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1 erm culture-induced MSC aging impaired their osteogenic ability and subsequent bony callus formation,
2 ous parathyroid hormone (PTH) blocks its own osteogenic actions in marrow stromal cell cultures by in
3 mBMSCs with Msx1 and Msx2 genes and compared osteogenic activity and expression levels of several Msx
5 olecular strategies are toward promoting pro-osteogenic activity of BMP2 while simultaneously suppres
6 l revealed distinct phases of osteolytic and osteogenic activity, a critical role for mesenchymal str
8 perivascular progenitor cell line that lacks osteogenic, adipogenic and angiogenic potential but is c
11 ir stem cell character demonstrated by their osteogenic and adipogenic differentiation capacity and t
12 in tethering, substrate deformations, or the osteogenic and adipogenic differentiation of human adipo
13 g epigenetic modifications that occur during osteogenic and adipogenic differentiation of mouse bone
14 ompared the inter-donor variability of their osteogenic and adipogenic differentiation potential, as
15 s from calcification in vivo, activated anti-osteogenic and anti-inflammatory networks in NOTCH1(+/+)
19 istinct subpopulation of MSCs, with enhanced osteogenic and decreased adipogenic differentiation capa
20 scription factor 2-mediated (Runx2-mediated) osteogenic and decreased PPARgamma-dependent adipogenic
22 concentration for microspheres, the combined osteogenic and mineralization effect of PRP and BMP2 on
25 , the authors compared and evaluated the pro-osteogenic and pro-odontogenic effects of 4 small bioact
26 ssive stiffness simultaneously increased the osteogenic and proangiogenic potential of entrapped cocu
28 progenitors, through the generation of both osteogenic and stromal cells, provide a supportive envir
29 helial growth factor (VEGF) on the extent of osteogenic and vasculogenic differentiation of human mes
30 ys from NG(21) resulted in highest extent of osteogenic and vasculogenic differentiation of the encap
31 ines, including proinflammatory TGFbeta1 and osteogenic BMP-2, as well as glycosaminoglycans such as
34 Cpdm primary calvarial cells display reduced osteogenic capacity ex vivo, and the same was observed w
35 afts from aged animals with L-WNT3A restored osteogenic capacity to autografts back to levels observe
36 fibroblasts respond to injury by adopting an osteogenic cell fate and creating damaging calcific depo
37 ression of Runx2 and Col1a1, which are early osteogenic cell markers, on day 10 after the subperioste
39 differentiation efficiency and they generate osteogenic cells comparable to osteogenic cells derived
40 they generate osteogenic cells comparable to osteogenic cells derived from mesenchymal stromal cells
41 of pro-angiogenic potential of transplanted osteogenic cells for effective cell-mediated bone repair
44 ults provide an insight into the response of osteogenic cells to individual substrate parameters and
45 ited normal bone morphology and responded to osteogenic chemical stimuli similar to wild-type mice.
54 ration and survival capacities, reduction in osteogenic differentiation and a decrease in the ability
56 lation of BMP4-pSMAD1/5 signaling, decreased osteogenic differentiation and lowered proliferation cap
57 of autophagy before day 3 strongly inhibited osteogenic differentiation and mineralization of ASCs in
58 dence that 25(OH)D3 at 250-500 nM can induce osteogenic differentiation and that 25(OH)D3 has great p
61 se of VEGFA in primary human MSCs to enhance osteogenic differentiation as a potential therapeutic.
62 ioactive, capable of stimulating odontogenic/osteogenic differentiation as observed by gene expressio
63 s induced by osteogenic stimuli and promotes osteogenic differentiation at least partly by targeting
64 tion in human smooth muscle cells undergoing osteogenic differentiation attenuated matrix mineralizat
67 that these hESCs/hiPSCs are similar in their osteogenic differentiation efficiency and they generate
68 inB1-EphB2 interaction regulates odontogenic/osteogenic differentiation from dental pulp cells (DPCs)
69 ZBTB16 is associated with the process of osteogenic differentiation in bone marrow-derived mesenc
70 reported that alpha5beta1 integrin promotes osteogenic differentiation in mesenchymal skeletal cells
71 we examined effects of OA on cell viability, osteogenic differentiation in MSCs, and the involvement
74 g medium, which in turn efficiently enhanced osteogenic differentiation in vitro and osteointegration
75 PRP from alginate beads on BMP2-modified MSC osteogenic differentiation in vitro and sustained releas
76 ated a reduction in cell survival and direct osteogenic differentiation in vitro These effects were m
77 ced alpha5beta1 integrin priming can promote osteogenic differentiation independently of the RRET seq
78 shows that ZBTB16 induced the expression of osteogenic differentiation markers independently of RUNX
79 ogenic differentiation and the expression of osteogenic differentiation markers were assessed by real
82 ively, our findings indicate Cdo1 suppresses osteogenic differentiation of BMSCs, through a potential
85 bone morphogenetic protein-2/BMP-2-directed osteogenic differentiation of bone marrow stromal cells
86 significantly improved potential for odonto/osteogenic differentiation of DPSCs both in vivo and in
88 Burn injury increases the predilection to osteogenic differentiation of ectopically implanted ossi
89 marrow stromal cells cultured in microwells, osteogenic differentiation of encapsulated cells depends
92 ersed the promoting or suppressing effect of osteogenic differentiation of hBMSCs, respectively, caus
94 e expression of miR-101 and its roles in the osteogenic differentiation of human bone marrow-derived
95 ohort of epigenetic regulators (>300) during osteogenic differentiation of human mesenchymal cells de
96 niques to synergistically improve growth and osteogenic differentiation of human mesenchymal stem cel
97 strated through localized cell spreading and osteogenic differentiation of human mesenchymal stem cel
98 easibility of our platform, we evaluated the osteogenic differentiation of human mesenchymal stem cel
99 e, we investigated the effect of 25(OH)D3 on osteogenic differentiation of human mesenchymal stem cel
100 BMP2-induced phosphorylation of Smad1/5 and osteogenic differentiation of human tenocytes in vitro.
101 and cartilage homeostasis by influencing the osteogenic differentiation of hypertrophic chondrocytes
102 of RhoA and ROCK activity partially restores osteogenic differentiation of IFT80-deficient OPCs by in
104 well as on the adhesion, proliferation, and osteogenic differentiation of MC3T3-E1 pre-osteoblastic
105 find that cell spreading, proliferation, and osteogenic differentiation of mesenchymal stem cells (MS
106 es also showed enhanced ability in promoting osteogenic differentiation of mesenchymal stromal cells.
107 ally relevant mechanical stimulus, regulates osteogenic differentiation of MSCs through Transient rec
111 te (CaP) moieties have been shown to support osteogenic differentiation of stem and progenitor cells
112 he potential of plant-produced OPN to induce osteogenic differentiation of stem cells from periodonta
119 abolic compound, parbendazole, which induces osteogenic differentiation through a combination of cyto
122 senchymal transition (EndoMT) and subsequent osteogenic differentiation with dramatically increased o
123 hogenic factors expressed by ESCs undergoing osteogenic differentiation yield a novel devitalized mat
124 in order to regulate their self-renewal and osteogenic differentiation, and H2S deficiency results i
125 atenin-independent defects in adipogenic and osteogenic differentiation, and knockdown of WTX reduced
126 ll LIV signals enhanced hBMSC proliferation, osteogenic differentiation, and upregulated genes associ
128 from Clec11a-deficient mice showed impaired osteogenic differentiation, but normal adipogenic and ch
129 ve Wnt signaling, including gene expression, osteogenic differentiation, cell migration, and antagoni
131 did not affect cell viability, apoptosis, or osteogenic differentiation, perhaps due to increased exp
132 Ppia(-/-) osteoblasts demonstrate decreased osteogenic differentiation, whereas Ppia(-/-) osteoclast
134 role of magnesium in promoting CGRP-mediated osteogenic differentiation, which suggests the therapeut
160 arance and transformed the bone marrow to an osteogenic environment with enhanced PTH anabolism.
161 re implanted ectopically in combination with osteogenic factors into mice to generate a physiological
162 ation, these IS cells differentially express osteogenic factors, mechanosensitive genes, and signalin
164 our results define the source of a critical osteogenic function in primary myelofibrosis that suppor
165 Msx2(fl/fl);LDLR(-/-) mice exhibited reduced osteogenic gene expression and mineralizing potential wi
166 yses of Mkx(-/-) PDL revealed an increase in osteogenic gene expression and no change in PDL- and inf
167 ng of the PDL space caused by an increase in osteogenic gene expression, a reduction in RANKL express
168 vivo validation of these pro-atherogenic and osteogenic genes also demonstrates a broad consistent di
172 epress Wnt signaling alter the expression of osteogenic genes within the PDL space, which in turn aff
173 tretching (1%) and induced expression of two osteogenic genes, collagen Ia (Col1a) and osteopontin (O
174 multivalent dendrons containing a bioactive osteogenic growth peptide (OGP) domain and surface-bindi
178 cing analyses, we found that genes vital for osteogenic identity were linked to RUNX2, C/EBPbeta, ret
180 ession in PDL-CD105(+) cells after 7 days of osteogenic induction, although mineral nodule formation
182 PCL+FA and PCL scaffolds to investigate the osteogenic inductive ability of FA crystals and we obser
184 onse in a FZD-selective fashion, enhance the osteogenic lineage commitment of primary mouse and human
185 ndeed, biophysical stimuli potently regulate osteogenic lineage commitmentin vitro In this study, we
186 anobiology model, mechanical signals enhance osteogenic lineage commitmentin vivoand that the primary
187 ng a lineage autonomous function of Shox2 in osteogenic lineage fate determination and skeleton patte
189 ls to bone surfaces and the commitment to an osteogenic lineage of these cellsin vivo Furthermore, we
199 as well as gene expression of Alpl and other osteogenic marker genes in mouse osteoblasts and mesench
202 were accompanied by increased expression of osteogenic markers and intramembranous bone formation an
203 romotes vascular calcification by increasing osteogenic markers with no adverse effect on bone format
205 further required for eventual expression of osteogenic markers, and RARG-antagonist strongly drives
206 -treated mice showed decreased expression of osteogenic markers, coupled with an increase in osteocla
208 th/differentiation through the activation of osteogenic master transcription factor Runx2, which is m
210 ved from EBs differentiated for 10 days with osteogenic media (+beta-glycerophosphate) exhibited simi
213 ed rat bone marrow stromal cells cultured in osteogenic medium in which the normal 5.6 mm glucose is
215 althy controls and cultured up to 24 d using osteogenic medium with standard phosphate concentration.
217 icinity of the hematopoietic niche where the osteogenic milieu propels the differentiation of MSCs to
218 gnatures were identified and used to uncover osteogenic miRs of interest for osteoblast differentiati
219 from day 7, the upregulation of several pro-osteogenic molecules (dmp1, dspp, runx2, ocn, spp1, col1
221 AJs) involving cancer-derived E-cadherin and osteogenic N-cadherin, the disruption of which abolishes
222 that disseminated breast cancer cells engage osteogenic niches in the bone through heterotypic adheri
223 t dental tissues have been described to have osteogenic/odontogenic-like differentiation capacity, bu
224 e specifically induced to differentiate down osteogenic or adipogenic pathways by controlling the con
228 ly increased and expanded expression of many osteogenic pathway genes, including Bmp3, Bmp5, Bmp7, Me
229 that suggested a default preference for the osteogenic pathway; however, these patterns were rapidly
230 of AMC, suggesting that Runx2 and downstream osteogenic pathways in SMCs may be useful therapeutic ta
233 experiments showed that H19 induces a strong osteogenic phenotype by altering the NOTCH1 pathway.
234 MC-specific Runx2 expression is required for osteogenic phenotype change and AMC remains unknown.
235 ata indicate a critical role of Runx2 in SMC osteogenic phenotype change and mineral deposition in a
236 n Runx2(f/f) mice expressed Runx2, underwent osteogenic phenotype change, and developed severe AMC.
237 Smooth muscle cell (SMC) transition to an osteogenic phenotype is a common feature of AMC, and is
239 zed lipid nanoparticles (LNPs) encapsulating osteogenic pleckstrin homology domain-containing family
240 ith limited differentiation capacity, having osteogenic potential (PC-O) or angiogenic support functi
241 ifferentiation characterized by an increased osteogenic potential and a TGFbeta1 signaling signature.
242 d the transfection efficiency, cytotoxicity, osteogenic potential and in vivo bone regenerative capac
243 esenchymal stem/stromal cells (MSCs) possess osteogenic potential and produce numerous angiogenic gro
244 DLX3 mutation (c.533 A>G; Q178R) attenuates osteogenic potential and senescence of bone mesenchymal
249 ion toward progenitor cell lines with either osteogenic potential or pericyte-like angiogenic functio
251 aspirin (ASA) on the proliferative capacity, osteogenic potential, and expression of growth factor-as
252 sed bone formation by compensating decreased osteogenic potentials with more generations and extended
253 ocess, mature osteoblasts dedifferentiate to osteogenic precursor cells and thus represent an importa
254 xc1 is preferentially expressed in the adipo-osteogenic progenitor CAR cells essential for haematopoi
255 and basic fibroblast growth factor in these osteogenic progenitor cells are markedly different, sugg
257 a femur non-union fracture demonstrate only osteogenic progenitor cells with higher pro-angiogenic p
258 c hedgehog (Shh) and Sca1, markers of aortic osteogenic progenitors, were also reduced, paralleling a
259 lpha and Sca-1 than the Sca-1-negative adipo-osteogenic progenitors, which create a niche for hematop
261 expression of this lncRNA, which promotes an osteogenic program by interfering with the expression of
262 ion of several Wnt genes, BMP2 activates the osteogenic program largely independently of de novo Wnt
264 ort vascular mineralization by directing the osteogenic programming of aortic progenitors in diabetic
268 ic activity, cell density, collagen content, osteogenic protein expression, and organization of the t
270 h non-viral vectors harboring cmRNA encoding osteogenic proteins may be a powerful tool for stimulati
272 1 by siRNA led to an increased expression of osteogenic related genes, elevated alkaline phosphatase
273 A1, and NH4Cl) attenuated the expression of osteogenic related markers (osteopontin, alkaline phosph
275 te the role of primary cilia in EFS-enhanced osteogenic response of human adipose-derived stem cells
276 to knockdown BMP-2 production abrogated the osteogenic response to levels observed with MSCs alone.
278 ated respectively with greater expression of osteogenic RUNX2 and with lower expression of several in
280 MP9 is also the most potent BMP for inducing osteogenic signaling in mesenchymal stem cells in vitro
281 th factors alone, we sustained mitogenic and osteogenic signals with these growth factors in an easil
282 vancing the targeted delivery selectivity of osteogenic siRNAs from the tissue level to the cellular
284 icone gels we show that harder gels are more osteogenic, softer gels are more adipogenic, and cell sp
285 hese data suggest that miR-101 is induced by osteogenic stimuli and promotes osteogenic differentiati
286 rogen deficiency (5 weeks), and exceeded the osteogenic strain threshold (10,000 muepsilon) in a simi
287 increased in Gja1(Jrt)/+ trabecular bone and osteogenic stromal cell cultures, which contributed to t
291 e present study investigates the role of the osteogenic transcription factor runt-related transcripti
292 cells and crucial for the expression of the osteogenic transcription factor runt-related transcripti
293 PDZ-binding domain (TAZ) as well as the pre-osteogenic transcription factor RUNX2 in human mesenchym
294 related transcription factor 2), encoding an osteogenic transcription factor, demonstrated some assoc
296 iRNA transfection promoted the expression of osteogenic transcription factors in normal jaw bone MSCs
297 d restricted the Wnt3a induced expression of osteogenic transcriptional factors, such as Runx2 and Dl
298 differentiation with dramatically increased osteogenic transcriptional program and calcium depositio
299 ed with 5 x 10(5) rat EPCs and 5 x 10(5) rat osteogenic transformed MSCs (EPC/otMSCs) were fixed to t
300 utant pigs primarily developed lymphomas and osteogenic tumors, recapitulating the tumor types observ
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