ライフサイエンスコーパス: orthostatic

1 l (21.2 percent), cardiac (9.5 percent), and orthostatic (9.4 percent); for 36.6 percent the cause wa

2 tial minority of patients, headaches are not orthostatic and may mimic other types of headache.

3 rtality associated with vasovagal (including orthostatic and medication-related) syncope.

4 ce data and prevalence estimates of impaired orthostatic blood pressure (BP) stabilization, initial o

5 rdiac conduction, ventricular arrhythmia, or orthostatic blood pressure.

6 drochloride, an alpha-agonist, could improve orthostatic BP by increasing vasomotor and venomotor ton

7 ed on the frequency of a 20 mm Hg or greater orthostatic BP decline during any of 8 postural change m

8 Orthostatic BP responses in adults aged 50 to 59 years s

9 OH is diagnosed on the basis of an orthostatic challenge and implies a persistent systolic/

10 ume expansion prior to the application of an orthostatic challenge attenuates heat stress-induced red

11 d and is capable of decreasing CVC during an orthostatic challenge in heat-stressed individuals.

12 contributing to reductions in CVC during an orthostatic challenge of heat-stressed individuals.

13 Following orthostatic challenge, the depressed patients exhibited

14 ical in maintaining postural stability under orthostatic challenge.

15 esistance response from the beginning of the orthostatic challenge.

16 jects after overnight bed rest and following orthostatic challenge.

17 preventing blood pressure instability during orthostatic challenges.

18 upper GI cause associated with hypotension, orthostatic changes in heart rate [>20 beats per minute]

19 ed duration of sleep (47 [92%] vs 39 [71%]), orthostatic dizziness (42 [78%] vs 46 [81%]), depression

20 Typical orthostatic symptoms such as orthostatic dizziness and blurred vision, and atypical s

21 autonomic dysfunction (as assessed using the Orthostatic Grading Scale [OGS]) were significantly more

22 An orthostatic headache is the prototypical manifestation b

23 The dominant clinical finding is an orthostatic headache.

24 l fluid (CSF) leaks and is known for causing orthostatic headaches.

25 Attenuated orthostatic HRR may reflect dysregulation of the parasym

26 Speed of orthostatic HRR predicts mortality and may aid clinical

27 ), urinary tract infections (n=9 [11%]), and orthostatic hypotension (n=8 [10%]).

28 In patients with neurogenic orthostatic hypotension (NOH), the availability of the s

29 Patients with Parkinson's disease (PD) and orthostatic hypotension (OH) (PD+OH) or with pure autono

30 arkinsonism and non-motor features including orthostatic hypotension (OH) and cognitive impairment.

31 An association between orthostatic hypotension (OH) and mortality has been repo

32 Four orthostatic hypotension (OH) groups were defined based o

33 Orthostatic hypotension (OH) is a common cardiovascular

34 Orthostatic hypotension (OH) is a common cause of transi

35 Orthostatic hypotension (OH) is a fall in blood pressure

36 Orthostatic hypotension (OH) is common in elderly people

37 sed on HUT results, we divided patients into orthostatic hypotension (OH), postural tachycardia syndr

38 n the heart and other organs, manifesting as orthostatic hypotension (OH; also known as postural hypo

39 measured in patients with PD with or without orthostatic hypotension (PD+OH, PD-No-OH); in patients w

40 It might be possible to improve treatment of orthostatic hypotension acutely with water imbibation an

41 gns of sympathetic neurocirculatory failure (orthostatic hypotension and abnormal blood-pressure resp

42 Screening autonomic function tests indicated orthostatic hypotension and confirmed chronic autonomic

43 ide an explanation for the predisposition to orthostatic hypotension and intolerance in well-trained

44 Orthostatic hypotension and parasympathetic dysfunction

45 Both orthostatic hypotension and postprandial hypotension inc

46 anding than before spaceflight, and in some, orthostatic hypotension and presyncope.

47 betes increases the risk of hypertension and orthostatic hypotension and raises the risk of cardiovas

48 Neurogenic orthostatic hypotension and supine hypertension are comm

49 comes in patients with coexistent neurogenic orthostatic hypotension and supine hypertension, clinici

50 isks for patients with coexistent neurogenic orthostatic hypotension and supine hypertension.

51 erapy in patients with coexistent neurogenic orthostatic hypotension and supine hypertension; and the

52 ration, leading to an increased incidence of orthostatic hypotension and syncope.

53 mediate benefits of treatment for neurogenic orthostatic hypotension and the long-term risks of supin

54 zation, initial orthostatic hypotension, and orthostatic hypotension are reported.

55 zation, initial orthostatic hypotension, and orthostatic hypotension based on beat-to-beat blood pres

56 thesis that short-term alcohol intake causes orthostatic hypotension because of an impairment in the

57 Orthostatic hypotension can reflect altered activity of

58 In Parkinson disease, orthostatic hypotension can result from L-dopa treatment

59 Orthostatic hypotension did not occur in PSP subjects or

60 Orthostatic hypotension did not predict falls after cont

61 Low incidence of orthostatic hypotension has been reported for silodosin,

62 Instead, patients with PD and orthostatic hypotension have clear evidence for barorefl

63 Orthostatic hypotension in patients with parkinsonism ha

64 Additional options for treatment of orthostatic hypotension include erythropoietin and, surp

65 Orthostatic hypotension is relatively uncommon, may be a

66 In LBD, orthostatic hypotension may be due primarily to involvem

67 Orthostatic hypotension may respond to erythropoietin or

68 Initial orthostatic hypotension occurred in 32.9% (95% CI, 31.2%

69 Orthostatic hypotension occurs in more than half of frai

70 available concerning the predictive value of orthostatic hypotension on mortality in ambulatory elder

71 Patients with orthostatic hypotension or absent sympathetic skin respo

72 No crew member exhibited orthostatic hypotension or presyncopal symptoms during t

73 cterised by autonomic failure, manifested as orthostatic hypotension or urogenital dysfunction, with

74 A total of 171 patients with orthostatic hypotension participated in a multicenter, r

75 Whereas neurogenic orthostatic hypotension poses risks for falls and can be

76 or autonomic failure in Parkinson disease), orthostatic hypotension reflects sympathetic neurocircul

77 uncomplicated faint, situational syncope, or orthostatic hypotension should receive electrocardiograp

78 apeutic requirements for managing neurogenic orthostatic hypotension that manifests with falls or cog

79 The prevalence of orthostatic hypotension was 6.9% (95% CI, 5.9%-7.8%) in

80 Overall prevalence of orthostatic hypotension was 6.9% and increased with age.

81 t stroke, coronary heart disease and cancer, orthostatic hypotension was a significant independent pr

82 Program's fourth examination (1991 to 1993), orthostatic hypotension was assessed in relation to subs

83 Orthostatic hypotension was defined as a drop in systoli

84 Orthostatic hypotension was most prevalent before breakf

85 ed mortality rates in those with and without orthostatic hypotension were 56.6 and 38.6 per 1000 pers

86 ay contribute to the increased prevalence of orthostatic hypotension with age.

87 ous events, two of which (hallucinations and orthostatic hypotension) were deemed related to study dr

88 In 9 patients without orthostatic hypotension, 6-[(18)F]fluorodopamine positro

89 sed a significant increase in heart rate and orthostatic hypotension, and 20% of the nortriptyline-tr

90 imates of impaired BP stabilization, initial orthostatic hypotension, and orthostatic hypotension are

91 c blood pressure (BP) stabilization, initial orthostatic hypotension, and orthostatic hypotension bas

92 re likely to have mild cognitive impairment, orthostatic hypotension, and RBD at baseline, and at pro

93 ients with PD for mild cognitive impairment, orthostatic hypotension, and RBD even at baseline visits

94 to Earth, including inordinate tachycardia, orthostatic hypotension, and uncommonly, syncope.

95 and all with Parkinson's disease-associated orthostatic hypotension, have a loss of cardiac sympathe

96 The best cluster solution found was based on orthostatic hypotension, mild cognitive impairment, rapi

97 n, upper gastrointestinal tract dysfunction, orthostatic hypotension, sweating abnormalities, or erec

98 gene encoding alpha-synuclein, also features orthostatic hypotension, sympathetic neurocirculatory fa

99 e symptomatic autonomic failure (symptomatic orthostatic hypotension, urinary incontinence, or both)

100 There was no effect by center, severity of orthostatic hypotension, use of fludrocortisone or compr

101 sk factors were identified across 6 domains: orthostatic hypotension, visual impairment, impairment o

102 ents were peripheral oedema, hypotension, or orthostatic hypotension.

103 oreceptor-cardiac reflex function and causes orthostatic hypotension.

104 m serve to protect against the occurrence of orthostatic hypotension.

105 Five of the LBD cases and all MSA cases had orthostatic hypotension.

106 action can be beneficial in the treatment of orthostatic hypotension.

107 ls, anemia, fatigue, nausea or vomiting, and orthostatic hypotension.

108 tive heart failure, cardiac arrhythmias, and orthostatic hypotension.

109 with standing, in the absence of significant orthostatic hypotension.

110 hort over 4 years; of those who died, 52 had orthostatic hypotension.

111 ious and safe in the treatment of neurogenic orthostatic hypotension.

112 One subject had evidence of orthostatic hypotension.

113 eral vascular resistance, often resulting in orthostatic hypotension.

114 supine hypertension when treating neurogenic orthostatic hypotension; the effectiveness of nocturnal

115 Identification of the gene responsible for orthostatic hypotensive disorder in these families may a

116 Familial orthostatic hypotensive disorder is characterized by lig

117 No orthostatic hypotensive or hypertensive reactions were o

118 A dynamic orthostatic hypovolemia and alpha1-adrenoreceptor hypers

119 Patients with POTS had a higher orthostatic increase in HR than controls (51+/-18 versus

120 phrine was normal supine (203.6+/-112.7) but orthostatic increment of 33.5+/-23.2% was reduced.

121 heat stress augments and cooling attenuates orthostatic-induced decreases in stroke volume (SV) via

122 Chronic orthostatic intolerance (COI) is a debilitating autonomi

123 Chronic orthostatic intolerance (COI) occurs in postural tachyca

124 ed by tilt-table testing on 15 subjects with orthostatic intolerance (OI) and UARS, five normotensive

125 Chronic orthostatic intolerance (OI) is characterized by symptom

126 in an individual with the autonomic disorder orthostatic intolerance (OI).

127 y are likely responsible for the symptoms of orthostatic intolerance across the menstrual cycle in wo

128 are probably responsible for the symptoms of orthostatic intolerance across the menstrual cycle in wo

129 Orthostatic intolerance after bed rest is characterized

130 In a patient with orthostatic intolerance and her relatives, we measured p

131 Chronic orthostatic intolerance associated with postural tachyca

132 Starling relationship, which contributes to orthostatic intolerance by causing an excessive reductio

133 s during head-up tilt (HUT) in patients with orthostatic intolerance during daily life, and to identi

134 orthostatic tolerance during cold stress and orthostatic intolerance during heat stress.

135 Patients with idiopathic orthostatic intolerance had lower cardiac vagal barorefl

136 Patients with idiopathic orthostatic intolerance have lower cardiac vagal baroref

137 the heart' is implicated in certain types of orthostatic intolerance in humans.

138 ation therapy are more effective in treating orthostatic intolerance in patients with CFS.

139 lt-table testing may be indicated to confirm orthostatic intolerance in subjects with UARS.

140 HUT fails to reproduce symptoms of orthostatic intolerance in the majority of patients.

141 Orthostatic intolerance is a syndrome characterized by l

142 Orthostatic intolerance is characterized by postural tac

143 Orthostatic intolerance is common when astronauts return

144 mild syndrome of orthostatic tachycardia or orthostatic intolerance may appear.

145 ia syndrome (POTS) induces disabling chronic orthostatic intolerance notable for an excessive increas

146 repeated neurocardiogenic presyncope (NCS), orthostatic intolerance occurs without persistent sympat

147 Patients diagnosed with idiopathic orthostatic intolerance report symptoms of lightheadedne

148 Young women are more susceptible to orthostatic intolerance than men, though the sex-specifi

149 ia syndrome (POTS) induces disabling chronic orthostatic intolerance with an excessive increase in he

150 re commonly used in the treatment of chronic orthostatic intolerance with postural tachycardia syndro

151 m onset (hazard ratio 1.67, P < 0.003); (iv) orthostatic intolerance within 1 year of symptom onset (

152 e hypothesized that patients with idiopathic orthostatic intolerance would have impaired cardiac vaga

153 rdiovascular adaptation to bed rest leads to orthostatic intolerance, characterized by an excessive f

154 by echocardiogram, weight loss > 10 pounds, orthostatic intolerance, fatigue) in combination were hi

155 uced red blood cell masses, hypovolaemia and orthostatic intolerance, marked by greater cardio-accele

156 Peak work capacity, activity level, orthostatic intolerance, salivary cortisol, and natural

157 (P< .001), primarily due to elevation of the orthostatic intolerance, secretomotor, upper gastrointes

158 Women are more susceptible to orthostatic intolerance.

159 a mechanism responsible for postspaceflight orthostatic intolerance.

160 chanism underlying individual variability in orthostatic intolerance.

161 iciency is linked to tachycardia in familial orthostatic intolerance.

162 that may contribute to, rather than offset, orthostatic intolerance.

163 ts in the treatment of patients with chronic orthostatic intolerance.

164 povolemia alone, potentially contributing to orthostatic intolerance.

165 changes that might contribute to postflight orthostatic intolerance.

166 ributes to the pathophysiologic mechanism of orthostatic intolerance.

167 underlie hyperadrenergic states that lead to orthostatic intolerance.

168 an norepinephrine transporter contributes to orthostatic intolerance.

169 ion between the chronic fatigue syndrome and orthostatic intolerance; however, treatment with the sal

170 Orthostatic intraocular pressure and mean arterial blood

171 load during thermal and combined thermal and orthostatic perturbations.

172 e series documented mild ptosis and striking orthostatic reductions in intraocular pressure and mean

173 and forearm vascular resistance (FVR) during orthostatic stress achieved by stepwise increases in low

174 ing leads to a greater decrease in SV during orthostatic stress after bed rest than hypovolemia alone

175 re and the Starling curve was steeper during orthostatic stress after HDTBR than after hypovolemia.

176 ia, astronauts respond normally to simulated orthostatic stress and are able to maintain their arteri

177 cohol consumption elicits hypotension during orthostatic stress because of impairment of vasoconstric

178 y assessed the heart variability response to orthostatic stress during tilt table testing before and

179 Impairment of the response to orthostatic stress may be involved.

180 The effect of orthostatic stress on dynamic cerebral autoregulation (C

181 n against cardiovascular collapse induced by orthostatic stress or hemorrhage.

182 Patients underwent a progressive orthostatic stress test, which continued to pre-syncope

183 Children appear to be more susceptible to orthostatic stress than adults.

184 Because orthostatic stress varies from moment to moment and drug

185 The symptoms vary with orthostatic stress, and subtle symptoms such as tirednes

186 easurements were made during supine rest and orthostatic stress, as simulated on Earth and in space b

187 ute to impaired AVP secretion in response to orthostatic stress.

188 t in the regulation of blood pressure during orthostatic stress.

189 activity and arterial blood pressure during orthostatic stress.

190 pathetic increases that occur in response to orthostatic stress.

191 and impairs sympathetic neural responses to orthostatic stress.

192 d hypotension (NMH) in response to prolonged orthostatic stress.

193 ility to increase vascular resistance during orthostatic stress.

194 mpairment in the vasoconstrictor response to orthostatic stress.

195 re and vasoconstriction in POTS women during orthostatic stress.

196 the maintenance of arterial pressure during orthostatic stress.

197 to investigate the frequency and pattern of orthostatic symptoms during head-up tilt (HUT) in patien

198 Only 25% of the patients reported orthostatic symptoms during HUT and 75% were asymptomati

199 and to identify the relationship between the orthostatic symptoms during HUT and autonomic parameters

200 We also investigated orthostatic symptoms during HUT.

201 Typical orthostatic symptoms such as orthostatic dizziness and b

202 yndrome (POTS) with exaggerated tachycardia, orthostatic symptoms, and "pooling" (which comprises acr

203 lected autonomic data from 464 patients with orthostatic symptoms.

204 iated with elevated catecholamine levels and orthostatic symptoms.

205 t and included headache, chest pressure, and orthostatic symptoms.

206 Polygraphic recordings revealed an orthostatic synchronic tremor with 17.5-Hz frequency.

207 e studied 53 otherwise healthy patients with orthostatic syncope.

208 Idiopathic orthostatic tachycardia (IOT) is characterized by an inc

209 ow dose in standing heart rate (P<0.001) and orthostatic tachycardia (P<0.001), the improvement in sy

210 New entities, such as postural orthostatic tachycardia and cerebral vasoconstrictive sy

211 yndrome (POTS) is characterized by excessive orthostatic tachycardia and significant functional disab

212 of baroreflex afferents, a mild syndrome of orthostatic tachycardia or orthostatic intolerance may a

213 ced blood volume contributes to the postural orthostatic tachycardia syndrome (POTS) and that exercis

214 Patients with the postural orthostatic tachycardia syndrome (POTS) are primarily pr

215 Women with the postural orthostatic tachycardia syndrome (POTS) report fluctuati

216 omponent of the pathogenesis of the postural orthostatic tachycardia syndrome (POTS), similar to phys

217 Fibroblasts from a patient with postural orthostatic tachycardia syndrome (POTS), who presented w

218 ropriate sinus tachycardia and from postural orthostatic tachycardia syndrome, with which overlap may

219 posture and may contribute to the subsequent orthostatic tachycardia that is the hallmark of this dis

220 Activity level, exercise tolerance, and orthostatic testing could not distinguish patients with

221 iorated the heat stress-induced reduction in orthostatic tolerance (1110 +/- 69 CSI, P < 0.001).

222 (18%), SV (12%), LVEDV (16%), V0 (33%), and orthostatic tolerance (24%) (all P<.05).

223 negative pressure test to determine level of orthostatic tolerance (cumulative stress index, CSI), wo

224 Orthostatic tolerance (expressed in cumulative stress in

225 nces adrenergic responses in women with high orthostatic tolerance (HT).

226 neous adrenergic responses in women with low orthostatic tolerance (LT), whereas progesterone enhance

227 We examined two novel hypotheses: (1) that orthostatic tolerance (OT) would be prolonged when hyper

228 Dehydration is known to decrease orthostatic tolerance and cause tachycardia, but little

229 Astronauts returning to Earth have reduced orthostatic tolerance and exercise capacity.

230 Phenylephrine, but not esmolol, improves orthostatic tolerance and hemodynamics in POTS.

231 Phenylephrine improved orthostatic tolerance and normalized hemodynamics and in

232 mpathetic tone in patients with NMS improves orthostatic tolerance and raises the possibility that th

233 Whole-body heat stress alone reduced orthostatic tolerance by approximately 80% compared to n

234 mechanism may contribute to improvements in orthostatic tolerance during cold stress and orthostatic

235 dicate that midodrine significantly improves orthostatic tolerance during head-up tilt in patients wi

236 rial blood pressure in an effort to preserve orthostatic tolerance during heat stress.

237 body mass index 22 +/- 1 kg m(-2)) or a high orthostatic tolerance group (HT, n = 7, 22 +/- 1 years o

238 and nonneural tissue, on blood pressure and orthostatic tolerance in 19 patients with severe NOH (8

239 00+/-6 mm Hg) for several hours and improved orthostatic tolerance in all patients.

240 soconstrictor capability is a contributor to orthostatic tolerance in humans.

241 whether prophylactic water drinking improves orthostatic tolerance in normal healthy adults.

242 L-DOPS increases blood pressure and improves orthostatic tolerance in patients with NOH.

243 rough an impedance threshold device (ITD) on orthostatic tolerance in patients with postural tachycar

244 cycle alter sympathetic neural activity and orthostatic tolerance in POTS women.

245 nderlying mechanism responsible for impaired orthostatic tolerance in the heat-stressed human.

246 ower stroke volume contribute to compromised orthostatic tolerance in women; this inability to vasoco

247 mechanisms contribute to sex differences in orthostatic tolerance in young humans.

248 he hypothesis that individual variability in orthostatic tolerance is dependent on the degree of neur

249 Esmolol did not improve orthostatic tolerance or hemodynamics.

250 ensated Fontan subjects demonstrate superior orthostatic tolerance resulting from decreased compartme

251 ardia syndrome (POTS) report fluctuations in orthostatic tolerance throughout the menstrual cycle.

252 Whole-body heat stress reduces orthostatic tolerance via a yet to be identified mechani

253 jects (age, 40 +/- 10 years: mean +/- S.D.), orthostatic tolerance was assessed using graded lower-bo

254 Orthostatic tolerance was determined by progressive lowe

255 tal conditions have the capacity to modulate orthostatic tolerance, where heat stress decreases and c

256 oxygenase pathway in women with high and low orthostatic tolerance.

257 attenuates heat stress-induced reductions in orthostatic tolerance.

258 heat stress decreases and cooling increases orthostatic tolerance.

259 sma volume (with Evans blue dye) and maximal orthostatic tolerance.

260 e sensitive to E2 exposure in women with low orthostatic tolerance.

261 ibute to sex differences in hypertension and orthostatic tolerance.

262 d heart rate responses to orthostasis in low orthostatic tolerant women, which is likely to be a comp

263 Patients with primary orthostatic tremor (OT) experience a disabling sense of

264 Orthostatic tremor (OT) is a high-frequency (13-18 Hz) l

265 s, 86.8% of patients presented with isolated orthostatic tremor and 13.2% had additional neurological

266 inical and electrophysiological diagnosis of orthostatic tremor and a minimum follow-up of 5 years is

267 Although the essential clinical features of orthostatic tremor are well established, little is known

268 There was no change in orthostatic tremor frequency over time.

269 Orthostatic tremor has an unknown pathophysiologic mecha

270 Orthostatic tremor is a progressive disorder with increa

271 Orthostatic tremor is a rare condition characterised by

272 Primary orthostatic tremor is characterized by unsteadiness and

273 p, seven patients who initially had isolated orthostatic tremor later developed further neurological

274 istic, action tremor, re-emergent tremor and orthostatic tremor may occur in Parkinson disease.

275 postural muscle EMG signals in five primary orthostatic tremor patients and in two normal controls t

276 In most cases, orthostatic tremor represents an isolated syndrome.

277 otal 79.4% of patients reported worsening of orthostatic tremor symptoms.

278 olated tongue tremor, Wilson's disease, slow orthostatic tremor, peripheral trauma-induced tremor, ta

279 The condition known as primary orthostatic tremor, which is not too well known to many

280 are due to the primary pathology of primary orthostatic tremor.

281 largest multicentre cohort of patients with orthostatic tremor.

282 Rest, Holmes' ('rubral') and primary orthostatic tremors were not encountered.

283 limb blood flow ("high flow") and defective orthostatic vasoconstriction or decreased limb blood flo

284 We studied hemodynamic changes leading to orthostatic vasovagal presyncope to determine whether ch

285 The final trigger of human orthostatic vasovagal reactions appears to be the abrupt

286 Patients with orthostatic vasovagal reactions have impaired vagal baro

287 Orthostatic vasovagal reactions occurred in 21 patients,

288 oregulation contributes to the occurrence of orthostatic vasovagal syncope.

289 rterial pressure reductions in patients with orthostatic vasovagal syncope.

290 sympathetic nerve activity in patients with orthostatic vasovagal syncope.

291 story and physical examination that includes orthostatic vital signs measured in both recumbent and v

292 mistry, hematology, coagulation, urinalysis, orthostatic vital signs, WSF, or 12-lead ECG parameters.

293 ose and postdose safety assessments included orthostatic vital signs; 6-lead continuous telemetry mon