ライフサイエンスコーパス: orthopoxvirus

1 ed from the lesion confirmed infection by an Orthopoxvirus.

2 s (Old World vs North American) of the genus Orthopoxvirus.

3 vaccinia virus gene I2L is conserved in all orthopoxviruses.

4 the first demonstration of its existence in orthopoxviruses.

5 rus formation and are highly conserved among orthopoxviruses.

6 underlying innate immunity against emerging orthopoxviruses.

7 ular contacts, this feature may be unique to orthopoxviruses.

8 t of infections caused by herpes viruses and orthopoxviruses.

9 ell epitopes that are highly conserved among orthopoxviruses.

10 , including the herpes group viruses and the orthopoxviruses.

11 viral evaluation against cytomegalovirus and orthopoxviruses.

12 life cycle and present in multiple distinct orthopoxviruses.

13 Most epitopes were conserved in other orthopoxviruses.

14 neutralizing antibody responses for diverse orthopoxviruses.

15 by a synthetic promoter designed for use in orthopoxviruses.

16 otes and are present in some prokaryotes and orthopoxviruses.

17 amics of the immune modulating mechanisms of orthopoxviruses.

18 diverged from a common ancestor of all known orthopoxviruses.

19 lticomponent DNA or protein vaccines against orthopoxviruses.

20 ration, safer vaccines for highly pathogenic orthopoxviruses.

21 o FDA-approved drug for humans infected with orthopoxviruses.

22 1R is an early gene present in MVA and other orthopoxviruses.

23 ed mouse strains are relatively resistant to orthopoxviruses.

24 g of the C7L family of host range genes from orthopoxviruses.

25 ich is most closely related to the Old World orthopoxviruses.

26 ontributing to host defense against zoonotic orthopoxviruses.

27 s (VV) in individuals exposed to 3 different orthopoxviruses: 154 individuals previously vaccinated w

28 ct all Eurasian-African species of the genus ORTHOPOXVIRUS: A single nucleotide mismatch resulting in

29 sis) of full-length vaccinia virus (VACV; an orthopoxvirus) A36 protein with the cellular microtubule

30 eoxyuridine, which was itself devoid of anti-orthopoxvirus activity in these assays.

31 The anti-orthopoxvirus activity of pyrimidine may be favored by t

32 As orthopoxviruses adapt to new environments, the selection

33 Vaccinia virus is the prototypic orthopoxvirus and was the vaccine used to eradicate smal

34 lyclonal antibodies cross-reacted with other orthopoxviruses and herpes simplex 1, but commercially a

35 Orthopoxviruses and leporipoxviruses are among the most

36 f the A36R protein is highly conserved among orthopoxviruses and may overlap binding sites for cellul

37 Orthopoxviruses and the human complement component C6 ge

38 All patients had detectable IgM responses to orthopoxvirus antigens.

39 Orthopoxviruses are dermatotropic DNA viruses that cause

40 nt from other poxviral subfamilies, however, orthopoxviruses are not known to evade recognition by CT

41 In the Orthopoxvirus assay, consensus Orthopoxvirus PCR primers

42 ose that the F1 orthologs represent the only orthopoxvirus Bcl-2 homolog to directly inhibit the Bak/

43 A related orthopoxvirus, but neither a flavivirus nor a rhabdoviru

44 f G1R are present in a variety of pathogenic orthopoxviruses, but not in vaccinia virus, and expressi

45 differentiation of smallpox virus from other orthopoxviruses by melting-curve analysis.

46 etent vaccinia protects against heterologous orthopoxvirus challenge.

47 Monkeypox virus (MPXV) is an orthopoxvirus closely related to variola virus, the caus

48 Monkeypox virus (MPXV) is an orthopoxvirus closely related to variola, the etiologica

49 Much of the threat posed by orthopoxviruses could be eliminated by vaccination; howe

50 fied nucleosides against cells infected with orthopoxviruses, cowpox, and vaccinia virus.

51 l-to-cell spread of vaccinia virus and other orthopoxviruses depends on the wrapping of infectious pa

52 in lesions of all 3 patients; 2 patients had orthopoxvirus detected by immunohistochemistry in skin l

53 Mouse models of orthopoxvirus disease provide great promise for probing

54 e it clear that naturally occurring zoonotic orthopoxvirus diseases remain a public health concern.

55 axis and immunotherapy of smallpox and other orthopoxvirus diseases.

56 Orthopoxvirus DNA was present in 3 of 20 environmental s

57 Some orthopoxviruses, e.g., the cowpox, ectromelia, and racco

58 le number of MOCV RNAs mapped to homologs of orthopoxvirus early genes, but few did so to homologs of

59 /6 mice to mousepox, a disease caused by the Orthopoxvirus ectromelia virus.

60 The orthopoxviruses ectromelia virus (ECTV) and vaccinia vir

61 lly bioavailable first-in-class inhibitor of orthopoxvirus egress from infected cells.

62 A series of novel, potent orthopoxvirus egress inhibitors was identified during hi

63 Genomes of orthopoxviruses encode proteins with sequences similar t

64 Orthopoxviruses evade host immune responses by using a n

65 O3 is conserved with 100% identity in all orthopoxviruses except for monkeypox viruses, whose O3 h

66 Smallpox and other orthopoxviruses express virulence factors that inhibit t

67 Vaccinia virus (VV), the prototypic orthopoxvirus, expresses products that inhibit this anti

68 wn structure that is highly conserved in the orthopoxvirus family.

69 The orthopoxvirus gene p4c has been identified in the genome

70 of numerous postreplicative as well as early orthopoxvirus genes.

71 While K1L is limited to orthopoxviruses, genes that are homologous to C7L are fo

72 hese evolutionary processes still present in orthopoxvirus genomes and suggests that these viruses ar

73 Comparative genomics has suggested that the Orthopoxvirus genus in particular has undergone reductiv

74 us is most closely related to viruses in the Orthopoxvirus genus, but it is clearly distinct from pre

75 s highly conserved among most members of the orthopoxvirus genus, including viruses that produce ATIs

76 is a human pathogen that is a member of the Orthopoxvirus genus, which includes Vaccinia virus and V

77 possesses one of the largest genomes in the Orthopoxvirus genus.

78 population that is immunologically naive to orthopoxviruses has increased significantly due to cessa

79 Orthopoxviruses have complex proteomes.

80 l the microorganisms and toxins, poxviruses (Orthopoxvirus) have the greatest potential for use by te

81 assay is based on TaqMan chemistry with the orthopoxvirus hemagglutinin gene used as the target sequ

82 strains examined and absent in various other orthopoxviruses; however, four strains of ectromelia vir

83 We conclude that the unique CTD of orthopoxvirus IFN-gammaBPs is important for the assembly

84 ive, yet this region is conserved within all orthopoxvirus IFN-gammaBPs.

85 is for rational design of inhibitors against orthopoxvirus IL-18BP (for treating orthopoxvirus infect

86 the 2.0-A resolution crystal structure of an orthopoxvirus IL-18BP, ectromelia virus IL-18BP (ectvIL-

87 family member, 14L, which is similar to the orthopoxvirus IL-18BPs.

88 s infection closely resembles human systemic orthopoxvirus illness.

89 The targeting of FCRL5 by an orthopoxvirus immunoevasin strongly implicates it in con

90 rence of monkeypox virus (MPXV), an emerging Orthopoxvirus in humans, under contemporary and future c

91 in controlling smallpox or other pathogenic orthopoxviruses in some immunodeficient human population

92 VARV is unique among orthopoxviruses in that it is an exclusively human patho

93 compound had broad-spectrum activity against orthopoxviruses in vitro.

94 Orthopoxviruses include many important pathogens such as

95 Orthopoxviruses include the prototypical vaccinia virus,

96 logs of Bcl-2 proteins that are conserved in orthopoxviruses, including A46, A52, B14, C1, C6, C16/B2

97 efficient antiviral drug against pathogenic orthopoxviruses, including smallpox.

98 A majority of the orthopoxviruses, including the variola virus that causes

99 % = >40 microM), and active against multiple orthopoxviruses, including vaccinia, monkeypox, camelpox

100 actor that is highly conserved (>90%) in all orthopoxviruses, including variola virus, the causative

101 homologs of human IL-18BP are encoded by all orthopoxviruses, including variola virus, the causative

102 te into full protection against the onset of orthopoxvirus-induced disease.

103 llular virus formation can protect mice from orthopoxvirus-induced disease.

104 This is of particular importance, since orthopoxviruses infect mammals and include variola, the

105 promising candidate for development to treat orthopoxvirus-infected individuals.

106 ementing modern diagnostic methods to assess orthopoxvirus infection and adverse events following vac

107 ived inbred strain, is highly susceptible to orthopoxvirus infection by intranasal and systemic route

108 long-term immunity against highly pathogenic orthopoxvirus infection of humans (smallpox) and mice (m

109 Orthopoxvirus infection should be considered in persons

110 against orthopoxvirus IL-18BP (for treating orthopoxvirus infection) or hIL-18 (for treating certain

111 equired for protection against a respiratory Orthopoxvirus infection, such as human smallpox or monke

112 of the skin immune response as a feature of orthopoxvirus infection.

113 on are needed for optimal protection against orthopoxvirus infection.

114 nus macrophages, IFN-gamma, and CXCR3 during orthopoxvirus infection.

115 humoral immune response induced by systemic orthopoxvirus infection.

116 rus (VACV-WR) to model a primary respiratory Orthopoxvirus infection.

117 ng the host endosomal trafficking pathway in orthopoxvirus infection.IMPORTANCE Human monkeypox is an

118 as been used therapeutically to treat severe orthopoxvirus infections but is in short supply.

119 e is now an increasing incidence of zoonotic orthopoxvirus infections for which there are no effectiv

120 killer (NK) cells provide in vivo control of orthopoxvirus infections in association with their expan

121 ule antiviral therapeutics approved to treat orthopoxvirus infections of humans.

122 ffort to evaluate new therapies for virulent orthopoxvirus infections of the respiratory tract in a s

123 ide potential new leads for the treatment of orthopoxvirus infections, the 5-position of the pyrimidi

124 be beneficial for prophylaxis or therapy of orthopoxvirus infections.

125 antiviral therapies for treatment of serious orthopoxvirus infections.

126 ing onset of rash illness, to treat systemic orthopoxvirus infections.

127 nd which exhibits selective activity against orthopoxviruses, inhibiting VV with 50% inhibitory conce

128 overies are the broad species specificity of orthopoxvirus interferon receptors, herpesvirus and poxv

129 The conservation of the p4c gene among the orthopoxviruses, irrespective of their capacities to pro

130 Human infection by orthopoxviruses is being reported with increasing freque

131 The threat of MPXV and other orthopoxviruses is increasing due to the absence of rout

132 amino-terminal domain, while conserved among orthopoxviruses, is dispensable in cell culture.

133 these GeneChips with some known non-Variola orthopoxvirus isolates, including monkeypox, cowpox, and

134 otein of 53 amino acids that is conserved in orthopoxviruses, leporipoxviruses, yatapoxiruses, and mo

135 Many pathogenic orthopoxviruses like variola virus, monkeypox virus, and

136 oach by encoding a soluble NKG2D ligand, the orthopoxvirus major histocompatibility complex (MHC) cla

137 This orthopoxvirus MHC class I-like protein (OMCP) is conserv

138 We previously described an orthopoxvirus MHC class I-like protein (OMCP) that binds

139 n comparable efficaciousness in three murine orthopoxvirus models and has entered Phase I clinical tr

140 In cells infected with some orthopoxviruses, numerous mature virions (MVs) become em

141 nvelope of extracellular virions produced by orthopoxviruses, one that requires A33 and one that does

142 ells and their ability to protect against an orthopoxvirus (OPV) infection in its natural host can de

143 of horsepox virus (HSPV) isolate MNR-76, an orthopoxvirus (OPV) isolated in 1976 from diseased Mongo

144 The orthopoxvirus (OPV) vaccinia virus (VACV) requires an in

145 Despite the eradication of smallpox, orthopoxviruses (OPV) remain public health concerns.

146 viral infections, including those caused by Orthopoxviruses (OPV), a genus that includes the human p

147 nd differentiate Old World, African-Eurasian orthopoxviruses (OPV): variola, vaccinia, cowpox, monkey

148 Orthopoxviruses (OPVs), such as the human smallpox virus

149 Orthopoxviruses (OPVs), which include the agent of small

150 ng rash illness is similar to human systemic orthopoxvirus (OPXV) infection, including a 7- to 9-day

151 Serologic cross-reactivity, a hallmark of orthopoxvirus (OPXV) infection, makes species-specific d

152 ce the eradication of smallpox (caused by an orthopoxvirus (OPXV) related to MPXV) and cessation of r

153 In the Orthopoxvirus assay, consensus Orthopoxvirus PCR primers were designed to amplify 266-2

154 need for continued development of novel anti-orthopoxvirus pharmaceuticals and the importance of both

155 irus and vaccinia virus, two closely related orthopoxviruses, prevents their efficient replication in

156 proteins), WR148 (a fragmented homolog of an orthopoxvirus protein that forms inclusions in cells), H

157 rained hidden Markov model, we discovered an orthopoxvirus protein, itself distantly class I-like, th

158 Using two highly related orthopoxvirus proteins, the vaccinia and variola (smallp

159 e the structural relationships among SCRs of orthopoxvirus RCA-like proteins and those of human compl

160 The patient with encephalitis had orthopoxvirus-reactive immunoglobulin M (IgM) in cerebro

161 ranscription alters our understanding of how orthopoxviruses regulate gene expression.

162 sistance to ectromelia virus (ECTV), a mouse orthopoxvirus related to the virus causing human smallpo

163 Orthopoxviruses show a widely varying degree of host spe

164 Vaccinia virus, another orthopoxvirus, showed no RNase P activity in vaccinia-in

165 gnment for representative isolates from each Orthopoxvirus species and used it to identify the nucleo

166 nts to test if predicted conservation across orthopoxvirus species matches experimental observation a

167 mplification of 120 strains belonging to the orthopoxvirus species variola, vaccinia, camelpox, mouse

168 in vaccinia virus and its homologs in other orthopoxvirus species, provides full protection from let

169 all genes present in any existing modern-day orthopoxvirus species, similar to the current Cowpox vir

170 into proteinaceous A-type inclusions in some orthopoxvirus species.

171 and DNA sequence analysis implicated a novel orthopoxvirus species.

172 ficity, diversity, or dominance hierarchy of orthopoxvirus-specific CD4 T cell responses.

173 We generated a large panel of orthopoxvirus-specific human monoclonal antibodies (Abs)

174 virus, the most virulent member of the genus Orthopoxvirus, specifically infects humans and has no ot

175 ruses that cause significant human diseases, orthopoxviruses spread from a peripheral site of infecti

176 n of virions into A-type inclusions in other orthopoxvirus strains.

177 us (VV) membrane proteins are candidates for orthopoxvirus subunit vaccines and potential targets for

178 be considered for inclusion in future human orthopoxvirus subunit vaccines.

179 lusion protein (ATIp), which is truncated in orthopoxviruses such as vaccinia virus (VACV) and variol

180 l protein called ATIp, which is truncated in orthopoxviruses such as vaccinia virus (VACV) that do no

181 This work reveals orthopoxvirus targets for human Abs that mediate cross-p

182 lpox virus DNA, but all viruses of the genus Orthopoxvirus tested could be detected by use of the hem

183 by the three MAbs was synthesized by all 11 orthopoxviruses tested: eight strains of vaccinia virus

184 Cowpox virus is an Orthopoxvirus that can cause infections in humans and a

185 ior to the eradication of variola virus, the orthopoxvirus that causes smallpox, one-third of infecte

186 nia virus Ankara (MVA) is a safe, attenuated orthopoxvirus that is being developed as a vaccine vecto

187 Ectromelia virus (ECTV), an orthopoxvirus that naturally infects the mouse, spreads

188 Vaccinia virus is a prototypal orthopoxvirus that was used as a vaccine to eradicate sm

189 assay was specific for members of the genus Orthopoxvirus; the DNAs of herpes simplex virus and vari

190 hanisms that drive virus variation, allowing orthopoxviruses to adapt to particular environmental nic

191 mily are utilized specifically by pathogenic orthopoxviruses to repress the NF-kappaB signaling pathw

192 ever, because the smallpox vaccine is a live orthopoxvirus vaccine (vaccinia virus) administered to t

193 egy: epicutaneous application of the related orthopoxvirus vaccinia virus (VACV) to superficially inj

194 The Orthopoxvirus vaccinia virus encodes the Bcl-2-like F1 p

195 Conversely, the prototype orthopoxvirus, vaccinia, causes no disease in immunocomp

196 Compound 2 inhibited the replication of two orthopoxviruses, vaccinia virus (VV) (EC(50) = 4.6 +/- 2

197 nsional NMR to determine the structure of an orthopoxvirus vCCI in complex with a human CC chemokine,

198 owever, serologic evidence of exposure to an orthopoxvirus was detected in cows in the patients' herd

199 ase P RNA gene in camelpox virus, one of the orthopoxviruses, was cloned and transcribed in vitro.

200 rpesviruses as well as poxviruses other than orthopoxviruses were not detected by this method.

201 e-chain-reaction assay for non-variola virus orthopoxviruses were positive, and DNA sequence analysis

202 izontally transferred from murine rodents to orthopoxviruses, where it is hypothesized to play a role

203 Monkeypox virus is an emerging, zoonotic orthopoxvirus which can cause severe and transmissible d

204 nd previously undescribed genetic lineage of Orthopoxvirus, which is most closely related to the Old

205 Human monkeypox is a zoonotic Orthopoxvirus with a presentation similar to smallpox.

206 be a reliable technique for the detection of orthopoxviruses, with the advantage that it can simultan