ライフサイエンスコーパス: otoconia

1 that we identified to be in wildtype murine otoconia.

2 ribute to the site-specific calcification of otoconia.

3 cule of the inner ear, which completely lack otoconia.

4 ium and occasional malformation of utricular otoconia.

5 ium used in the formation and maintenance of otoconia.

6 ation in a thickened sensory epithelium, and otoconia, all of which are found in the endogenous otic

7 anistic similarities and differences between otoconia and bone calcification.

8 eration of sensory cells and malformation of otoconia and otoconial membranes occur, as revealed by s

9 required for the normal biomineralization of otoconia and otoliths in the inner ear of vertebrates.

10 ies could direct the formation and growth of otoconia and regulate other biomineralization processes.

11 Otoconia are biominerals of the vestibular system that a

12 Otoconia are biominerals within the utricle and saccule

13 Otoconia are complex calcium carbonate (CaCO(3)) biomine

14 In mammals, otoconia are composed of proteins (otoconins) and calciu

15 canalithiasis and cupulolithiasis, in which otoconia are dislocated.

16 This underscores the need to understand how otoconia are formed and maintained and how to prevent th

17 The skeleton, teeth, and otoconia are normally the only mineralized tissues or or

18 ntial for formation of the organic matrix of otoconia by specifically recruiting other matrix compone

19 review postulates a working model of how the otoconia complex is assembled specifically above the mac

20 balance system is the embryonic formation of otoconia, composite crystals that overlie and provide op

21 lamus was assessed in wild-type C57BL/6J and otoconia-deficient tilted mice during locomotion within

22 ers upon the elderly population that involve otoconia degeneration, as well as by canalithiasis and c

23 During otoconia development, the organic matrix forms prior to

24 nlarged otic vesicles and various defects of otoconia development; they also showed abnormal circular

25 endolymph fluid space, and abnormally formed otoconia (extracellular calcite-protein composites) at l

26 Otoliths and otoconia form over sensory maculae and are attached to t

27 ependent vestibular oxidase are critical for otoconia formation and may be required for interactions

28 Despite their importance, the process of otoconia genesis is largely unknown.

29 ochemically inactive and led to an arrest of otoconia genesis, characterized by a complete lack of ca

30 We show that this matrix controls otoconia growth and morphology by embedding the crystall

31 eir counterparts in the mammalian inner ear, otoconia, have a primarily vestibular function.

32 ry organs are the biomineralized structures--otoconia in higher vertebrates or otoliths in fish--that

33 led about the development and maintenance of otoconia in humans.

34 The loss of otoconia in the mutants may be attributed, at least in p

35 and a significant reduction in the number of otoconia in the saccule and the utricle, were consistent

36 domain protein required for the formation of otoconia in the vertebrate inner ear.

37 ckness of the molecular layer, an absence of otoconia in the vestibular system, and a range of abnorm

38 Degeneration or displacement of otoconia is a significant etiology of age-related balanc

39 The importance of otoconia is clearly demonstrated by the impact of balanc

40 formation of abnormally shaped, or ectopic, otoconia, or otoconial agenesis.

41 agy and showed defects in the development of otoconia, organic particles that contain calcium carbona

42 cloned the major protein component of murine otoconia, otoconin-90 (OC90).

43 To date, a number of otoconia-related proteins have been identified mostly in

44 We propose that normal generation of otoconia requires a complex temporal and spatial control

45 monstrate the critical roles of otoconins in otoconia seeding, growth and anchoring and suggest mecha

46 contain thousands of small particles called otoconia that serve a similar function.

47 -het mouse strain (het), which lacks macular otoconia, to elucidate the contribution of specific vest

48 to gravity requires dense particles, called otoconia, which are localized in the vestibular macular