ライフサイエンスコーパス: orthologue

1 C-terminal dimerization domain of Bim1 (EB1 orthologue).

2 s in a pattern conserved with the human Cdh1 orthologue.

3 t4p substrates, its Saccharomyces cerevisiae orthologue.

4 d scox expression, the single Drosophila Sco orthologue.

5 Sfp-PPTase with no activity toward the human orthologue.

6 nly affected the activation of Mgv1, an Mps1 orthologue.

7 n, HEBO, specifically present in Hebo direct orthologues.

8 e robust to small amounts of mislabelling of orthologues.

9 conservation of active sites with the human orthologues.

10 pts, including an overlapping subset of 8331 orthologues.

11 e homology Sac2 domain conserved in all Sac2 orthologues.

12 le functional diversity observed for the two orthologues.

13 and is not a global regulator like some NsrR orthologues.

14 mately 20% of mouse TF footprints have human orthologues.

15 reminiscent of the expression of vertebrate orthologues.

16 th the static and dynamic differences of two orthologues.

17 ar domains and X-ray structures of bacterial orthologues.

18 lish putative M. truncatula and L. japonicus orthologues.

19 imilar evolutionary dynamics in the metazoan orthologues.

20 or correlations in methylation levels across orthologues(1,2).

21 ng these high effect size genes was a single orthologue (14-3-3 protein zeta/YWHAZ) that was downregu

22 mong tested genes, 30 had a single zebrafish orthologue, 14 had 2 homologues, and 5 had >/=3 homologu

23 The human 12/15-lipoxygenase orthologue, ALOX12, is expressed in cavitary tuberculosi

24 Sik3 orthologues also regulate sleep in fruitflies and roundw

25 Lentiviral co-expression of specific BacNav orthologues, an inward-rectifying potassium channel, and

26 t we characterized the Arabidopsis ABI1 gene orthologue and Brassica napus gene paralogues encoding p

27 small-molecule inhibitors of the human CTF4 orthologue AND-1.

28 conserved among primate and carnivore TRIM5 orthologues and among 3 of the 7 mouse Trim5 homologues

29 limitations, we screened eleven diverse Cas9 orthologues and identified four that are broadly functio

30 Here, we characterize six smaller Cas9 orthologues and show that Cas9 from Staphylococcus aureu

31 representing the C-terminal domains of ProP orthologues and variants in vitro was compared with subc

32 ubcellular localization of the corresponding orthologues and variants in vivo.

33 activity of Minion is conserved in the human orthologue, and co-expression of Minion and the transmem

34 viously reported for the Anopheles albimanus orthologue anophelin, cE5 binds both thrombin exosite I

35 a bioinformatic analysis, we found that PqqD orthologues are associated with the RS-SPASM family of p

36 ized to this lineage in the mouse, the human orthologues are either absent or expressed in alternativ

37 Interestingly, putative METTL20 orthologues are found in a subset of alpha-proteobacteri

38 BamA orthologues are found in all Gram-negative bacteria and

39 te that the beta-barrel domains of many BamA orthologues are functionally interchangeable.

40 K cell receptors evolve at a rapid rate, and orthologues are nearly impossible to identify in differe

41 Using a FOXP3 orthologue as a marker, we identified CD4-enriched, matu

42 ific markers, and validate genomic predicted orthologues as expressed biomarkers.

43 elegans CEP-290 (mammalian Cep290/Mks4/Nphp6 orthologue) as a central assembly factor that is specifi

44 ive born domestic pigs with the warthog RELA orthologue, associated with resilience to African Swine

45 from Arabidopsis thaliana and its functional orthologue Atm1 from Saccharomyces cerevisiae were expre

46 he P4 and P3 positions, similar to the human orthologue autophagin-1 (HsAtg4B).

47 Comparison of expression patterns of orthologues between two chironomid species provides evid

48 inase-like tertiary fold similar to archaeal orthologues but with significant differences in some sec

49 A mammalian cloche orthologue can also rescue blood vessel formation in zeb

50 gene family of only six genes, whose direct orthologues can be identified in lineages as far as that

51 ta-barrel or POTRA domains from various BamA orthologues, can functionally replace E. coli BamA.

52 Insillicoanalysis identified two putative orthologue candidate proteins in mammals.

53 is required for up-regulation of caspase-11 orthologues, caspase-4 and -5, in primary human macropha

54 e element that is directly bound by the NRF2 orthologue, CncC, which can induce ref(2)P expression al

55 CCR2 is the sole murine receptor orthologue compatible with gamma-haemolysin.

56 Synima takes orthologues computed from reciprocal best BLAST hits or

57 These assemblies can include different sHSP orthologues, creating additional complexity that may aff

58 or future research, the data revealed a YtfE orthologue, Ddes_1165, that is implicated in the repair

59 ed with a habitat in both species, but these orthologues did not show parallel expression patterns ac

60 , while overexpression of the human dnTCF7L2 orthologue (dnTCF4) in human chondrocytes promoted the e

61 olino knockdown to test the function of each orthologue during zebrafish development.

62 a panel of seven primate and Carnivora TRIM5 orthologues, each of which has potential for potent retr

63 that manifests persuasive evidence that Nrf2 orthologues emerged, and then diverged, at two time poin

64 cation and characterization of secreted S1PL orthologues encoded by the facultative intracellular bac

65 east and demonstrate that fibrillarin is the orthologue enzyme in human cells.

66 chimeras derived from functionally distinct orthologues: Escherichia coli and Staphylococcus aureus.

67 mbined with a lack of parallel expression of orthologues (except 14-3-3 protein zeta) suggests that p

68 In contrast, both human and trypanosome Atg4 orthologues exhibited exclusive preference for aromatic

69 These bacterial orthologues exhibited S1PL enzymatic activity, functiona

70 oliferation is regulated by Eyeless, a Pax-6 orthologue, expressed in mushroom body neuroblasts.

71 ding Syp1 in budding yeast and its mammalian orthologue, FCHo1.

72 transcriptional repression of MYC by the Hfp orthologue, FIR, might provide one mechanism for cancer

73 ested vmhc and vmhcl as functional zebrafish orthologues for human genes MYH6 and MYH7, respectively,

74 not CHG or CHH levels, are correlated across orthologues for species as distantly related as ferns an

75 The isatin hydrolase orthologues found in human gut bacteria raise the questi

76 PR2) but low activity for the mouse receptor orthologue (Fpr2), rendering them inapplicable in murine

77 ochemical similarities between POMT1 and its orthologue from bakers' yeast Pmt4.

78 serine-rich Asn-63-Glu-82 region (absent in orthologues from anophelines of the New World species A.

79 hase is conserved during evolution, and HvyA orthologues from related Sinorhizobia can prevent capsul

80 report X-ray crystal structures of the Mep2 orthologues from Saccharomyces cerevisiae and Candida al

81 ted large structural differences between the orthologues from these two eukaryotic kingdoms.

82 The membrane-spanning proteins DivIB and its orthologue FtsQ are crucial divisome components in Gram-

83 Nv-derived SDR orthologues generally had higher epimerisation rates, wh

84 gene expression (by RT-qPCR) of A. thaliana orthologue genes were performed across different plant s

85 revisiae showed that the loss of HRP1 (yeast orthologue) had pronounced effects on both protein level

86 ailing view, Doa10 (and presumably its human orthologue) has the capacity for recognizing intramembra

87 Leucine transporter (LeuT), a bacterial orthologue, has been broadly adopted as a prototype in t

88 meronasal receptor mFpr-rs1 and its sequence orthologue hFPR3 also react to signal peptides but are m

89 d transcription of pro-apoptotic Smac/DIABLO orthologue, Hid in germline stem cells.

90 ous studies established that, like the human orthologue HtrA1, BbHtrA is proteolytically active again

91 ns between the fitness landscapes of distant orthologues implicate both sequence and structure as pri

92 ically enriched in increasing-level enhancer orthologues, implicating immune processes in AD predispo

93 that the M. marinum mimG mutant, an Rv3242c orthologue in a pathogenic M. marinum strain, was strong

94 hemolytic activity associated with the choA orthologue in Bacteroides fragilis.

95 Secondly, we show that the NEK9 orthologue in Caenorhabditis elegans, nekl-1, is almost

96 Here we characterize the single Nin orthologue in Drosophila Drosophila Nin localizes to the

97 Attempts to delete the NCgl2760 orthologue in Mycobacterium smegmatis were unsuccessful,

98 We have now identified a functional lpxT orthologue in P. aeruginosa.

99 We have identified the single Dig1 orthologue in the fungal pathogen Candida albicans.

100 We identified BILF1 receptor orthologues in 12 previously uncharacterized LCVs from n

101 A phylogenetic analysis identified PmC11 orthologues in bacteria, archaea, Chromerids, Coccidia,

102 elerated compared with their divergence from orthologues in closely related species.

103 c steatosis and that mutation of the SLC13A5 orthologues in Drosophila melanogaster and Caenorhabditi

104 indicated that these proteins are functional orthologues in eukaryotes.

105 ne 8 subgroups corresponding to each cognate orthologues in metazoans.

106 of these enzymes that distinguish them from orthologues in other bacteria.

107 hat have just 20% to 50% or less identity to orthologues in other herpesviruses, we propose that EEHV

108 h S. latifolia PAR boundary genes with their orthologues in S. dioica, including all three regions of

109 ghly conserved in angiosperm and there are 4 orthologues in soybean (GmBZL1-4).

110 e development and the roles of vasa and piwi orthologues in the common house spider Parasteatoda (for

111 dy demonstrates the presence of nine Jumonji orthologues in the oyster C. gigas.

112 lico analyses, we characterized nine Jumonji orthologues in the oyster, called Cg-Jmj, bearing conser

113 rpholino-mediated knockdown of the two MYO9A orthologues in zebrafish, myo9aa/ab, demonstrated a requ

114 l model species and human; alignments of the orthologues including information on known SNPs (Single

115 nosarcina mazei (MmCPDII) as well as plantal orthologues indicated several differences in terms of DN

116 We isolated the insect oxytocin/vasopressin orthologue inotocin from the black garden ant (Lasius ni

117 lopoiesis, but, in contrast to its mammalian orthologue, is not involved in neutrophil migration towa

118 d coiled-coil domain also found in the human orthologue, KIAA1430.

119 properties are readily transferrable onto an orthologue Kv channel by transplanting the voltage-senso

120 we show that the Caenorhabditis elegans EGFR orthologue LET-23 is constitutively dimeric, yet respond

121 idae and of other Lepidoptera, combined with orthologue-level comparisons of chromosomes, we conclude

122 th impaired subcellular localization of Mint orthologue LIN-10, internalization of glutamate receptor

123 e are co-expressed and, like their mammalian orthologues, localize to the cytoplasm.

124 Phosphorylation of Rpb1 Ser2 by the Cdk12 orthologue Lsk1 positively regulated H3K36me but negativ

125 The mammalian ATG8 orthologues (MAP1LC3A/B/C and GABARAP/L1/L2) are ubiquit

126 D is a novel peptide chaperone and that PqqD orthologues may play a similar role in peptide modificat

127 Podocin and its Caenorhabditis elegans orthologue MEC-2 have emerged as key components of mecha

128 found that human G9a (hG9a) unlike its mouse orthologue (mG9a) potently stimulated p53 transcriptiona

129 ration during development and its C. elegans orthologue MIG-10 also supports synaptogenesis.

130 de significance at MLH1, a locus whose mouse orthologue modifies CAG length-dependent phenotypes in a

131 e homology to FAM86A, is a functional FAM86A orthologue, modifying the corresponding residue (Lys-509

132 determined the crystal structures of the PC4 orthologue MoSub1 and a PC4 W89Y mutant in complex with

133 mNARK, but is present upstream of the GmNARK orthologues, MtSUNN and PvNARK.

134 ort region at the end of the Drosophila NPAT orthologue, multi sex combs (Mxc).

135 osophila, similar to the effect of its mouse orthologue Nr2e1.

136 We also report that Traffic Jam (an orthologue of a large Maf transcription factor in mammal

137 TRAPPC8, the mammalian orthologue of a yeast autophagy-specific TRAPP subunit,

138 Drosophila melanogaster, which has a single orthologue of ATP7A and ATP7B.

139 e DNA-binding activity of the S. globisporus orthologue of AtrA, which was initially described as a t

140 The Drosophila orthologue of BDNF is the highly conserved Neurotrophin

141 a highly conserved region of the Drosophila orthologue of BICD2 to further-explore how the p.Glu774G

142 In this study, the orthologue of BRI1 in the model legume species Medicago

143 Asterless (Asl), the Drosophila melanogaster orthologue of Cep152, prevents centriole duplication, wh

144 an Sperm Associated Antigen 6 (SPAG6) is the orthologue of Chlamydomonas PF16, a protein localized in

145 Mammalian Spag6 is the orthologue of Chlamydomonas PF16, which encodes a protei

146 entify the fission yeast protein Sdj1 as the orthologue of DJ-1 and calculate by in silico saturation

147 mutating dnj-14, the Caenorhabditis elegans orthologue of DNAJC5, results in shortened lifespan and

148 s elegans mutant strains of dnj-14, the worm orthologue of DNAJC5.

149 emonstrate a role for Plexin A1, a zebrafish orthologue of Drosophila PlexA, in epithelial repair in

150 Here we studied variants of Mpk1, a yeast orthologue of Erk, which is essential for cell wall inte

151 eria monocytogenes Ca(2+)-ATPase (LMCA1), an orthologue of eukaryotic Ca(2+)-ATPases.

152 ediated depletion of fibulin-7B, a zebrafish orthologue of fibulin-7 (FBLN7), resulted in cardiac hyp

153 he mutant, and was identified as a bacterial orthologue of fungal DPP5, because of its substrate spec

154 Here, we show that mutation of the mouse orthologue of GPSM2 affects actin-rich stereocilia elong

155 An orthologue of granulin from the human parasitic liver fl

156 We identified the Xenopus orthologue of heparanase 2 and showed that the protein i

157 Sgs1, the orthologue of human Bloom's syndrome helicase BLM, is a

158 ent TEX1 or in the mRNA export factor MOS11 (orthologue of human CIP29) are mildly affected.

159 Here we show that yeast Coa6 is an orthologue of human COA6, and like Cox2, is regulated by

160 to flies deficient in boule, the Drosophila orthologue of human Dazl.

161 n gba1 (gba1(c.1276_1298del)), the zebrafish orthologue of human GBA1.

162 osphatidylinositol 4-kinase effector and the orthologue of human GOLPH3.

163 The Saccharomyces cerevisiae TAZ1 gene is an orthologue of human TAZ; both encode the protein tafazzi

164 nd basal body protein HYLS-1, the C. elegans orthologue of hydrolethalus syndrome protein 1, is requi

165 urthermore, genetic analysis showed that the orthologue of IME2, a 'diploid-specific' factor in S. ce

166 Here, we demonstrate RasG, the Dictyostelium orthologue of K-Ras, is targeted for degradation by poly

167 receptor tyrosine kinase, and the Drosophila orthologue of Kalrn into the same signaling pathway, Abl

168 Hereby we characterize the phylogenetic orthologue of Ls in Antirrhinum, ERAMOSA (ERA).

169 ed the hypothesis that ERA is a phylogenetic orthologue of Ls, although it plays a broader role.

170 li, PqiB and YebT, the latter of which is an orthologue of MAM-7 that was previously reported to be a

171 of the Mec1 kinase that is the budding yeast orthologue of mammalian ATR.

172 xpressed connexin 35b (cx35b), the zebrafish orthologue of mammalian connexin (Cx) 36.

173 Here, we identified the C. elegans orthologue of mammalian mediator of ErbB2-driven cell mo

174 We found that Yju3p, the functional orthologue of mammalian monoacylglycerol lipase (MGL), c

175 show that Ce-Punctin/madd-4, the C. elegans orthologue of mammalian punctin-1 and punctin-2, encodes

176 One interactor is MAK-1, C. elegans orthologue of MAPKAP kinase 2.

177 e of the DBD of PCG2, the Magnaporthe oryzae orthologue of MBP1, bound to MCB-DNA.

178 ntified a spontaneous exonic deletion in the orthologue of MutL-Homolog 3 (HvMlh3) as the causal lesi

179 e have identified and characterized the MceG orthologue of Mycobacterium smegmatis.

180 xported from the nucleus and the trypanosome orthologue of NMD3 has been confirmed to be involved in

181 Prc1E, the egg orthologue of Prc1, and Kif4A were recruited to anti-par

182 er, Nin shares the property of its mammalian orthologue of promoting microtubule assembly.

183 re initially found to act on Ypt1, the yeast orthologue of Rab1, but recent studies have found that y

184 Atlastin, the vertebrate orthologue of Sey1p, forms a GTP-hydrolysis-dependent ne

185 so linked to the activity of Nrf2, the human orthologue of SKN-1, and regulates the expression of lip

186 FGT1 encodes the Arabidopsis thaliana orthologue of Strawberry notch (Sno), and the protein gl

187 equires signalling via Shark, the Drosophila orthologue of Syk, and Src42A, a Drosophila Src-family k

188 lethality and lethargy of unc-64 (C. elegans orthologue of syntaxin-1)-null mutants.

189 ian population, and mapping data suggest the orthologue of TERMINAL FLOWER1 (FvTFL1) as the causal fl

190 to function similarly in mammals, where the orthologue of the central ATPase, Get3, is known as TRC4

191 n pathways for Sdj1-L169P, the fission yeast orthologue of the disease-causing DJ-1 L166P protein.

192 Cby1, the mammalian orthologue of the Drosophila Chibby protein, localizes t

193 g protein) is the endoplasmic reticulum (ER) orthologue of the Hsp70 family of molecular chaperones a

194 vivo through a single receptor, Mrgprb2, the orthologue of the human G-protein-coupled receptor MRGPR

195 netically with CWC21, that encodes the yeast orthologue of the human SR protein, SRm300/SRRM2.

196 Furthermore, we show that the C. elegans orthologue of the Mad2 inhibitor p31(comet)(CMT-1) inter

197 hila melanogaster Rootletin (Root), the sole orthologue of the mammalian paralogs Rootletin and C-Nap

198 R349P desmin knock-in mice, which carry the orthologue of the most frequent human desmin missense mu

199 gene over-expression, we identified a rabbit orthologue of the mouse Rosa26 locus through genomic seq

200 insertion polymorphism in the R2R3 myb-like orthologue of the oil palm virescens gene associated wit

201 We define YvyG as an orthologue of the Salmonella enterica serovar Typhimuriu

202 MOD-5, the C. elegans orthologue of the serotonin transporter and cellular tar

203 the gene parcas that encodes the Drosophila orthologue of the SH3BP5 family of Rab11 guanine nucleot

204 The yeast orthologue of this protein is encoded by the hitherto un

205 As in mouse, the Caenorhabditis elegans orthologue of Tmem231 localizes to and controls transiti

206 Here we show that YmoB, the Yersinia orthologue of TomB, and its single cysteine variant [C11

207 Coexpression of a plant orthologue of U2AF65 alleviated the splicing repression

208 biquitin in vivo We found that the fruit fly orthologue of USP5 has catalytic preferences similar to

209 Coracle, the orthologue of vertebrate band 4.1, functions in the anch

210 ssion variation of the gene Bo2g050970.1, an orthologue of VTE4 (which encodes a gamma-tocopherol met

211 ss-of-function mutations in RLTPR, the mouse orthologue of which is essential for CD28 signaling.

212 with the fetal haemoglobin level, the mouse orthologue of which is necessary for erythroid BCL11A ex

213 Chlamydomonas genome encodes presumed plant orthologues of a chloroplast lipid transporter consistin

214 cation tolerance in seeds and involvement of orthologues of ABI3 and ABI5, both key regulators of see

215 rst analyse the expression of the Drosophila orthologues of all mammalian CPA factors and note that t

216 Orthologues of BamA are found in all Gram-negative bacte

217 demonstrate that these calcisponges possess orthologues of bilaterian NK genes (Hex, Hmx and Msx), a

218 t Lactococcus lactis possesses two different orthologues of birA (birA1_LL and birA2_LL).

219 Here, we identify orthologues of both O-GlcNAc cycling enzymes in the geno

220 Distinct putative orthologues of both pairs are maintained in the genomes

221 We have characterised three orthologues of BslA from Bacillus amyloliquefaciens, Bac

222 and CD1(+) populations were enriched for the orthologues of cDC1 and cDC2 subsets respectively.

223 hylogenetic and functional data showing that orthologues of choA are found only in the order Bacteroi

224 aled that this pathogen's genome encodes two orthologues of Escherichia coli LpxL.

225 re required for the expression of the spider orthologues of even-skipped (eve) and runt-1 (run-1), at

226 an previously sequenced arthropods, and many orthologues of genes conserved from the bilaterian ances

227 Human orthologues of genes in the mouse QTL are implicated in

228 ted genetic interference (RNAi) of planarian orthologues of human CKD genes and inhibition of tubule

229 In C. elegans neurons, orthologues of LRRK2 and RAB7L1 act coordinately in an o

230 Silencing the orthologues of mosGCTL in another major mosquito vector

231 This includes orthologues of nodulation-suppressing CLE peptides and A

232 We demonstrate that orthologues of Nrf2 first appeared in fungi around 1.5 G

233 vement of two other mak-1 paralogues and two orthologues of p38 MAP kinase.

234 In this paper, we identify orthologues of Sld2, a CDK target that is important for

235 sters in the genome apart from the classical orthologues of the corresponding genes shared by both ch

236 The orthologues of the murine Notch1 receptor, Notch1a and N

237 correlated with interaction with the grivet orthologues of the SLX4 complex, suggesting a level of h

238 Silencing of orthologues of these candidate genes enhanced the DeltaF

239 Although isolated apparent orthologues of these enzymes are present in bacterial ge

240 PTM patterns are divergent on orthologues of two closely related, but ecologically dif

241 o acid sequences between the human and mouse orthologues of two essential host factors, the tetraspan

242 ounds do not appear to activate DAF-16 (FOXO orthologue) or mimic dietary restriction (DR) effects, b

243 ind that loss of Mst1/2, the mammalian Hippo orthologues, or their regulator WW45, leads to a remarka

244 ry receptor 23 (MOR23, olfr16) and its human orthologue, OR10J5, have been found to be functionally e

245 These correspond to 492 Arabidopsis orthologues, over 90% of which form a coherent protein-p

246 the most prominent effect of the Drosophila orthologue, pentagone (pent), is expanding the range of

247 PTPN22 (also known as LYP) and its mouse orthologue PEP play important roles in antigen and Toll-

248 ession of either human Lpd or its Drosophila orthologue Pico can promote growth and invasion of Ras(V

249 The yeast ATP2C1 orthologue PMR1 codes for a Mn(2+)/Ca(2+) transporter th

250 identification and characterization of a C11 orthologue, PNT1, in the parasitic protozoon Trypanosoma

251 Drosophila melanogaster Polo and its human orthologue Polo-like kinase 1 fulfill essential roles du

252 The O-GlcNAcase orthologue possesses activity against O-GlcNAc proteins

253 y of 'basic' FKBPs is shared amongst related orthologues present in fungi, plants, and insects.

254 ecretory vesicles (SVs) containing the RAB11 orthologue RabE engage myosin-5 as well as plus end- and

255 wn as ERCC6) protein in humans (or its yeast orthologues, Rad26 in Saccharomyces cerevisiae and Rhp26

256 rystal structure that captures the yeast XPC orthologue (Rad4) on a single register of undamaged DNA.

257 Finally, the human HemW orthologue radical SAM domain-containing 1 (RSAD1) stabl

258 Here, we show that the Drosophila p62/SQSTM1 orthologue, Ref(2)P, interacts directly with DmAtg8a via

259 The coiled-coil domain present on only some orthologues renders that phenomenon CL-dependent.

260 MAAMD was utilized to identify gene orthologues responding to hypoxia or hyperoxia in both m

261 e Caenorhabditis elegans choline transporter orthologue revealed deficits in transporter export to ax

262 studies indicating that the M. tuberculosis orthologue, Rv0227c, is an essential gene.

263 ofiles from baseline to week 12 of the human orthologues selected on the basis of the murine transcri

264 trols the seed shattering phenotype like its orthologue SH4 gene in Asian rice.

265 ProP orthologues share an extended, cytoplasmic C-terminal do

266 trait loci, while decreasing-level enhancer orthologues show fetal-brain-specific enhancer activity.

267 and requires the Nrf (NF-E2-related factor) orthologue SKN-1 acting in parallel to DAF-16.

268 ay and demonstrate that Hem25p and its human orthologue SLC25A38 are the main mitochondrial glycine t

269 in the catalytic domain of the MAP kinase 7 orthologue sma-5(kc1) In sma-5(kc1) mutants, pockets of

270 induced in these conditions through the AMPK orthologue Snf1 and downstream transcriptional repressor

271 s indicate the existence of GTP-loaded K-Ras orthologue-specific degradation system in Dictyostelium,

272 We also find that two smaller-size Cas9 orthologues, Streptococcus thermophilus Cas9 (St1Cas9) a

273 atory regions of invertebrate and vertebrate orthologues, such that both regulatory elements can corr

274 ects, but selectively induce SKN-1 (Nrf1/2/3 orthologue) targets involved in oxidative stress defense

275 by RNAi-mediated knockdown of the fly TDP-43 orthologue, TBPH.

276 A picture is emerging of sperm channel orthologues that employ different activation mechanisms

277 que properties compared with their mammalian orthologues that support electrosensory functions: struc

278 We identify 'functional orthologues' that share similar molecular interactions,

279 e WelNDLY, WelLFY shares with its angiosperm orthologue the capacity to bind promoters of Welwitschia

280 Here we show that its orthologue, the vacuolar glucose transporter OsSWEET2b f

281 e recognizes the C-terminal sequence of NPAT orthologues, thus acting as a signal targeting proteins

282 Overexpression of the human orthologue TMEM258 in Drosophila proved functional conse

283 tural analyses demonstrated the apicomplexan orthologue to be a functional, homodimeric serine palmit

284 genetically interacts with an ARL13B (JBTS8) orthologue to control cilium integrity.

285 inoblastoma (Rb)-related gene, and fzr-1, an orthologue to the APC/C co-activator Cdh1, completely el

286 In Caenorhabditis elegans, the TRPC orthologues TRP-1 and -2 genetically complement the loss

287 By performing live-cell imaging of the DCC orthologue UNC-40 during anchor cell invasion in Caenorh

288 Similar to Cmr1, its human orthologue WDR76 responds to proteasome inhibition and D

289 Although mice lack a P2RY8 orthologue, we show that mouse GC B cell clustering is a

290 ISPR/Cas9 to genetically inactivate a TWIST2 orthologue, we suppressed the effects of BRAF(V600E) and

291 g the expression of Strigamia vasa and nanos orthologues, we find that the primordial germ cells are

292 After initial screening of 15 orthologues, we identified Cas13a from Leptotrichia wade

293 Only 20 orthologues were associated with a habitat in both speci

294 In yeast, there is a single VPS13 orthologue, which is required for at least two different

295 ardiomyopathy have a corresponding zebrafish orthologue, which supports the use of zebrafish as a con

296 drug resistance transcription factor (Pdr1) orthologues, which are key regulators of the multidrug r

297 ure of MtHDH is similar to the two bacterial orthologues whose three-dimensional structures have been

298 Orthologues with and without a C-terminal, alpha-helical

299 of strain ZYK(T) implies that it shares more orthologues with B. subtilis subsp. subtilis NCIB 3610(T

300 at yeast TRAPPII can also activate the Rab11 orthologues Ypt31/32.