ライフサイエンスコーパス: osteoarthritis

1 ) had an association with the presence of OA osteoarthritis .

2 of cancer, and degenerative bone disorders (osteoarthritis).

3 537 outpatients with symptomatic hip or knee osteoarthritis.

4 leading to the destruction of cartilage and osteoarthritis.

5 a materials-based treatment for early-stage osteoarthritis.

6 levels and inhibit cartilage degradation in osteoarthritis.

7 ave therapeutic benefits in the treatment of osteoarthritis.

8 scade of chondrocytes during the progress of osteoarthritis.

9 in adolescents and is a major cause of early osteoarthritis.

10 reat long-term pain and disability from knee osteoarthritis.

11 cartilage matrix leads to the development of osteoarthritis.

12 treatment for patients with symptomatic knee osteoarthritis.

13 compared Tai Chi with standard therapies for osteoarthritis.

14 ent of cartilage degeneration that occurs in osteoarthritis.

15 r is recommended for self-management of knee osteoarthritis.

16 ay between circadian rhythm and cartilage in osteoarthritis.

17 such as intervertebral disc degeneration and osteoarthritis.

18 ant therapeutic potential as a treatment for osteoarthritis.

19 liest events that occurs in association with osteoarthritis.

20 T transgenic mice exhibited less age-related osteoarthritis.

21 as a therapeutic agent for the management of osteoarthritis.

22 roving WOMAC knee pain in patients with knee osteoarthritis.

23 known apoptosis trigger during the course of osteoarthritis.

24 sical function in patients with hip and knee osteoarthritis.

25 of physical therapy in the treatment of knee osteoarthritis.

26 ee joints in mice against the development of osteoarthritis.

27 abnormal gait, joint laxity, and early-onset osteoarthritis.

28 remodeling in temporomandibular joint (TMJ) osteoarthritis.

29 ameters between volunteers and patients with osteoarthritis.

30 is, ischaemic stroke, leukemia, lymphoma and osteoarthritis.

31 isease prevention and the treatment of early osteoarthritis.

32 h factor beta 1 (TGF-beta1) is implicated in osteoarthritis.

33 pain and is a risk factor for disability and osteoarthritis.

34 jority (n = 50) focused on older adults with osteoarthritis.

35 ion is associated with joint arthropathy and osteoarthritis.

36 ading and protect against the development of osteoarthritis.

37 e supporting use of physical therapy for hip osteoarthritis.

38 bers in whom the risk allele segregates with osteoarthritis.

39 nes associated with cartilage degradation in osteoarthritis.

40 omeostasis as well as in the pathogenesis of osteoarthritis.

41 ions of posttraumatic injury and early stage osteoarthritis.

42 ondrocyte function and in the development of osteoarthritis.

43 d showed efficacy in a rat chemical model of osteoarthritis.

44 novel markers of musculoskeletal ageing and osteoarthritis.

45 one erosion, and resorption processes during osteoarthritis.

46 ovide a means of altering the progression of osteoarthritis.

47 oxicity and efficacy in a clinical trial for osteoarthritis.

48 in cells, in in vitro and in vivo models of osteoarthritis.

49 into highly proteolytic environments such as osteoarthritis.

50 ed for covariates) but not with radiographic osteoarthritis.

51 ession of structural characteristics of knee osteoarthritis.

52 ion or no intervention in patients with knee osteoarthritis?

53 Among patients with symptomatic knee osteoarthritis, 2 years of intra-articular triamcinolone

54 r players, (0.28, 95% CI 0.11-0.66), whereas osteoarthritis (4.00, 95% CI 3.32-4.81), joint replaceme

55 tested in 62 individuals affected with knee osteoarthritis and 52 age matched controls and tested fo

56 al with participants aged >50 y who had knee osteoarthritis and a body mass index [BMI (in kg/m(2))]

57 strong analgesic effect in animal models of osteoarthritis and acute inflammatory pain, but has not

58 Consistent with animal studies in osteoarthritis and head and neck cancer, early blockade

59 of histamine was higher in RA, compared with osteoarthritis and healthy controls.

60 Two case studies, in subchondral bone in osteoarthritis and in Pax5 in acute lymphoblastic leukae

61 Participants with symptomatic knee osteoarthritis and low 25-hydroxyvitamin D (12.5-60 nmol

62 Among patients with symptomatic knee osteoarthritis and low serum 25-hydroxyvitamin D levels,

63 treatment for numerous conditions, including osteoarthritis and lower back pain.

64 g are precursors of morphologic defects with osteoarthritis and may serve as imaging biomarkers with

65 Applying this model to 450K data of RA, osteoarthritis and normal FLS, we successfully expanded

66 ration, Parkinson's, Huntington's, diabetes, osteoarthritis and other degenerative conditions.

67 al physiological signaling and contribute to osteoarthritis and suggest peroxiredoxin hyperoxidation

68 ctive treatments for the age-related disease osteoarthritis and the ability to predict disease progre

69 sease-promoting immune cells in experimental osteoarthritis and their functional interaction is promo

70 or degradation of articular cartilage during osteoarthritis and therefore represents a target for dru

71 NK cells in the pathogenesis of experimental osteoarthritis and whether and how neutrophils can regul

72 ecan is an early event in the development of osteoarthritis, and a disintegrin and metalloproteinase

73 pain conditions (chronic low back pain, knee osteoarthritis, and fibromyalgia).

74 diseases including cancer, type 2 diabetes, osteoarthritis, and neuroinflammation.

75 their functional significance in ageing and osteoarthritis, and provides potential diagnostic biomar

76 regression adjusting for the baseline score, osteoarthritis, and taxane use, adjusted 12-week BPI-SF

77 tivity is associated with chondrocalcinosis, osteoarthritis, and type 2 diabetes.

78 normal morphology and imaging features of OA osteoarthritis are relatively common in contralateral as

79 uction for the treatment of diseases such as osteoarthritis, as well as to enhance matrix formation a

80 n subjects with and those without underlying osteoarthritis at baseline and knee replacement (KR) ass

81 urate and cost-effective diagnostics of knee osteoarthritis at the primary healthcare level.

82 n, vault depth, erosion), injury or disease (osteoarthritis, Bankart and Hill-Sachs lesions, subchond

83 cells that accumulate in the synovium during osteoarthritis, both exerting a pathogenic role.

84 ntation is associated with benefits for knee osteoarthritis, but current trial evidence is contradict

85 ion improved outcomes for patients with knee osteoarthritis, but it did not assess separate effects o

86 ight effectively in obese patients with knee osteoarthritis, but the role of LED in long-term weight-

87 reducing cartilage injury and posttraumatic osteoarthritis by attenuating Piezo-mediated cartilage m

88 or mild to moderate radiographic findings of osteoarthritis, categorized into groups with (a) weight

89 (P = .124) values were seen in patients with osteoarthritis compared with those in asymptomatic volun

90 ; 100 indicates worst pain possible) and hip osteoarthritis confirmed by radiograph.

91 -1beta played the major pathological role in osteoarthritis, contributing to the maintenance of the d

92 hysical activity, symptoms, and radiographic osteoarthritis features (Kellgren and Lawrence [KL] grad

93 e RA fibroblast-like synoviocytes (FLS) from osteoarthritis FLS, but also distinguish RA FLS isolated

94 usculoskeletal degenerative diseases such as osteoarthritis have revealed a critical role for immune

95 The development of hand osteoarthritis (HOA) could be linked to hyperlipidaemia.

96 bone plays a key role in the development of osteoarthritis, however, epigenetics of subchondral bone

97 mbined patient and provider intervention for osteoarthritis in a Department of Veterans Affairs medic

98 of TGF-beta1 signaling in the development of osteoarthritis in a developmental stage-dependent manner

99 luding the knees, the joint most affected by osteoarthritis in Dolly, and compare all health paramete

100 ee osteoarthritis [PROOF (PRevention of knee Osteoarthritis in Overweight Females) study].

101 se apart from mild, or in one case moderate, osteoarthritis in some animals.

102 zation of the medial meniscus (DMM) model of osteoarthritis in the mouse were used to assess chondrop

103 Current description of osteoarthritis includes the involvement of synovial infl

104 sion of key metalloproteinases implicated in osteoarthritis, independently of Nrf2, and blocks inflam

105 provement using the Western Ontario McMaster Osteoarthritis Index (ie, improvement of >/=9.7 pain poi

106 he Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at 12 months.

107 as Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score at 12 weeks.

108 he Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total score at 12 months.

109 n (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]) at 6 months.

110 nd Western Ontario and McMaster Universities Osteoarthritis index collected every 3 months (Likert pa

111 ain, a Western Ontario McMaster Universities Osteoarthritis Index score of at least 39, and radiograp

112 n (Western Ontario and McMaster Universities Osteoarthritis Index) at 3 months.

113 n (Western Ontario and McMaster Universities Osteoarthritis Index, 0 [no difficulty] to 68 [extreme d

114 n (Western Ontario and McMaster Universities Osteoarthritis Index, 0 no difficulty to 68 extreme diff

115 Right knees of 90 subjects from the Osteoarthritis Initiative (mean age, 55 years +/- 8 [sta

116 those without (n = 147) were drawn from the Osteoarthritis Initiative cohort (n = 4796).

117 y at baseline with an 8-y follow-up from the Osteoarthritis Initiative cohort study.

118 cipants (55% women, aged 45-55 years) in the Osteoarthritis Initiative without radiographic knee oste

119 Participants were drawn from the Osteoarthritis Initiative, a longitudinal observational

120 of 25 and 30 kg/m(2), respectively) from the Osteoarthritis Initiative, with risk factors for osteoar

121 n a large cohort of North Americans from the Osteoarthritis Initiative.

122 for knee OA were randomly selected from the Osteoarthritis Initiative.

123 Although more patients in the osteoarthritis intervention group received provider refe

124 points lower (indicating improvement) in the osteoarthritis intervention group versus usual care (95%

125 tatistically significant improvements in the osteoarthritis intervention groups compared with usual c

126 atments and showing radiological evidence of osteoarthritis into 2 groups of 15 patients.

127 Osteoarthritis is a common degenerative joint disease fo

128 Age-related osteoarthritis is a common form of arthritis that has be

129 Osteoarthritis is a common, complex disease with no cura

130 Osteoarthritis is a degenerative joint disease that rank

131 Osteoarthritis is a leading cause of disability in the U

132 Osteoarthritis is a major cause of disability and there

133 Osteoarthritis is a major source of pain, disability, an

134 Osteoarthritis is an age-related disease and cellular se

135 Osteoarthritis is the most common form of arthritis and

136 Osteoarthritis is the most prevalent joint disease and a

137 implication of two mediators present in the osteoarthritis joint, IL-1beta as proinflammatory cytoki

138 at 3.0-T MR imaging and without radiographic osteoarthritis (Kellgren-Lawrence score, 0-1) were frequ

139 f Rheumatology criteria for symptomatic knee osteoarthritis, Kellgren-Lawrence grades 2 or 3, were en

140 The cartilage repair osteoarthritis knee score (CROAKS) optimizes comprehensi

141 iabetes mellitus (diabetes) and risk of knee osteoarthritis (KOA) is confounded by high body mass ind

142 Knee osteoarthritis (KOA) is most common in the medial tibial

143 Knee osteoarthritis (KOA) is reported to have characteristic

144 ers are often associated with development of osteoarthritis-like changes in the mandibular condyle.

145 gressive loss of TMJ articular integrity and osteoarthritis-like changes.

146 her chronic disorders (eg, cardiac diseases, osteoarthritis, lung disease, and poor hearing).

147 escribes a prioritized research agenda about osteoarthritis management developed for the Patient-Cent

148 culoskeletal morbidity may warrant proactive osteoarthritis management within this population.

149 ity in the acute rat monoiodoacetate-induced osteoarthritis model of pain, and subchronic dosing of 4

150 In a surgical rat osteoarthritis model, a once-weekly injection of recombi

151 Finally, in the experimental mouse osteoarthritis model, ADAMTS5 and RelA were co-localized

152 livery system to decrease inflammation in an osteoarthritis model.

153 women with advanced-stage, symptomatic knee osteoarthritis (OA) (n = 16).

154 patients with rheumatoid arthritis (RA) and osteoarthritis (OA) after accounting for factors associa

155 ongoing to develop drug therapies to manage osteoarthritis (OA) and articular cartilage (AC) injurie

156 t-induced obesity is a major risk factor for osteoarthritis (OA) and diminished wound healing.

157 tigate the role of laminins and nidogen-2 in osteoarthritis (OA) and their potential to support chond

158 thritis Initiative without radiographic knee osteoarthritis (OA) and without medial meniscal tear at

159 Early descriptions of osteoarthritis (OA) appeared in Radiology.

160 cloned from adult cells) whose diagnoses of osteoarthritis (OA) at 5(1/2) years of age led to consid

161 s an emerging treatment for symptomatic knee osteoarthritis (OA) but its efficacy is uncertain.

162 e expression profile of miRNAs in normal and osteoarthritis (OA) chondrocytes.

163 y and depression in patients consulting with osteoarthritis (OA) improves pain outcomes.

164 hich protects from cartilage degradation and osteoarthritis (OA) in mice.

165 Osteoarthritis (OA) is a chronic disease of articular jo

166 Osteoarthritis (OA) is a common cause of pain and disabi

167 Osteoarthritis (OA) is a common complex disease with hig

168 Osteoarthritis (OA) is a common degenerative musculoskel

169 Osteoarthritis (OA) is a common disease characterized by

170 Osteoarthritis (OA) is a common joint disorder with vary

171 Osteoarthritis (OA) is a common, painful and debilitatin

172 Osteoarthritis (OA) is a low-grade chronic inflammatory

173 Osteoarthritis (OA) is a major cause of disability and m

174 Osteoarthritis (OA) is a progressive degenerative diseas

175 Osteoarthritis (OA) is a whole joint disorder that invol

176 Knee osteoarthritis (OA) is believed to be highly prevalent t

177 Osteoarthritis (OA) is characterised by progressive dest

178 Osteoarthritis (OA) is characterized by cartilage destru

179 Osteoarthritis (OA) is characterized by chronic degenera

180 Osteoarthritis (OA) is characterized by remodeling and d

181 The pathogenesis of osteoarthritis (OA) is poorly understood, and therapeuti

182 Osteoarthritis (OA) is the most common whole-joint disea

183 Osteoarthritis (OA) is the most prevalent and debilitati

184 Curiously, osteoarthritis (OA) is thought to be a recapitulation of

185 MSCs) and enhances cartilage repair in mouse osteoarthritis (OA) models.

186 ive efficacy of available treatments of knee osteoarthritis (OA) must be determined for rational trea

187 Black patients with advanced osteoarthritis (OA) of the knee are significantly less l

188 one marrow mesenchymal stem cells (BMSCs) on osteoarthritis (OA) of the temporomandibular joint (TMJ)

189 Chronic knee osteoarthritis (OA) pain patients (n = 56) underwent pre

190 o redifferentiate chondrocytes isolated from osteoarthritis (OA) patients.

191 teinase 13 (MMP13) represents a key event in osteoarthritis (OA) progression.

192 Reduced SIRT1 activity and levels during osteoarthritis (OA) promote gradual loss of cartilage.

193 oid arthritis (RA) synovium and RASF than in osteoarthritis (OA) samples.

194 We found that human RA and osteoarthritis (OA) synovial fibroblasts derived from in

195 hibitors of these enzymes could be potential osteoarthritis (OA) therapies.

196 A rat destabilization model of osteoarthritis (OA) was used to determine if lubricin in

197 ynoviocytes (FLSs) from patients with RA and osteoarthritis (OA) were successfully reprogrammed into

198 d arthritis (RA), psoriatic arthritis (PsA), osteoarthritis (OA)) or chronic inflammatory conditions

199 auma are risk factors for the development of osteoarthritis (OA), a chronic disease characterized by

200 al growth factor A (VEGF) is associated with osteoarthritis (OA), and increased VEGF expression corre

201 Upon immunohistochemical inspection of RA, osteoarthritis (OA), and psoriatic arthritis synovium, e

202 Osteoarthritis (OA), characterized by degeneration of th

203 in articular chondrocytes is associated with osteoarthritis (OA), we assessed whether miR-146a is lin

204 Age is the primary risk factor for osteoarthritis (OA), yet surgical OA mouse models such a

205 leads to the development of an early-onset, osteoarthritis (OA)-like disorder in multiple synovial j

206 d pathologies associated with Panx3, such as osteoarthritis (OA).

207 , and degeneration of articular cartilage in osteoarthritis (OA).

208 may play an important role in development of osteoarthritis (OA).

209 and bone-forming activities is a hallmark of osteoarthritis (OA).

210 ar matrix protein, in the pathophysiology of osteoarthritis (OA).

211 ors contribute to progressive development of osteoarthritis (OA).

212 acupuncture treatments in patients with knee osteoarthritis (OA).

213 reflect changes in joint remodelling during osteoarthritis (OA).

214 extracellular matrices such as cartilage in osteoarthritis (OA).

215 iabetes mellitus (T2DM) is a risk factor for osteoarthritis (OA).

216 ajor contributor to cartilage degradation in osteoarthritis (OA).

217 ing joint pathology in certain patients with osteoarthritis (OA).

218 s (RA) patients versus control patients with osteoarthritis (OA); and 2) the association of ABL with

219 ch for sequence variants that confer risk of osteoarthritis of the hand, we carried out a genome-wide

220 Total joint replacements for end-stage osteoarthritis of the hip and knee are cost-effective an

221 Patients with osteoarthritis of the knee had significantly higher cart

222 rt study of older adults with or at risk for osteoarthritis of the knee.

223 on MR images in subjects with or at risk for osteoarthritis of the knee.

224 asymptomatic volunteers and 14 patients with osteoarthritis of the knee.

225 ) images in older adults with or at risk for osteoarthritis of the knee.

226 The application of gene therapy in osteoarthritis offers insights because it faces similar

227 hat includes 4796 participants who have knee osteoarthritis or are at risk.

228 oarthritis Initiative, with risk factors for osteoarthritis or mild to moderate radiographic findings

229 Hence, the influence of SF from osteoarthritis or RA patients on total Th cells or diffe

230 Patients who required NSAIDs for osteoarthritis or rheumatoid arthritis and were at incre

231 OR 1.36 [95% CI 1.00-1.84]; p < 0.049), knee osteoarthritis (OR 1.17 [95% CI 1.01-1.36]; p < 0.04), a

232 ids from patients with rheumatoid arthritis, osteoarthritis, or acute trauma.

233 athogenesis of cartilage diseases, including osteoarthritis, osteosarcoma, and chondrosarcoma.

234 owed a significantly greater Knee Injury and Osteoarthritis Outcome Score (KOOS) pain score (improvem

235 hs in the mean score on four Knee Injury and Osteoarthritis Outcome Score subscales, covering pain, s

236 , and patient-provider interventions improve osteoarthritis outcomes.

237 Participants were recruited from the osteoarthritis outpatient clinic at Copenhagen Universit

238 nes (all P < 0.001), depression (P = 0.003), osteoarthritis (P = 0.008), and the use of antidepressan

239 nd resolvins in heat pain sensitivity and in osteoarthritis pain in humans.

240 file, and demonstrates good efficacy against osteoarthritis pain in rodents.

241 ses to acupuncture treatment in chronic knee osteoarthritis pain patients (n = 45).

242 onstant knee pain (Intermittent and Constant Osteoarthritis Pain questionnaire), quality of life (Ass

243 ns of 17-HDHA with heat pain sensitivity and osteoarthritis pain were independent of DHA levels.

244 Mechanisms underlying osteoarthritis pathogenesis are not yet fully elucidated

245 loading might be a new potential therapy for osteoarthritis patients.

246 ovium and synovial fluid from RA compared to osteoarthritis patients.

247 d with cartilage joint degeneration in human osteoarthritis patients.

248 Among adults with painful hip osteoarthritis, physical therapy did not result in great

249 To follow osteoarthritis progression, cartilage damage, synovial t

250 circadian pacemaker, BMAL1, decreases during osteoarthritis progression.

251 d controlled trial on the prevention of knee osteoarthritis [PROOF (PRevention of knee Osteoarthritis

252 of lesions characteristic of post-traumatic osteoarthritis (PTOA) across the knee joint in response

253 Management of osteoarthritis requires both medical and behavioral stra

254 aphic JSN progression was evaluated by using Osteoarthritis Research Society International grading (p

255 lateral wedges and lower pain in medial knee osteoarthritis, restriction of studies to those using a

256 matic patients with a meniscal tear and knee osteoarthritis results in better functional outcomes tha

257 onship of elevated CRP levels with psoriatic osteoarthritis, rheumatoid arthritis, knee osteoarthriti

258 ofile and the incidence of radiographic hand osteoarthritis (RHOA).

259 ermine the impact of early radiographic knee osteoarthritis (ROA) and ROA risk factors on femorotibia

260 r Th cell suppressive capacity compared with osteoarthritis SF.

261 tors of cartilage functional performance and osteoarthritis stage.

262 ealed the most frequent main diagnoses to be osteoarthritis, stress fracture, and bone marrow edema.

263 The Multicenter Osteoarthritis Study is a prospective cohort study of ol

264 quantifying cartilage sGAG content in human osteoarthritis subjects in clinical research.

265 fic regulation of ADAMTS-12 were observed in osteoarthritis, suggesting them as new potential therape

266 Knee symptomatic osteoarthritis (SxOA) was associated with all-cause mort

267 erentially methylated genes between RASF and osteoarthritis synovial fibroblasts (OASF) were identifi

268 control cells showed opposite effects (e.g., osteoarthritis synovial fibroblasts [SF]; GF(-) versus G

269 During osteoarthritis, synovial fibroblasts exposed to anomalou

270 racterize the inflammatory cells involved in osteoarthritis, synovial fluid was collected early after

271 c osteoarthritis, rheumatoid arthritis, knee osteoarthritis, systolic blood pressure, diastolic blood

272 lternative for the treatment of chronic knee osteoarthritis that is more logistically convenient than

273 In cases of inflamed osteoarthritis, the H2O2 at low concentration diffuses t

274 ion is critical to cartilage degeneration in osteoarthritis, this report reveals an intimate relation

275 d treatment of temporomandibular joint (TMJ) osteoarthritis (TMJOA) remain complex and unclear.

276 wo rare signals that strongly associate with osteoarthritis total hip replacement: a missense variant

277 ention involved delivery of patient-specific osteoarthritis treatment recommendations to primary care

278 lved electronic delivery of patient-specific osteoarthritis treatment recommendations to providers.

279 , and they have the potential to progress to osteoarthritis, treatment to alleviate symptoms and dela

280 Targeted delivery of anti-inflammatory osteoarthritis treatments have the potential to signific

281 p received provider referral for recommended osteoarthritis treatments, the numbers who received them

282 onal cohort data from the Vitamin D for Knee Osteoarthritis trial.

283 (July 2012-December 2015), 940 patients with osteoarthritis undergoing primary total knee arthroplast

284 research, we enrolled 40 patients with knee osteoarthritis undergoing total knee replacement into a

285 Twelve patients with knee osteoarthritis underwent dGEMRIC and T1rho mapping at 3.

286 on study (GWAS) in subjects with severe hand osteoarthritis, using variants identified through the wh

287 whether different placebo interventions for osteoarthritis vary in efficacy, systematic differences

288 OA osteoarthritis was detected in 40% of asymmetrical contr

289 Experimental osteoarthritis was elicited by intra-articular injection

290 gnaling is implicated in the pathogenesis of osteoarthritis, we investigated the consequence of disru

291 the synovial tissues of patients with RA or osteoarthritis were stimulated with TNFalpha and assayed

292 Hedgehog signaling is activated in osteoarthritis, where it promotes chondrocyte hypertroph

293 PET/CT was more precise in visualizing osteoarthritis, whereas PET/MR was more specific in nond

294 e sGAG content in vivo in patients with knee osteoarthritis, whereas T1rho mapping does not appear su

295 ed 100 patients with moderate-to-severe knee osteoarthritis who were eligible for unilateral total kn

296 In patients with knee osteoarthritis who were eligible for unilateral total kn

297 ssess the feasibility and safety of treating osteoarthritis with allogeneic MSCs, and we obtain infor

298 coagulant use (OR, 1.58; 95% CI, 1.51-1.66), osteoarthritis with rheumatoid arthritis (OR, 1.58; 95%

299 triamcinolone vs saline for symptomatic knee osteoarthritis with ultrasonic features of synovitis in

300 I, Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index, and Disabilities of the Ar