1 ntration, and undetermined solute (idiogenic osmole).

2 ents are minimized, for example by idiogenic osmoles.

3                    We compared the admission osmole gap between all 18 NNICU patients and healthy con

4 tudent's t-test was used to compare the mean osmole gap between control and patient groups.We found t

5 R =.60), significantly lower than any of the osmole gap calculations.

6 cific mannitol serum concentration, a normal osmole gap concentration, as we find at trough times, in

7                                          The osmole gap correlates better with mannitol serum concent

8 ignificant differences between any of the 11 osmole gap formulas and the correlation of osmole gap wi

9 ol and patient groups.We found that the mean osmole gap in healthy subjects and NNICU patients was no

10 healthy controls and the correlation between osmole gap or osmolality and mannitol serum concentratio

11                                          The osmole gap was calculated using 11 osmolarity formulas (

12 1 osmole gap formulas and the correlation of osmole gap with serum mannitol concentrations; the highe

13                                          The osmole gap-mannitol serum concentrations relationship is

14  Hydrostatic pressures, fixed charges and/or osmoles in the t-system can influence the magnitude of t

15 itution of isotonic conditions with specific osmoles or inhibition with mechanosensitive ion channel

16 o failure of brain amino acids and idiogenic osmoles to dissipate as plasma [Na+] is decreased to nor