ライフサイエンスコーパス: otitis media

1 use of pneumonia, meningitis, sinusitis, and otitis media.

2 iseases including pneumonia, meningitis, and otitis media.

3 tenuated during pulmonary infection, but not otitis media.

4 luding pneumonia, bronchitis, sinusitis, and otitis media.

5 brosis, burn wounds, and chronic suppurative otitis media.

6 ldren younger than 2 years of age with acute otitis media.

7 were not significantly associated with acute otitis media.

8 pper respiratory tract infections, including otitis media.

9 ion, and Eustachian tubes in the etiology of otitis media.

10 pared with nonbacteremic pneumonia and acute otitis media.

11 ehiscence is usually associated with chronic otitis media.

12 nflammatory infections such as pneumonia and otitis media.

13 molecular pathogenesis and host response to otitis media.

14 nce and disease severity during experimental otitis media.

15 s, such as pneumonia, meningitis, sepsis and otitis media.

16 acterial persistence in chronic pneumococcal otitis media.

17 is the most common pathogen associated with otitis media.

18 diseases such as pneumonia, meningitis, and otitis media.

19 observation in children diagnosed with acute otitis media.

20 verity in a chinchilla model of experimental otitis media.

21 hyperplasia is a characteristic component of otitis media.

22 al hyperplasia in animal models of bacterial otitis media.

23 oat and ear specimens of eight children with otitis media.

24 ble role in middle ear survival and/or acute otitis media.

25 two H. influenzae pathotypes associated with otitis media.

26 iddle ear aspirates from children with acute otitis media.

27 ng that they may play a role in virulence in otitis media.

28 a chinchilla (Chinchilla lanigera) model of otitis media.

29 enzae (NTHi) is a leading causative agent of otitis media.

30 ivo analyses of the middle ear mucosa during otitis media.

31 (NTHi) are frequently implicated in complex otitis media.

32 tract infection, asthma, bronchiolitis, and otitis media.

33 lower than in samples from children without otitis media.

34 iddle ear effusions of patients with chronic otitis media.

35 inclusion in a vaccine against pneumococcal otitis media.

36 nfections such as pneumonia, meningitis, and otitis media.

37 crobial resistance among children with acute otitis media.

38 play between bacterial species implicated in otitis media.

39 use of pneumonia, meningitis, bacteremia and otitis media.

40 omes including all-cause pneumonia and acute otitis media.

41 f disease in an animal model of experimental otitis media.

42 crease the risk of clinically relevant acute otitis media.

43 t a role for A2ML1 in the pathophysiology of otitis media.

44 coccus and influenza virus in the context of otitis media.

45 halis has become a high-priority pathogen in otitis media.

46 had microscopic haemorrhages (5/5) and mild otitis media (1/5) in the freshest cases.

47 ns [95% CI, 48-64]), followed by suppurative otitis media (47 antibiotic prescriptions [95% CI, 41-54

48 n the retrospective cohort (19179 with acute otitis media; 6746, group A streptococcal pharyngitis; a

49 d in the prospective cohort (1100 with acute otitis media; 705, group A streptococcal pharyngitis; an

50 the pneumococcus) remains a leading cause of otitis media, a significant public health burden, in lar

51 tious diseases of the upper airways, such as otitis media, adenotonsillitis, rhinosinusitis and adeno

52 d a leading cause of bacterial pneumonia and otitis media, among other invasive diseases.

53 described by the doctor to be due to a cold, otitis media, an upper respiratory infection, croup, ast

54 ins many of the observations seen in chronic otitis media and chronic bronchitis.

55 t in Haemophilus influenzae isolates causing otitis media and chronic obstructive pulmonary disease (

56 formed a biofilm in the chinchilla model of otitis media and demonstrated a propensity to also form

57 axella catarrhalis (Mx) is a common cause of otitis media and exacerbation of chronic obstructive pul

58 axella catarrhalis is a significant cause of otitis media and exacerbations of chronic obstructive pu

59 nflammatory diseases that include sinusitis, otitis media and exacerbations of chronic obstructive pu

60 The introduction of vaccines for otitis media and global shifts in antimicrobial suscepti

61 young children and is an important cause of otitis media and invasive disease.

62 For example, NTHI is a leading cause of otitis media and is the most common cause of airway infe

63 e human nasopharynx and a causative agent of otitis media and other diseases of the upper and lower h

64 tential target for new therapies for chronic otitis media and other eardrum injuries.

65 ecies persist in vivo within biofilms during otitis media and other persistent infections.

66 educed cost, and improved protection against otitis media and pneumococcal pneumonia.

67 portant human pathogen causing both mucosal (otitis media and pneumonia) and systemic (sepsis and men

68 oronasopharynx can cause diseases including otitis media and pneumonia.

69 formation available developed complications; otitis media and sinusitis were the most common complica

70 vescence and decreased both the incidence of otitis media and the concomitant use of antibiotics.

71 specific gene regions among a large panel of otitis media and throat strains was determined by dot bl

72 Inflammation of the middle ear cavity (otitis media) and the abnormal deposition of bone at the

73 ination for measles, antibiotic treatment of otitis media, and antiviral treatment of pandemic influe

74 receptive language disorder, chronic serous otitis media, and expressive language disorder.

75 Our findings indicate that the short nose, otitis media, and hearing impairment in Jacobsen syndrom

76 ine, providing protection against pneumonia, otitis media, and other diseases caused by S. pneumoniae

77 ations (eg, quinsy, impetigo and cellulitis, otitis media, and sinusitis) or reconsultation with new

78 Vaccines to prevent acute otitis media (AOM) caused by non-typeable Haemophilus in

79 Subjects were followed closely for acute otitis media (AOM) development.

80 en to be prone to repeated episodes of acute otitis media (AOM) has long been sought.

81 )-approved antibiotics and that causes acute otitis media (AOM) in children.

82 Acute otitis media (AOM) is a common complication of upper res

83 Acute otitis media (AOM) is a leading cause of bacterial pedia

84 Acute otitis media (AOM) is a leading cause of visits to physi

85 Acute otitis media (AOM) is among the most common pediatric di

86 Acute otitis media (AOM) is the most common condition for whic

87 Acute otitis media (AOM) is the most common diagnosis for whic

88 Acute otitis media (AOM) was detected in 50% of these children

89 se against Streptococcus pneumoniae in acute otitis media (AOM), we investigated the susceptibility t

90 vaccine trial FinOM for prevention of acute otitis media (AOM), with a focus on disease replacement

91 bial treatment reduces the symptoms of acute otitis media (AOM).

92 to be involved in the pathogenesis of acute otitis media (AOM).

93 respiratory tract infections, such as acute otitis media (AOM).

94 efects in the chinchilla infection model for otitis media, as well as in a murine model for COPD.

95 We examined risks of acute otitis media associated with specific combinations of re

96 agent in serious diseases such as pneumonia, otitis media, bacteremia, and meningitis.

97 causes serious diseases in humans, including otitis media, bacteremia, meningitis, and pneumonia.

98 cavirus, and adenovirus in addition to acute otitis media bacterial pathogens.

99 ombinations of respiratory viruses and acute otitis media bacterial pathogens.

100 ing otitis media with effusion and recurrent otitis media, biofilms commonly develop.

101 olated from the middle ears of children with otitis media but that are not associated with NT H. infl

102 st that GAS naturally forms a biofilm during otitis media but that biofilm formation is not required

103 It is clear that most otitis media cases involve simultaneous infection with m

104 effective against both systemic disease and otitis media caused by serotypes contained in the vaccin

105 e human respiratory tract diseases including otitis media, chronic rhinosinusitis, and exacerbations

106 e middle ear mucosa of children with chronic otitis media (COM) and may contribute to the persistence

107 Among 94 additional otitis media, commensal, and serotype b-negative invasiv

108 ability to survive in a chinchilla model of otitis media compared with the parent strain.

109 fic viruses, bacteria, and the risk of acute otitis media complicating upper respiratory tract infect

110 Chronic suppurative otitis media (CSOM) refers to the middle ear inflammatio

111 a major cause of bacteremia, pneumonia, and otitis media despite vaccines and effective antibiotics.

112 In children aged <3 years, acute otitis media developed in 58%, and 66% of children in th

113 viral load plays an important role in acute otitis media development, but symptomatic upper respirat

114 s interact and play important roles in acute otitis media development.

115 1 children 6 to 23 months of age, with acute otitis media diagnosed with the use of stringent criteri

116 increasing proportion of children with acute otitis media due to Streptococcus pneumoniae have seroty

117 o address these serotypes, and the remaining otitis media due to Streptococcus pneumoniae, efforts ha

118 seen limited use as a model for experimental otitis media, due primarily to the small size of its mid

119 hearing impairment associated with bouts of otitis media during human infancy.

120 haryngeal (NP) colonization and experimental otitis media (EOM) in an animal model.

121 ulence in a chinchilla model of experimental otitis media (EOM).

122 Otitis media, for which antibiotic treatment failure is

123 uL and with a history of recurrent sinusitis/otitis media, frequent episodes of shingles, a widesprea

124 They exhibited hearing impairment, otitis media, fusions of ossicles to the middle ear wall

125 e health conditions: respiratory infections, otitis media, gastroenteritis, necrotizing enterocolitis

126 y of children to recurrent episodes of acute otitis media (hereafter, "otitis-prone children").

127 PCVs) target only a few serotypes that cause otitis media; however, results from studies suggest that

128 le ear-specific gene A2ML1 cosegregates with otitis media in an indigenous Filipino pedigree (LOD sco

129 respiratory tract pathogen commonly causing otitis media in children and acute exacerbations in pati

130 e is an opportunistic human pathogen causing otitis media in children and chronic bronchitis and pneu

131 Moraxella catarrhalis causes otitis media in children and exacerbations of chronic ob

132 halis is a strict human pathogen that causes otitis media in children and exacerbations of chronic ob

133 ommon respiratory tract pathogen that causes otitis media in children and infections in adults with c

134 mophilus influenzae is an important cause of otitis media in children and lower respiratory infection

135 human respiratory tract pathogen that causes otitis media in children and lower respiratory tract inf

136 oraxella catarrhalis is a causative agent of otitis media in children and lower respiratory tract inf

137 s an important respiratory pathogen, causing otitis media in children and lower respiratory tract inf

138 mportant respiratory tract pathogen, causing otitis media in children and lower respiratory tract inf

139 an important human mucosal pathogen causing otitis media in children and lower respiratory tract inf

140 human pathogen that is an important cause of otitis media in children and lower respiratory tract inf

141 opportunistic pathogen and a common cause of otitis media in children and of chronic bronchitis and p

142 Moraxella catarrhalis is a common cause of otitis media in children and of lower respiratory tract

143 tarrhalis is an important bacterial cause of otitis media in children and respiratory tract infection

144 ypeable Haemophilus influenzae, which causes otitis media in children and respiratory tract infection

145 raxella catarrhalis is an important cause of otitis media in children and respiratory tract infection

146 he bactericidal activity of serum and causes otitis media in children and respiratory tract infection

147 se organisms have an important role in acute otitis media in children as well as other respiratory di

148 meningitis, pneumonia, sinusitis, and acute otitis media in children.

149 ause of respiratory infections in adults and otitis media in children.

150 mophilus influenzae is an important cause of otitis media in children.

151 e primary pathogens of chronic and recurrent otitis media in children.

152 obstructive pulmonary disease (COPD) and of otitis media in children.

153 mucosal hyperplasia during in vivo bacterial otitis media in guinea pigs.

154 ella catarrhalis is a human pathogen causing otitis media in infants and respiratory infections in ad

155 tors, as well as characterization of induced otitis media in several mouse strains.

156 toward the reduction of the burden of acute otitis media in the last decade.

157 The results indicate that induced otitis media in the normal mouse is in most respects com

158 catarrhalis is a human pathogen that causes otitis media in young children and lung infections in pa

159 Success in reducing acute otitis media incidence will rely mainly on prevention of

160 se events were mild, and no complications of otitis media, including local cellulitis, perichondritis

161 review the contemporary management of acute otitis media, including symptomatic care, the rationale

162 In the serum samples from children with otitis media infected with M. catarrhalis, antibody leve

163 nt persistence defect in vivo during chronic otitis media infection.

164 ilus influenzae (NTHI) is a leading cause of otitis media infections, which are often chronic and/or

165 s NTHI virulence in the chinchilla model for otitis media infections.

166 cterially induced mucosal hyperplasia during otitis media, influencing tissue proliferation.

167 Otitis media is a common childhood infection of the midd

168 Otitis media is an extremely common pediatric infection

169 Otitis media is an extremely common pediatric inflammati

170 Vulnerability to otitis media is due to eustachian tube dysfunction as we

171 te from the chinchilla model of experimental otitis media is insufficient for direct analysis of gene

172 he actual burden of bacteria in experimental otitis media is significantly greater than was previousl

173 A case of AAS secondary to an otitis media is studied.

174 Treatment of acute otitis media is the most frequent indication for prescri

175 agent of pharyngitis, but the role of GAS in otitis media is underappreciated.

176 rane (TM) perforation, in particular chronic otitis media, is one of the most common clinical problem

177 Virulence of an otitis media isolate (NTHi strain 86-028NP) was compared

178 at the homologous gene cluster pilABCD in an otitis media isolate of nontypeable H. influenzae strain

179 zation and virulence, we transformed an NTHI otitis media isolate with a reporter plasmid containing

180 A10, account for over two-thirds of clinical otitis media isolates surveyed.

181 ically significant association of modM3 with otitis media isolates.

182 enzae attenuated virulence in the chinchilla otitis media model of noninvasive disease.

183 onclude from these studies that a chinchilla otitis media model provides a means to evaluate pathogen

184 ritonitis (n = 1), septic arthritis (n = 1), otitis media (n = 10), and sinusitis (n = 3).

185 n = 76,243), chronic sinusitis (n = 15,745), otitis media (n = 237,833), pneumonia (n = 52,946), and

186 ing 14 isolates, isolated from patients with otitis media (n = 6), bacteremia (n = 6), meningitis (n

187 and 48 isolates from pediatric patients with otitis media (noninvasive) from 2011 to 2014 was charact

188 s operon was significantly more prevalent in otitis media NTHI strains (106/121; 87.7%) than in throa

189 Acute otitis media occurs as a complication of viral upper res

190 here has been increasing evidence that acute otitis media occurs during upper respiratory infection,

191 hilus influenzae (NTHI)-induced experimental otitis media (OM) after intranasal immunization of chinc

192 nized as an important pathogenetic factor in otitis media (OM) and associated diseases.

193 Reductions in otitis media (OM) burden following rollout of pneumococc

194 treptococcus pneumoniae is a common cause of otitis media (OM) in children; mastoiditis remains an im

195 gainst Streptococcus pneumoniae during acute otitis media (OM) in mice.

196 Otitis media (OM) is a common pediatric disease for whic

197 Chronic otitis media (OM) is a common pediatric infectious disea

198 Otitis media (OM) is a leading cause of pediatric health

199 Otitis media (OM) is common in early childhood.

200 x (ie, recurrent, nonresponsive, or chronic) otitis media (OM) is frequent and is often caused by a m

201 The pathogenesis of otitis media (OM) is multifactorial and includes infecti

202 Otitis media (OM) is the most common childhood bacterial

203 Otitis media (OM) is the most common childhood bacterial

204 Otitis media (OM) is the most common disease of childhoo

205 Otitis media (OM) is the most common illness in childhoo

206 cT are potentially essential in a chinchilla otitis media (OM) model.

207 Otitis media (OM) remains the most common childhood dise

208 Otitis media (OM), a middle-ear infection, is the most c

209 Inner ear dysfunction secondary to chronic otitis media (OM), including high-frequency sensorineura

210 Otitis media (OM), inflammation of the middle ear, is th

211 Otitis media (OM), the inflammation of the middle ear, i

212 from almost all TLRs, we studied its role in otitis media (OM), the most common upper respiratory tra

213 tions, including infectious endocarditis and otitis media (OM).

214 mococcal disease, including the incidence of otitis media (OM).

215 n in respiratory tract infections, including otitis media (OM).

216 ant viral pathogen predisposing to bacterial otitis media (OM).

217 Mucin overproduction is a hallmark of otitis media (OM).

218 be a potent effector of inflammation during otitis media (OM): exogenous CCL3 rescues the OM phenoty

219 conjugated vaccines (PCVs) impact on complex otitis media (OM; including recurrent, nonresponsive, an

220 pread nasal colonizer and a leading cause of otitis media, one of the most common diseases of childho

221 ore likely to be from the throat than either otitis media or COPD isolates.

222 n-otitis-prone children at the time of acute otitis media or nasopharyngeal colonization with S. pneu

223 2432 participants), Streptococcus pneumoniae otitis media (OR = 2.51; 95% CI = 1.29-4.88; n = 921 par

224 al of replacing clones to cause local (e.g., otitis media) or invasive disease.

225 Her parents denied a history of acute otitis media, otorrhea, otalgia, vertigo, autophony, or

226 attributed to non-neoplastic causes, such as otitis media, otosclerosis, or trauma.

227 o outline the precise role of these genes in otitis media pathogenesis.

228 e material, resembling the biofilms of other otitis media pathogens, was visible in the middle ear as

229 episodes (700 each) were identified in which otitis media, pharyngitis, and urinary tract infection (

230 ed upper respiratory tract encounters (acute otitis media, pharyngitis, sinusitis, presumed viral inf

231 This response protected mice from otitis media, pneumonia, and septicemia and averted the

232 cus pneumoniae is a major causative agent of otitis media, pneumonia, bacteremia, and meningitis.

233 sative agent of multiple diseases, including otitis media, pneumonia, bacteremia, and meningitis.

234 terial carriage and complications such acute otitis media, pneumonia, bacteremia, and meningitis.

235 n protected mice from pneumococcal carriage, otitis media, pneumonia, bacteremia, meningitis, and men

236 infection was associated with cough, fever, otitis media, pneumonia, hepatomegaly, splenomegaly, and

237 in mouse models of nasopharyngeal carriage, otitis media, pneumonia, sepsis, and meningitis.

238 x but can cause invasive diseases, including otitis media, pneumonia, sepsis, and meningitis.

239 Acute otitis media prevention efforts should consider methods

240 lthough it does not appear to greatly affect otitis media rates.

241 ng children 6 to 23 months of age with acute otitis media, reduced-duration antimicrobial treatment r

242 For example, otitis media reduces sound to the ear, which can cause l

243 luenza vaccines, has led to the reduction in otitis media-related healthcare use between 2001 and 201

244 g the types of viruses associated with acute otitis media, respiratory syncytial virus continues to b

245 philus influenzae in the chinchilla model of otitis media results in the formation of adherent mucosa

246 n or middle ear effusions from patients with otitis media, revealed a statistically significant assoc

247 We report that otitis media, rhinitis and nasopharyngitis occur at high

248 Acute otitis media risk differs by the specific viruses and ba

249 presence of key viruses, bacteria, and acute otitis media risk factors, acute otitis media risk was i

250 , and acute otitis media risk factors, acute otitis media risk was independently associated with high

251 10(7) copies/ml) experienced increased acute otitis media risk.

252 of a modA2 strain in the chinchilla model of otitis media show a clear selection for ON switching of

253 ection studies using the chinchilla model of otitis media showed a direct correlation between PCho ex

254 ower respiratory tract infections, including otitis media, sinusitis and chronic obstructive pulmonar

255 e of respiratory infections, including acute otitis media, sinusitis, and chronic bronchitis, which a

256 ptococcus pneumoniae is the leading cause of otitis media, sinusitis, and pneumonia.

257 Patients had recurrent otitis media, sinusitis, and pneumonias; recurrent Staph

258 a major cause of mucosal infections such as otitis media, sinusitis, conjunctivitis, and exacerbatio

259 NTHi causes a number of diseases, including otitis media, sinusitis, conjunctivitis, exacerbations o

260 ause respiratory tract diseases that include otitis media, sinusitis, exacerbations of chronic obstru

261 luenzae (NTHI) that was more prevalent among otitis media strains than among throat commensal NTHI st

262 found to be significantly more prevalent in otitis media strains.

263 ificant association of the modM3 allele with otitis media, suggests a key role for ModM phasevarions

264 We suggest that some human otitis media susceptibility reflects underlying genetic

265 revalent in NTHi isolates from children with otitis media than in those from the throats of healthy c

266 A wait-and-see approach to acute otitis media that empowers families by using a shared de

267 In a murine model of acute pneumococcal otitis media, the administration of annexin A2 increased

268 has significant implications for diagnosing otitis media, the overdiagnosis of which is a primary fa

269 hypothesis' as we found common pathogens of otitis media to be both prevalent and abundant.

270 en that causes infections ranging from acute otitis media to life-threatening invasive disease.

271 niae (the pneumococcus) causes diseases from otitis media to life-threatening invasive infection.

272 clinical syndromes from uncomplicated acute otitis media to more complex recurrent and chronic cases

273 children, 6 to 23 months of age, with acute otitis media to receive amoxicillin-clavulanate either f

274 ng children 6 to 23 months of age with acute otitis media, treatment with amoxicillin-clavulanate for

275 ial component of a nontypeable H. influenzae otitis media vaccine.

276 s of lic2B, hmwA, and the nine new potential otitis media virulence genes revealed two H. influenzae

277 ntified two genes of potential importance in otitis media virulence.

278 Otitis media was induced by the inoculation of nontypeab

279 -028NP, isolated from a patient with chronic otitis media was therefore sequenced and annotated.

280 In a mammalian model of human otitis media, we determined that Fur was critical for ba

281 n vivo studies using the chinchilla model of otitis media were performed using a beta-lactamase-produ

282 li are expressed by NTHI during experimental otitis media when these bacteria form a biofilm in the m

283 We used a chinchilla model of otitis media, which has previously been used to study pe

284 onductive hearing loss (CHL) associated with otitis media, which may lead to long-term perceptual def

285 enza A viruses developed either sinusitis or otitis media, while only 1 out of 11 ferrets infected wi

286 ntal abnormality, congenital defect, chronic otitis media with cholesteatoma, and high-riding jugular

287 Chronic otitis media with effusion (COME) is the most common cau

288 tympanostomy tube placement for treatment of otitis media with effusion (OME) and recurrent OM and we

289 Otitis media with effusion (OME) is characterized by the

290 Otitis media with effusion (OME) is the most common caus

291 Chronic Otitis media with effusion (OME) often leads to conducti

292 avity, enlarged Eustachian tube, and chronic otitis media with effusion all beginning at around 3 wee

293 During otitis media with effusion and recurrent otitis media, b

294 Using a mouse model of otitis media with effusion, administration of heat-inact

295 ost common pathogens associated with chronic otitis media with effusion, which has been hypothesized

296 ng deficits, such as hyperacusis and chronic otitis media with effusion, which is prevalent in young

297 In addition, all Eya4(-/-) mice developed otitis media with effusion.

298 rtaken in young children who have persistent otitis media with effusion.

299 dies that have also suggested association of otitis media with polymorphism at FBX011, but this is th

300 e strains are the leading cause of bacterial otitis media, yet little is known about specific bacteri