 origins of DNA replication are bound by the origin recognition complex (ORC), which scaffolds assemb

205 eported that a WD repeat-containing protein, origin recognition complex (ORC)-associated (ORCA/LRWD1)

206 ne response element directly adjacent to the origin recognition complex (ORC)-binding site in the II/

207 MCM) double hexamer, its precursors, and the origin recognition complex (ORC)-Cdc6-Cdt1-Mcm2-7 (OCCM)

208 o chromatin states during the cell cycle: an origin recognition complex (ORC)-dependent post-replicat

209 in S phase requires the prior assembly of an origin recognition complex (ORC)-dependent pre-replicati

210 recognized by the replication initiator, the origin recognition complex (ORC).

211 ogy (BAH) domain of the Orc1p subunit of the origin recognition complex (ORC).

212 eracetylated, coincident with binding of the origin recognition complex (ORC).

213 cyclin Clb5 binds stably and directly to the origin recognition complex (ORC).

214 nism independent of its interaction with the origin recognition complex (ORC).

215 ght to occur at sites bound by a heteromeric origin recognition complex (ORC).

216 that are important for silencing include the origin recognition complex (ORC).

217 es replication factor Orp2, a subunit of the origin recognition complex (ORC).

218 identified as the sixth member of the human origin recognition complex (ORC).

219 bind the silencer DNA directly, such as the origin recognition complex (ORC).

220 el protein with homology to a subunit of the origin recognition complex (ORC).

221 ncer, thus arguing for an involvement of the origin recognition complex (ORC).

222 subunit complex of six proteins known as the origin recognition complex (ORC).

223 n factor subunit of Saccharomyces cerevisiae origin recognition complex (ORC).

224 s cerevisiae these sites are occupied by the origin recognition complex (ORC).

225 proteins and protein complexes, such as the origin recognition complex (ORC).

226 aryotes this role is played by a six-protein origin recognition complex (ORC).

227 ein-protein interaction between Sir1 and the origin recognition complex (ORC).

228 Current models suggest that the origin-recognition complex (ORC) and cell-division cycle

229 During loading, Cdc6, Cdt1, and the origin-recognition complex (ORC) assemble two heterohexa

230 the two pre-replicative complex components (origin recognition complex [ORC] and minichromosome main

231 in components of the prereplicative complex (origin recognition complex [ORC], Cdc6, and minichromoso

232 The function of the 'origin recognition complex' (ORC) in eukaryotic cells is

233 the gene encoding the second subunit of the origin recognition complex, ORC, and MCM3, another membe

234 Here, we report that the human origin recognition complex, ORC, can be detected in asso

235 cerevisiae Orc2 protein is a subunit of the origin recognition complex, ORC, which binds in a sequen

236 gest subunit of the Saccharomyces cerevisiae origin recognition complex (Orc1p) functions in transcri

237 of subunit 5 of the Drosophila melanogaster origin recognition complex (Orc5) and have characterized

238 ition correlate with the activity of hamster origin recognition complexes (ORCs) and the appearance o

239 mammalian chromosomes, the time when hamster origin recognition complexes (ORCs) became functional wa

240 The mechanism by which origin recognition complexes (ORCs) identify replication

241 When the quantity of origin recognition complexes (ORCs) on the chromatin was

242 Eukaryotic initiator proteins form origin recognition complexes (ORCs) that bind to replica

243 Here we report that LANA associates with origin recognition complexes (ORCs) when bound to its 17

244 protein (Orc1p), the largest subunit of the origin recognition complex, plays an important role in t

245 In Drosophila, the largest subunit of the origin recognition complex protein 1 (ORC1) is degraded

246 binding patterns of EBNA1 with those of the origin recognition complex protein ORC2, the chromatin b

247 We report the structure of an archaeal origin recognition complex protein, ORC1, bound to an or

248 ised the interaction of the Aeropyrum pernix origin recognition complex proteins (ORC1 and ORC2) with

249 rget sites that in tissue-culture cells bind origin recognition complex proteins and function as repl

250 enetically interacts and coprecipitates with origin recognition complex proteins Orp1/Orc1 and Orp2/O

251 ats (TR), leading to recruitment of cellular origin recognition complex proteins.

252 , and restriction (including subunits of the origin recognition complex, replication factor C protein

253 n turn, suggest the existence of a mammalian origin recognition complex, similar to that found in yea

254 o OriP in vivo as well as for assembling the origin recognition complex subunit 2 (ORC2) and trimethy

255 Antibody to the origin recognition complex subunit 2 (ORC2) recognizes l

256 encodes the Drosophila homolog of the yeast origin recognition complex subunit 2 (Orc2p), a protein

257 onsisting of the meiotic ATPase Pch2 and the origin recognition complex subunit Orc1.

258 We report that the smallest of Drosophila origin recognition complex subunits, Orc6, was found in

259 n an orderly association, beginning with the origin recognition complex, that culminates in the initi

260 ard B2, adjacent to the binding site for the origin recognition complex, the putative initiator prote

261 consisting of a single binding site for the origin recognition complex, the replication initiator pr

262 Strikingly, DUP protein colocalizes with the origin recognition complex to specific sites in the ovar

263 NA gene amplification, is the T. thermophila origin recognition complex (TtORC).

264 We have immunopurified the Xenopus origin recognition complex with anti-Xorc2 antibodies an

265 atin before licensing can occur: the Xenopus origin recognition complex (XORC) [8] [9] and Xenopus Cd