ライフサイエンスコーパス: ossification

1 tinct from archetypical physeal endochondral ossification.

2 t stature, joint laxity, and advanced carpal ossification.

3 der, thereby explaining the overall delay in ossification.

4 transcriptional repertoire that can lead to ossification.

5 ensive placoid fibrous metaplasia with focal ossification.

6 ed metalloproteinase ADAM17, in endochondral ossification.

7 tropic control groups underwent endochondral ossification.

8 cification and has many similarities to bone ossification.

9 P63alpha and TAP63alpha, during endochondral ossification.

10 abnormal tissue repair: fibrosis and ectopic ossification.

11 hondrocytes during growth plate endochondral ossification.

12 ion to osteoblasts and impaired endochondral ossification.

13 ian skull vault form through intramembranous ossification.

14 ification centers and disrupted endochondral ossification.

15 reducing hedgehog signaling and endochondral ossification.

16 of de novo appositional and intramembraneous ossification.

17 by bone through the process of endochondral ossification.

18 d in digit/limb development and endochondral ossification.

19 of Atf4 in chondrocytes during endochondral ossification.

20 egion of the mandible undergoes endochondral ossification.

21 minantly through the process of endochondral ossification.

22 th plates reflecting defects in endochondral ossification.

23 se hypertrophy would result in apoptosis and ossification.

24 eletal elements derived through endochondral ossification.

25 I) is an important regulator of endochondral ossification.

26 is of normal cartilage and thus endochondral ossification.

27 lage formation and excessive intramembranous ossification.

28 and bifid sternum as well as delayed sternal ossification.

29 of HMGB1 in cartilage regulates endochondral ossification.

30 fication is a progressive process resembling ossification.

31 gmentation, joint formation and endochondral ossification.

32 s in growth, chondrogenesis and endochondral ossification.

33 r a chondrogenic lineage during endochondral ossification.

34 stained chondrocyte maturation and occipital ossification.

35 malformations and progressive extraskeletal ossification.

36 e (MAPK) pathway is involved in endochondral ossification.

37 Nell1 in signal transduction in endochondral ossification.

38 suggest an underlying defect in endochondral ossification.

39 en and Osteocalcin), suggesting endochondral ossification.

40 tilage boundary definition, and endochondral ossification.

41 losure of the PF suture through endochondral ossification.

42 al base are both formed through endochondral ossification.

43 ding reduced cartilage formation and delayed ossification.

44 areas where repair occurs by intramembranous ossification.

45 hondrogenic differentiation and endochondral ossification.

46 ne union, and resulted in robust heterotopic ossification.

47 ypertrophic chondrocytes during endochondral ossification.

48 revealed delayed or incomplete endochondral ossification.

49 repair and substantially limited heterotopic ossification.

50 hondrogenic differentiation and endochondral ossification.

51 of TRPM7 in endochondral and intramembranous ossification.

52 expression rheostatically controls skeletal ossification.

53 in phosphatase Phlpp1 regulates endochondral ossification.

54 hondrogenic differentiation and endochondral ossification.

55 olysis syndromes are regions of subarticular ossification.

56 oliferating chondrocytes during endochondral ossification.

57 1/2/4 may regulate Runx2 during endochondral ossification.

58 scular invasion, and subsequent endochondral ossification.

59 uted tomography in the exact localization of ossifications.

60 particularly in MSX1/2, through endochondral ossification 6 weeks post-injection.

61 gamma (RARgamma) agonist blocks heterotopic ossification, a pathological bone formation that mostly

62 tissues, including excessive intramembranous ossification all along the perichondrial border and the

63 ian hedgehog signaling activity, and ectopic ossification along its lateral border.

64 he palatal shelves accompanied by a delay in ossification along the fusion area of secondary palatal

65 stingly, there was excessive intramembranous ossification along the perichondrium, accompanied by exc

66 stingly, there was excessive intramembranous ossification along the perichondrium, accompanied by loc

67 d a lack of endochondral and intramembranous ossification and a lack of mature osteoblasts comparable

68 lanx forms late in gestation by endochondral ossification and continues to elongate until sexual matu

69 p107 in cartilage development, endochondral ossification and enchondroma formation that reflects the

70 p107 in cartilage development, endochondral ossification and enchondroma formation that reflects the

71 owards abnormal tissue growth and perfusion, ossification and endochondral bone development, leading

72 se model is the first with both subcutaneous ossification and fibroepithelial polyps related to G(s)a

73 e undergoes intramembranous and endochondral ossification and forms a trabecular-like bone organ incl

74 rant mechanical loading leads to accelerated ossification and hypertrophy of EP, decreased IVD volume

75 o severe skeletal defects, including delayed ossification and low bone mass, short stature and short

76 uces not only genes commonly associated with ossification and mineralization but also genes important

77 We report here both the late onset ossification and occurrence of benign cutaneous fibroepi

78 sibly be repurposed for treating heterotopic ossification and other diseases caused by GNAS inactivat

79 Relationships among pulmonary ossification and parenchymal patterns, clinical paramete

80 Low levels of phosphate can disrupt bone ossification and predispose to fractures.

81 evidence for the role of p38 in endochondral ossification and suggests that Sox9 is a likely downstre

82 with Wnt antagonists results in endochondral ossification and suture closure.

83 n 4 is functionally involved in endochondral ossification and that its loss impairs fracture healing,

84 processes of chondrogenesis and endochondral ossification and their control at the molecular level.

85 canonical Wnt signaling enable endochondral ossification and therefore PF-suture closure, whereas co

86 aling in the PF suture inhibits endochondral ossification and therefore, suture closure, In contrast,

87 ype lectin domain in regulating endochondral ossification and, thereby, height.

88 critical role in the control of endochondral ossification, and bone growth and mutations that cause h

89 , impaired formation of secondary centres of ossification, and joint abnormalities including elbow di

90 impairs hypertrophy, cartilage angiogenesis, ossification, and longitudinal bone growth in mice.

91 r of Ihh-Gli2 signalling during endochondral ossification, and that disruption of the Foxc1-Gli2 inte

92 epiphyseal and metaphyseal shape, secondary ossification, and the perichondrium on 1.5-T echo-planar

93 a rare genetic disease in which heterotopic ossifications appear in early childhood and are accompan

94 etal elements that form through endochondral ossification are absent, and the ones that form are rudi

95 y which gadolinium could induce fibrosis and ossification are not known.

96 Chondrogenesis and endochondral ossification are precisely controlled by cellular intera

97 Chondrogenesis and endochondral ossification are the cartilage differentiation processes

98 pression to control the rate of endochondral ossification as a negative feedback mechanism.

99 and had enhanced early and late endochondral ossification as demonstrated by Safranin O, Picrosirius

100 ral ossification but delayed intramembranous ossification, as well as skeletal deformities.

101 reviously unrecognized delay in endochondral ossification associated with the loss of Gpc3 function.

102 formation at CT, with a subtle focus of new ossification at 3 weeks and a larger focus of ossificati

103 ssification at 3 weeks and a larger focus of ossification at 6 weeks.

104 rophic chondrocytes accelerates endochondral ossification at both E17.5 and P1 stages.

105 ressed in chondrocytes inhibits endochondral ossification at the epiphysis by suppressing HIF signali

106 irment to the middle ear, demonstrating over-ossification at the round window ridge, ectopic depositi

107 The absolute size at which limb ossification began differs greatly between individuals,

108 ollectively, our data implicate endochondral ossification, bone formation that proceeds through a car

109 egulate Fmn1 function at the hypertrophic-to-ossification border, thereby explaining the overall dela

110 se in Fmn1 expression at the hypertrophic-to-ossification border.

111 n via either intramembranous or endochondral ossification, both within and outside of the craniofacia

112 fferentiation does not occur by endochondral ossification but by the direct ossification of blastema

113 alterations include accelerated endochondral ossification but delayed intramembranous ossification, a

114 growth plate maturation during endochondral ossification but simultaneously results in massively ele

115 (BM) is tightly associated with endochondral ossification, but little is known about the mechanisms i

116 ntiation of chondrocytes during endochondral ossification by activating the TGFalpha/EGFR signaling a

117 the early steps of heterotopic endochondral ossification by lowering oxygen tension in adjacent tiss

118 athway plays essential roles in endochondral ossification by regulating osteoblast proliferation and

119 e deacetylases (Hdacs) regulate endochondral ossification by suppressing gene transcription and modul

120 sized that hMSCs pushed through endochondral ossification can engineer a scaled-up ossicle with featu

121 se, a mouse model with impaired endochondral ossification caused by a loss of osteoclast (OCL) activi

122 physis, epiphyseal cartilage, and secondary ossification center (P < .05).

123 in a delay in the formation of the secondary ossification center (SOC).

124 thus impairing the formation of the primary ossification center and causing severe limb shortening.

125 c mice showed delayed formation of secondary ossification center and localized increase of bone mass

126 clast numbers were reduced in both secondary ossification center and proximal metaphysis.

127 vascular invasion and formation of the early ossification center at least in part by interfering with

128 lowed by the formation of a new endochondral ossification center at the distal end of the bone stump.

129 The endochondral ossification center contains proliferating chondrocytes

130 zone comes to be subdivided by the secondary ossification center into distinct articular and growth c

131 le due to repetitive strain on the secondary ossification center of the tibial tuberosity.

132 he chondrocytes of the prospective secondary ossification center precludes its development.

133 structures by stimulating a new endochondral ossification center that utilizes an existing network of

134 ication orientation in the condylar ramus (1 ossification center) versus long bone ossification forma

135 the physis, epiphyseal cartilage, secondary ossification center, and metaphysis was qualitatively as

136 portant role in the formation of the primary ossification centers (POCs) and secondary ossification c

137 ry ossification centers (POCs) and secondary ossification centers (SOCs) of mammalian long bones.

138 ociated with poor vascularization of primary ossification centers and disrupted endochondral ossifica

139 one formation would accelerate the fusion of ossification centers and limit the endochondral bone gro

140 In addition, secondary ossification centers do not form in the central regions

141 have neither craniosynostosis nor additional ossification centers in interfrontal suture and displaye

142 Using the polarity of the endochondral ossification centers induced by BMP2 at two different am

143 asts migrate from perichondrium into primary ossification centers of cartilage templates of future bo

144 ) versus long bone ossification formation (2 ossification centers).

145 ed protein accumulation in marrow, secondary ossification centers, and periosteum.

146 adiograph: the appearance, size and shape of ossification centers, the width and the shape of growth

147 During vascular invasion and formation of ossification centers, these Nes(+) cells were closely as

148 promote synchondrosis closure and fusion of ossification centers.

149 ay in the formation of primary and secondary ossification centers.

150 sect the causative relationships between neo-ossification, cholesterol crystal deposition, and Eustac

151 During endochondral ossification, chondrocytes embed themselves in a proteog

152 periosteal cells during primary endochondral ossification, consistent with a role in bone development

153 Heterotopic ossification consists of ectopic bone formation within s

154 ) PF-sutures lack physiological endochondral ossification, contain ectopic cartilage and display dela

155 We show that this ossification defect is not attributable to a permanent a

156 g to severe intramembranous and perichondral ossification defects.

157 was defined as 10 or more bilateral nodular ossifications (definition 1) or as one or more lobes wit

158 re lobes with five or more bilateral nodular ossifications (definition 2).

159 by defects in skeletal structures, including ossification delay in several membranous bones and enlar

160 ent of the appendicular skeleton, and carpal ossification delay.

161 Endochondral ossification depends on an avascular cartilage template

162 Moreover, physiological endochondral ossification did not occur, rather an ectopic cartilage

163 , a debilitating and progressive heterotopic ossification disease caused by activating mutations of A

164 estigate the prevalence of diffuse pulmonary ossification (DPO) in patients with fibrosing interstiti

165 east in part, as a regulator of endochondral ossification during osteogenesis.

166 ysplasia and a complete lack of endochondral ossification even though Runx2 expression, Indian hedgeh

167 pathway promotes chondrocyte maturation and ossification events, and may exert this important role b

168 se that involves redifferentiation by direct ossification (evolved regeneration), the BMP-induced res

169 nchymal stem cells in vitro and endochondral ossification ex vivo, and GEP-knockdown mice display ske

170 mus (1 ossification center) versus long bone ossification formation (2 ossification centers).

171 or calvaria that do not undergo endochondral ossification formed only bone without marrow in our assa

172 n of the digit tip occurs by intramembranous ossification forming a trabecular bone network that repl

173 During endochondral ossification, growth plate chondrocytes release plasma m

174 to 20% of civilians who develop heterotopic ossification (HO) after blast-related extremity injury a

175 Heterotopic ossification (HO) and fatty infiltration (FI) often occu

176 a rare developmental disorder of heterotopic ossification (HO) caused by heterozygous inactivating ge

177 extraskeletal bone formation, or heterotopic ossification (HO), occurs following mechanical trauma, b

178 Heterotopic ossification (HO), or the abnormal formation of bone in

179 Heterotopic ossification (HO), the abnormal formation of bone within

180 genetic disorder of progressive heterotopic ossification (HO).

181 according to risk of developing heterotopic ossification (HO).

182 tribution of lymphatic tissue to heterotopic ossification (HO).

183 The classic model of endochondral ossification holds that chondrocytes mature to hypertrop

184 ion at its distal end occurs by appositional ossification, i.e. direct ossification on the surface of

185 racterized by hypotonia, cataracts, abnormal ossification, impaired motor development, and intellectu

186 Indian hedgehog (Ihh) regulates endochondral ossification in both a parathyroid hormone-related prote

187 ermore, FST-loaded microbeads decreased bone ossification in developing chick femora (6%) and tibiae

188 a phenotype paralleled by premature clavicle ossification in Eif4a3 haploinsufficient embryos.

189 Endochondral ossification in embryos from embryonic day 16.5 was asse

190 understand the mechanisms of intramembranous ossification in general, which occurs not only during cr

191 be rescued by an Hdac4 mutation, and ectopic ossification in Hdac4 null mice can be diminished by a h

192 st injury-induced and congenital heterotopic ossification in humans.

193 al cartilage origin and subsequent stages of ossification in JOCD.

194 or postnatal day 1 (P1) observed accelerated ossification in long bone, digit and tail bones compared

195 l cartilage differentiation and endochondral ossification in mandibular condylar cartilage.

196 Lineage tracing of heterotopic ossification in mice using a Tie2-Cre construct also sug

197 lls and disrupted caALK2-induced heterotopic ossification in mice.

198 delay of osteoblast differentiation and bone ossification in mice.

199 gonists are potent inhibitors of heterotopic ossification in mouse models and, thus, may also be effe

200 play a role in systemic fibrosis and ectopic ossification in nephrogenic systemic fibrosis.

201 ormed the rudiment elongates by appositional ossification in parallel with unamputated control digits

202 Endochondral ossification in the diaphysis of long bones has been stu

203 rocyte proliferation and an overall delay in ossification in the double-knockout mice.

204 arded chondrocyte development and enchondral ossification in the epiphyseal growth plate.

205 ee joint and remarkable defects of postnatal ossification in the long bones.

206 on of cartilage and promotes intramembranous ossification in the skull.

207 on, an RAR-gamma agonist blocked heterotopic ossification in transgenic mice expressing activin recep

208 Smad7 is actually required for endochondral ossification in vivo is unclear.

209 composed of distinct cartilages and gnathal ossifications in both jaws, and a dermal element in the

210 sible to precisely determine the position of ossifications in relation to the internal organs and blo

211 ositis ossificans refers to the formation of ossifications in the muscles, ligaments and fascias, usu

212 ibute to suture closure through endochondral ossification, in a process regulated in part by PI3K/AKT

213 , a major negative regulator of endochondral ossification, in Col2a1-TAP63alpha transgenic mice.

214 The gnathal ossification is a composite of distinct teeth that devel

215 Endochondral ossification is a highly regulated process that relies o

216 The ossification is confined to subcutaneous tissues and so

217 function mouse (Foxc1(ch/ch)), endochondral ossification is delayed and the expression of Ihh target

218 Moreover, ossification is initiated from the inferior portion of m

219 Ossification is severely reduced after condensation of t

220 ng embryogenesis and found that endochondral ossification is significantly impaired due to the delay

221 dothelial cell masses, abnormal endochondral ossification, leading to stunted long bone growth and in

222 Disruption to endochondral ossification leads to delayed and irregular bone formati

223 cle architecture adjacent to the heterotopic ossification lesion, suggesting that RARgamma agonist ma

224 rmal bone formation in areas of subarticular ossification may explain the site-specific distribution

225 origin effects on the age of femoral capital ossification measured at the left and right hips of a ca

226 repair of most bones proceed by endochondral ossification, namely through formation of a cartilage in

227 to subcutaneous tissues and so resembles the ossification observed with AHO.

228 sts that two different forms of endochondral ossification occur.

229 Murine forepaw ossification occurred sequentially.

230 essiva (FOP), a disease in which heterotopic ossification occurs as a result of activating ALK2 mutat

231 res, caused by deficiency in intramembranous ossification, occurs at early postnatal stages.

232 ssive sesamoids that employ a patchy mode of ossification of a massive cartilaginous precursor and th

233 endochondral ossification but by the direct ossification of blastema cells that form the rudiment of

234 ion of articular chondrocytes and the timely ossification of bones in joint regions.

235 bone malformations resulting from premature ossification of developing bones.

236 osteoblasts, negatively regulates secondary ossification of epiphyses.

237 C causes precocious chondrocyte hypertrophy, ossification of growth plates, and dwarfism.

238 and FGFR3 have roles during intramembranous ossification of mandibular bones.

239 unctional role of syndecan 4 in endochondral ossification of mouse embryos and in adult fracture repa

240 d to inappropriate signaling and heterotopic ossification of soft tissues.

241 Except for sloths, all mammals show the late ossification of the caudal-most centra in the neck after

242 Ossification of the cranial skeleton varies from 20% in

243 nvestigated the role of Phd2 on endochondral ossification of the epiphyses by conditionally deleting

244 Although endochondral ossification of the limb and axial skeleton is relativel

245 All three displayed a severely disturbed ossification of the skull and multiple fractures with pr

246 (RA) direct target gene, results in abnormal ossification of the skull, hindbrain, and inner ear defi

247 rs by appositional ossification, i.e. direct ossification on the surface of the terminal phalanx, whe

248 Heterotopic ossification or postoperative osteolysis was not signifi

249 Endochondral ossification orchestrates formation of the vertebrate sk

250 ide new evidence of a distinct difference in ossification orientation in the condylar ramus (1 ossifi

251 ial roles in crucial aspects of endochondral ossification: osteoblast differentiation, chondrocyte pr

252 roteoglycans regulate postnatal endochondral ossification partially through the mediation of WNT sign

253 he association of these two key endochondral ossification pathway genes with BMD and osteoporosis in

254 focused on two key genes in the endochondral ossification pathway, IBSP and PTHLH.

255 be a skeletal structure in which growth and ossification patterns along its antero-posterior axis ar

256 equired modification of frontal neurocranial ossification patterns.

257 Endochondral ossification plays an important role in the formation of

258 growth and bone healing via intramembranous ossification proceeded normally in the absence of B cell

259 cellular transitions involved in the dermal ossification process in both chick and mouse.

260 light on the key role of the XT-I during the ossification process.

261 were independently associated with pulmonary ossification profusion.

262 Secondary ossification (r(2) = 0.777) was not observed until 25 we

263 e BMP-induced response involves endochondral ossification (redevelopment).

264 that drives skeletal growth and endochondral ossification, remain unclear.

265 progenitor cells can lead to mosaic ectopic ossification reminiscent of that seen in POH.

266 al regulation in vitro resisted endochondral ossification, retained the expression of cartilage marke

267 ion of behavioural types, and stress-induced ossification schedules.

268 g a possible posterior-to-anterior vertebral ossification sequence and the first evolutionary appeara

269 Subarticular regions of endochondral ossification showed morphologic and calcification patter

270 ndylar cartilage, in contrast to the initial ossification site in long bone, which is in the center.

271 During endochondral ossification, small, immature chondrocytes enlarge to fo

272 During endochondral ossification, Spry genes are expressed in prehypertrophi

273 pair site during the periosteal endochondral ossification stage.

274 Thus, vascular invasion and ossification start in the femoral heads of TSP3-null mic

275 pression of factors involved in endochondral ossification, such as osterix and vascular endothelial g

276 The late onset of limb ossification suggests that the juveniles were exclusivel

277 g also led to osteophyte formation, meniscal ossification, synovial hyperplasia and fibrosis, and cru

278 mandibular primordium where intramembranous ossification takes place.

279 tion mutations of GNAS can result in ectopic ossification that tends to be superficial and attributab

280 The factors contributing to heterotopic ossification, the formation of bone in abnormal soft-tis

281 Heterotopic ossification, the pathologic formation of extraskeletal

282 in cartilage development during endochondral ossification, the process by which long bones form.

283 the calvarium, indicating that endochondral ossification, the process needed for the formation of HS

284 ysis decreases endochondral angiogenesis and ossification, thereby inhibiting fracture repair.

285 TAP63a may promote endochondral ossification through interaction with genes relevant to

286 ly regulates chondrogenesis and endochondral ossification via associating with progranulin growth fac

287 Endochondral ossification was delayed in much of the Ihh(-/-) cranial

288 typical growth plate zones, and endochondral ossification was delayed.

289 Here we show that heterotopic ossification was essentially prevented in mice receiving

290 Endochondral ossification was not disrupted any further in mice with

291 l2a1-DeltaNP63alpha transgenic mice, reduced ossification was observed in the digit and tail bones of

292 n of chondrocytes was increased, and ectopic ossification was observed.

293 ate the role of this pathway in endochondral ossification, we generated transgenic mice with expressi

294 Pulmonary ossifications were recorded when nodules (<4 mm diameter

295 e mandible is formed through intramembranous ossification whereas the proximal region of the mandible

296 ignaling is sufficient to induce heterotopic ossification, whereas inhibition of this signaling pathw

297 r frontal (PF) suture closes by endochondral ossification, whereas sagittal (SAG) remain patent life

298 ted chondrocyte hypertrophy during secondary ossification, which in turn caused reduction of joint ca

299 iofacial cartilage malformations and delayed ossification, which is shown to be associated with aberr

300 he cranial vault closes through endochondral ossification, while other sutures remain patent.

301 a 31-year-old woman with massive heterotopic ossifications who suffered multiple injuries.