ライフサイエンスコーパス: osteopontin

1 F-alpha, IFN-gamma, IL-6, CCL2, CCL3, G-CSF, osteopontin).

2 ralization inhibitors matrix Gla protein and osteopontin.

3 in the pleural space by elaborating CCL2 and osteopontin.

4 his was reversed by neutralizing antibody to osteopontin.

5 iators, like Calgranulin A, Cathepsin S, and Osteopontin.

6 peptidase-9 (MMP-9), a protease that cleaves osteopontin.

7 sporter 1 (encoded by the SLC20A1 gene), and osteopontin.

8 cantly associated, aside from that of plasma osteopontin.

9 tion and reduction in the retentive molecule osteopontin.

10 tory mediators, such as C5a, bradykinin, and osteopontin.

11 d extracellular matrix genes fibronectin and osteopontin.

12 olecule-1, vascular adhesion molecule-1, and osteopontin.

13 ors osteoprotegerin, matrix Gla protein, and osteopontin.

14 of even a highly disordered protein such as osteopontin.

15 3 are the major integrins for this effect on osteopontin.

16 on in fibroblasts plated on fibrotic matrix, osteopontin.

17 C) signal sequence with that of prolactin or osteopontin.

18 tion and expression of p65, TLR4, MCP-1, and osteopontin.

19 ion of plasminogen activator inhibitor 1 and osteopontin 1.

20 quantify the putative ovarian cancer markers osteopontin (38 mum diameter sphere), CA-125 (53 mum dia

21 a-enolase (9%); heat-shock protein 90 (13%); osteopontin (4%); ubiquitin-conjugating enzyme (15%); tr

22 The most highly upregulated gene was osteopontin (47-fold increase; P=9.6x10(-45)), an inflam

23 pressed, also in a CD44-dependent manner, by osteopontin, a component of chronically inflamed ECM, in

24 owth factors, such as IL1beta, IL6 and SPP1 (osteopontin, a key biomarker for PCa), were upregulated

25 lammatory gene expression, including that of osteopontin, a known contributor to the development of m

26 r volume, as well as the expression level of osteopontin, a known factor of bone remodeling and osteo

27 Although it has been reported that osteopontin, a matrix glycoprotein and proinflammatory c

28 e was to determine the effect of recombinant osteopontin, a pleiotropic extracellular matrix glycopro

29 bited elevated macrophages and deposition of osteopontin, a potent macrophage chemokine.

30 breast cancer cells, and tumor cell-secreted osteopontin activated a CAF phenotypes in normal mammary

31 AE (P = .033) and the mean percent change in osteopontin after TAE (P = .024) were significantly grea

32 dosages (0.02 and 0.1 microg) of recombinant osteopontin, albumin, or vehicle.

33 he expression of osteogenic related markers (osteopontin, alkaline phosphatase activity, Alizarin red

34 Finally, our experiments have revealed that osteopontin, an important immunomodulator, contributes t

35 nalysis of cytoskeleton, Ki67, expression of osteopontin and alkaline phosphatase, and formation of m

36 extracellular matrix phosphoproteins such as osteopontin and bone sialoprotein have yielded important

37 entin matrix protein 1, and higher levels of osteopontin and bone sialoprotein than the normal.

38 ffects with the integrin-activating proteins osteopontin and CD44.

39 eral matrix molecules including fibronectin, osteopontin and fibrillin-1.

40 When osteopontin and hyaluronic acid, the two major ligands o

41 o was associated with elevated deposition of osteopontin and macrophage recruitment.

42 known regulators of mineralization, such as osteopontin and matrix Gla protein, but not osteocalcin,

43 Osteopontin and matrix metalloproteinase-9 were confirme

44 ponse mechanisms, in part, via regulation of osteopontin and MMP-9 activity.

45 ith hypertrophy, increased oxidative stress (osteopontin and NOX4 gene expression), and normal systol

46 Osteopontin and osteoprotegerin were significantly eleva

47 he nucleus where it led to the expression of osteopontin and other FN-type matrix in both mouse embry

48 ng theme in these diseases is a link between osteopontin and pathogenic T cells, particularly T helpe

49 pression of the WNT-pathway surrogate marker osteopontin and the metastasis-associated genes SASH1 an

50 Osteopontin and VCAM-1 demonstrated sustained upregulati

51 metastasis-related genes (MMP9, MMP13, VEGF, Osteopontin) and secreted bone-resorbing factors (PTHrP,

52 line phosphatase, secreted phosphoprotein 1 (osteopontin), and bone gamma-carboxyglutamate protein (o

53 mation (high-sensitivity C-reactive protein, osteopontin), and leukocyte adhesion (soluble vascular c

54 metastasis-inducing proteins S100A4, S100P, osteopontin, and AGR2 (P < or = 0.002).

55 associated with mineralized differentiation, osteopontin, and alkaline phosphatase in DPSCs cultured

56 inct molecular mechanisms, such as fetuin-A, osteopontin, and bone morphogenic protein 7, among other

57 f bone morphogenetic protein (BMP)-2, BMP-7, osteopontin, and bone sialoprotein were evaluated in alv

58 elated transcription factor 2), osteocalcin, osteopontin, and bone sialoprotein, were reduced proport

59 alpha-Casein, beta-casein, osteopontin, and chordin-like protein 2 phosphoproteins

60 glycoproteins (SIBLINGs): bone sialoprotein, osteopontin, and dentin matrix protein 1, respectively.

61 renal macrophages that expressed Il10, MMPs, osteopontin, and growth factors, including Pdgfc and Hbe

62 kaline phosphatase, osteocalcin, osteonectin/osteopontin, and in vitro mineralized nodule formation c

63 threads coated with antibodies against CRP, osteopontin, and leptin proteins.

64 ms (SNPs) in candidate genes (SPP1, encoding osteopontin, and LTBP4, encoding latent transforming gro

65 glycan secretion and production of aggrecan, osteopontin, and matrix extracellular phosphoglycoprotei

66 thases, adhesion molecules, myeloperoxidase, osteopontin, and matrix metalloproteinase (MMP) were mea

67 ins, such as alpha-lactalbumin, lactoferrin, osteopontin, and milk fat globule membrane proteins.

68 uced the expression of matricellular protein osteopontin, and modestly enhanced the expression of typ

69 e responsible for degrading type I collagen, osteopontin, and other bone matrix proteins.

70 d the specific role of alpha/beta integrins, osteopontin, and related extracellular matrix proteins;

71 vels of RANKL, osteoprotegerin, osteocalcin, osteopontin, and serum glycosylated hemoglobin A1c, insu

72 f cholangiocytes including cytokeratin 7 and osteopontin, and the transcription factors SOX9 and hepa

73 ch the staining profile for the MIPs S100A4, osteopontin, anterior gradient-2, and S100P has already

74 Thus, plasma levels of osteopontin are significantly correlated with HIV-induce

75 ndent transcriptional effects and implicates osteopontin as a contributor to these phenotypes.

76 d (RANKL), osteoprotegerin, osteocalcin, and osteopontin as potential biomarkers of alveolar bone los

77 onal assay with physiological TRAP substrate osteopontin, AubipyOMe inhibited mouse macrophage migrat

78 beta3, but not alphaIIbbeta3 (D552A), caused osteopontin binding to alphavbeta3, but not fibrinogen b

79 We report that macrophage-secreted osteopontin binds to CD44s on the tumor cells and promot

80 gramming and neutralizing antibodies against osteopontin-blocked fibroblast activation induced by tum

81 The total NCPs were separated into osteopontin-, bone sialoprotein-, and dentin matrix prot

82 ression of alkaline phosphatase, MMP-13, and osteopontin but decreased expression of osteocalcin, ost

83 tested for their role in Th differentiation, osteopontin, but not hyaluronic acid, promoted Th1/Th17

84 bone matrix proteins dentin sialoprotein and osteopontin, but not transforming growth factor-beta, st

85 active protein by 13% (95% CI, -14% to -9%), osteopontin by 12% (95% CI, -14% to -10%), soluble vascu

86 sms, and involves the processing of elevated osteopontin by activated MMP-9, and subsequent macrophag

87 Secretion of osteopontin by instigating tumors is necessary for BMC a

88 and the up-regulation in liver production of osteopontin by NKT cells and hepatic macrophages.

89 e production of the mMDSC chemotactic factor osteopontin by tumor cells.

90 e show by in vitro experiments that secreted osteopontin can be processed by extracellular proteasome

91 egulate chemotaxis-related proteins, such as osteopontin, CCR2, and CXCR6.

92 These data identify osteopontin-CD44-TIAM1-Rac1 axis as a RhoGDI2-sensitive

93 Osteopontin-CD44s-TIAM1 promotes clonal growth in vitro

94 Osteoprogenitor cells and endosteal-lining osteopontin(+) cells were reduced, and osteocalcin mRNA

95 Recently, coagulation-activated osteopontin, chemerin, and protease-activated receptor s

96 Me inhibited mouse macrophage migration over osteopontin-coated membranes.

97 In general, osteopontin contributes to pathology in these diseases,

98 Salivary osteopontin correlated positively with serum and salivar

99 IL-6 and osteopontin correlated significantly with radiologic res

100 g with reduction in malignant serum markers (osteopontin, Cxcl12) were noted.

101 VCAM-1 and osteopontin demonstrated sustained upregulation, whereas

102 c (up- and then down-regulation) of the Spp1/osteopontin-dependent network and up-regulation of mRNA

103 tions of interleukin 6, interleukin 8, VEGF, osteopontin, E-selectin, and HGF with continuous tumour

104 A biomarker index of SP-D, MMP-7, and osteopontin enhanced diagnostic accuracy in patients wit

105 1 alpha (p<0.0001) expression, and increased osteopontin expression (p=0.0005) were each significantl

106 ited reduced mesodermal fibronectin (FN) and osteopontin expression and died during mesoderm developm

107 ipocyte-derived soluble factor may stimulate osteopontin expression by U937 cells.

108 n essential role in the coculture-stimulated osteopontin expression by U937 cells.

109 Osteopontin expression correlates with tumor aggressiven

110 ILK also regulated osteopontin expression in cardiomyocytes in vitro.

111 n vitro, and results in a marked increase in osteopontin expression in vitro.

112 structure with distinct Ihh, collagen X, and osteopontin expression patterns.

113 Thymic stromal lymphopoietin and osteopontin expression were detected by means of reverse

114 LR4 activation, and high glucose up-regulate osteopontin expression, and adipocyte-derived IL-6 playe

115 AT3KO) mice are defective in alpha4beta1 and osteopontin expression, defects that correlated with ina

116 ot attenuate AngII-induced cardiac fibrosis, osteopontin expression, or macrophage accumulation in mo

117 s effectively inhibited coculture-stimulated osteopontin expression, suggesting that IL-6 released by

118 7 and 28 days and evaluated by histology and osteopontin expression.

119 m and studied how cell interaction regulated osteopontin expression.

120 scular endothelial growth factor (VEGF), and osteopontin expression.

121 ular mechanisms involved in ePi induction of osteopontin gene expression, we transfected a series of

122 lts demonstrate that ePi can directly induce osteopontin gene transcription.

123 r alpha genes, and a high level of IGF-1 and osteopontin genes compared to mdx(5cv) controls.

124 metalloproteinase (MMP)-7 > 1.75 ng/ml, and osteopontin > 6 ng/ml each significantly distinguished p

125 ally secreted form, an intracellular form of osteopontin has been identified, which participates in s

126 he calcium-regulating proteins, fetuin-A and osteopontin, have been found in the serum of patients wi

127 f this study is to produce recombinant human osteopontin (hOPN) in plants for inducing dental bone re

128 Unlike osteopontin, however, it was found to contain high level

129 In this review, we focus on the role of osteopontin in a series of immune-related diseases, part

130 inent association for matrix Gla protein and osteopontin in ABCC6-related dystrophic cardiac calcific

131 In addition, a role for osteopontin in B-cell differentiation is becoming clear.

132 esmon in stromal cells and the expression of osteopontin in both tumor cells and stroma were signific

133 ence the inflammatory cytokines TNF-alpha or osteopontin in epididymal ATMs of obese mice caused sign

134 ltered levels of dentin matrix protein 1 and osteopontin in Fam20C-deficient bone may be significant

135 evelopment of Sjogren's disease, the role of osteopontin in inflammatory conditions in the oral cavit

136 ole for paracrine signaling by tumor-derived osteopontin in reprograming normal fibroblasts into tumo

137 We found increased levels of osteopontin in the brains of humans with HIV encephaliti

138 creted phosphoprotein 1 (SPP1, also known as osteopontin) increases in pulmonary fibrosis, and Spp1 t

139 aracterized by increased expression of COX2, osteopontin, inflammatory cytokines, and chemokines but

140 actor 2 (TRAF2) and intracellular isoform of osteopontin (iOPN) whereas TLR4 signaling provides IFN r

141 Osteopontin is a pleiotropic cytokine that is involved i

142 Osteopontin is a protein known to be associated with can

143 Osteopontin is a secreted, integrin-binding and phosphor

144 Secreted osteopontin is cleaved by few known proteases, modulatin

145 roperty of highly phosphorylated isoforms of osteopontin is their ability to sequester nanoclusters o

146 d insulin resistance, it remains unclear how osteopontin is up-regulated in adipose tissue in obese h

147 Osteopontin levels in splenic macrophages were upregulat

148 Indeed, the detection limit falls within the osteopontin levels reported in the literature for patien

149 In cerebrospinal fluid, osteopontin levels were found to be elevated in HIV-infe

150 However, plasma osteopontin levels were significantly increased in indiv

151 we hypothesized that increased production of osteopontin might contribute to the persistence of centr

152 Importantly, blocking antibodies to osteopontin mitigated but did not fully rescue the funct

153 Osteopontin mRNA and cleaved protein was up-regulated in

154 Cathepsin K, NFATc1, and osteopontin mRNA expression decreased in EPAC1/2-KO cell

155 Cathepsin K and osteopontin mRNA expression increased in control and ZM2

156 lture of U937 cells and adipocytes increased osteopontin mRNA in U937 cells, but not adipocytes, sugg

157 Osteopontin null kidney grafts had reduced injury after

158 ormed to determine the effect of recombinant osteopontin on matrix metalloproteinase-9, substrates of

159 gher cell viability and larger extracellular osteopontin (OPN) accumulation.

160 Tissue expression of osteopontin (Opn) and 11 osteogenic transcription factor

161 grin binding ligand N-linked glycoproteins), osteopontin (OPN) and bone sialoprotein (BSP) in the Gal

162 factors were selected for further analysis: osteopontin (OPN) and clusterin (CLU) which were upregul

163 vels among RGCs and also selectively express osteopontin (OPN) and receptors for the insulin-like gro

164 We identified osteopontin (OPN) as one of the most highly elevated tra

165 s of patients with alcoholic hepatitis (AH), osteopontin (OPN) as one of the most up-regulated genes.

166 18 cirrhosis and 17 HCC patients identified osteopontin (OPN) as significantly up-regulated in HCC c

167 Thrombin cleavage alters the function of osteopontin (OPN) by exposing an integrin binding site a

168 s), IgG anti-Helicobacter pylori (HpAb), and osteopontin (OPN) can be used as a panel for GC diagnose

169 Osteopontin (Opn) contributes to diverse biological proc

170 Moreover, PC3 cells overexpressing osteopontin (OPN) displayed an increase in the number of

171 er proinflammatory cytokines, high levels of osteopontin (Opn) during experimental colitis.

172 ,000 mg/kg groups, concomitant with elevated osteopontin (OPN) expression in prostates and LNs.

173 critical mediator of the CAF phenotype, and osteopontin (OPN) expression in tumors is associated wit

174 Recent in vivo studies establish that osteopontin (OPN) expression is hydrogen peroxide (H2O2)

175 A promoter polymorphism of the osteopontin (OPN) gene (rs28357094) has been associated

176 Recently, osteopontin (OPN) has attracted attention as a promising

177 umulation of the macrophage-derived cytokine osteopontin (OPN) in adipose tissue and induction of loc

178 We found that absence of osteopontin (OPN) in immunocompromised Rag2(-/-) mice, w

179 he expression of the proatherogenic cytokine osteopontin (OPN) in mouse arteries via local release of

180 sma levels of the hypoxia-associated protein osteopontin (OPN) in patients on this protocol.

181 To characterize the role of osteopontin (OPN) in primary open-angle glaucoma (POAG)

182 Upon aging, the expression of osteopontin (OPN) in the murine bone marrow stroma is re

183 study we report that expression of GLI1 and osteopontin (OPN) increase progressively with the progre

184 stimulation, we previously demonstrated that osteopontin (OPN) increased STAT1 ubiquitination and 26

185 Osteopontin (Opn) is a broadly expressed pleiotropic cyt

186 Osteopontin (OPN) is a chemokine that is produced follow

187 Osteopontin (OPN) is a component of tumor extracellular

188 Osteopontin (OPN) is a cytokine implicated in mediating

189 Osteopontin (OPN) is a cytokine up-regulated after cell

190 Osteopontin (OPN) is a glycoprotein that is secreted by

191 Osteopontin (OPN) is a matricellular protein with proinf

192 Osteopontin (OPN) is a multifunctional phosphorylated pr

193 Osteopontin (OPN) is a phosphorylated glycoprotein that

194 Osteopontin (OPN) is a pro-inflammatory cytokine which i

195 Osteopontin (OPN) is a proinflammatory cytokine that pla

196 Osteopontin (OPN) is a secreted phosphoprotein, original

197 Osteopontin (OPN) is an immunomodulator highly expressed

198 Osteopontin (OPN) is an important component of the extra

199 Here, we report that osteopontin (OPN) is highly expressed and secreted by er

200 Although osteopontin (OPN) is induced in alcoholic patients, its

201 The proinflammatory chemokine osteopontin (OPN) is induced in multiple neuroinflammato

202 Overexpression of osteopontin (OPN) is strongly associated with the invasi

203 rine asbestos inhalation model, we show that osteopontin (OPN) is up-regulated by bronchiolar epithel

204 PURPOSE Plasma osteopontin (OPN) levels in advanced non-small-cell lung

205 in vitro and in vivo and that IFITM3 reduces osteopontin (OPN) mRNA expression, possibly by affecting

206 sforming growth factor beta1 (TGF-beta1) and osteopontin (OPN) play important roles in bone remodelin

207 ion and its inhibition by the phosphoprotein osteopontin (OPN) plays a key role in COM stone-forming

208 IL-10-producing regulatory T cells, whereas osteopontin (OPN) promotes pathogenic IL-17 T cell respo

209 l adhesion with the gene Spp1, also known as osteopontin (OPN) serving as a key common node connectin

210 Here we found that osteopontin (OPN) skewed this balance during pathogenic

211 vious studies of tissue repair have revealed osteopontin (OPN) to be up-regulated in association with

212 es, deposition of mineral-regulating protein osteopontin (OPN) was increased in alveolar bone in Phos

213 ellular RNA levels showed that expression of osteopontin (OPN) was strongly induced by MT expression.

214 ns of phosphatidylserine (DPPS) bilayers and osteopontin (OPN) were fabricated on silica substrates t

215 tory cytokines (IL1beta, TNF-alpha, IL6, and osteopontin (OPN)) were increased in MacGHR KO AT stroma

216 orm causally implicated in autoimmunity, and osteopontin (OPN), a CD44v7 ligand implicated in chronic

217 These cells expressed high levels of osteopontin (OPN), a cytokine that promotes immune cell

218 The expression of osteopontin (OPN), a gene regulating every step in tumor

219 c osteochondrogenic programs and circulating osteopontin (OPN), a matricellular regulator of arterios

220 s expression of the SPP1 gene, which encodes osteopontin (OPN), a pleiotropic cytokine implicated in

221 Osteopontin (OPN), a pleiotropic extracellular matrix gl

222 The gene encoding osteopontin (OPN), a profibrogenic extracellular matrix

223 Osteopontin (OPN), a protein present in several body flu

224 We hypothesized that osteopontin (OPN), an extracellular matrix (ECM) cytokin

225 Here we show that osteopontin (OPN), an extracellular matrix molecule secr

226 Osteopontin (OPN), an extracellular matrix protein, has

227 Elevated levels of the oncoprotein, osteopontin (OPN), are associated with poor outcome of s

228 sthma where high levels of the glycoprotein, osteopontin (OPN), are present in the airways.

229 re stained for SIBLING proteins: full-length osteopontin (OPN), bone sialoprotein (BSP), dentin matri

230 tures, immunoblotting revealed more abundant osteopontin (OPN), dentin matrix protein 1 (DMP1), and m

231 mely insulin-like growth factor 1 (IGF1) and osteopontin (OPN), in cortical neurons leads to robust C

232 ntal chain of events by the up-regulation of osteopontin (OPN), which in turn enhances osteoclastic a

233 Osteopontin (OPN), which is highly expressed in malignan

234 e osteoprotegerin (OPG)-RANK-RANKL system or osteopontin (OPN)-play a role in the bone abnormalities

235 wo osteogenic genes, collagen Ia (Col1a) and osteopontin (OPN).

236 y up-regulated by the inflammatory cytokine, osteopontin (OPN).

237 f among which is Spp1, encoding the cytokine osteopontin (OPN).

238 two adjacent proteins, osteocalcin (OC) and osteopontin (OPN).

239 ctivation, focusing on the known SASP factor osteopontin (OPN).

240 d expression of the tumor-promoting protein, osteopontin (OPN).

241 d SOCS3 co-deletion, or co-overexpression of osteopontin (OPN)/insulin-like growth factor 1 (IGF1)/ci

242 The matricellular protein osteopontin (OPN, Spp-1) is widely associated with cance

243 he signaling kinase PI(3)K and intracellular osteopontin (OPN-i), followed by translocation of OPN-i

244 (8.2+/-4.6-fold), RANKL (21+/-5.9-fold), and osteopontin (OPN; 17+/-5.3-fold), whereas C2 had little

245 showed a strong activation of Spp1 (encoding osteopontin [OPN]) in VAT.

246 T plasma (not urine) kidney injury proteins (osteopontin [OPN], neutrophil gelatinase-associated lipo

247 3 integrin with soluble RGD ligands, such as osteopontin or cilengitide, promoted association of Rab-

248 t highly upregulated upon T-cell activation, osteopontin (or Eta-1, as it was designated then) has be

249 ce had significantly higher plasma levels of osteopontin, osteocalcin, and osteoprotegerin (204%, 148

250 n 6 (p<0.0001), interleukin 8 (p=0.002), and osteopontin (p<0.0001) were all prognostically associate

251 ative to median) of interleukin 8 (p=0.006), osteopontin (p=0.0004), HGF (p=0.010), and TIMP-1 (p=0.0

252 cells, particularly T helper 17 cells, where osteopontin produced by dendritic cells supports IL-17 e

253 the development of interventions to modulate osteopontin production or signaling might be beneficial

254 with adipocytes led to a marked increase in osteopontin production when compared with that released

255 gene expression, we transfected a series of osteopontin promoter-luciferase constructs into OCCM-30

256 ggest that in the glioma perivascular niche, osteopontin promotes stem cell-like properties and radia

257 Furthermore, osteopontin reduces the release of proteasomes in the ex

258 n-inducible Cre recombinase under control of osteopontin regulatory region crossed with yelow fluores

259 le osteoblast markers, bone sialoprotein and osteopontin, remained unchanged.

260 classified by epithelium-derived CCL-26 and osteopontin, respectively.

261 sordered protein, the recombinant human-like osteopontin rOPN.

262 stology and immunohistochemical analyses for osteopontin, runt-related transcription factor 2 (Runx2)

263 ceptor, and the metastasis-inducing proteins osteopontin, S100P, and S100A4.

264 er, our results indicate a possible way that osteopontin secreted from both NFPA cells and surroundin

265 e further augmented the coculture-stimulated osteopontin secretion.

266 Osteopontin, selected for this study due to its key role

267 as the main receptor for hyaluronic acid and osteopontin, serving as coreceptor for growth factor pat

268 The CD44 ligand osteopontin shared a perivascular expression pattern wit

269 Strikingly, osteopontin silencing in tumor cells in vivo attenuated

270 In this study, we demonstrate that secreted osteopontin (sOPN) plays a role in the T cell migration

271 Although a recent study implicates osteopontin (SPP1) in AH, SPP1 is also shown to have pro

272 icantly up-regulated gene is the ECM-related osteopontin (SPP1).

273 snail family member (Snai3; P < 0.001), and osteopontin (Spp1; P < 0.001).

274 one marker genes (alkaline phosphatase/ALPL, osteopontin/SPP1, and bone sialoprotein II/IBSP) in a su

275 collagen 4A1/COL4A1, laminin gamma 2/LAMC2, osteopontin/SPP1, KIAA0101, and TGFbeta2 genes in the st

276 es were YFP(+) lineage-labeled; positive for osteopontin, SRY (sex determining region Y)-box 9, and e

277 BMP2 was a potent inducer of osteocalcin/osteopontin (statistically significant at P <0.01) and o

278 features demonstrated that the expression of osteopontin, TGFbeta2, and laminin in the stroma of ICC

279 arkers of renal injury including Cystatin C, Osteopontin, Tissue Inhibitor of Metalloproteinases-1 (T

280 The ability of secreted osteopontin to activate mammary fibroblasts relied upon

281 othelial growth factor receptor 1, 2, and 3; osteopontin; transforming growth factor beta1 and beta2;

282 These results demonstrate that recombinant osteopontin treatment is effective for early brain injur

283 ansforming growth factor beta (TGF-beta)(1), osteopontin, tumor necrosis factor alpha (TNF-alpha), le

284 demonstrated that the stromal expression of osteopontin was an independent prognostic marker for ove

285 Osteopontin was highly secreted by mouse and human breas

286 ized within areas of mineralization, whereas osteopontin was more diffusely distributed in the area o

287 ubcutaneous specimens, whereas expression of osteopontin was more prominent in the GDBM group.

288 The secreted proteins analysis found that osteopontin was significantly upregulated in BD-NFPAs fi

289 Osteopontin was sufficient to induce fibroblast reprogra

290 e phosphatase, osteocalcin, osteonectin, and osteopontin were analyzed along with in vitro mineralize

291 ry concentrations of RANKL, osteocalcin, and osteopontin were higher, and osteoprotegerin was lower i

292 ntrol group, whereas RANKL, osteocalcin, and osteopontin were not related with periodontal status.

293 Furthermore, IL-1alpha and osteopontin were suggested to be mediators of M2-like ma

294 (ST2, CXCL9, matrix metalloproteinase 3, and osteopontin) were necessary to compose a four-biomarker

295 bumin, beta-2-microglobulin, cystatin C, and osteopontin) were undetectable in most AASK-N samples.

296 ls to sites of inflammation, including SPP1 (osteopontin), were highly overexpressed in LCH CD207(+)

297 Osteopontin, which can activate NK cells to mediate tubu

298 tified the secreted proinflammatory mediator osteopontin, which has been implicated in inflammation,

299 e differences and the specific receptors for osteopontin will be a research challenge for the future.

300 a phosphoprotein has some characteristics of osteopontin with respect to amino acid composition and s