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   7 et of gene families to allow traversal among orthologous and paralogous sequences across the legumes.
     8 eoxy-d-glucose (2DG) on ADPKD progression in orthologous and slowly progressive murine models created
     9 RH-type and the protostomian AKH systems are orthologous and the origin of a paralogous CRZ-type sign
  
  
  
    13  structure of the equivalent region from the orthologous barley powdery mildew resistance protein, ML
    14     Human and mouse genomes contain pairs of orthologous bitter receptor genes that have been conserv
  
    16 Moreover, we have demonstrated that sequence-orthologous bitter taste receptors have distinct agonist
  
  
    19 3B predicted genes are non-syntenic with the orthologous chromosomes of Brachypodium distachyon, Oryz
    20  incompatibility, or 'unintelligibility', of orthologous cis-regulatory sequences between Molgula and
  
    22 i, plants and bacteria for the comparison of orthologous clusters and also supports uploading of cust
  
  
  
  
  
    28 nerability in Ewing sarcoma cells, providing orthologous confirmation of the chemical screen findings
    29 se morpholino oligonucleotides to target the orthologous Danio rerio gene, dlx4b, and found reduced c
    30  of conditionally degradable or stabilisable orthologous dCas9 or Cpf1 effector proteins, thus openin
  
  
    33 e and conservation of surface residues among orthologous domains, we mapped the BMP-binding epitope o
    34 racterized OCR-4 TRPV subunit as well as the orthologous Drosophila Nan-Iav TRPV channel, and we exam
  
    36 ssays to show that transport activity of the orthologous endosomal NHE Nhx1 is important for multives
  
  
    39 in which Fzd8 expression is under control of orthologous enhancers (Pt-HARE5::Fzd8 and Hs-HARE5::Fzd8
    40     (2) Enhancer in-vivo activity, revealing orthologous enhancers with conserved activity despite di
    41  per neutral site), identifying thousands of orthologous enhancers with conserved or diverged combina
    42 ble to genetic variation within TF motifs at orthologous enhancers, with a novel motif being most pre
  
    44 opment in the mouse, a species that exhibits orthologous epigenetic silencing of paternal Ube3a in ne
  
    46 notype in mice that are heterozygous for the orthologous factor, impeding the study of complex phenot
    47 ctional annotation of gene models identified orthologous families for the majority ( approximately 73
    48 omallei FliC epitope also cross-reacted with orthologous FliC sequences from Burkholderia multivorans
  
    50 ional changes led to a reduced expression of orthologous functions between the coexisting species.   
  
    52 lly, while the mammalian genome contains two orthologous Gcm genes, their function has been demonstra
  
    54 ximum likelihood phylogenetic trees for each orthologous gene and corresponding 16S rRNA reference sp
  
  
  
  
    59 osotalea genomes contained a core set of 103 orthologous gene families absent from all other ammonia-
    60  lifestyle led to the simplification of many orthologous gene families involved in the saprophytic tr
    61 s database represents a comprehensive set of orthologous gene families shared across multiple complet
    62 ome that is caused by point mutations in the orthologous gene in humans, and the AID(R112H) mutation 
  
    64 benzenoid II [FaEOBII]) that seems to be the orthologous gene of PhEOBII from Petunia hybrida, which 
  
    66 n this syndrome, knockdowns of the zebrafish orthologous gene resulted in embryos with hydrocephaly a
  
  
    69  We generated a knockout yeast model for the orthologous gene that showed a defect in respiration and
  
    71 e identification of functionally equivalent, orthologous genes (functional orthologs) across genomes 
  
    73 MCL method identified 11,362 and 8,174 1:1:1 orthologous genes (one ortholog is represented in each o
    74 ed the expression dynamics of the conserved, orthologous genes (orthologs), seeing the degree to whic
  
  
    77     Frequently, for one query gene, multiple orthologous genes are predicted in the other genome, and
    78 ith a sequenced genome, the need to identify orthologous genes between them has emerged as a central 
  
    80 tronger and more confident identification of orthologous genes encoding isatin hydrolases within the 
    81 patterns across a wide range of tissues with orthologous genes from a pre-Ss4R outgroup unexpectedly 
  
    83 ypic consequences of loss of function of the orthologous genes in mice and medaka fish and further ex
  
  
    86  non-coding motifs associated with groups of orthologous genes in Steinernema and Caenorhabditis invo
    87 coding regulatory motifs are associated with orthologous genes in Steinernema and Caenorhabditis.    
    88 itis elegans, knockout of uba-5 and of human orthologous genes in the UFM1 cascade alter cholinergic,
    89 restricted to the core genome; however, some orthologous genes in these strains exhibit differential 
    90 ate the data from the promoters of conserved orthologous genes in three or more species was developed
  
    92 alian immune cells, a subset of which are in orthologous genes of mouse and human, suggests a conserv
  
    94 blished knockouts of the fruit fly and mouse orthologous genes resulted in lethality or severe neurol
    95 (fl/fl) mammary carcinomas and comparison of orthologous genes with a human metaplastic carcinoma sig
  
    97 d data, in particular ATGC-COGs (Clusters of Orthologous Genes), multiple sequence alignments, a set 
    98 l mouse embryos maintained the expression of orthologous genes, and blastocyst development was establ
    99 between the physiological roles of seemingly orthologous genes, as xylem loading depends on SKOR and 
   100 ged through differences in the regulation of orthologous genes, the formation of new genes by gene du
  
  
  
  
  
   106 e a more scalable procedure for hierarchical orthologous group (HOG) clustering, which are several or
  
  
   109 c domains of CheA and chemoreceptors from an orthologous group exemplified by the Salmonella McpC pro
   110 hese families, classified within clusters of orthologous groups (COG) 1900, possesses two conserved c
   111 pVOGs are constructed within the Clusters of Orthologous Groups (COGs) framework that is widely used 
   112 y-based term classification (GO), EuKaryotic Orthologous Groups (KOG) and Kyoto Encyclopedia of Genes
   113 Nr), Gene Ontology database (GO), eukaryotic orthologous groups (KOGs) and Kyoto Encyclopedia of Gene
   114    eggNOG is a public resource that provides Orthologous Groups (OGs) of proteins at different taxono
  
  
  
   118 l of this study was to set up a framework of orthologous groups determined by an expert sequence comp
  
   120 Arabidopsis lyrata, approximately 70% of the orthologous groups experienced gene losses in R. raphani
  
  
  
   124 rt NAC sequence comparison, we propose forty orthologous groups of NAC sequences that were probably d
  
  
   127  in the individual genomes into hierarchical orthologous groups reveals a high-resolution picture of 
   128 hologs; (v) statically computed hierarchical orthologous groups subsets downloadable in OrthoXML form
  
   130  as Protein families database or Clusters of orthologous groups thus extending its applications to fu
   131    Users can access the complete database of orthologous groups via a web interface, as well as throu
   132 cording to KOG (The annotation of Eukaryotic Orthologous Groups) and KO (KEGG Orthology) in addition 
   133 ologous Groups (pVOGs, formerly called Phage Orthologous Groups, POGs) resource has aided in this tas
  
  
   136 eletion of STI1 in yeast or knockdown of the orthologous Hop cochaperone in plants leads to increased
   137 se in CIRV replication, and knockdown of the orthologous Hop cochaperone in plants results in a 3-fol
   138 cting mouse TF genes have been maintained in orthologous human cell types through evolutionary innova
   139 EER-associated genes contained an EER in the orthologous human gene, although nucleotide sequence and
   140  structure of zebrafish duplicates to the co-orthologous human gene, we have demonstrated that a cons
   141 enous H19/Igf2 ICR (mIC1) is replaced by the orthologous human ICR (hIC1) sequence, designated H19(hI
   142 selection hypothesis, we find that diverged, orthologous IDRs can mostly recapitulate wild-type funct
   143 bilizing selection, the functional output of orthologous IDRs could be maintained, such that diverse 
   144 ep, modelling the proteins, chemicals, their orthologous in other species and their composition in co
   145 st proliferation and PKD progression in four orthologous, including two long-lived, mouse models of A
   146 h Yap1, a Yorkie homolog, in human cells, an orthologous interaction was not detected in Drosophila c
   147 egree to which these can be accounted for by orthologous (internal) versus species-specific (external
  
   149 tron groups of dicotyledonous plants, 28,519 orthologous intron groups of angiosperms, and 15,726 of 
   150 ive plants we generated a database of 40,512 orthologous intron groups of dicotyledonous plants, 28,5
  
  
   153 e found that humans and rhesus macaques used orthologous lambda variable gene segments encoding a glu
  
  
   156 espite changes in its gene content, a single orthologous locus (MAT/MTL) has controlled cell type thr
  
   158  (FLC) and PERPETUAL FLOWERING 1 (PEP1), two orthologous MADS-box TFs that repress flowering and conf
  
  
  
  
   163     Microorganisms often encode multiple non-orthologous metabolic modules that catalyze the same rea
  
   165    Polycystic kidneys of Pkd2WS25/- mice, an orthologous model of human ADPKD caused by a mutation in
  
  
   168 of individual cis-regulatory regions, within orthologous mouse and human cell types the global fracti
  
   170 iliary gene expression was also perturbed in orthologous mouse models, raising the possibility that c
   171  Poly(A)-tail lengths were conserved between orthologous mRNAs, with mRNAs encoding ribosomal protein
  
  
  
   175 ion through inhibiting histone demethylases, orthologous mutations to those known to cause accumulati
   176 icient to distinguish previously unknown and orthologous neuronal subtypes as well as regional identi
  
   178 defective (Pkhd1(del4/del4)) mouse, which is orthologous of CHF, we show that Pkhd1(del4/del4) cholan
   179 sadB gene is located in an operon with sadA; orthologous operons are only found in enterobacteria, wh
   180 s many different OPR proteins, only a single orthologous OPR protein is encoded in the genomes of mos
  
   182   Mouse stx promotes degradation of Cbx4, an orthologous Pc protein, in vertebrate cells and induces 
  
   184 acterization and difficulties in identifying orthologous phenotypes and cell types, which are beginni
   185 ed in a child with Brugada syndrome into the orthologous position (E558X) in the pig SCN5A gene.     
   186 onditional expression of Myd88(p.L252P) (the orthologous position of the human MYD88(p.L265P) mutatio
  
   188 -BART-18 precursor miRNA (pre-miRNA) and the orthologous pre-miRNA from Rhesus lymphocryptovirus cont
  
   190 n divergence and functional turnover between orthologous promoters, finding only the latter is associ
  
   192 lete conservation of the IE62 epitope in the orthologous protein ICP4 of HSV-1 and HSV-2, the TCC rec
   193 lgae, the serine/threonine kinase STN7/STT7, orthologous protein kinases in Chlamydomonas reinhardtii
   194 ast and metazoans, and a family of conserved orthologous protein O-mannosyltransferases is believed t
   195 cans, deep sequencing of mutants lacking the orthologous protein, Zfs1, revealed significant increase
   196 ligonucleotide composition-based analysis of orthologous proteins (n = 791) across three genomes reve
   197 s of animal cells, involving the activity of orthologous proteins [10, 11], we anticipate that our re
  
   199 the information of subcellular localization, orthologous proteins and PPI networks, we propose a nove
  
  
  
   203 e estimated scores can be used for detecting orthologous proteins in conserved functional modules thr
   204  To do this, we tagged with the same epitope orthologous proteins in Saccharomyces cerevisiae and Can
   205 ere strongly connected through essential and orthologous proteins in their immediate network vicinity
   206 ding on the cellular and organismal context, orthologous proteins may exert both overlapping and oppo
   207 exhibited limited sequence homology with the orthologous proteins of other emaraviruses, while protei
   208 up users' search of detailed information for orthologous proteins related to secretion systems of the
   209 we call delta-bitscore (DBS) for identifying orthologous proteins that have diverged at the amino aci
  
   211 the information of subcellular localization, orthologous proteins with PPI networks, the accuracy of 
   212 ng the steady-state network Flow to IDentify orthologous proteins) framework combined with an efficie
  
   214  and apply it to a proof-of-concept study of orthologous proteomes in an investigation of host adapta
   215 thesized that the introduction of the murine orthologous Ptpn22(R619W) mutation to the NOD genome wou
   216 -genetic responses are largely distinct from orthologous published profiles of Saccharomyces cerevisi
   217 omoter region of the human SLICK (KCNT2) and orthologous rat Slick (Kcnt2) genes, suggesting that con
  
  
   220  was generated by hemizygous deletion of the orthologous region and characterized with focus on schiz
   221 bryonic craniofacial tissues showed that the orthologous region in mice exhibits Satb2 expression-dep
  
  
   224 d transgenic PML-RARA APL mouse model at the orthologous region on chromosome 12, including the CTCF 
   225 tion spanning the entire human chromosome 21 orthologous region on mouse chromosome 16 [Dp(16)1Yey] a
  
  
   228 veals that PspA orthologs associate with non-orthologous regulatory and effector proteins retaining f
   229 y networks are remarkably conserved and that orthologous regulatory factor families recognize similar
  
   231  in P. axillaris Furthermore, where putative orthologous relationships of ASATs are predicted between
  
  
  
  
  
   237 ficiently delete and replace the L2-CRM with orthologous sequences from other divergent fly species. 
   238  gene ontology, protein tertiary structures, orthologous sequences, kinase/phosphatase classification
  
  
   241 of this phosphorylation mark by mutating the orthologous site of CAP-D3 (CAP-D3(T1403A)) in chicken D
   242 uman genome or exhibit no p63 binding in the orthologous syntenic regions, typifying an occupancy los
   243 roteobacterium Caulobacter crescentus and an orthologous system from an obligate intracellular (ricke
   244 us virus genes have been coopted, forming an orthologous tandem gene family that has been maintained 
  
   246 nsively mapped binding sites for 26 pairs of orthologous TFs in two pairs of human and mouse cell lin
   247  which orthologous DNA segments are bound by orthologous TFs varies both among TFs and with genomic l
   248 between Drosophila and mammals, and that for orthologous TFs, the similarity extends even to the leve
  
   250 tion of Hordeum vulgare VIVIPAROUS1 (HvVP1), orthologous to ABA-INSENSITIVE3 from Arabidopsis thalian
  
   252 at these bHLH transcription factor genes are orthologous to Arabidopsis (Arabidopsis thaliana) SPEECH
  
  
  
  
   257  illustrated that most goldfish markers were orthologous to genes in common carp, which had four roun
  
   259 We show that the yeast Rim15-Igo1,2 pathway, orthologous to Gwl-Arpp19/ENSA, is up-regulated in early
  
   261  that germline triplication of only 31 genes orthologous to human chromosome 21q22 confers mouse prog
  
   263 acterized two genes, PPRD1 and -2, which are orthologous to human SRD5A3 (steroid 5alpha reductase ty
  
  
   266 tudy, the FGK3 glycogen synthase kinase gene orthologous to mammalian GSK3 was identified as an impor
  
   268 ocus that conditions flower and seed colors, orthologous to Mendel's A gene of garden pea, whose loss
   269 As during soybean seed development and mRNAs orthologous to MUTE, FAMA, and inducer of C-repeat/dehyd
   270 as well as with a set of O. glaberrima genes orthologous to O. sativa genes that are known to be asso
   271 mutation in TP53 (which encodes p53) that is orthologous to one commonly found in humans (R175H in pe
   272 ns affected conserved residues, and R291Q is orthologous to R294, which is mutated in the BXH2 IRF8-d
   273 and C-terminal domains (TprC(N) and TprC(C)) orthologous to regions in the major outer sheath protein
   274  and Br140, another bromodomain protein, are orthologous to subunits of a mammalian MOZ/MORF acetyltr
   275 tein denoted PPR53 (GRMZM2G438524), which is orthologous to the Arabidopsis protein SOT1 (AT5G46580).
  
  
  
  
   280 ied alphaTC1/betaTC6 cis-regulatory elements orthologous to those containing type 2 diabetes (T2D)-as
   281 ointed out that DRPs of chlorophytes are not orthologous to those of embryophytes: some of them were 
   282 SCRM1) in the moss Physcomitrella patens are orthologous to transcriptional regulators of stomatal de
   283 illi and cilia and express proteins that are orthologous to transporters in microvillar and ciliary o
   284 rpholinos against N-terminal zebrafish Ahi1, orthologous to where human mutations cluster, produced a
  
  
   287 isms, we generated occupancy profiles for 34 orthologous transcription factors (TFs) in human-mouse e
   288 lincRNAs expressed in these tissues, we find orthologous transcripts for 80% in chimpanzee, 63% in rh
  
   290  5'ss and 3'ss sequences from the well-known orthologous U12-type spliceosomal intron database U12DB.
   291 hole-genome duplications, and the concept of orthologous versus paralogous relationships at different
   292    ATP1B4 genes represent a rare instance of orthologous vertebrate gene co-option that radically cha
   293 lution of repeats within proteins with their orthologous (vertical) evolution through speciation.    
   294  and vesicular components, identification of orthologous vesicular components, bioinformatic tools an
   295 the vipp1 mutation was complemented with the orthologous vipp1 gene from Synechocystis sp. PCC 6803 t
   296 l characterization of functionally important orthologous viral proteins can be used to complement phy
   297     The chromosomal regions across the human orthologous were interrogated for putative periodontitis
   298 d for Rpg1b, we determined that Rpg1r is not orthologous with RPM1, indicating that the ability to de
   299 formation of the cerebellum, and loss of the orthologous Zic1 gene in the mouse causes cerebellar hyp
   300 sgenic lines, which were generated using the orthologous ZmSHR1 gene to avoid potential silencing of 
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