ライフサイエンスコーパス: osteoarthritic

1 oenzymatic studies were performed on normal, osteoarthritic, and RA synovium and tonsil with antibodi

2 lockite crystals have been found not only in osteoarthritic articular cartilage but also in normal ca

3 ification and dys-regulated matrix repair in osteoarthritic articular cartilage.

4 iochemistry of the collagenous matrix within osteoarthritic bone has received scant attention.

5 a three- to fourfold increase in TGF-beta in osteoarthritic bone indicates that this might represent

6 In addition, the degradative potential of osteoarthritic bone was considerably higher as demonstra

7 flammatory enzyme expressed in rheumatic and osteoarthritic, but not normal, cartilage.

8 , which is differentially expressed in human osteoarthritic cartilage and after SV40 transformation o

9 -3 has low affinity for the surface layer of osteoarthritic cartilage and has reduced affinity for si

10 The expression of MMP-13 in osteoarthritic cartilage and its activity against type I

11 Cell death occurs in osteoarthritic cartilage and recent studies suggest auto

12 t Galectin-1 upregulation is associated with osteoarthritic cartilage and subchondral bone histopatho

13 cytokine-induced PGE(2) production by human osteoarthritic cartilage as well as by a synovial sarcom

14 ar chondrocytes and up-regulation of TLR2 in osteoarthritic cartilage chondrocytes in situ.

15 oepitope were significantly more abundant in osteoarthritic cartilage compared with cartilage from he

16 eals an intimate relation of glycobiology to osteoarthritic cartilage degeneration.

17 Chondrocytes from osteoarthritic cartilage exhibited CD44 fragmentation as

18 itogenic effect, and crude extracts of human osteoarthritic cartilage induced a 100% incidence with a

19 ility (up to 25-fold), suggesting that early osteoarthritic cartilage is more vulnerable to higher lo

20 Primary human osteoarthritic cartilage predominantly expressed TCF4 an

21 s derived from single and multiple donors of osteoarthritic cartilage revealed the presence of a dive

22 both cytokine-stimulated cells as well as in osteoarthritic cartilage tissues.

23 tores the inferior compressive properties of osteoarthritic cartilage to that of healthy cartilage, p

24 mine chondroprogenitor numbers in normal and osteoarthritic cartilage where we observed a 2-fold incr

25 icular cartilage, in chondrocyte clusters of osteoarthritic cartilage, and in the zone of proliferati

26 Similar to osteoarthritic cartilage, antisense-treated cartilage sl

27 In summary, the -104 CpG is demethylated in osteoarthritic cartilage, correlating with the elevated

28 llular matrix, including breast tumours, and osteoarthritic cartilage.

29 ated, it was reduced to approximately 30% in osteoarthritic cartilage.

30 display analysis of transcripts expressed in osteoarthritic cartilage.

31 oth types of G1 fragments were isolated from osteoarthritic cartilage.

32 inoma, is expressed by chondrocytes in human osteoarthritic cartilage.

33 cartilage sections from older adults and in osteoarthritic cartilage.

34 ize with MMP13 protein and activity in human osteoarthritic cartilage.

35 ed kinase (ERK) around chondrocytes in human osteoarthritic cartilage.

36 y and regenerative potential residing within osteoarthritic cartilage.

37 lage matrix synthesis is reduced in aged and osteoarthritic cartilage.

38 truction of extracellular matrix proteins in osteoarthritic cartilage.

39 ype II collagen was strongly up-regulated in osteoarthritic cartilage.

40 ed at a specific 'aggrecanase' site in human osteoarthritic cartilage; this cleavage can be performed

41 ecan and small proteoglycans from normal and osteoarthritic cartilages were analyzed for chain intern

42 approximately 10% of chains from normal and osteoarthritic cartilages, respectively.

43 d population, as well as prevention of early osteoarthritic changes in the injured athletic populatio

44 ssociation between cartilaginous lesions and osteoarthritic changes was calculated.

45 All ACLT knees demonstrated osteoarthritic changes.

46 which has many of the characteristics of an osteoarthritic chondrocyte in terms of the cytokines, ch

47 d cartilage, through phenotype modulation of osteoarthritic chondrocytes in order to stimulate growth

48 tro, the lectin was secreted and it bound to osteoarthritic chondrocytes inhibitable by cognate sugar

49 n RNA, protein extracts, and nuclei of human osteoarthritic chondrocytes left untreated or treated wi

50 Osteoarthritic chondrocytes secrete matrix metalloprotei

51 In osteoarthritic chondrocytes, the antioxidants Mn(III) te

52 Osteoarthritic chondrocytes, which are deficient in auto

53 In contrast, in osteoarthritic chondrocytes, which possessed elevated ba

54 d medium from normal adult porcine and human osteoarthritic chondrocytes.

55 lation of its cognate receptor expression in osteoarthritic chondrocytes.

56 ave undergone dedifferentiation in vitro and osteoarthritic chondrocytes.

57 fic CpG dinucleotides within its promoter in osteoarthritic compared to normal cartilage, which corre

58 with age, some of which are consistent with osteoarthritic degeneration.

59 y 6 months of age, mutant condyles displayed osteoarthritic degradation with apical/mid-zone separati

60 for cartilage homeostasis and prevention of osteoarthritic disease.

61 hich no oral or parenteral disease-modifying osteoarthritic drug (DMOAD) is currently available.

62 and that nidogen-2-null mice exhibit typical osteoarthritic features.

63 eposited collagen in the subchondral zone of osteoarthritic femoral heads, supporting a greater propo

64 bone collagen metabolism is increased within osteoarthritic femoral heads, with the greatest changes

65 ited in the metabolism of bone collagen from osteoarthritic hips might exacerbate the processes invol

66 We compared IGF-I signaling in normal and osteoarthritic human articular chondrocytes and investig

67 id shear stress (20 dyn/cm(2))-activated and osteoarthritic human chondrocytes, however, the precise

68 s upregulated in middle zone chondrocytes in osteoarthritic joint cartilage (where hypertrophic marke

69 Osteoarthritic joint damage may be associated with clini

70 In osteoarthritic joint disease, expression of bFGF and MMP

71 in angiogenic RA compared with nonangiogenic osteoarthritic joint fluid.

72 hate (BCP) crystals are common components of osteoarthritic joint fluids and tissues.

73 secreted protein pattern of explants from 12 osteoarthritic joints (knee, hip, and shoulder) and 14 n

74 ms of calcium crystals that are found within osteoarthritic joints continues to challenge and confoun

75 turnover in intact, moving, human joints or osteoarthritic joints treated by HA injections.

76 variety of inflammatory disorders and 9 from osteoarthritic joints.

77 ols to the chronicity and destruction of the osteoarthritic joints.

78 on of complement is abnormally high in human osteoarthritic joints.

79 snoRNAs in old sham versus old experimental osteoarthritic joints.

80 ht hyaluronan (LMW-HA) is often increased in osteoarthritic joints; however, its biological function

81 mean rate of joint space narrowing (JSN) in osteoarthritic knees by 26% (P = not significant).

82 ilage: cartilage adjacent to the site of the osteoarthritic lesion and cartilage distal from the lesi

83 ilage through crosstalk of bone-cartilage in osteoarthritic mice.

84 the hyper responsiveness of knee loading in osteoarthritic mice.

85 chondrocyte hypertrophy develops in situ in osteoarthritic (OA) articular cartilage and promotes dys

86 o be transcriptionally up-regulated in human osteoarthritic (OA) articular cartilage.

87 zed by immunohistochemistry using normal and osteoarthritic (OA) cartilage and by immunoblotting of c

88 WISP-3/CCN6 by determining its expression in osteoarthritic (OA) cartilage and by investigating its e

89 Pathologic mineralization is common in osteoarthritic (OA) cartilage and may be mediated by ext

90 S100A4 has been shown to be increased in osteoarthritic (OA) cartilage and to stimulate chondrocy

91 drocyte hypertrophy that commonly develop in osteoarthritic (OA) cartilage can promote dysregulated m

92 Aging and osteoarthritic (OA) cartilage commonly demonstrate enhan

93 zed by immunohistochemistry using normal and osteoarthritic (OA) cartilage from young and old monkeys

94 icular chondrocytes, to determine changes in osteoarthritic (OA) cartilage, and to address the functi

95 ge from mice, and in chondrocytes from human osteoarthritic (OA) cartilage.

96 genes was also investigated in preserved and osteoarthritic (OA) cartilage.

97 assess the role of SirT1 in the survival of osteoarthritic (OA) chondrocytes in humans.

98 Osteoarthritic (OA) degeneration of the lumbar facet joi

99 s of inhibition of each enzyme in normal and osteoarthritic (OA) explants.

100 anizations, and they commonly aggregate near osteoarthritic (OA) fissures.

101 Normal and osteoarthritic (OA) human articular cartilage was used f

102 ry cell cultures established from normal and osteoarthritic (OA) human knee articular cartilage were

103 l protein 1 (HMGB-1), which are increased in osteoarthritic (OA) joints, drive procatabolic chondrocy

104 Calcium deposition occurs frequently in osteoarthritic (OA) joints.

105 mal ankle cartilage of organ donors and from osteoarthritic (OA) knee tissue obtained from patients u

106 ens from adult human donors with and without osteoarthritic (OA) lesions were stained by immunohistoc

107 a rat model of monoiodoacetate (MIA) induced osteoarthritic (OA) pain as evaluated by hindlimb grip f

108 ls of pathological pain, including models of osteoarthritic (OA) pain.

109 tracellular matrix, which can progress to an osteoarthritic (OA) phenotype.

110 active cellular process and was enhanced in osteoarthritic (OA) tissue.

111 terns of MUC1, MUC2, MUC3, and MUC5AC in RA, osteoarthritic (OA), and normal human ST.

112 s available for small and large experimental osteoarthritic pain animal models.

113 d capsaicin-induced mechanical allodynia and osteoarthritic pain.

114 ly identified HTRA1 as being up-regulated in osteoarthritic patients and as having the potential to r

115 atoid arthritis, but it was not detected for osteoarthritic patients from either clinic.

116 In osteoarthritic patients, as in other patient groups, eff

117 in levels were elevated in chondrocytes from osteoarthritic patients, consistent with a down-regulati

118 of SirT1 in human chondrocytes derived from osteoarthritic patients.

119 e tissues of arthritic mice as well as human osteoarthritic patients.

120 recan at several sites detected in joints of osteoarthritic patients.

121 rizes to activin A) were produced by all the osteoarthritic samples and half of the normals.

122 ot blot was within the normal range for most osteoarthritic samples, with only 5 of 24 displaying ele

123 snoRNAs in old sham versus old experimental osteoarthritic serum.

124 e generalized and greater increase in BMD in osteoarthritic subjects seen in previous studies of unre

125 rthritis, and vascular growth is enhanced in osteoarthritic synovia when infiltrating macrophages gen

126 c acid (mRNA) was compared between RASFs and osteoarthritic synovial fibroblast (OASFs) using quantit

127 phosphate crystals are common components of osteoarthritic synovial fluids and define subsets of pat

128 icromasses, ions with or without IL-1beta or osteoarthritic synovial fluids for 48 h.

129 or AAT abrogated the effects of IL-1beta and osteoarthritic synovial fluids on anabolic gene expressi

130 med joints, considerably higher than that in osteoarthritic synovial fluids.