ライフサイエンスコーパス: otitis

1 tanding of the pathogenesis of pneumonia and otitis.

2 sma are important pathogens in pneumonia and otitis.

3 al conjugate vaccine (PCV13) on pneumococcal otitis.

4 iratory tract infections (0.77 [0.59-0.99]), otitis (0.14 [0.05-0.42]), and fever (0.69 [0.47-1.01]).

5 ally cause the same disorders (pneumonia and otitis), and that high neonatal bacterial load is a key

6 e of rhinitis, respiratory tract infections, otitis, and fever were assessed by weekly health diaries

7 presentations in cattle, including mastitis, otitis, arthritis, and reproductive disorders.

8 t Staphylococcus aureus skin infections with otitis externa; recurrent, severe herpes simplex virus o

9 sulting in recurring respiratory infections, otitis, hydrocephaly and infertility.

10 d to the development of methods for inducing otitis in mice.

11 had microscopic haemorrhages (5/5) and mild otitis media (1/5) in the freshest cases.

12 ns [95% CI, 48-64]), followed by suppurative otitis media (47 antibiotic prescriptions [95% CI, 41-54

13 Vaccines to prevent acute otitis media (AOM) caused by non-typeable Haemophilus in

14 Subjects were followed closely for acute otitis media (AOM) development.

15 en to be prone to repeated episodes of acute otitis media (AOM) has long been sought.

16 )-approved antibiotics and that causes acute otitis media (AOM) in children.

17 Acute otitis media (AOM) is a common complication of upper res

18 Acute otitis media (AOM) is a leading cause of bacterial pedia

19 Acute otitis media (AOM) is a leading cause of visits to physi

20 Acute otitis media (AOM) is among the most common pediatric di

21 Acute otitis media (AOM) is the most common condition for whic

22 Acute otitis media (AOM) is the most common diagnosis for whic

23 Acute otitis media (AOM) was detected in 50% of these children

24 se against Streptococcus pneumoniae in acute otitis media (AOM), we investigated the susceptibility t

25 vaccine trial FinOM for prevention of acute otitis media (AOM), with a focus on disease replacement

26 bial treatment reduces the symptoms of acute otitis media (AOM).

27 to be involved in the pathogenesis of acute otitis media (AOM).

28 respiratory tract infections, such as acute otitis media (AOM).

29 e middle ear mucosa of children with chronic otitis media (COM) and may contribute to the persistence

30 Chronic suppurative otitis media (CSOM) refers to the middle ear inflammatio

31 haryngeal (NP) colonization and experimental otitis media (EOM) in an animal model.

32 ulence in a chinchilla model of experimental otitis media (EOM).

33 y of children to recurrent episodes of acute otitis media (hereafter, "otitis-prone children").

34 ritonitis (n = 1), septic arthritis (n = 1), otitis media (n = 10), and sinusitis (n = 3).

35 n = 76,243), chronic sinusitis (n = 15,745), otitis media (n = 237,833), pneumonia (n = 52,946), and

36 ing 14 isolates, isolated from patients with otitis media (n = 6), bacteremia (n = 6), meningitis (n

37 and 48 isolates from pediatric patients with otitis media (noninvasive) from 2011 to 2014 was charact

38 hilus influenzae (NTHI)-induced experimental otitis media (OM) after intranasal immunization of chinc

39 nized as an important pathogenetic factor in otitis media (OM) and associated diseases.

40 Reductions in otitis media (OM) burden following rollout of pneumococc

41 treptococcus pneumoniae is a common cause of otitis media (OM) in children; mastoiditis remains an im

42 gainst Streptococcus pneumoniae during acute otitis media (OM) in mice.

43 Otitis media (OM) is a common pediatric disease for whic

44 Chronic otitis media (OM) is a common pediatric infectious disea

45 Otitis media (OM) is a leading cause of pediatric health

46 Otitis media (OM) is common in early childhood.

47 x (ie, recurrent, nonresponsive, or chronic) otitis media (OM) is frequent and is often caused by a m

48 The pathogenesis of otitis media (OM) is multifactorial and includes infecti

49 Otitis media (OM) is the most common childhood bacterial

50 Otitis media (OM) is the most common childhood bacterial

51 Otitis media (OM) is the most common disease of childhoo

52 Otitis media (OM) is the most common illness in childhoo

53 cT are potentially essential in a chinchilla otitis media (OM) model.

54 Otitis media (OM) remains the most common childhood dise

55 Otitis media (OM), a middle-ear infection, is the most c

56 Inner ear dysfunction secondary to chronic otitis media (OM), including high-frequency sensorineura

57 Otitis media (OM), inflammation of the middle ear, is th

58 Otitis media (OM), the inflammation of the middle ear, i

59 from almost all TLRs, we studied its role in otitis media (OM), the most common upper respiratory tra

60 tions, including infectious endocarditis and otitis media (OM).

61 mococcal disease, including the incidence of otitis media (OM).

62 Mucin overproduction is a hallmark of otitis media (OM).

63 be a potent effector of inflammation during otitis media (OM): exogenous CCL3 rescues the OM phenoty

64 conjugated vaccines (PCVs) impact on complex otitis media (OM; including recurrent, nonresponsive, an

65 2432 participants), Streptococcus pneumoniae otitis media (OR = 2.51; 95% CI = 1.29-4.88; n = 921 par

66 ins many of the observations seen in chronic otitis media and chronic bronchitis.

67 t in Haemophilus influenzae isolates causing otitis media and chronic obstructive pulmonary disease (

68 formed a biofilm in the chinchilla model of otitis media and demonstrated a propensity to also form

69 axella catarrhalis (Mx) is a common cause of otitis media and exacerbation of chronic obstructive pul

70 nflammatory diseases that include sinusitis, otitis media and exacerbations of chronic obstructive pu

71 axella catarrhalis is a significant cause of otitis media and exacerbations of chronic obstructive pu

72 The introduction of vaccines for otitis media and global shifts in antimicrobial suscepti

73 young children and is an important cause of otitis media and invasive disease.

74 For example, NTHI is a leading cause of otitis media and is the most common cause of airway infe

75 e human nasopharynx and a causative agent of otitis media and other diseases of the upper and lower h

76 tential target for new therapies for chronic otitis media and other eardrum injuries.

77 ecies persist in vivo within biofilms during otitis media and other persistent infections.

78 educed cost, and improved protection against otitis media and pneumococcal pneumonia.

79 portant human pathogen causing both mucosal (otitis media and pneumonia) and systemic (sepsis and men

80 oronasopharynx can cause diseases including otitis media and pneumonia.

81 formation available developed complications; otitis media and sinusitis were the most common complica

82 vescence and decreased both the incidence of otitis media and the concomitant use of antibiotics.

83 specific gene regions among a large panel of otitis media and throat strains was determined by dot bl

84 We examined risks of acute otitis media associated with specific combinations of re

85 cavirus, and adenovirus in addition to acute otitis media bacterial pathogens.

86 ombinations of respiratory viruses and acute otitis media bacterial pathogens.

87 olated from the middle ears of children with otitis media but that are not associated with NT H. infl

88 st that GAS naturally forms a biofilm during otitis media but that biofilm formation is not required

89 It is clear that most otitis media cases involve simultaneous infection with m

90 ability to survive in a chinchilla model of otitis media compared with the parent strain.

91 fic viruses, bacteria, and the risk of acute otitis media complicating upper respiratory tract infect

92 a major cause of bacteremia, pneumonia, and otitis media despite vaccines and effective antibiotics.

93 In children aged <3 years, acute otitis media developed in 58%, and 66% of children in th

94 viral load plays an important role in acute otitis media development, but symptomatic upper respirat

95 s interact and play important roles in acute otitis media development.

96 1 children 6 to 23 months of age, with acute otitis media diagnosed with the use of stringent criteri

97 increasing proportion of children with acute otitis media due to Streptococcus pneumoniae have seroty

98 hearing impairment associated with bouts of otitis media during human infancy.

99 le ear-specific gene A2ML1 cosegregates with otitis media in an indigenous Filipino pedigree (LOD sco

100 respiratory tract pathogen commonly causing otitis media in children and acute exacerbations in pati

101 e is an opportunistic human pathogen causing otitis media in children and chronic bronchitis and pneu

102 Moraxella catarrhalis causes otitis media in children and exacerbations of chronic ob

103 halis is a strict human pathogen that causes otitis media in children and exacerbations of chronic ob

104 ommon respiratory tract pathogen that causes otitis media in children and infections in adults with c

105 mophilus influenzae is an important cause of otitis media in children and lower respiratory infection

106 human respiratory tract pathogen that causes otitis media in children and lower respiratory tract inf

107 oraxella catarrhalis is a causative agent of otitis media in children and lower respiratory tract inf

108 s an important respiratory pathogen, causing otitis media in children and lower respiratory tract inf

109 human pathogen that is an important cause of otitis media in children and lower respiratory tract inf

110 Moraxella catarrhalis is a common cause of otitis media in children and of lower respiratory tract

111 he bactericidal activity of serum and causes otitis media in children and respiratory tract infection

112 tarrhalis is an important bacterial cause of otitis media in children and respiratory tract infection

113 ypeable Haemophilus influenzae, which causes otitis media in children and respiratory tract infection

114 meningitis, pneumonia, sinusitis, and acute otitis media in children.

115 ause of respiratory infections in adults and otitis media in children.

116 mophilus influenzae is an important cause of otitis media in children.

117 mucosal hyperplasia during in vivo bacterial otitis media in guinea pigs.

118 ella catarrhalis is a human pathogen causing otitis media in infants and respiratory infections in ad

119 tors, as well as characterization of induced otitis media in several mouse strains.

120 toward the reduction of the burden of acute otitis media in the last decade.

121 The results indicate that induced otitis media in the normal mouse is in most respects com

122 Success in reducing acute otitis media incidence will rely mainly on prevention of

123 In the serum samples from children with otitis media infected with M. catarrhalis, antibody leve

124 nt persistence defect in vivo during chronic otitis media infection.

125 ilus influenzae (NTHI) is a leading cause of otitis media infections, which are often chronic and/or

126 s NTHI virulence in the chinchilla model for otitis media infections.

127 Otitis media is a common childhood infection of the midd

128 Otitis media is an extremely common pediatric infection

129 Otitis media is an extremely common pediatric inflammati

130 Vulnerability to otitis media is due to eustachian tube dysfunction as we

131 te from the chinchilla model of experimental otitis media is insufficient for direct analysis of gene

132 he actual burden of bacteria in experimental otitis media is significantly greater than was previousl

133 A case of AAS secondary to an otitis media is studied.

134 Treatment of acute otitis media is the most frequent indication for prescri

135 agent of pharyngitis, but the role of GAS in otitis media is underappreciated.

136 Virulence of an otitis media isolate (NTHi strain 86-028NP) was compared

137 zation and virulence, we transformed an NTHI otitis media isolate with a reporter plasmid containing

138 A10, account for over two-thirds of clinical otitis media isolates surveyed.

139 ically significant association of modM3 with otitis media isolates.

140 enzae attenuated virulence in the chinchilla otitis media model of noninvasive disease.

141 onclude from these studies that a chinchilla otitis media model provides a means to evaluate pathogen

142 s operon was significantly more prevalent in otitis media NTHI strains (106/121; 87.7%) than in throa

143 Acute otitis media occurs as a complication of viral upper res

144 here has been increasing evidence that acute otitis media occurs during upper respiratory infection,

145 ore likely to be from the throat than either otitis media or COPD isolates.

146 n-otitis-prone children at the time of acute otitis media or nasopharyngeal colonization with S. pneu

147 e material, resembling the biofilms of other otitis media pathogens, was visible in the middle ear as

148 Acute otitis media prevention efforts should consider methods

149 For example, otitis media reduces sound to the ear, which can cause l

150 philus influenzae in the chinchilla model of otitis media results in the formation of adherent mucosa

151 Acute otitis media risk differs by the specific viruses and ba

152 presence of key viruses, bacteria, and acute otitis media risk factors, acute otitis media risk was i

153 , and acute otitis media risk factors, acute otitis media risk was independently associated with high

154 10(7) copies/ml) experienced increased acute otitis media risk.

155 of a modA2 strain in the chinchilla model of otitis media show a clear selection for ON switching of

156 ection studies using the chinchilla model of otitis media showed a direct correlation between PCho ex

157 luenzae (NTHI) that was more prevalent among otitis media strains than among throat commensal NTHI st

158 found to be significantly more prevalent in otitis media strains.

159 We suggest that some human otitis media susceptibility reflects underlying genetic

160 revalent in NTHi isolates from children with otitis media than in those from the throats of healthy c

161 A wait-and-see approach to acute otitis media that empowers families by using a shared de

162 hypothesis' as we found common pathogens of otitis media to be both prevalent and abundant.

163 en that causes infections ranging from acute otitis media to life-threatening invasive disease.

164 clinical syndromes from uncomplicated acute otitis media to more complex recurrent and chronic cases

165 children, 6 to 23 months of age, with acute otitis media to receive amoxicillin-clavulanate either f

166 s of lic2B, hmwA, and the nine new potential otitis media virulence genes revealed two H. influenzae

167 Otitis media was induced by the inoculation of nontypeab

168 n vivo studies using the chinchilla model of otitis media were performed using a beta-lactamase-produ

169 li are expressed by NTHI during experimental otitis media when these bacteria form a biofilm in the m

170 ntal abnormality, congenital defect, chronic otitis media with cholesteatoma, and high-riding jugular

171 Chronic otitis media with effusion (COME) is the most common cau

172 tympanostomy tube placement for treatment of otitis media with effusion (OME) and recurrent OM and we

173 Otitis media with effusion (OME) is characterized by the

174 Otitis media with effusion (OME) is the most common caus

175 Chronic Otitis media with effusion (OME) often leads to conducti

176 avity, enlarged Eustachian tube, and chronic otitis media with effusion all beginning at around 3 wee

177 During otitis media with effusion and recurrent otitis media, b

178 ost common pathogens associated with chronic otitis media with effusion, which has been hypothesized

179 ng deficits, such as hyperacusis and chronic otitis media with effusion, which is prevalent in young

180 In addition, all Eya4(-/-) mice developed otitis media with effusion.

181 dies that have also suggested association of otitis media with polymorphism at FBX011, but this is th

182 Inflammation of the middle ear cavity (otitis media) and the abnormal deposition of bone at the

183 al of replacing clones to cause local (e.g., otitis media) or invasive disease.

184 the pneumococcus) remains a leading cause of otitis media, a significant public health burden, in lar

185 tious diseases of the upper airways, such as otitis media, adenotonsillitis, rhinosinusitis and adeno

186 d a leading cause of bacterial pneumonia and otitis media, among other invasive diseases.

187 described by the doctor to be due to a cold, otitis media, an upper respiratory infection, croup, ast

188 ination for measles, antibiotic treatment of otitis media, and antiviral treatment of pandemic influe

189 receptive language disorder, chronic serous otitis media, and expressive language disorder.

190 Our findings indicate that the short nose, otitis media, and hearing impairment in Jacobsen syndrom

191 ine, providing protection against pneumonia, otitis media, and other diseases caused by S. pneumoniae

192 ations (eg, quinsy, impetigo and cellulitis, otitis media, and sinusitis) or reconsultation with new

193 efects in the chinchilla infection model for otitis media, as well as in a murine model for COPD.

194 agent in serious diseases such as pneumonia, otitis media, bacteremia, and meningitis.

195 causes serious diseases in humans, including otitis media, bacteremia, meningitis, and pneumonia.

196 ing otitis media with effusion and recurrent otitis media, biofilms commonly develop.

197 e human respiratory tract diseases including otitis media, chronic rhinosinusitis, and exacerbations

198 Among 94 additional otitis media, commensal, and serotype b-negative invasiv

199 seen limited use as a model for experimental otitis media, due primarily to the small size of its mid

200 Otitis media, for which antibiotic treatment failure is

201 uL and with a history of recurrent sinusitis/otitis media, frequent episodes of shingles, a widesprea

202 They exhibited hearing impairment, otitis media, fusions of ossicles to the middle ear wall

203 e health conditions: respiratory infections, otitis media, gastroenteritis, necrotizing enterocolitis

204 se events were mild, and no complications of otitis media, including local cellulitis, perichondritis

205 review the contemporary management of acute otitis media, including symptomatic care, the rationale

206 cterially induced mucosal hyperplasia during otitis media, influencing tissue proliferation.

207 rane (TM) perforation, in particular chronic otitis media, is one of the most common clinical problem

208 pread nasal colonizer and a leading cause of otitis media, one of the most common diseases of childho

209 Her parents denied a history of acute otitis media, otorrhea, otalgia, vertigo, autophony, or

210 episodes (700 each) were identified in which otitis media, pharyngitis, and urinary tract infection (

211 ed upper respiratory tract encounters (acute otitis media, pharyngitis, sinusitis, presumed viral inf

212 This response protected mice from otitis media, pneumonia, and septicemia and averted the

213 cus pneumoniae is a major causative agent of otitis media, pneumonia, bacteremia, and meningitis.

214 sative agent of multiple diseases, including otitis media, pneumonia, bacteremia, and meningitis.

215 terial carriage and complications such acute otitis media, pneumonia, bacteremia, and meningitis.

216 n protected mice from pneumococcal carriage, otitis media, pneumonia, bacteremia, meningitis, and men

217 infection was associated with cough, fever, otitis media, pneumonia, hepatomegaly, splenomegaly, and

218 x but can cause invasive diseases, including otitis media, pneumonia, sepsis, and meningitis.

219 in mouse models of nasopharyngeal carriage, otitis media, pneumonia, sepsis, and meningitis.

220 ng children 6 to 23 months of age with acute otitis media, reduced-duration antimicrobial treatment r

221 g the types of viruses associated with acute otitis media, respiratory syncytial virus continues to b

222 n or middle ear effusions from patients with otitis media, revealed a statistically significant assoc

223 We report that otitis media, rhinitis and nasopharyngitis occur at high

224 ower respiratory tract infections, including otitis media, sinusitis and chronic obstructive pulmonar

225 e of respiratory infections, including acute otitis media, sinusitis, and chronic bronchitis, which a

226 ptococcus pneumoniae is the leading cause of otitis media, sinusitis, and pneumonia.

227 Patients had recurrent otitis media, sinusitis, and pneumonias; recurrent Staph

228 a major cause of mucosal infections such as otitis media, sinusitis, conjunctivitis, and exacerbatio

229 NTHi causes a number of diseases, including otitis media, sinusitis, conjunctivitis, exacerbations o

230 ause respiratory tract diseases that include otitis media, sinusitis, exacerbations of chronic obstru

231 ificant association of the modM3 allele with otitis media, suggests a key role for ModM phasevarions

232 In a murine model of acute pneumococcal otitis media, the administration of annexin A2 increased

233 has significant implications for diagnosing otitis media, the overdiagnosis of which is a primary fa

234 ng children 6 to 23 months of age with acute otitis media, treatment with amoxicillin-clavulanate for

235 In a mammalian model of human otitis media, we determined that Fur was critical for ba

236 We used a chinchilla model of otitis media, which has previously been used to study pe

237 onductive hearing loss (CHL) associated with otitis media, which may lead to long-term perceptual def

238 enza A viruses developed either sinusitis or otitis media, while only 1 out of 11 ferrets infected wi

239 luenza vaccines, has led to the reduction in otitis media-related healthcare use between 2001 and 201

240 coccus and influenza virus in the context of otitis media.

241 halis has become a high-priority pathogen in otitis media.

242 use of pneumonia, meningitis, sinusitis, and otitis media.

243 iseases including pneumonia, meningitis, and otitis media.

244 tenuated during pulmonary infection, but not otitis media.

245 luding pneumonia, bronchitis, sinusitis, and otitis media.

246 brosis, burn wounds, and chronic suppurative otitis media.

247 ldren younger than 2 years of age with acute otitis media.

248 were not significantly associated with acute otitis media.

249 pper respiratory tract infections, including otitis media.

250 ion, and Eustachian tubes in the etiology of otitis media.

251 pared with nonbacteremic pneumonia and acute otitis media.

252 ehiscence is usually associated with chronic otitis media.

253 nflammatory infections such as pneumonia and otitis media.

254 molecular pathogenesis and host response to otitis media.

255 nce and disease severity during experimental otitis media.

256 s, such as pneumonia, meningitis, sepsis and otitis media.

257 acterial persistence in chronic pneumococcal otitis media.

258 is the most common pathogen associated with otitis media.

259 diseases such as pneumonia, meningitis, and otitis media.

260 verity in a chinchilla model of experimental otitis media.

261 observation in children diagnosed with acute otitis media.

262 hyperplasia is a characteristic component of otitis media.

263 al hyperplasia in animal models of bacterial otitis media.

264 oat and ear specimens of eight children with otitis media.

265 ble role in middle ear survival and/or acute otitis media.

266 two H. influenzae pathotypes associated with otitis media.

267 iddle ear aspirates from children with acute otitis media.

268 (NTHi) are frequently implicated in complex otitis media.

269 ng that they may play a role in virulence in otitis media.

270 a chinchilla (Chinchilla lanigera) model of otitis media.

271 enzae (NTHi) is a leading causative agent of otitis media.

272 ivo analyses of the middle ear mucosa during otitis media.

273 tract infection, asthma, bronchiolitis, and otitis media.

274 lower than in samples from children without otitis media.

275 crobial resistance among children with acute otitis media.

276 play between bacterial species implicated in otitis media.

277 omes including all-cause pneumonia and acute otitis media.

278 use of pneumonia, meningitis, bacteremia and otitis media.

279 f disease in an animal model of experimental otitis media.

280 crease the risk of clinically relevant acute otitis media.

281 t a role for A2ML1 in the pathophysiology of otitis media.

282 n the retrospective cohort (19179 with acute otitis media; 6746, group A streptococcal pharyngitis; a

283 d in the prospective cohort (1100 with acute otitis media; 705, group A streptococcal pharyngitis; an

284 PCVs) target only a few serotypes that cause otitis media; however, results from studies suggest that

285 thy calves, calves diagnosed with pneumonia, otitis or both diseases.

286 ringently defined otitis-prone (sOP) and non-otitis-prone (NOP) children as a potential mechanism to

287 lus influenzae (NTHi) in stringently defined otitis-prone (sOP) and non-otitis-prone (NOP) children a

288 B, PcpA, PhtE, and Ply were compared between otitis-prone and non-otitis-prone children at the time o

289 Non-otitis-prone and otitis-prone children with AOM or nasop

290 panic-American children but is absent in non-otitis-prone children and >62,000 next-generation sequen

291 y were compared between otitis-prone and non-otitis-prone children at the time of acute otitis media

292 in [IL]-2, IL-4 and IL-17a) were observed in otitis-prone children following AOM and NP colonization

293 Otitis-prone children have suboptimal circulating functi

294 Non-otitis-prone and otitis-prone children with AOM or nasopharyngeal (NP) co

295 episodes of acute otitis media (hereafter, "otitis-prone children").

296 -specific immunoglobulin G concentrations in otitis-prone children, compared with non-otitis-prone ch

297 in otitis-prone children, compared with non-otitis-prone children.

298 ified seven additional A2ML1 variants in six otitis-prone children.

299 tibody response has been associated with the otitis-prone condition; however, there is no precise mec

300 a founder haplotype that is also shared by 3 otitis-prone European-American and Hispanic-American chi