ライフサイエンスコーパス: osteoporotic fracture

1 oteins increase the risk of osteoporosis and osteoporotic fracture.

2 Vertebral fractures are the most common osteoporotic fracture.

3 d bone mineral density and increased risk of osteoporotic fracture.

4 to maximize efficacy in patients at risk for osteoporotic fracture.

5 ross-linking, thereby increasing the risk of osteoporotic fracture.

6 ed to low bone density and increased risk of osteoporotic fracture.

7 , bone mineral density, and the incidence of osteoporotic fracture.

8 functioning and thus may reduce the risk for osteoporotic fracture.

9 ement bone densitometry in assessing risk of osteoporotic fracture.

10 at is significantly related to bone mass and osteoporotic fracture.

11 ccurately identify those at greatest risk of osteoporotic fracture.

12 The primary endpoint was time to first osteoporotic fracture.

13 rs) after cohort entry for an incident major osteoporotic fracture.

14 ral density (BMD) predicts the likelihood of osteoporotic fracture.

15 lomipramine (CLP), have an increased risk of osteoporotic fracture.

16 up, 21 (4.6%) recipients experienced a major osteoporotic fracture.

17 ure and 113 participants experienced a major osteoporotic fracture.

18 fully improve the prediction of hip or major osteoporotic fracture.

19 a means to improve bone strength and reduce osteoporotic fracture.

20 tate cancer is associated with bone loss and osteoporotic fractures.

21 ars of age who were enrolled in the Study of Osteoporotic Fractures.

22 independent risk factor for osteoporosis and osteoporotic fractures.

23 Patients with RA are at increased risk of osteoporotic fractures.

24 gnificant gene BDNF was also associated with osteoporotic fractures.

25 or =65 years of age enrolled in the Study of Osteoporotic Fractures.

26 of the hip in elderly women in the Study of Osteoporotic Fractures.

27 at the baseline examination of the Study of Osteoporotic Fractures.

28 at the baseline examination of the Study of Osteoporotic Fractures.

29 hosphonates are a common treatment to reduce osteoporotic fractures.

30 rly women are associated with a reduction in osteoporotic fractures.

31 uman beings and thereby decrease the risk of osteoporotic fractures.

32 c kidney disease, chronic liver disease, and osteoporotic fractures.

33 es may be consistent with a reduction in all osteoporotic fractures.

34 at 26 million American women are at risk for osteoporotic fractures.

35 od most often used to determine the risk for osteoporotic fractures.

36 of sex and racial differences in the risk of osteoporotic fractures.

37 of age or older and enrolled in the Study of Osteoporotic Fractures.

38 Ps in the setting of secondary prevention of osteoporotic fractures.

39 ysteine concentrations are a risk factor for osteoporotic fractures.

40 but also to contribute to the development of osteoporotic fractures.

41 frican-American participants in the Study of Osteoporotic Fractures.

42 associated with a 4-fold increased risk for osteoporotic fractures.

43 hniques should be used to diagnose prevalent osteoporotic fractures.

44 om bisphosphonate-treated women with typical osteoporotic fractures.

45 1 older US women from the Caregiver-Study of Osteoporotic Fractures.

46 and April 2004 in a substudy of the Study of Osteoporotic Fractures.

47 eric femur that are infrequently affected by osteoporotic fractures.

48 d the exercise type most effective to reduce osteoporotic fractures.

49 t been systematically studied in relation to osteoporotic fractures.

50 tive was to examine FA intake in relation to osteoporotic fractures.

51 wered hip BMD but did not change the risk of osteoporotic fractures.

52 , and low risk of fractures [HR (95% CI) for osteoporotic fractures: 0.90 (0.83, 0.96); for hip fract

53 and high risk of fractures [HR (95% CI) for osteoporotic fractures: 1.08 (1.00, 1.06); for hip fract

54 Osteoporotic fracture (11.9%) was also more common in cl

55 52 patients were reviewed (121 patients with osteoporotic fractures, 30 with malignant disease, and o

56 Following an osteoporotic fracture, a multidisciplinary rehabilitatio

57 ls, among 6,653 participants in the Study of Osteoporotic Fractures, a community-based, prospective c

58 linical centers and enrolled in the Study of Osteoporotic Fractures, a longitudinal cohort study.

59 The Study of Osteoporotic Fractures, a prospective cohort study of wh

60 did not have a significantly reduced risk of osteoporotic fracture, although there was a trend toward

61 mitigating bone loss and in reducing risk of osteoporotic fractures among older adults.

62 The decreased risks seen for osteoporotic fracture and colorectal cancer were outweig

63 treatment, including reductions in risks of osteoporotic fracture and coronary heart disease, and th

64 ted whether MI constitutes a risk factor for osteoporotic fracture and examined secular trends in thi

65 erved for higher intake of flavonols for any osteoporotic fracture and major osteoporotic fracture, a

66 amined magnesium intake as a risk factor for osteoporotic fractures and altered bone mineral density

67 Benefits of HRT include prevention of osteoporotic fractures and colorectal cancer, while prev

68 Osteoporotic fractures and osteoporosis were found in 37

69 e-related disorder leading to an increase in osteoporotic fractures and resulting in significant suff

70 vity, prolonged corticosteroid use, previous osteoporotic fracture, and androgen deprivation therapy.

71 omen; 212 (17.8%) were identified as a major osteoporotic fracture, and of these, 129 (10.9%) were a

72 0-60% in persons with low bone mass or prior osteoporotic fracture, and SREs by one-third in cancer p

73 ncer risk factors, clinical risk factors for osteoporotic fractures, and bone mineral density surveil

74 D) is highly heritable, a major predictor of osteoporotic fractures, and has been previously associat

75 elderly white women enrolled in the Study of Osteoporotic Fractures, and initial breast cancer status

76 Osteoporotic fractures are a leading cause of disability

77 Although methods to identify risk for osteoporotic fractures are available and medications to

78 Osteoporotic fractures are common among elderly men.

79 of the use of cimetidine on osteoporosis and osteoporotic fractures are indicated.

80 at BPs dispensed for secondary prevention of osteoporotic fractures are not associated with increased

81 nols for any osteoporotic fracture and major osteoporotic fracture, as well as flavones for hip fract

82 This study [B-vitamins for the PRevention Of Osteoporotic Fractures (B-PROOF)] aimed to determine whe

83 Furthermore, paraffin sections of human osteoporotic fractured bone exhibited increased RANKL im

84 an women, age >/=65 years, from the Study of Osteoporotic Fractures cohort was performed.

85 with adjudicated fracture outcomes (Study of Osteoporotic Fractures [December 1998-July 2008]; Osteop

86 rea under the curve (AUC) for incident major osteoporotic fracture discrimination (AUC: FRAX with BMD

87 The Study of Osteoporotic Fractures followed up 8022 women for 9.1 ye

88 ars or older, who have been hospitalized for osteoporotic fracture from 2003 until 2005.

89 udies, the Beijing OA Study and the Study of Osteoporotic Fractures from the US.

90 THR patients who had experienced a previous osteoporotic fracture (HR 0.48, 95% CI 0.23-0.99).

91 [HR], 1.43 [95% CI, 1.16 to 1.78]) and major osteoporotic fracture (HR, 1.21 [95% CI, 1.01 to 1.45])

92 the highest tertile had a lower risk of any osteoporotic fracture (HR: 0.65; 95% CI: 0.47, 0.88), ma

93 acture (HR: 0.65; 95% CI: 0.47, 0.88), major osteoporotic fracture (HR: 0.66; 95% CI: 0.45, 0.95), an

94 iated with a 30% decrease in the risk of any osteoporotic fracture (HR: 0.70; 95% CI: 0.50, 0.96).

95 to LMWH) in 0.11% (95% CI, 0.02%-0.32%), and osteoporotic fracture in 0.04% (95% CI, < 0.01%-0.20%) o

96 ncreasing evidence suggests that the risk of osteoporotic fracture in adulthood could be determined p

97 risk factors for low bone mineral density or osteoporotic fracture in men or comparing 2 different me

98 eveloping strategies to reduce the burden of osteoporotic fracture in the population.

99 ead to longlasting reductions in the risk of osteoporotic fracture in their offspring.

100 ce in transfer are significant predictors of osteoporotic fracture in white female nursing home resid

101 The aims are to establish the prevalence of osteoporotic fractures in ISM and to investigate the ass

102 ation-based age-specific fracture rates; the Osteoporotic Fractures in Men (MrOS) study and published

103 n Older Men Study (an ancillary study to the Osteoporotic Fractures in Men (MrOS) Study conducted in

104 The Osteoporotic Fractures in Men (MrOS) study is the first

105 porotic Fractures [December 1998-July 2008]; Osteoporotic Fractures in Men Study [March 2000-March 20

106 The Osteoporotic Fractures in Men Study followed up 5995 men

107 d DHEA-S in the prospective population-based Osteoporotic Fractures in Men study in Sweden (2,416 men

108 In a cohort of 1,104 elderly men from the Osteoporotic Fractures in Men Study, 25(OH)D serum level

109 sical performance with incident falls in the Osteoporotic Fractures in Men Study, a large prospective

110 study of 2,865 participants derived from the Osteoporotic Fractures in Men Study, a prospective multi

111 Participants were recruited from the Osteoporotic Fractures in Men Study.

112 >/=65 years of age who were enrolled in the Osteoporotic Fractures in Men Study.

113 to osteoporosis and to estimate the risk of osteoporotic fractures in relation to body weight, lean

114 The number of osteoporotic fractures in the groups was similar.

115 Participants in the Study of Osteoporotic Fractures in whom pelvic radiographs had be

116 B-12 and folic acid supplementation reduces osteoporotic fracture incidence in hyperhomocysteinemic

117 folic acid supplementation had no effect on osteoporotic fracture incidence in this elderly populati

118 ach of the studies and at each major site of osteoporotic fracture, including the hip and wrist.

119 past decades, the association between MI and osteoporotic fractures increased steadily.

120 assessed at the baseline Caregiver-Study of Osteoporotic Fractures interview, conducted in 1999-2001

121 Osteoporotic fracture is a significant source of morbidi

122 in patients with ISM shows that the risk of osteoporotic fractures is high, especially in men.

123 Protection against osteoporotic fractures is supported by a meta-analysis o

124 ssary component of bone, but its relation to osteoporotic fractures is unclear.

125 ing health outcomes, including prevention of osteoporotic fractures, is essential for promoting the w

126 Incident nontraumatic major osteoporotic fractures (MOFs) and hip fractures.

127 Falls are the chief mechanism by which osteoporotic fractures occur.

128 A total of 223 osteoporotic fractures occurred among 180 women.

129 Osteoporotic fractures occurred in 61 persons (4.2%) in

130 Documented osteoporotic fracture occurring during follow-up as a fu

131 me fracture (occurring after age 13 y) or an osteoporotic fracture (occurring after age 50 y).

132 femoral neck) and an increased risk of both osteoporotic fractures (odds ratio [OR] 1.3, 95% CI 1.09

133 Only osteoporotic fractures of the hip, vertebrae, and wrist

134 e of both risk alleles increased the risk of osteoporotic fractures (OR 1.3, 1.08-1.63, p=0.006) and

135 Outcome measures were time to osteoporotic fracture, overall and by anatomic site, and

136 study population was drawn from the Study of Osteoporotic Fractures, Pittsburgh, Pennsylvania, during

137 Osteoporotic fractures present a significant social and

138 Although osteoporotic fractures present an enormous health burden

139 roup analyses suggest a beneficial effect on osteoporotic fracture prevention in compliant persons ag

140 ificantly associated with the development of osteoporotic fractures (relative risk [RR] 2.5, 95% conf

141 Osteoporotic fractures represent an enormous public heal

142 Incidence of osteoporotic fracture requiring hospitalization was dete

143 or modulator) have each been shown to reduce osteoporotic fracture risk among men receiving androgen-

144 drugs available for these diseases, reducing osteoporotic fracture risk by 50-60% in persons with low

145 concentrations may be associated with lower osteoporotic fracture risk in older adults, particularly

146 sorders and psychotropic medication use with osteoporotic fracture risk in routine clinical practice.

147 The observed 10-year major osteoporotic fracture risk of 6.3% (95% CI, 3.4-9.2%) wa

148 ersons aged >80 y, in per-protocol analyses, osteoporotic fracture risk was lower in the intervention

149 Osteoporotic fracture risk was not significantly differe

150 Research shows that optimal screening for osteoporotic fracture risk will require risk factor info

151 hly heritable trait and a key determinant of osteoporotic fracture risk, but the genes responsible ar

152 as a clinical aid to assess an individual's osteoporotic fracture risk, with or without bone mineral

153 etic component and an important predictor of osteoporotic fracture risk.

154 n in early life, midlife, and late life with osteoporotic fracture risk.

155 n, vitamin D and calcium deficiency increase osteoporotic fracture risk.

156 bone remodeling associated with an increased osteoporotic fracture risk.

157 proves bone mineral density, a surrogate for osteoporotic fracture risk.

158 e important dietary components that modulate osteoporotic fracture risk.

159 ociated with a small increase in the risk of osteoporotic fractures (RR 1.3, 95% CI 1.0, 1.8); howeve

160 01 elderly women from the Caregiver-Study of Osteoporotic Fractures sample.

161 men with DM; HRs for 1-unit increase in FRAX osteoporotic fracture score, 1.04; 95% CI, 1.02-1.05, fo

162 Major osteoporotic fracture scores showed significant fracture

163 women ages > or = 65 years from the Study of Osteoporotic Fractures (SOF) and white men and women age

164 y community-dwelling women from the Study of Osteoporotic Fractures (SOF) cohort (mean age 83 years)

165 The Study of Osteoporotic Fractures (SOF) is a prospective, observati

166 Pittsburgh Clinical Center for the Study of Osteoporotic Fractures (SOF), a prospective cohort study

167 the Pittsburgh Field Center of the Study of Osteoporotic Fractures (SOF), a prospective study of a c

168 Given the economic and social costs of osteoporotic fractures, strategies to identify and manag

169 aging needs to be used to diagnose prevalent osteoporotic fractures, such as spine fractures on chest

170 Despite African Americans' reduced risk of osteoporotic fractures, such fractures remain an importa

171 treatment to limit the enormous increase in osteoporotic fractures that has been predicted as the ag

172 five families with X-linked osteoporosis and osteoporotic fractures that we report here.

173 In elderly men, who are at greatest risk for osteoporotic fracture, the influence of hypogonadism on

174 that many agents are effective in preventing osteoporotic fractures, the data are insufficient to det

175 Risk of hip or major osteoporotic fracture through 2009 or 12 years following

176 We used data from the prospective Study of Osteoporotic Fractures to estimate risk of fracture from

177 , 0.6-1.4), whereas the relative risk for an osteoporotic fracture was 1.4 (95% CI, 0.7-2.7).

178 Tool score, or FRAX), 10-year risk for major osteoporotic fracture was greater than 20% (FRAX), quant

179 A family history of osteoporotic fracture was strongly associated with low B

180 The ability to identify patients with osteoporotic fractures was evaluated by using receiver o

181 ort of 5,552 elderly women from the Study of Osteoporotic Fractures was followed up prospectively for

182 Osteoporotic fractures were determined from medical reco

183 Over 10 y of follow-up, osteoporotic fractures were identified in 288 (24.2%) wo

184 We studied 5,839 women from the Study of Osteoporotic Fractures who had had serial pelvic radiogr

185 Reducing osteoporotic fractures will require more effective appro

186 ith AFFs to those from patients with typical osteoporotic fractures with and without bisphosphonate t

187 association between the replicated SNPs and osteoporotic fractures with data from two studies.

188 > or =74 years participating in the Study of Osteoporotic Fractures year 10 follow-up (n = 906) in 19