ライフサイエンスコーパス: ortholog

1 t cells lacking ChdC, a Type III CHD protein ortholog.

2 ted to angiosperms with a functional CMT3 or ortholog.

3 ssion and function of the zebrafish myomixer ortholog.

4 Melanogaster Esrp1 ortholog.

5 shares close to 50% identity with its human ortholog.

6 ing TDE1658, a spirochete-specific SurA/PrsA ortholog.

7 f for its identification as the true chicken ortholog.

8 ed redox sensitivity compared with its yeast ortholog.

9 acterization of BB0794 revealed it is a TamB ortholog.

10 served and that fungi contain a viperin-like ortholog.

11 three protein-coding genes across mammalian orthologs.

12 owed us to identify differentially regulated orthologs.

13 cognition by the PHD fingers of Set3 and its orthologs.

14 markedly differential binding to these GusR orthologs.

15 and host protein targets among the NleB/SseK orthologs.

16 nes could replace their essential eukaryotic orthologs.

17 gnificant alterations in 3' end usage across orthologs.

18 assays to characterize holozoan Src and Csk orthologs.

19 egulatory rewiring involving a subset of PRG orthologs.

20 is pattern depends on the expression of both orthologs.

21 veral of the TZPs identified here have human orthologs.

22 (men, chimpanzees) express 15-lipoxygenating orthologs.

23 hila model of GD that lacks the two fly GBA1 orthologs.

24 sion, and identified the corresponding human orthologs.

25 rger Lys and Arg residues in yeast and plant orthologs.

26 We find the complete PRDM9 ortholog across distantly related vertebrates but, despi

27 ycosylation plays an important role in these orthologs, additional sequence and structural determinan

28 Biochemical characterization of orthologs along the phylogenetic lineage from cassava to

29 Hugin neuropeptide, a neuromedin U ortholog, also regulates behavioral rhythms.

30 the expression of a barley (Hordeum vulgare) ortholog and demonstrate that when overexpressed HvEPF1

31 st, AcrIIC3 blocks activity of a single Cas9 ortholog and induces Cas9 dimerization while preventing

32 alassemia-mental Retardation X-linked (ATRX) ortholog and show that ATRX is involved in histone H3 de

33 ave adenosine deaminase acting on RNA (ADAR) orthologs and are believed to lack A-to-I RNA editing, w

34 We extended our studies to human orthologs and found that the exosome as well as TRAMP co

35 Structure-based alignments of CsrR orthologs and other anti-sigma factors identified a CsrR

36 s have been developed to distinguish between orthologs and paralogs and to classify paralogs into sub

37 europeptides, including hypothalamic peptide orthologs and their receptors.

38 of both of the poplar Proline Dehydrogenase orthologs and two of the Flavonol Synthases genes was al

39 helial-specific deletion of miR-322 (miR-424 ortholog) and miR-503 have augmented angiogenic response

40 e dsRNA transport activity of its C. elegans ortholog, and this transport is important for antiviral

41 re highly divergent from their corresponding orthologs, and display an alternative genetic code.

42 Roq1 orthologs appear to be present only in the Nicotiana gen

43 in several model species, we identified its ortholog AqJAG in the lower eudicot species Aquilegia co

44 We found that these earliest-diverged AID orthologs are active cytidine deaminases that exhibit un

45 essed housekeeping genes, 43% of whose human orthologs are also housekeeping genes.

46 We show that eight of nine Drosophila PRG orthologs are expressed in stripes in Dermestes Function

47 GFP localized to the ascus membrane and Amd1 orthologs are only present in ascocarp-forming fungi tha

48 Although Src and Csk orthologs are present across holozoan organisms, includi

49 he odorant-binding protein (OBP) family, and orthologs are present in the genomes of Aedes, Culex, an

50 PIMMS2 orthologs are present in the genomes of all plasmodia an

51 ivity in lower eukaryotes, but the mammalian orthologs are unknown.

52 /C) coactivator genes CDC20 and CCS52B (CDH1 ortholog) are co-expressed with their target cyclin B ge

53 the expression of the highly conserved ARL15 ortholog arl15b, and arl15b knockdown resulted in renal

54 Also, Tyr-insensitive BvADHalpha orthologs arose during the evolution of betalain pigment

55 micutes and Actinobacteria reveals that PspA orthologs associate with non-orthologous regulatory and

56 maf musculoaponeurotic fibrosarcoma oncogene ortholog B (MAFB), matrix metalloproteinase (MMP) 2, and

57 h analogous co-occupancy of PRC1 and a Br140 ortholog, BRD1, at bivalent loci in human embryonic stem

58 Benchmarking Universal Single-Copy Orthologs (BUSCO) analysis showed that the pipeline was

59 Piezo2 is functionally similar to the mouse ortholog but with prolonged inactivation kinetics, parti

60 All spirochetes lack a TamA ortholog, but computational and physicochemical characte

61 could be rescued by the intact human ARPC1B ortholog, but not by the p.V208VfsX20 variant identified

62 es with amino acid sequence identity between orthologs, but varies considerably between the four prot

63 ensitivity can be reengineered in both TRPV1 orthologs by a single amino acid substitution in the N-t

64 here measures genome-wide binding of Tbrain orthologs by using ChIP-sequencing and associates these

65 lly identified EgWRI1-1, one of three EgWRI1 orthologs, by genetic complementation of the Arabidopsis

66 RNA containing 83.0% homology with the mouse ortholog (C130071C03Rik) for a region over 2500 bp in le

67 otein substrates reveal that mammalian FTase orthologs can also prenylate C(x)3X sequences.

68 cidate active-site features that explain how orthologs can generate rigid macrocyclic scaffolds of di

69 Glass bottom boat (Gbb), the Drosophila BMP7 ortholog, can produce distinct ligand forms.

70 type VI systems in order to engineer a Cas13 ortholog capable of robust knockdown and demonstrated RN

71 sophila nephrocytes, deficiency of the Pals1 ortholog caused alterations in slit-diaphragm-like struc

72 mammalian cells, and, importantly, the human ortholog CHD2 physically interacts with TDP-43 and is st

73 Furthermore, unlike the other Cas9 orthologs, CjCas9 contacts the nucleotide sequences in b

74 del with a targeted disruption of the murine ortholog ClC-K2.

75 gether, our findings demonstrate that hidden orthologs comprise a significant proportion of the gene

76 Using the Quest for Orthologs consortium orthology benchmark service, we sho

77 SpArsR orthologs control expression of two MAs(III) resistance

78 However, in comparison with other Csk orthologs, Corallochytrium Csk displays broad substrate

79 amino acid and a potent metal chelator, CAT4 orthologs could be considered as candidate genes for see

80 cues the loss not only of its cyanobacterial ortholog, cycI, in Synechocystis sp. PCC 6803, but also

81 tively from its highly similar S. cerevisiae ortholog Ded1p.

82 its closely related Saccharomyces cerevisiae ortholog Ded1p.

83 mammalian neurons as well as the Drosophila ortholog dNMNAT in motoneurons.

84 Hidden orthologs do not show unusual sequence composition biase

85 in studying this receptor is that the mouse ortholog does not have significant affinity for antagoni

86 R in part by activating the mammalian Msn2/4 ortholog early growth response protein 1 (EGR1).

87 e translation factor eIF5A and its bacterial ortholog EF-P bind in the E site of the ribosome where t

88 losely related virus SIVmac316 uses both CD4 orthologs equally well.

89 een the MBNL1/2 ortholog mbl-1 and the ELAVL ortholog exc-7, double mutants displayed a severely shor

90 tions of sucrose, respectively, and no clear orthologs exist in tomato.

91 No functional ortholog for any ERMES protein has been identified in me

92 ACV mutant that had A6 replaced with a close ortholog from the Yaba-like disease virus YLDV-97 also f

93 Our phylogenetic analysis of 37 GET3 orthologs from 18 different species revealed the presenc

94 The two Cpf1 orthologs from Acidaminococcus sp. (AsCpf1) and Lachnosp

95 This catalytic profile is not conserved; orthologs from Arabidopsis thaliana and Saccharomyces ce

96 enic hairy roots, we show that RDN1 and RDN2 orthologs from dicots as well as a related RDN gene from

97 placed essential genes in yeast by their 1:1 orthologs from Escherichia coli.

98 Here, we identify PRDM9 orthologs from genome and transcriptome data in 225 spec

99 Structures of putative GusR orthologs from GUS-encoding Firmicutes species also reve

100 tionarily conserved mechanism whereby HopAF1 orthologs from multiple plant pathogens contribute to di

101 We further demonstrate EptA orthologs from non-cholerae Vibrio species are functiona

102 ing, we now show that the ectodomain of HAP2 orthologs from Tetrahymena thermophila and other species

103 the C. elegans M2 muscarinic receptor (m2R) ortholog, GAR-2.

104 derm formation but the role of the zebrafish ortholog, Growth differentiation factor 3 (Gdf3), has no

105 Here, we report that two putative NEF orthologs, GrpE-like 1 (GrpEL1) and GrpEL2, modulate mtH

106 - arginine variation between human and mouse orthologs had limited effect on G protein-mediated signa

107 e glycoproteins to bind or utilize these CD4 orthologs has not been reported.

108 BB0405 orthologs have also been shown to bind the complement re

109 Dozens of strategies for predicting orthologs have been developed using combinations of gene

110 ation of chemotaxis by c-di-GMP through MapZ orthologs/homologs is widespread in proteobacteria and t

111 ith MDS to interrogate the role of the yeast ortholog, Hsh155, in BS selection and splicing.

112 ownstream expression of the alpha-crystallin ortholog HSP-16.48 Using a combination of pharmacology,

113 like rice in comparison with its Arabidopsis ortholog, HY5.

114 complement of an organism consists of hidden orthologs, i.e., those with no apparent homology to sequ

115 as surrogates for expression of translocator orthologs identified from an extensive phylogenetic anal

116 ing', have known RNA-binding domains or have orthologs identified in mammals, C. elegans, or S. cerev

117 The closest Pic2 ortholog in mammalian cells is the mitochondrial phospha

118 racterize ODDSOC2, a recently identified FLC ortholog in monocots, knowing that it belongs to the FLC

119 lation between the number of putative hidden orthologs in a lineage and its "average" evolutionary ra

120 , Clade 1 contained 12 genes whose predicted orthologs in Arabidopsis have been reported as key durin

121 onary distances and identify putative hidden orthologs in large transcriptomic databases by transitiv

122 native proteins translated from altORFs have orthologs in many species and contain functional domains

123 Overexpression of Rv3802 orthologs in Mycobacterium smegmatis and Corynebacterium

124 Nonsyntenic genes that lack syntenic orthologs in other grass species, and thus evolved late

125 hese protein families revealed they all have orthologs in other phytopathogenic or symbiotic bacteria

126 We report that MC005, which has no orthologs in other poxvirus genomes, is a novel inhibito

127 We also identify myomixer orthologs in other species of fish and reptiles, which c

128 Here we defined PF orthologs in Pseudomonas aeruginosa, Moraxella catarrhal

129 D structure of FlgK differs from that of its orthologs in Salmonella and Burkholderia, whose structur

130 niquine therapy despite the presence of SULT orthologs in Schistosoma hematobium and Schistosoma japo

131 discovered that RAMPs and GPCRs tend to have orthologs in the same species and have correlated phylog

132 e paralogous loci encode maize CRABS CLAW co-orthologs in the YABBY family of transcriptional regulat

133 cations) and between Arabidopsis and soybean orthologs in this single plant cell type.

134 res may be more important substrates for Gen orthologs in vivo, and highlight the utility of using th

135 33 and its splice variant TaAGL22 as the FLC orthologs in wheat (Triticum aestivum) behaving most sim

136 Downregulation of INPP5K orthologs in zebrafish embryos disrupted muscle fiber mo

137 There are three Nodal orthologs in zebrafish; southpaw directs left-right asym

138 juni Cas9 (CjCas9), one of the smallest Cas9 orthologs, in complex with an sgRNA and its target DNA.

139 PP4 support MERS-CoV infection, several DPP4 orthologs, including mouse, ferret, hamster, and guinea

140 ast two independent rewiring events for PUF3 orthologs, independent but convergent evolution of PUF4/

141 and their Arabidopsis thaliana (Arabidopsis) orthologs indicated that they can be classified into 23

142 ong conservation of the RXG motif among NgBR orthologs indicates that this subunit is critical for th

143 In S. cerevisiae, less Pho2-dependent Pho4 orthologs induce more genes.

144 Consistently, suppression of the zebrafish ortholog induced an increase of proliferation and macroc

145 synteny is likely to improve the quality of ortholog inference.

146 ion scores are elevated in genes whose human orthologs interact with HIV and in genes that show a res

147 Recently, a new RBP-J (mammalian CSL ortholog)-interacting protein termed RITA has been ident

148 ration induced by loss of the sole fly Nmnat ortholog is also fully blocked by axed, but not dsarm, m

149 Its human ortholog is linked to type 2 spinocerebellar ataxia and

150 ated chaperone activity of the two zebrafish orthologs is critical for lens development.

151 ino acid sequence divergence among these AID orthologs is predicted to manifest as notable structural

152 n 1, present in human and sooty mangabey CD4 orthologs, largely restored rhCD4-Ig neutralization of S

153 aternary structure compared with that of its ortholog LecA from Pseudomonas aeruginosa We also invest

154 For one interaction between the MBNL1/2 ortholog mbl-1 and the ELAVL ortholog exc-7, double muta

155 at increased levels of the C. elegans Gemin3 ortholog, MEL-46, ameliorates these defects.

156 t Mx1 genes cluster closely with their human ortholog MxA.

157 The Paspalum BT068773 predicted ortholog (N13TAR) originates floral transcript variants

158 lla enterica strains encode up to three NleB orthologs named SseK1, SseK2, and SseK3.

159 cause insulin resistance, we examined murine ortholog Nat1 knockout (KO) mice.

160 relationship between miR-1 and the mammalian ortholog Nedd4-like (Nedd4l) is evolutionarily conserved

161 1A2, but not OATP1B1 or OATP1B3, and the rat ortholog Oatp1a4 were capable of significant doxorubicin

162 anscript coding for AtCPSF30, an Arabidopsis ortholog of 30 kDa subunit of the Cleavage and Polyadeny

163 nd characterized Early flowering3 (Efl3), an ortholog of Arabidopsis (Arabidopsis thaliana) EARLY FLO

164 We found that LFS encodes the single tomato ortholog of Arabidopsis DORNRONSCHEN (DRN) and DRN-like

165 An analysis of the human ortholog of Arf6 and orthologs of Efa6 (PSD1-4) revealed

166 sesses a vertebrate-like CRY (dpCRY2) and an ortholog of BMAL1, to show that insect CRY2 regulates ci

167 Fs(1)h is a TrxG member and the ortholog of BRD4, a bromodomain protein that binds to ac

168 The cov-3 locus encodes the O. tipulae ortholog of C. elegans mig-13, and we further show that

169 stribution of promoter activity of the mouse ortholog of C9orf72 in the central nervous system.

170 UBC-3 is the ortholog of CDC34 that functions specifically with Culli

171 neuropeptide diuretic hormone 44 (DH44), an ortholog of corticotropin-releasing factor.

172 reatment, tribbles pseudokinase 3 (Trib3, an ortholog of Drosophila Tribbles) is up-regulated in neur

173 BERRANT LATERAL ROOT FORMATION4 (ALF4) is an ortholog of GLMN The alf4 mutant exhibits a phenotype th

174 -1, which encodes the Caenorhabditis elegans ortholog of HCS.

175 e defined polymorphism of Papa-B, the bonobo ortholog of HLA-B, for six wild bonobo populations.

176 enes in DNA damage response: C34F6.1, him-3 (ortholog of HORMAD1, HORMAD2), sdc-1, and set-2 (ortholo

177 n part to increased expression of the murine ortholog of human chymase.

178 dation of Mrc1, the Saccharomyces cerevisiae ortholog of human Claspin, is facilitated by the SCFDia2

179 Because mice do not have a clear ortholog of IFI16, this system is not suitable for genet

180 Here, we show that Tomt/Comt2, the murine ortholog of LRTOMT, has an unexpected function in the re

181 The mechanisms by which AHR2 (functional ortholog of mammalian AHR) activation leads to reduced s

182 erevisiae DNA damage-responsive kinase Tel1 (ortholog of mammalian ATM).

183 s were recruited to chromosomes by Zip3, the ortholog of mammalian E3 ligase RNF212, and SC protein Z

184 he C. elegans transcription factor ETS-5, an ortholog of mammalian FEV/Pet1, controls satiety-induced

185 A screen identified pasilla, the fly ortholog of mammalian Nova-1/2, as a mediator of Orb2A m

186 ce that overexpression of miR-183, the human ortholog of miR-263a, can also directly target the expre

187 -1 gene of Caenorhabditis elegans encodes an ortholog of neutral cholesterol ester hydrolase 1 (NCEH-

188 firmed that Arabidopsis TGS1 is a functional ortholog of other trimethylguanosine synthases based bot

189 Strikingly, taxa carrying the complete ortholog of PRDM9 are precisely those with rapid evoluti

190 olog of HORMAD1, HORMAD2), sdc-1, and set-2 (ortholog of SETD1A, SETD1B, KMT2C, KMT2D), validating th

191 oup at the R3' position, and congruently, an ortholog of SlASAT3, which catalyzes acylation at the R3

192 nal role of SOX5, we silenced the Drosophila ortholog of SOX5, Sox102F, by RNAi in various neuronal s

193 present crystal structures of SuiB, a close ortholog of StrB, in various forms, including apo SuiB,

194 We present evidence that Drk, the Drosophila ortholog of the adaptor protein Grb2, is essential for A

195 tation assay revealed that SlCBL10 is a true ortholog of the Arabidopsis (Arabidopsis thaliana) CBL10

196 Llgl1 (Nestin-Cre/Llgl1(fl/fl)), a mammalian ortholog of the Drosophila cell polarity gene lgl, exhib

197 ian Ecdysoneless (ECD) is a highly conserved ortholog of the DrosophilaEcd gene product whose mutatio

198 (bHLH) transcription factor HLH-2, the sole ortholog of the E proteins mammalian E2A and Drosophila

199 of swip-13, which encodes a highly conserved ortholog of the human atypical MAP kinase ERK8.

200 ranscriptional down-regulation of nhr-49 (an ortholog of the human peroxisome proliferator-activated

201 n IL-36beta mRNA was isoform 2, which is the ortholog of the known mouse IL-36beta mRNA.

202 galactan length variation, a C. diphtheriae ortholog of the M. tuberculosis carbohydrate polymerase

203 Drosophila gp93 was identified as the ortholog of the mammalian endoplasmic reticulum-resident

204 Eros is an ortholog of the plant protein Ycf4, which is necessary f

205 paired 2 (Upd2), a structural and functional ortholog of the primary human adipokine leptin, is relea

206 ternative strategies to counteract the human ortholog of the restriction factor tetherin.

207 Unexpectedly, the transcription factor is an ortholog of the stomatal regulator AtMUTE, which defines

208 egalovirus opening reading frame UL144 is an ortholog of the TNF receptor superfamily member, herpesv

209 Our work unmasks Ac45 as the functional ortholog of yeast V-ATPase assembly factor Voa1 and reve

210 Orthologs of 112 of the Ciona notochord genes have known

211 2-like and StCASP1-like genes, which are two orthologs of a protein family that mediates the formatio

212 cause only chimpanzee and bonobo have strict orthologs of all HLA class I, their study gives unique p

213 ), have recently been shown to correspond to orthologs of Arabidopsis (Arabidopsis thaliana) circadia

214 These cells expressed orthologs of astrocyte-associated genes involved in neur

215 Vertebrates express two orthologs of Eco1, called Esco1 and Esco2, both of which

216 n analysis of the human ortholog of Arf6 and orthologs of Efa6 (PSD1-4) revealed that the minor G all

217 (shRNAs) corresponding to the Aedes aegypti orthologs of fasciculation and elongation protein zeta 2

218 nse or loss-of-function DNMs showed that the orthologs of four genes (DENND3, NCLN, NUP98, and TBATA)

219 Here, we show that the Plasmodium yoelii orthologs of four Plasmodium falciparum proteins identif

220 ing of elongation and segment formation; and orthologs of ftz, ftz-f1, h and opa show more variable f

221 functions with the Sgs1 and Mph1 helicases (orthologs of human BLM and FANCM, respectively) in the r

222 galovirus encodes 2 viral cytokines that are orthologs of human cellular interleukin 10 (cIL-10).

223 functional read-out, we screened Drosophila orthologs of human monogenic causes of nephrotic syndrom

224 Finally, orthologs of Lef1-dependent genes from both zebrafish an

225 alog genes, H03-IPSE and H06-IPSE, which are orthologs of M-IPSE, from egg cDNA of S. haematobium Usi

226 PU.1 levels affected the expression of mouse orthologs of many AD risk genes and the phagocytic activ

227 SbcC-SbcD are the bacterial orthologs of Mre11-Rad50, a nuclease complex essential f

228 Finally, orthologs of nearly 50% of candidate MS risk genes and 4

229 jirovecii and Pneumocystis carinii Potential orthologs of Pca1 have been identified in P. jirovecii S

230 re, we demonstrate that silencing C. elegans orthologs of PD-related genes also increases the accumul

231 ound light-regulated genes that are putative orthologs of PIF-controlled genes in Arabidopsis.

232 sis we first cloned and characterized ALOX15 orthologs of selected Catarrhini representing different

233 tromal fibroblast-specific deletion of mouse orthologs of several candidates resulted in the hyper-pr

234 Closely related orthologs of Ssl2245 and Sll1130 exist in widely differe

235 nin is thus a highly important target for PF orthologs of the bacterial species examined.

236 found to interact with brc-1 and brd-1, the orthologs of the human breast cancer genes BRCA1 and BAR

237 that two Drosophila slit diaphragm proteins, orthologs of the human genes encoding nephrin and nephri

238 Furthermore, we identify potential orthologs of the key toolbox genes in a hornwort, furthe

239 anscriptional regulators and are adjacent to orthologs of the mmpS5-mmpL5 drug efflux operon.

240 and angiogenin (ANG), showed that the human orthologs of the yeast toxicity modifiers of these ALS g

241 extant lineages to possess stomata, possess orthologs of these Arabidopsis (Arabidopsis thaliana) st

242 B cell development in zebrafish, we isolated orthologs of these genes and performed in situ hybridiza

243 rated antibodies against the human and mouse orthologs of THSD7A in rabbits by coimmunization with th

244 Ago1 and Ago2, including 12 new miRNAs, the orthologs of which are found thus far only in other Anop

245 s-but actually representing rapidly evolving orthologs or undetected paralogs.

246 for the function of Cdc48 and its mammalian ortholog p97/VCP.

247 uence homology (48.2%-77.3% similarity), all orthologs (Paf, AfeA, and MntC) interacted with laminin.

248 The two PKC orthologs Pck1 and Pck2 in the fission yeast Schizosacch

249 Compared with their bacterial orthologs, plant UreGs possess an N-terminal extension c

250 bulin complement-related (Mcr), a complement ortholog, plays an essential role during developmental c

251 Phytophthora species, and the P. parasitica orthologs PpXEG1 and PpXLP1 have similar functions.

252 Ortholog prediction and synteny visualization across who

253 Median CPU time for ortholog prediction per gene by OrthoReD executed on a d

254 etter understand this role, the two GlsA/ZFR orthologs present in the genome of Arabidopsis thaliana

255 The Quest for Orthologs (QfO) is an open collaboration framework for e

256 with reduced growth in pep1-1 Therefore, FLC orthologs regulate a set of conserved target genes mainl

257 but the physiological role of SID-1 and its orthologs remains unclear.

258 ltiple sequence alignments, a set of 'index' orthologs representing the most well-conserved members o

259 MPK1 and MPK6 (Arabidopsis AtMPK6 and AtMPK4 orthologs, respectively) as essential genes for rice dev

260 We identify a functional EptA ortholog responsible for the transfer of the amino-resid

261 Disruption of the mouse ortholog results in microcephaly underlain by reduced pr

262 Deficiency of its mouse ortholog results in widespread hypomyelination in the br

263 equence comparison of these diverse myomixer orthologs reveals key amino acid residues and a minimal

264 imilarly, elevated amounts of the Drosophila ortholog RhoBTB in vivo were associated with seizure sus

265 d to fly Trithorax, including two yeast Set1 orthologs: Setd1a and Setd1b.

266 l fish carrying only a partial but conserved ortholog share recombination properties with PRDM9 knock

267 osensitivities, and structural features, all orthologs share the unusually high DNA binding affinitie

268 o complement yeast strains lacking the EEF1A ortholog showing a major growth defect.

269 Here, we show that the mammalian SID-1 ortholog, SIDT2, is required to transport internalized e

270 ved 2)-like 2 and its Caenorhabditis elegans ortholog, SKN-1, are transcription factors that have a p

271 Loss of the C. elegans SMN ortholog, SMN-1, causes NMJ defects.

272 orm lineages to recover 3427 putative hidden orthologs, some unidentified by OrthoFinder and HaMStR,

273 eplaceable by its bacterial, human, or plant ortholog, suggesting it as a near-universally swappable

274 ted silencing of the Trypanosoma brucei SODA ortholog suggests that SODA is essential for trypanosoma

275 Using the Drosophila TDP-43 ortholog TBPH, we previously showed that TBPH-null anima

276 ssion rhythms and identify PPD as an ELF3 co-ortholog, termed ELF3b Genetic interactions between pea

277 ilis, and B. subtilis encodes the first EF-P ortholog that retains function in the absence of modific

278 ficiency, and identified several Inv/Mxi-Spa orthologs that can functionally substitute for the S.

279 d soybean (Glycine max) CDPKbeta are RcCDPK1 orthologs that effectively phosphorylated castor BTPC at

280 satellites can specifically regulate an ATG8 ortholog, the centrosomal GABARAP reservoir, and centros

281 and accumulated destructive mutations in Ms2 orthologs, the Ms2 allele in the ms2 mutant has acquired

282 vents DNA cutting by multiple divergent Cas9 orthologs through direct binding to the conserved HNH ca

283 Knockdown of the THSD7A ortholog, thsd7aa, in zebrafish larvae resulted in alter

284 RFamide-related peptide-3 [RFRP-3; mammalian ortholog to gonadotropin-inhibitory hormone (GnIH)] in n

285 DEGs specific in nod+ genotypes included orthologs to some known symbiotic signaling pathway gene

286 Using the C. elegans Munc13 ortholog UNC-13, we show that deletion of the C2B domain

287 Furthermore, a 33-gene signature of human orthologs was selectively enriched in the tumor stroma o

288 Unlike the human ortholog, we show that yeast Usb1 has cyclic phosphodies

289 onserved residues from a diverse set of BAM2 orthologs were mapped onto a homology model of the prote

290 We studied 69 genes whose C. elegans orthologs were neuronal signalling genes with significan

291 ssion of the glial nexin Serpine2, the human ortholog, which was increased in advanced human colorect

292 The screen identified 16 genes with human orthologs whose knockdown reduced hypercapnic suppressio

293 e virus-receptor interactions for these DPP4 orthologs will help in the development of additional ani

294 To date, all identified ArsM orthologs with As(III) methylation activities have four

295 actrian camels (Camelus ferus) express TRPV1 orthologs with dramatically reduced temperature sensitiv

296 lethal growth defect and replace their yeast orthologs with minimal effects on growth rate.

297 monstrate that most fungal species have ArsM orthologs with only three conserved cysteine residues.

298 y using ChIP-sequencing and associates these orthologs with putative target genes to assess global fu

299 both these gene sets, and conserved in SARD1 orthologs within the Brassicaceae.

300 The occurrence of ExAD orthologs within the Viridiplantae along with its' produ

301 the inflammasome, including caspase b, NLRC3 ortholog (wu: fb15h11) and il1beta.