ライフサイエンスコーパス: ouabain

1 0.9 versus 1.6 +/- 0.5 mmHg with intravenous ouabain).

2 /K(+) -ATPase (l-NMMA + ketorolac + BaCl2 + ouabain).

3 ) channels and Na(+) /K(+) -ATPase (BaCl2 + ouabain).

4 before or after administration of BaCl2 plus ouabain.

5 ively inhibiting alpha2 enzyme activity with ouabain.

6 e measured with and without NKA inhibited by ouabain.

7 ensitive to the Na+/K+-ATPase pump inhibitor ouabain.

8 of Na/K-ATPase, like the pumping pump, binds ouabain.

9 umps were silenced by continuous exposure to ouabain.

10 /K pump and the site of its interaction with ouabain.

11 ent arteriole to contract in the presence of ouabain.

12 n ADPKD cells exhibits a higher affinity for ouabain.

13 ked by a saturating concentration of dihydro-ouabain.

14 nal Na+/K+-ATPases induced by the binding of ouabain.

15 ibition of FGF2 secretion in the presence of ouabain.

16 of action potential fall in the presence of ouabain.

17 zation of the pump or affect the response to ouabain.

18 TPase with subtoxic doses of gramicidin A or ouabain.

19 by comparison with digoxin, digoxigenin, or ouabain.

20 c; and L-NMMA plus ketorolac plus BaCl2 plus ouabain.

21 podocyte primary cell cultures with low-dose ouabain.

22 s of these experiments showed that 20 microM ouabain, 0.3 microM ionomycin, or their combination incr

23 Ouabain (10 mumol l(-1)), a specific inhibitor of Na/K-A

24 Ouabain (3 nm) also increased ER Ca(2+) release and enha

25 Ouabain (3 nm) pre-incubation also augmented 10 muM cycl

26 urve) was attenuated by BaCl2 (-61+/-3%) and ouabain (-44+/-12%) alone, and this effect was enhanced

27 unction of Na(+),K(+)-ATPase is activated by ouabain, a mammalian steroid hormone, at far lower conce

28 sistance in other species to the cardenolide ouabain, a plant toxin capable of blocking ATPases.

29 2V vs. Ag/AgCl in the presence or absence of ouabain, a specific NKA inhibitor.

30 Ouabain, a steroid present in the circulation and in var

31 bition of the NKA alpha2 isoform by low dose ouabain abolished the ability of low Ko to reduce NKA cu

32 Ouabain, acting from the basolateral side of the cells,

33 Ouabain activated the NF-kappaB antiapoptotic subunit p6

34 two mutants caused significant inhibition of ouabain-activated signal transduction and cell growth.

35 We have shown that ouabain activates Src, resulting in subsequent tyrosine

36 ptor function as evidenced by the failure of ouabain administration to induce the activation of Src a

37 The increased ouabain affinity of ADPKD cells was not due to differenc

38 loop, known to make a major contribution to ouabain affinity, strongly influenced conductance of sin

39 d astrocytes express Na(+) pumps with a high-ouabain-affinity catalytic subunit (alpha3 and alpha2, r

40 brain as a result of its actions on the high-ouabain-affinity Na(+) pumps in both neurones and astroc

41 Treatment of hTMC with sodium fluoride or ouabain, agents shown to cause morphological changes to

42 Ouabain alone reduced pH(i) recovery, but SNP+ouabain ca

43 Treatment with 20 microM ouabain also increased the ultimate tensile strength of

44 By binding to the Na,K-ATPase, ouabain also induces proliferation in some cell types.

45 This suggests that ouabain also inhibits an ion resorptive function of Na/K

46 ns, resulting from intravitreal injection of ouabain, also exhibited increased TNFalpha expression th

47 at inhibit Na,K-ATPases, such as digoxin and ouabain, alter cardiac myocyte contractility.

48 ibitor of cytochrome-P450 enzymes or dihydro-ouabain, an inhibitor of Na+,K+-ATPase blocked the effec

49 was phenocopied by treatment of embryos with ouabain, an inhibitor of Na,K-ATPase activity.

50 onensin, a Na(+) ionophore, with and without ouabain, an NKA inhibitor, in suspensions of human eryth

51 vity to the electrolyte transport inhibitors ouabain and bumetanide, as well as bath Cl(-) and HCO(3)

52 We further characterized ouabain and demonstrated that it inhibits sFlt1 mRNA and

53 ied a group of cardiac glycosides, including ouabain and digoxin, as potent inhibitors of NMD.

54 veral cardiotonic steroids (CTSs), including ouabain and digoxin, increased RGS2 but not RGS4 protein

55 extracellular K(+) did not reduce p53 as did ouabain and digoxin, it did potentiate both digoxin- and

56 CX) blocker, antagonized the effects of both ouabain and digoxin.

57 mally sensitive to the Na+/K+ pump inhibitor ouabain and exhibited age-dependent changes, including d

58 In contrast, ouabain and extracellular K(+) failed to produce detecta

59 ies, we used the Na(+)/K(+) ATPase inhibitor ouabain and found conditions in which SD was always prev

60 Fluid absorption was sensitive to ouabain and gadolinium but insensitive to benzamil, bafi

61 Ouabain and ionomycin may be useful pharmacologic agents

62 The enzyme is strongly inhibited by ouabain and its derivatives, some that are therapeutical

63 reduced peak FBF (-50+/-6%; P<0.05), whereas ouabain and L-NMMA plus ketorolac did not.

64 The effects of ouabain and low-Na(+) solutions were determined under op

65 We have also determined the effects of ouabain and reduced bath [Na(+)].

66 demonstrated by reduction of the current by ouabain and the K(+) channel blockers Ba(2+), XE991, and

67 d by the beta-surface of the steroid core of ouabain and the side chains of alphaM1, alphaM2, and alp

68 e, or combined NO, PGs, Na(+) /K(+) -ATPase (ouabain) and KIR channel inhibition (n = 6; Protocol 2).

69 were cardiac glycosides, including digoxin, ouabain, and proscillaridin A, which inhibited HIF-1alph

70 n carbonylation is reversed after removal of ouabain, and this reversibility is largely independent o

71 -interacting pool of Src and act as a potent ouabain antagonist in cultured cells: 1) pNaKtide, unlik

72 Ouabain antagonists (PST 2238 and canrenone) and NCX blo

73 that intraperitoneal administration of anti-ouabain antibodies to pregnant mice resulted in a >80% d

74 Consistently, exposure of intact cells to ouabain apparently increased the distance between the Na

75 Cardiotonic steroids, such as ouabain, are specific inhibitors of the Na/K pump.

76 bule of the E2P model explains high-affinity ouabain binding in a mutant of the H,K ATPase.

77 and ouabain-resistant mutation of the alpha2 ouabain binding site (alpha2(R/R) mice) confers resistan

78 he CTS binding pocket of [Mg]E2P allows deep ouabain binding with possible long-range interactions be

79 d the cation site and thereby hindering deep ouabain binding.

80 ypes of cells, may function as non-canonical ouabain-binding receptors.

81 cardiotonic steroids, which act through the ouabain-binding site and are important in cardiovascular

82 The amino acids that constitute the ouabain-binding site are highly conserved across the evo

83 These data suggest that the ouabain-binding site of the alpha1 Na,K-ATPase can parti

84 is important to characterize the role of the ouabain-binding sites in this context.

85 lute and water transport in ADPKD cells, and ouabain blocks fluid secretion in these cells.

86 triggered by a conformational change of the ouabain-bound Na(+)/K(+)-ATPase molecule or more general

87 structures of Na,K-ATPase in the unbound and ouabain-bound states.

88 T inhibitors and the Na+/K+-ATPase inhibitor ouabain, but not 5-HT2 and 5-HT1B/1D receptor inhibitors

89 ht: prolonged subcutaneous administration of ouabain, but not digoxin, induces hypertension, and digo

90 of hypertension, antagonized the effects of ouabain, but not digoxin.

91 Taken together, these results suggest that ouabain can protect the kidney from the apoptotic effect

92 uabain alone reduced pH(i) recovery, but SNP+ouabain caused significant further reduction.

93 On the other hand, ouabain causes a gradual depletion of Na/K-ATPase and an

94 iotonic steroids, most notably the digitalis/ouabain class of compounds, which have been used for cen

95 g kinetics with the previously described E2P-ouabain complex to derive specific details and the gener

96 g(2+) is bound in site II of the digoxin and ouabain complexes, whereas both sites are occupied by K(

97 sh retina by intravitreal injection of a low ouabain concentration to rapidly damage the ganglion cel

98 Although much higher ouabain concentration was required to stimulate Src in I

99 of the sensitivity of the alpha2 isoform to ouabain, conferring ouabain sensitivity to alpha1 augmen

100 resistant mice were inhibited by intravenous ouabain (control stop-flow pressure = 9.7 +/- 0.9 versus

101 nse light and recovered for up to 8 weeks or ouabain-damaged retinas that recovered for up to 3 weeks

102 rate at detecting the inner nuclear layer in ouabain-damaged retinas, but accurately detected the und

103 Ouabain decreased glycolysis by 25% and decreased (14)CO

104 ents, loop of Henle perfusion with 50 microM ouabain decreased TGF responses (control stop-flow press

105 evidence points to a role of Na,K-ATPase in ouabain-dependent signal transduction.

106 Ouabain-dependent signaling is thought to be mediated wi

107 ng requires reassessment of the mechanism of ouabain-dependent signaling.

108 ing various cardiac glycoside compounds like ouabain, digoxin, digitoxin, and gitoxin with their agly

109 eyes that were injected intracamerally with ouabain, disodium 4,4'-diisothiocyanatostilbene-2,2'-dis

110 Ouabain down-regulated sFlt1 production by inhibiting hy

111 Pre-incubation (0.5-10 min) with 1-10 nm ouabain (EC50 < 1 nm) augmented Glu- and CCh-evoked sign

112 tion and cell proliferation, suggesting that ouabain effect is mediated through the MEK-ERK pathway.

113 rd E2 species reduced glutathionylation, and ouabain eliminated a ONOO(-)-induced increase.

114 reased by inhibition of the Na(+)/K(+) pump (ouabain), ENaC (amiloride), CF transmembrane conductance

115 ted by both brain and circulating endogenous ouabain (EO).

116 one another in both assays: For example, the ouabain-evoked (3 nm) increases in MT70 and neuronal Ca2

117 TPase in complex with the CTS representative ouabain, extending to 3.4 A resolution.

118 NaKtide may be used as a novel antagonist of ouabain for probing the physiological and pathological s

119 , a digoxigenin derivative that displaces 3H-ouabain from Na+, K+ -ATPase, and attenuates some forms

120 Ouabain further reduced glutathionylation in E2 and elim

121 3 compounds in the cardiac glycoside family, ouabain, gitoxigenin, and digitoxin, that inhibit placen

122 Ouabain had similar effects to those of MBG, suggesting

123 somer of the plant-derived cardiac glycoside ouabain, if not ouabain itself.

124 inding abolished the antiapoptotic effect of ouabain in Stx2-exposed tubular cells.

125 related to the presence of plants containing ouabain in the geographic locations where both inversion

126 ated the involvement of maternal circulating ouabain in the regulation of fetal growth and organ deve

127 tubular cells, cardiotonic steroids such as ouabain in vitro signal through Na/K-ATPase, which resul

128 ut was evoked using dorsal-root stimulation, ouabain increased burst frequency and extended locomotor

129 The sodium pump inhibitor, ouabain, increased the frequency and decreased the ampli

130 Ouabain increases the endocytosis and degradation of Na/

131 The O2 dependence of ouabain-independent K+ transport mechanisms has been stu

132 aft model of retinoblastoma, the cardenolide ouabain induced complete tumor regression in the treated

133 In this system, ouabain induced Na/K-ATPase/c-Src signaling and redistri

134 cal inhibition of the Na(+)/K(+)-ATPase with ouabain induced neurite degeneration, which was attenuat

135 Second, ouabain induced phosphorylation of PLC-gamma1 at Tyr(783

136 -K(+) ATPase antagonists (ouabain or dihydro-ouabain) induced either a membrane depolarization in cur

137 ly, both Src and caveolin-1 are required for ouabain-induced activation of Akt and up-regulation of N

138 Concomitantly it also abolished ouabain-induced activation of Src and ERK1/2.

139 Consequently, it blocks ouabain-induced activation of Src, ERK, and hypertrophic

140 d Ca2+ transients were augmented, and 100 nM ouabain-induced amplification was abolished.

141 Here we show that ouabain-induced cell growth regulation is intrinsically

142 fish alpha1a.1 or rat alpha1 mRNA, while the ouabain-induced defect was rescued by expression of ouab

143 kinase kinase (MEK) inhibitor U0126 blocked ouabain-induced ERK activation and cell proliferation, s

144 /mTOR pathway by rapamycin completely blocks ouabain-induced expression of Na/K-ATPase and converts o

145 duced expression of Na/K-ATPase and converts ouabain-induced growth stimulation to growth inhibition

146 Na(+)] was increased to 20 mm or more (using ouabain-induced inhibition of the Na(+),K(+)-ATPase or t

147 damage and regeneration of photoreceptors or ouabain-induced inner retinal damage.

148 nlike previous studies in other systems, the ouabain-induced internalization was insensitive to Src o

149 digoxin, it did potentiate both digoxin- and ouabain-induced p53 reduction in sensitive lines.

150 -ATPase/Src receptor complex and antagonizes ouabain-induced protein kinase cascades.

151 he Na/K-ATPase affect basal Src activity and ouabain-induced signal transduction.

152 In alpha1-resistant/alpha2-resistant mice, ouabain infusion had no effect on TGF responses.

153 Prolonged ouabain infusion induces hypertension in rodents, and ou

154 However, ouabain-inhibitable respiration did not decrease during

155 pproximately 85% in both cell types, whereas ouabain inhibited K(+)-hyperpolarization differently in

156 Ouabain inhibited the FF from either side of the prepara

157 Ouabain inhibited the fluid flow across both species, in

158 ility of digoxin-like CTSs to reactivate the ouabain-inhibited complex can be explained by de-oligome

159 st to NHK cells, the dose-response curve for ouabain inhibition of Na,K-ATPase activity indicated tha

160 The implication is that nanomolar ouabain inhibits alpha3 Na(+) pumps, increases (local) i

161 Ouabain-initiated phosphorylation of Ser(16) alpha1 was

162 ine and ganglion cells were lost by 7 d post-ouabain injection (dpi).

163 By 24 h after ouabain injection, maximal numbers of terminal deoxynucl

164 After ouabain injection, receptor and postreceptor uptake of m

165 wildtype zebrafish at 0, 3 and 18 days after Ouabain injection.

166 rgeted mouse (alpha2(R/R)) which expresses a ouabain-insensitive alpha2 isoform of the Na,K-ATPase to

167 Overexpression of ouabain-insensitive rat alpha1 failed to inhibit interna

168 specific reduction in NCX1 protein and were ouabain-insensitive.

169 These results support the notion that ouabain is a growth factor and suggest that a reduction

170 Endogenous ouabain is an adrenal stress hormone associated with adv

171 e effects is heightened by the evidence that ouabain is endogenous in mammals.

172 The final model shows that ouabain is trapped within the external ion permeation pa

173 nd Ser(16), respectively, the latter because ouabain itself increased Ser(16) phosphorylation; thus,

174 nt-derived cardiac glycoside ouabain, if not ouabain itself.

175 After the reduction in maternal circulating ouabain, kidney expression of cyclin D1 was reduced and

176 /K(+)-ATPase, NO, and prostaglandins (BaCl2, ouabain, L-NMMA [N(G)-monomethyl-L-arginine] and ketorol

177 ng human pregnancy, the circulating maternal ouabain level increased and the highest concentration of

178 esulted in a >80% decline in the circulating ouabain level.

179 Preoperative plasma endogenous ouabain levels are powerful biomarkers of acute kidney i

180 Furthermore, circulating ouabain levels in women with small-for-gestational age n

181 Most CTSs could be divided into ouabain-like (ouabagenin, dihydroouabain (DHO), strophan

182 n each group, the CTSs were synergistic, but ouabain-like and digoxin-like CTSs antagonized one anoth

183 hronic salt retention elevates an endogenous ouabain-like compound (EOLC) and induces salt-dependent

184 train has a 10-fold increase in hypothalamic ouabain-like compound that is linked to the pathogenesis

185 n of the latter gene decreased production of ouabain-like factor from neural tissue.

186 hat preoperative plasma levels of endogenous ouabain may function as this type of biomarker.

187 Thus, nanomolar ouabain may strongly influence synaptic transmission in

188 The ouabain-mediated downregulation of GlyT2 also occurs in

189 in a feed-forward mechanism of regulation of ouabain-mediated renal proximal tubule Na/K-ATPase signa

190 Bcl-xL, an inhibitor of Bax, suggesting that ouabain might protect renal cells from Stx2-triggered ap

191 w and high levels of the specific NKA ligand ouabain modulate the endocytosis and total expression of

192 Using a systematic approach, we applied ouabain (Na(+)/K(+)-ATPase inhibitor), bumetanide (Na(+)

193 red due to the very slow dissociation of the ouabain.Na(+)/K(+)-ATPase complex.

194 Signaling via the ouabain/Na,K-ATPase/IP3R/NF-kappaB pathway increases exp

195 We tested nanomolar ouabain on Ca(2+) signalling (fura-2) in rat hippocampal

196 ase dictate the growth regulatory effects of ouabain on cells.

197 enal parameters in rats and the influence of ouabain on podocyte proteins both "in vivo" and "in vitr

198 rolonged elevations of circulating exogenous ouabain on renal parameters in rats and the influence of

199 tion of cholesterol abolished the effects of ouabain on this interaction.

200 G and a similar Na(+)/K(+)-ATPase inhibitor, ouabain, on the phosphorylation status of Jnk, p38, and

201 perfusion of Na(+)-K(+) ATPase antagonists (ouabain or dihydro-ouabain) induced either a membrane de

202 Preincubation of lenses with either ouabain or low-[Na(+)] solutions resulted in reduced rat

203 e pumps that have been blocked by endogenous ouabain or other cardiac glycosides.

204 lace-cell-train-induced AHPs were blocked by ouabain or removal of extracellular potassium, but not b

205 a1 and alpha3 isoforms of Na(+)/K(+)-ATPase, ouabain or strophanthidin, inhibited this Na(+) current.

206 This delay was abolished by ouabain or zero K(+) saline, which eliminate the usAHP.

207 hate-buffered saline (PBS, vehicle) or PBS + ouabain, or after intraperitoneal injection of sodium io

208 r calcium, but were blocked by tetrodotoxin, ouabain, or the removal of extracellular potassium.

209 Here we tested the ability of ouabain (OUA, 3 microm), digoxin (DIG, 20 microm) or ace

210 ot different than that observed for combined ouabain plus BaCl(2) administration.

211 verage 56 +/- 5% (n = 16) following combined ouabain plus BaCl(2) infusion.

212 lated by cardiac glycoside drugs digoxin and ouabain, potent inhibitors of Na(+)/K(+)-ATPase.

213 A Na(+)/K(+)-ATPase inhibitor (ouabain) potentiated EA-induced cytotoxicity and direct

214 e survival factor Bcl-xL; co-incubation with ouabain prevented all of these effects.

215 Bound ouabain protects the site with the strongest influence o

216 Group 2 received ouabain rather than BaCl2 in the second trial.

217 The Na,K-ATPase inhibitor ouabain reduced and enhanced the carbachol-promoted phos

218 ally, in the rat model, elevated circulating ouabain reduced creatinine clearance (-18%, p < 0.05), i

219 rat model of pregnancy-induced hypertension, ouabain reduced mean arterial pressure and enhanced plac

220 arities in the Atpalpha variants, conferring ouabain resistance in both arrangements, may be the resu

221 Ouabain-resistance test detecting mutations in the Na(+)

222 lpha1 isoform of mice and rats is relatively ouabain resistant, gene-targeting strategies were used t

223 e alpha1 isoform mice were equivalent to the ouabain-resistant alpha1 isoform mice.

224 eloped mice in which the naturally occurring ouabain-resistant alpha1 isoform was made ouabain-sensit

225 espectively); both also express pumps with a ouabain-resistant alpha1 subunit.

226 ertension in WT mice but not in mice with an ouabain-resistant alpha2 isoform of Na,K-ATPase.

227 opus alpha1beta3 Na/K pumps, which were made ouabain-resistant by point mutation, after expressing th

228 nfusion induces hypertension in rodents, and ouabain-resistant mutation of the alpha2 ouabain binding

229 Na/K pumps from ventricular myocytes and in ouabain-resistant pumps expressed in Xenopus oocytes.

230 -induced defect was rescued by expression of ouabain-resistant zebrafish alpha1a.1 or rat alpha1 mRNA

231 lpha1 is ouabain-sensitive and NKA-alpha2 is ouabain-resistant, we assessed the effects of PLM phosph

232 IR channels and Na(+)/K(+)-ATPase (BaCl2 and ouabain, respectively), and combined inhibition of KIR c

233 low concentration of the cardiac glycoside, ouabain, resulted in a modest increase in intracellular

234 Furthermore, in vivo, administration of ouabain reversed the imbalance between Bax and Bcl-xL in

235 nduces hypertension, and digoxin antagonizes ouabain's hypertensinogenic effect.

236 mitochondrial depolarization observed before ouabain-SD was abolished by L-type channel block, and Zn

237 ) and Zn(2+) removal was required to prevent ouabain-SD when A(1) receptors were blocked.

238 ncreases were observed in CA1 neurons before ouabain-SD, and L-type channel block prevented the intra

239 oval of extracellular Ca(2+) did not prevent ouabain-SD.

240 an play a critical role in the generation of ouabain-SD.

241 e into susceptible eucaryotic cells under an ouabain selection regime.

242 diotonic steroids (CTSs) such as digoxin and ouabain selectively inhibit Na+, K+ -ATPase (the Na+ pum

243 In all cases, the ouabain sensitive component of the influx contributed ap

244 es Na(+),K(+)-ATPase activity as assessed by ouabain-sensitive (86)Rb(+) uptake.

245 fragment, the sodium excretion rates in the ouabain-sensitive alpha1 isoform mice were equivalent to

246 Circulating EO modulates ouabain-sensitive alpha2 Na(+) pump activity and Ca(2+)

247 Elevated hydrostatic pressure induced ouabain-sensitive alveolar fluid secretion that coincide

248 wild-type mice and mice where NKA-alpha1 is ouabain-sensitive and NKA-alpha2 is ouabain-resistant, w

249 Measurement of ouabain-sensitive ATPase activity and radiolabeled catio

250 sgenic mice also exhibited a 36% decrease in ouabain-sensitive sodium reabsorption and a significantl

251 pNBTEA concentration and V(M) dependence of ouabain-sensitive transient charge movements in whole-ce

252 ep changes in V(M) elicited pNBTEA-activated ouabain-sensitive transient currents that had similariti

253 ximately 60 s), activity-dependent, TTX- and ouabain-sensitive, hyperpolarization ( approximately 5 m

254 Endogenous, ouabain-sensitive, Xenopus alpha1beta3 Na/K pumps were s

255 ng ouabain-resistant alpha1 isoform was made ouabain-sensitive.

256 nsistent with the established differences in ouabain sensitivity between pig and rat alpha1.

257 Currently, the basis for the differences in ouabain sensitivity of NHK and ADPKD cells is unknown.

258 by micropuncture in mutant mice with altered ouabain sensitivity of the alpha1 and alpha2 Na,K-ATPase

259 of the alpha2 isoform to ouabain, conferring ouabain sensitivity to alpha1 augmented the natriuretic

260 Cardiotonic steroids (such as ouabain) signaling through Na/K-ATPase regulate sodium r

261 hown that the caveolar Na/K-ATPase transmits ouabain signals via multiple signalplexes.

262 Values for preoperative endogenous ouabain significantly improved (area under curve: 0.85)

263 t was found that nanomolar concentrations of ouabain, similar to those circulating in blood, induced

264 Furthermore, ouabain stimulated direct carbonylation of two amino aci

265 Ouabain-stimulated Na(+),K(+)-ATPase signaling has recen

266 he antioxidant N-acetyl-L-cysteine prevented ouabain-stimulated Na/K-ATPase.c-Src signaling, protein

267 tive oxygen species are required to initiate ouabain-stimulated Na/K-ATPase.c-Src signaling.

268 Ouabain-stimulated protein carbonylation is reversed aft

269 /K-ATPase.c-Src signaling complex attenuated ouabain-stimulated protein carbonylation.

270 It is concluded that ouabain stimulates proliferation in ADPKD cells by bindi

271 However, ouabain stimulates the PI3K/Akt/mTOR pathway and consequ

272 mparison with the low-affinity [K2]E2-MgF(x)-ouabain structure shows that the CTS binding pocket of [

273 reveal that SSA78 binding is antagonized by ouabain, supporting the interaction of SSA78 at one of t

274 ) increased with the preoperative endogenous ouabain tertile.

275 ith each incremental preoperative endogenous ouabain tertile.

276 by bath application of low concentrations of ouabain that selectively inhibit NKAalpha3 while alpha-m

277 In the presence of ouabain, the action potential collapses.

278 In constructs exposed to ouabain, the increased percentage of collagen per constr

279 At 1 mumol l(-1), ouabain, the secreted saliva was hyperosmotic.

280 Src kinase and inhibit its activity, whereas ouabain, the specific Na,K-ATPase inhibitor, binds and s

281 c activity but also serves as a receptor for ouabain to activate protein kinases.

282 nses of the alpha1 and/or alpha2 isoforms to ouabain to assess for altered natriuretic responses to a

283 wn converts the growth stimulatory effect of ouabain to growth inhibition in LLC-PK1 cells.

284 t-shock protein 27 (HSP27) was necessary for ouabain to inhibit HIF-1alpha translation.

285 Combined infusion of ouabain (to inhibit Na(+)/K(+)-ATPase) and barium chlori

286 a receptor for cardiotonic steroids, such as ouabain, to regulate cellular protein kinase cascades.

287 400 and KB-R7943) normalize myogenic tone in ouabain-treated arteries.

288 ) current was fully inhibited by basolateral ouabain treatment, suggesting that the Na(+),K(+)-ATPase

289 ression analysis, the circulating endogenous ouabain value before surgery was the strongest predictor

290 ffected differently by Na(+) modulation with ouabain versus Ca(2+) modulation with ionomycin.

291 Surprisingly, ouabain virtually abolished NKA-PLM FRET but only partia

292 In addition, ouabain was able to stimulate Src and ERK1/2 in the resc

293 Preoperative endogenous ouabain was measured in 407 patients admitted for electi

294 TP hydrolysis in the presence and absence of ouabain was used to measure Na,K-ATPase activity.

295 nergy transfer distances measured with bound ouabain, we carried out molecular dynamics simulations w

296 Low concentrations of ouabain were also found to disrupt cortical network osci

297 Dopamine/ouabain were not involved in activation of protein secre

298 ternalization of alpha1 induced by >/=100 nm ouabain which occurs in a time scale of hours.

299 were subjected to intravitreal injections of ouabain, which destroys the inner retina.

300 diac glycosides (CGs) digoxin, digitoxin and ouabain, which directly inhibit ATP1A1 function, exhibit