ライフサイエンスコーパス: orthovanadate

1 osine and dual-specific phosphatases, sodium orthovanadate.

2 y ligands such as MgATP, MgADP, or inorganic orthovanadate.

3 ts in its apparent affinity for ATP, H+, and orthovanadate.

4 UV-C, gamma radiation, TNF-alpha, and sodium orthovanadate.

5 ), with optimal effects seen at 25 microg/ml orthovanadate.

6 aration containing vanadyl ribonucleoside or orthovanadate.

7 were reversed by pertussis toxin and sodium orthovanadate.

8 in surface AMPAR clusters was unaffected by orthovanadate.

9 eptor (AMPAR) subunits, an effect blocked by orthovanadate.

10 opiperazines and the ATPase inhibitor sodium orthovanadate.

11 more sensitive to beryllium fluoride than to orthovanadate.

12 state at NBD2 by the gamma-phosphate analog orthovanadate.

13 ited by TNF, and this was reversed by sodium orthovanadate.

14 presence of the phosphatase inhibitor sodium orthovanadate.

15 ase inhibitors phenylarsine oxide and sodium orthovanadate.

16 n cells pretreated with the PTPase inhibitor orthovanadate.

17 e in either apoptosis or survival induced by orthovanadate.

18 otein-tyrosine phosphatase inhibitor, sodium orthovanadate.

19 PP inhibition with sodium orthovanadate (100 microM), okadaic acid (10 nM), or Ro

20 D98,059 (20 microM) or phosphatase inhibitor orthovanadate (30 microM) completely blocked the potenti

21 However, treatment with orthovanadate (50 microM), a widely used tyrosine phosph

22 n of phosphatase inhibitors (5 mmol/l sodium orthovanadate, 50 mmol/l sodium fluoride, or 5 mmol/l ED

23 ysis with the tyrosine phosphatase inhibitor orthovanadate (500 microM) prevented the actions of both

24 r cells treated with interleukin-6 (IL-6) or orthovanadate (a general activator of STATs) were fracti

25 er preincubation of oocytes with 1 mM sodium orthovanadate (a protein tyrosine phosphatase inhibitor)

26 red insulin's effect on MAPK activity, while orthovanadate (a tyrosine phosphatase inhibitor), inhibi

27 Sodium orthovanadate, a known inhibitor of TDP2, inhibits produ

28 Indeed, infusion of sodium orthovanadate, a nonspecific MKP inhibitor, attenuated M

29 hat the inhibitory form is usually monomeric orthovanadate, a particularly good inhibitor of phosphat

30 nt HCD57 murine cell line with 70 micromol/L orthovanadate, a tyrosine phosphatase inhibitor, resulte

31 The tyrosine phosphatase inhibitor sodium orthovanadate ablated the inhibitory effects of roscovit

32 Orthovanadate activated JAK2, STAT1, STAT5, the phosphat

33 ally, we show that the phosphatase inhibitor orthovanadate acts as does CHI to render cells susceptib

34 Orthovanadate also delayed apoptosis in primary human er

35 rthermore, the well studied PTPase inhibitor orthovanadate also induced protein tyrosine phosphorylat

36 (Sp)-cAMP, cells were pretreated with sodium orthovanadate, an inhibitor of phosphotyrosine phosphata

37 Culture of normal erythroid progenitors with orthovanadate, an inhibitor of protein tyrosine phosphat

38 zes ATP (Km, 0.62 mm), which is inhibited by orthovanadate and beryllium fluoride.

39 tion, and two general PTP inhibitors, sodium orthovanadate and bpV(pic), dramatically rescued the cel

40 otein-tyrosine-phosphatase inhibitors sodium orthovanadate and dephostatin prevented PPARgamma ligand

41 It was inhibited by orthovanadate and fluoride compounds.

42 that was abolished in the presence of sodium orthovanadate and inhibited significantly by the sulfhyd

43 ibited by the tyrosine phosphatase inhibitor orthovanadate and is particularly sensitive to inhibitio

44 Other PTP inhibitors--orthovanadate and phenylarsine oxide (PAO)-inhibited PTP

45 otein tyrosine phosphatase (PTP) inhibitors, orthovanadate and phenylarsine oxide, selectively block

46 he Camnn9Delta strain is resistant to sodium orthovanadate and sensitive to hygromycin B.

47 nd the protein phosphatase inhibitors sodium orthovanadate and sodium fluoride.

48 inhibitors of tyrosine phosphatases (sodium orthovanadate and sodium molybdate) but not by inhibitor

49 ith a tyrosine phosphatase inhibitor (sodium orthovanadate) and T-cell activation signals (phorbol 12

50 rotein kinase (MAPK) was poorly activated by orthovanadate, and inhibition of MAPK with PD98059 block

51 The PTP inhibitors ALN, orthovanadate, and PAO suppressed in vitro formation of

52 vely high Km for ATP (1.9 mM), inhibition by orthovanadate, and the ability to specifically bind an a

53 ptimal at pH 7; 2) potently inhibited by F-, orthovanadate, and Zn2+ > Co2+ > Mn2+ but unaffected by

54 Vanadyl ribonucleoside and orthovanadate are commonly employed as inhibitors of rib

55 Orthovanadate, BeFx, and AlFx effectively inhibited ABCG

56 Pertussis toxin and orthovanadate blocked AT2 receptor-mediated ceramide pro

57 Finally, in dissociated hippocampal neurons, orthovanadate blocked the ability of DHPG to reduce the

58 Pretreatment of neurons with sodium orthovanadate blocked the ability of insulin to inhibit

59 Additionally, orthovanadate blunted the effect of sarcomere length on

60 The enzyme is inhibited by sodium orthovanadate but not by sodium fluoride or okadaic acid

61 The activity is inhibited by orthovanadate, but not by N-ethylmaleimide, bafilomycin

62 (B44) and a tyrosine phosphatase inhibitor (orthovanadate), changes in both CCK- and TPA-stimulated

63 te is due to formation of a pentacoordinated orthovanadate complex at the phosphorylation site, corre

64 The ATPase inhibitor sodium orthovanadate demonstrated dose-dependent inhibition of

65 Sodium orthovanadate had a slight but significant inhibitory ef

66 -1 cells with either cycloheximide or sodium orthovanadate had little effect on the early peak of ERK

67 eral other ABC proteins and was inhibited by orthovanadate in a profile diagnostic of ABC transporter

68 Inactivation of PTPs with sodium orthovanadate in human and rodent islets and beta-cells

69 cal for the survival of erythroid cells, and orthovanadate in the absence of EPO both maintained expr

70 ells with the tyrosine phosphatase inhibitor orthovanadate in the presence of insulin or okadaic acid

71 promotion of pro-MMP-2 activation by sodium orthovanadate in the presence of suboptimal concentratio

72 posure to the tyrosine phosphatase inhibitor orthovanadate increases tyrosine phosphorylation of beta

73 otein tyrosine phosphatase inhibitor, sodium orthovanadate, increases eNOS tyrosine phosphorylation.

74 Both showed orthovanadate-independent retention of ATP and ADP.

75 Furthermore, sodium orthovanadate-induced phosphorylation of ASC Y144, neces

76 plete inhibition of ATPase activity, whereas orthovanadate inhibited exclusively the PC-stimulated AT

77 A phosphatase inhibitor, sodium orthovanadate, inhibited endothelial cell apoptosis and

78 rotein tyrosine phosphatase inhibitor sodium orthovanadate inhibits fertilization suggest that protei

79 dimer is most prominent upon the addition of orthovanadate (K(i) = 0.70 +/- 0.20 microM) and PhAH, in

80 Thus, orthovanadate likely acts to greatly increase JAK/STAT a

81 In the presence of orthovanadate, Lys-174 at the boundary between M2 and th

82 ts or T-cells with the phosphatase inhibitor orthovanadate markedly abolished MIP1beta-induced chemot

83 tase (PTP), because the PTP inhibitor sodium orthovanadate mimicked the effects of Go6976.

84 rt that the addition of BeF(3)(-) and sodium orthovanadate (Na(3)VO(4)) to medium containing digitoni

85 Sodium orthovanadate (Na3VO4), sodium oxodiperoxo(1,10-phenanth

86 n via the patch pipette of 200 microM sodium orthovanadate (Na3VO4), which inhibits tyrosine phosphat

87 yrosine phosphatases (PTPs) inhibitor sodium orthovanadate (Na3VO4).

88 SHP1 overrecruitment, treatment with sodium orthovanadate or a novel inhibitor with micromolar activ

89 sing either the phosphatase inhibitor sodium orthovanadate or antisense oligonucleotides prevents the

90 Global phosphatase inhibition by orthovanadate or depletion of protein tyrosine phosphata

91 hibition of phosphoprotein phosphatases with orthovanadate or fluoride yielded a global protein phosp

92 otactic activity in HAEC treated with sodium orthovanadate or MKP-1 antisense oligonucleotides is due

93 tion of the intracellular stores with either orthovanadate or thapsigargin.

94 presence of a phosphatase inhibitor, sodium orthovanadate, or antisense oligonucleotides, suggesting

95 tyrosine phosphatase (PTPase) inhibition by orthovanadate (OVA) showed that this Src activity is hig

96 Three such compounds, sodium orthovanadate, peroxovanadate, and bpV(phen), had no eff

97 Inclusion of 2 mM orthovanadate, polymerized primarily to decavanadate, in

98 of the tyrosine phosphatase inhibitor sodium orthovanadate prior to ethanol restored tyrosine phospho

99 splayed a 40-fold decrease in sensitivity to orthovanadate, reflecting a shift in equilibrium from th

100 a mixture of hydrogen peroxidase and sodium orthovanadate, respectively.

101 ld type or mutant forms of PECAM-1 to sodium orthovanadate resulted in high levels of cytoplasmic tyr

102 mutant cells with the phosphatase inhibitor orthovanadate resulted in strong coordinate elevation of

103 Orthovanadate-sensitive (45)Ca(2+) transport into vesicl

104 ct, like S1P-mediated ERK1/2 inhibition, was orthovanadate-sensitive and pertussis toxin-insensitive.

105 via an ATP-driven, protonophore-insensitive, orthovanadate-sensitive mechanism, equating with export

106 These results suggest that a TPA-inducible, orthovanadate-sensitive protein-tyrosine phosphatase may

107 ase activity by phenylarsine oxide or sodium orthovanadate shifted ventricular hyperpolarization-acti

108 d the reversal and phosphatase inhibition by orthovanadate significantly accelerated the recovery.

109 suggesting a critical role of PI-3 kinase in orthovanadate-stimulated survival.

110 ocytes also displayed GTP gamma S and sodium orthovanadate stimulation of actin comet tails on GLUT4

111 a-thio]triphosphate (GTP gamma S) and sodium orthovanadate stimulation of actin comet tails.

112 imulated KDR activity was impaired by sodium orthovanadate, suggesting that the inhibitory activity o

113 1/2 activity was abolished by treatment with orthovanadate, suggesting the involvement of a tyrosine

114 Inhibition of dephosphorylation with sodium orthovanadate suggests that this effect is at least part

115 Upon activation of signaling by IL-6 or orthovanadate the respective Tyr-phosphorylated STAT spe

116 one in the presence of 100 micromol/L sodium orthovanadate to prevent enzymatic redistribution of lip

117 sence and presence of the phosphate analogue orthovanadate, to determine the roles the nucleoside moi

118 Orthovanadate-trapping experiments showed that mutation

119 PI-3 kinase activity, triggered apoptosis in orthovanadate-treated cells, suggesting a critical role

120 ated what survival signals were activated by orthovanadate treatment.

121 Orthophosphate and the oxoanion analogues orthovanadate, tungstate, molybdate, arsenate, and sulfa

122 ormation in the presence of Mg(2+), ADP, and orthovanadate (V(i)), a photoreactive phosphate analog w

123 of the stable myosin subfragment 1(S1).MgADP.orthovanadate (Vi) complex results in oxidation of an ac

124 The loss of coupling in the presence of orthovanadate (Vi) suggests that the gamma-phosphate of

125 his reason, we have carried out studies with orthovanadate (Vi), a phosphate analog which has the pot

126 can hydrolyze ATP simultaneously, we used an orthovanadate (Vi)-induced ADP-trapping technique (P-gp.

127 Sensitivity toward orthovanadate was increased when Asn-106 was substituted

128 Mg(2+)-ADP and orthovanadate were used to examine the structural effect

129 Orthovanadate, which inhibits dynein activity, specifica

130 ructure of AcpA complexed with the inhibitor orthovanadate, which is the first structure of any F. tu

131 h Gly-371 were highly resistant to inorganic orthovanadate, with IC(50) values at least 10-fold above

132 Application of orthovanadate, Zn(2+), or poly(Glu, Tyr) (4:1), each of