ライフサイエンスコーパス: outbred

1 that some blind individuals were relatively outbred.

2 el of Neisseria meningitidis colonization in outbred adult mice that included daily administration of

3 lso increased the lifespan of inbred but not outbred adults, suggesting that the beneficial buffering

4 n extreme quantitative trait locus GWA on an outbred advanced intercross population derived from extr

5 r Genetic Reference Panel (DGRP) and a large outbred, advanced intercross population derived from 40

6 tion analyses in the DGRP and a DGRP-derived outbred, advanced intercross population identified candi

7 urden of ROHs among patients with AD from an outbred African American population, which could reflect

8 dy using a well-characterized model in which outbred, aged, male Long-Evans rats exhibit a spectrum o

9 NIH:Swiss outbred and Apc(Min/+) mice were infected with CR (10(8)

10 tgb8 deletion (Itgb8(-/-)) were generated on outbred and C57BL/6 congenic backgrounds.

11 autosomal and X-linked haplotypes from both outbred and consanguineous pedigrees.

12 TS intragenic mutations, and TP53 status in outbred and experimental cancer cell lines did not predi

13 te the study of immune control, we sought an outbred and immunocompetent laboratory mouse strain in w

14 nd converged to a mortality plateau for both outbred and inbred beetles.

15 Both genetically outbred and inbred HCM mice had variable susceptibility

16 nflammatory cytokines and chemokines in both outbred and inbred mice.

17 ted for identifying SNPs in polyploids, both outbred and inbred, but would tend to be conservative fo

18 s than strangers, in marked contrast to both outbred and rederived wild mice.

19 eptible vs -resistant populations using both outbred and selectively bred models of susceptibility.

20 t on the donor, and not the recipient, being outbred and that it is characterized by hemorrhagic necr

21 e transgene to their offspring with both the outbred and the inbred EIII/JC genetic background.

22 Both divergent alleles are maintained in outbred and wild mice under selection for fecundity and

23 turally existing polymorphisms among inbred, outbred and wild rats.

24 ges in the T cell compartment of long-lived, outbred, and pathogen-exposed organisms, their relevance

25 ss Ib loci and their polymorphism in inbred, outbred, and wild-derived mice.

26 ivo response to miHA vaccination in a large, outbred animal model without using recipient cells to se

27 ays a role in graft rejection and GVHD in an outbred animal model, and ICOS blockade may be an approa

28 y compared to experimental designs involving outbred animal populations.

29 Gene expression in pig BMDM from outbred animals responding to LPS was profiled using Aff

30 types and facilitates extinction learning in outbred animals, therefore we examined the effects of ea

31 ounder mutation of the MSH2 gene in a large, outbred (as opposed to genetically isolated) population,

32 Seven outbred baboons underwent renal allotransplantation from

33 deemed acute, in 54% of Hyal2 KO mice on an outbred background; Hyal2 KO mice without the severe car

34 MMS) of 12 hypomorphic y mutants and matched-outbred-background controls using a y+ rescue element on

35 e congenic lines argues against heterosis of outbred backgrounds contributing to Egfrtm1Mag phenotypi

36 were approximately 5% shorter than those of outbred beetles, and there was no difference in inbreedi

37 Genetically outbred Black Swiss (BS) alphaMHC403/+ mice showed only

38 ion of chickens was created by crossing four outbred broiler sires to dams of two highly inbred lines

39 ncrease in larval survival in inbred than in outbred broods.

40 ne pancreata of RD-fed Grp78(+/-) mice in an outbred C57BL/6 x 129/sv genetic background exhibited ER

41 most effective in inbred BALB/c followed by outbred CD-1 and inbred B6J mice.

42 tal muscle tissues of the hind limbs in both outbred CD-1 mice and adult C57BL/6J mice.

43 Outbred CD-1 mice carry a spectrum of genetic susceptibi

44 d DsRed, respectively), into the footpads of outbred CD-1 mice to simulate transmission by a mosquito

45 Outbred CD-1 mice were immunized twice with the antigens

46 ap background modifiers using Swiss-derived, outbred CD-1 mice were unsuccessful.

47 6, C57BL/10, DBA/2, SJL, SWR, 129P3) and one outbred (CD-1) mouse strains following treatment with ve

48 J, DBA/2J, SJL/J, SWR/J and 129P3/J) and one outbred (CD-1) mouse strains previously tested with nalt

49 /10J, DBA/2J, SJL/J, SWR/J, 129P3/J) and one outbred (CD-1) mouse strains.

50 2 gene in all backgrounds examined including outbred CD1 and inbred C3H and C57BL/6J.

51 We exposed pregnant outbred CD1 female mice and the male progeny was crossed

52 in human ascites fluid, and the survival of outbred CD1 mice challenged subcutaneously or intraperit

53 th survival and competition experiments with outbred CD1 mice demonstrated that PEG344 was required f

54 Outbred CD1 neonatal mice were orally gavaged with one o

55 and electroolfactogram defects were found in outbred (CD1) and inbred (C57/bl6) mouse genetic backgro

56 n, with large and robust differences in both outbred (CD1) and inbred (C57bl/6) mouse strains without

57 -deficient mice in both inbred (C57/bl6) and outbred (CD1) genetic backgrounds.

58 its ability to persist in the intestines of outbred chickens relative to the parent strain.

59 We show that in an outbred cohort (n = 2,093) of HIV C-clade-infected indiv

60 complex statistical methods as in studies of outbred cohorts.

61 nd we included Wistar rats as an additional, outbred control strain.

62 bbits were more susceptible to TB than their outbred counterparts and had an impaired ability to cont

63 8- to 12-week-old inbred C57BL/6JCrl (B6J), outbred Crl:CD1(ICR) (CD-1), and inbred BALB/cAnNCrl (BA

64 Here, a QTL analysis using an outbred cross was initiated to determine the molecular b

65 difier; and Mom3, which was discovered in an outbred cross.

66 population structures, including inbred and outbred crosses as well as natural populations, and can

67 o discuss the suitability of this design for outbred crosses in organisms with large genomes and for

68 y of multilocus genotypes residing within an outbred deme.

69 We sought to evaluate Diversity Outbred (DO) mice as a tool for exposure threshold asses

70 e the Collaborative Cross (CC) and Diversity Outbred (DO) models.

71 ultiparent populations such as the Diversity Outbred (DO) mouse stock accumulate large numbers of cro

72 % homozygous compared to the genomes of the outbred domestic cat (24.08 % homozygous), Virunga Mount

73 ransplants were successfully performed in 22 outbred domestic ferrets in the absence of immunosuppres

74 d the potential for purging using inbred and outbred Drosophila melanogaster larvae exposed to biotic

75 ouring outbred offspring, but rather because outbred embryos exert a rescuing effect on inbred half-s

76 resent in one-third of familial ALS cases of outbred European descent, making it the most common gene

77 R19X is rare (<0.05% frequency) in outbred European populations.

78 11 well-described population isolates and an outbred European-derived sample, using SNP markers space

79 d results were confirmed in three additional outbred F(2) families (n=96 per family).

80 ome-wide mapping was initiated using a large outbred F(2) rainbow trout family (n=480) and results we

81 ally-induced skin cancer in NIH/Ola by SPRET/Outbred F1 backcrosses.

82 Second, via tracking survival in inbred and outbred families, we demonstrate that inbred families ha

83 This was applied to wild-stock outbred female house mice, which nest socially and often

84 We also found that both inbred and outbred females had higher immunity than males in PO act

85 nd mortality patterns produced by inbred and outbred females, we were able to rule out sl-CSD as a se

86 ales was 9-13% shorter than the life span of outbred females, whereas the life span of inbred males d

87 water temperature in inbred fish but not in outbred fish.

88 inbred lines with that of crickets from the outbred founder population.

89 ween genetic diversity and macroparasites in outbred, free-ranging populations of raccoons (Procyon l

90 encing forking defects were identified in an outbred full-sibling family of loblolly pine, using sing

91 trophil depletion prevented early failure of outbred grafts, whereas transplanting CD73-deficient inb

92 ng 1184 STR/indel markers, were found in the outbred group (P < 0.0001) and were associated with lowe

93 cell-mediated and protective immunity in the outbred guinea pig model of pulmonary tuberculosis.

94 These findings suggest that the outbred guinea pig model recapitulates ZEBOV infection o

95 Uniformly lethal outbred guinea pig models of MARV-Angola (MARV-Ang) and

96 Thirty-six outbred guinea pigs were infected with guinea pig-adapte

97 Features of disease in ZEBOV-infected outbred guinea pigs were largely consistent with disease

98 duction of allergen-specific blocking IgG in outbred guinea pigs which had been immunized with recomb

99 ong tracts of homozygosity in the apparently outbred HapMap populations.

100 MARV-, ZEBOV-, and SEBOV-induced disease in outbred Hartley guinea pigs where we observed protection

101 nce MHC class I 7-6 presented both epitopes, outbred horses with this allele can be immunized with th

102 -gamma production was observed in inbred and outbred hosts and controlled by extrinsic (but not cell-

103 ed memory CD8 T cell responses in inbred and outbred hosts generated in response to different types o

104 tude and kinetics of CD8 T cell responses in outbred hosts.

105 echanisms and are directly applicable to the outbred human population.

106 ikely essential for maximum protection in an outbred human population.

107 gabase-scale ancestral haplotypes persist in outbred human populations in broad genomic regions which

108 rect relevance to development of vaccines in outbred humans.

109 small-molecule MIF antagonist, CPSI-1306, to outbred ICR mice following induction of NIDDM significan

110 mids were next introduced into the livers of outbred ICR mice via hydrodynamic tail vein injection.

111 lity, which was overcome by crossing them to outbred ICR mice.

112 MIP-2 (a CXC chemokine) levels after CLP in outbred (ICR/CD-1) mice.

113 We used the outbred, immune-competent Skh-1 hairless mouse model of

114 We show that MmuPV1 challenge of the outbred immunocompetent SKH1 strain produces both transi

115 ome, but not other, wild mice that were kept outbred in the laboratory.

116 n the absence of an independent set of known outbred individuals from which to estimate allele freque

117 ovel immunogenic T4SS proteins recognized by outbred individuals with common MHC haplotypes further j

118 more resources to this form of immunity than outbred individuals.

119 s in protective memory CD8 T cell numbers in outbred individuals.

120 suring up to 4 Mb are common in demonstrably outbred individuals.

121 requencies can be estimated from a subset of outbred individuals.

122 ully inbred genotype will exceed the mean of outbred individuals.

123 he phenotypic variance present in ostensibly outbred individuals.

124 Adult, female, outbred Institute of Cancer Research mice.

125 als from three genetic backgrounds (inbred - outbred) into a novel environment at three founding size

126 n SNPs at a mean r(2) value of 0.98 in 2,073 outbred laboratory mice (0.15x sequencing coverage).

127 s of inbred lines that had been derived from outbred laboratory populations that had different mean l

128 ed immobility, are also prevalent in healthy outbred laboratory rats.

129 ximately equal, averaging a 42% reduction in outbred larval survival relative to controls.

130 a cross between C57BL/6J and an ICR-derived outbred line (HR).

131 assembled and phased genomes, termed Phased Outbred Lines (POLs).

132 Here, we studied an F2 intercross of two outbred lines of rats selected for tame and aggressive b

133 To circumvent this, we used two outbred lines of rats, which are genetically similar exc

134 air design," for use with F2 crosses between outbred lines.

135 Brattleboro rats are a variety of the outbred Long-Evans strain that possess a single nucleoti

136 In Experiment 1, outbred male Wistar rats self-administered sweetened alc

137 d males did not differ from the life span of outbred males.

138 n, time post infection) and was validated in outbred mice (AUC>0.97).

139 In outbred mice and rats, familiarity determined willingnes

140 on density in early generations of Diversity Outbred mice are consistent with expectations based on s

141 an estimated human dose injected into young outbred mice as a saline solution, were bactericidal aga

142 IgG antibody levels induced in young outbred mice by the S. sonnei O-SPC conjugates were sign

143 e, we demonstrate that adult immunocompetent outbred mice can be effectively colonized with the proto

144 Therefore, outbred mice could provide broader insight into donor an

145 ne expression profiles of multi-tissues from outbred mice fed with a high-fat diet (HFD) or regular c

146 e rAls1p-N vaccine also improves survival of outbred mice from disseminated candidiasis and that it i

147 y (6-16 days posttransplantation), untreated outbred mice had heterogeneous outcomes, with grafts fai

148 everity was dependent on genetic background: outbred mice or those on a CD1 background are highly sus

149 For the present study, an outbred mice population containing 1,904 individuals and

150 n this study, we demonstrate that inbred and outbred mice recovering from a septic event are more sus

151 ion of antibody responses in both inbred and outbred mice strains, with both constructs eliciting hig

152 Outbred mice were exposed to cockroach allergens on Days

153 Male outbred mice were placed into an environment where they

154 Immunizations in outbred mice with rMSP1-IO achieved 100% responsiveness

155 holangiocarcinoma growth in vivo in hairless outbred mice with severe combined immunodeficiency (SHO-

156 Inoculation of outbred mice with the H. pylori SS1 wild-type strain eli

157 n LS in virgin and postpartum mice, 2) using outbred mice, and 3) evaluating the role of sensory inpu

158 ong-term graft acceptance in both inbred and outbred mice, but did not prevent the early graft failur

159 show that a commercially available strain of outbred mice, MF1, can be treated as an ultrafine mosaic

160 w here, in a survey of 97 traits measured in outbred mice, that most phenotypes display parent-of-ori

161 tein expression in livers from 192 Diversity outbred mice, we identify 2,866 protein quantitative tra

162 By examining 4n embryos from F2 hybrid and outbred mice, we show that 4n developmental potential is

163 re immunogenic than their parental strain in outbred mice, while MVvac2-H2 additionally proved more i

164 ogenicities of new peptides were assessed in outbred mice.

165 ly with exploratory tendencies in individual outbred mice.

166 This study included adult, female outbred mice.

167 on of immunocompetent hemophiliac and normal outbred mice.

168 red C3H/HeJ mice longer than in the blood of outbred mice.

169 lotype space in 1,887 commercially available outbred mice.

170 and puncture model of sepsis in adult female outbred mice.

171 gave high antibody titers in both inbred and outbred mice.

172 , NOD2(-/-), ob/ob, and Rag1(-/-)), and >200 outbred mice.

173 from Collaborative Cross lines and Diversity Outbred mice.

174 Four groups of outbred, mixed lymphocyte culture (MLC)-reactive pigs un

175 aque offers an intriguing, non-human primate outbred model organism with which hypotheses concerning

176 e of other isoform (GR(wt)), is found in two outbred mouse lines that were produced by selection for

177 for protein quantification with an emerging outbred mouse model containing extensive genetic variati

178 hite (CFW) mice are a commercially available outbred mouse population that exhibit rapid LD decay in

179 In an application to data from an outbred mouse population, we find that mixed random fore

180 had genetic variations not present in other outbred mouse populations.

181 Outbred mouse stocks, often used in genetics, toxicology

182 rs located on 39 pairs of chromosomes for an outbred multigenerational pedigree, initiated with a lim

183 ells (iPSCs) and hESC-derived progenitors in outbred murine recipients.

184 We describe here a comparison of inbred and outbred New Zealand White rabbits infected by aerosol wi

185 5 receptor blockade using Mut-IL-15/Fc in an outbred non-human primate model of renal allotransplanta

186 The linear peptide was also immunogenic in outbred nonhuman primates (Aotus nancymaae), eliciting a

187 rough paternity-biasing mechanisms favouring outbred offspring, but rather because outbred embryos ex

188 rmance of inbred offspring more than that of outbred offspring.

189 during larval development and (ii) inbred or outbred offspring.

190 rast, swine derived by nuclear transfer into outbred oocytes differed in the HV1 region sequence from

191 identical knockout counterparts derived from outbred oocytes were rejected within 2 weeks, whereas tr

192 , we performed heart transplantation between outbred or inbred mice.

193 llular immune response induced by AS01 in an outbred ovine model, 2) to develop a lymphatic cannulati

194 Outbred pigs were recipients of allogeneic pig hepatocyt

195 The JAX Diversity Outbred population is a new mouse resource derived from

196 cted a significant association at MC22 in an outbred population maintained under laboratory condition

197 equence divergences, is endemic in the large outbred population of lions in the Serengeti ecosystem i

198 ach inbred line was derived from a different outbred population that had undergone long-term selectio

199 e genetic variability segregating within the outbred population was partitioned by surveying viabilit

200 time in the accessions and genotyped in the outbred population were replicated in both mapping popul

201 tion ability compared with crickets from the outbred population.

202 components method to model complex traits in outbred populations (e.g., humans).

203 gosity (ROH) in the genome are detectable in outbred populations and can be associated with an increa

204 f homozygosity in coronary artery disease in outbred populations and suggest the potential biological

205 ions of low amounts of epistatic variance in outbred populations are concordant.

206 terious recessive alleles that are masked in outbred populations are predicted to be expressed in sma

207 extended beyond experimental intercrosses to outbred populations by exploiting long-range linkage dis

208 vealed by changing allele frequencies in the outbred populations derived from extreme DGRP lines.

209 d pedigrees, this method may also be used in outbred populations for case-control studies in which so

210 xperiments, methods for viability mapping in outbred populations have not been developed yet.

211 The standard model for outbred populations is based on premises of genetic equi

212 Our results suggest that in outbred populations multi-locus diversity might be impor

213 eost fish Fundulus heteroclitus from natural outbred populations raised in a common environment: meta

214 s of disease together with genetic data from outbred populations represents a promising strategy to u

215 ied experimentally with greater ease than in outbred populations such as humans.

216 htly controlled, their large variation among outbred populations suggests genetic factors.

217 e distance at which r2=0.2 extends <10 kb in outbred populations to >1.7 Mb in populations that have

218 Linkage disequilibrium (LD) analysis in outbred populations uses historical recombinations to de

219 Even among outbred populations, autozygosity can occur to varying d

220 ly because they are derived from genetically outbred populations, but also because they may undergo p

221 mmetry (FA) in inbred compared to relatively outbred populations, but many studies have failed to fin

222 hough statistical methods for QTL mapping in outbred populations, e.g., humans, can be applied for su

223 ge of population sizes, including inbred and outbred populations, monogamous and polygamous mating pa

224 tification in genetic association studies of outbred populations, such as in the United States.

225 However, for outbred populations, very large sample sizes may be requ

226 ions exhibit a greater range of kinship than outbred populations, which helps in fitting the epistati

227 s in recombination rate between the sexes in outbred populations.

228 homozygous polymorphisms in individuals from outbred populations.

229 ot be utilized through methods developed for outbred populations.

230 equencing to species with highly recombinant outbred populations.

231 or role in defining HL risk in predominantly outbred populations.

232 ations occurred at lower male skews than for outbred populations.

233 teractions, which is difficult to measure in outbred populations.

234 from distant common ancestors in apparently "outbred" populations.

235 ical profile for WKY rats as compared to the outbred progenitor controls, Wistar rats.

236 PS) stimulation in vitro than those from the outbred rabbits (2,413 +/- 1,154 versus 8,879 +/- 966 pg

237 ficantly larger pulmonary tubercles than did outbred rabbits (2.7 versus 1.4 mm in diameter; P < 0.01

238 cantly more pulmonary tubercles than did the outbred rabbits (98 +/- 12 versus 33 +/- 13; P < 0.01),

239 The 597-626 epitope was immunogenic in outbred rabbits eliciting Abs which recognized HER-2, co

240 stologic examination of lung granulomas from outbred rabbits, histologic examination of those from in

241 cles that were larger than those observed in outbred rabbits.

242 antagonism potently reduce sucrose intake in outbred rat and mouse strains, the present study examine

243 o identify impulsive action phenotypes in an outbred rat population before cocaine self-administratio

244 whether this is due to the use of different outbred rat strains.

245 Their equal occurrence in outbred rats also implies a major potential confound for

246 directly influences social dominance in male outbred rats and identify an important mediating role fo

247 ed immobility may be nonepileptic in healthy outbred rats and reflect instead voluntary rodent behavi

248 nce and voluntary control of SWDs in healthy outbred rats could indicate that these phenomena do not

249 We discovered that both inbred and outbred rats could shorten the duration of SWDs to obtai

250 CANCE STATEMENT Our evidence that inbred and outbred rats learn to control the duration of spike-wave

251 ned sequence and genetic mapping analysis in outbred rats that maps 355 quantitative trait loci for 1

252 Here, we use outbred rats to investigate if cAMP response element-bin

253 usceptible and stress-resilient subgroups in outbred rats.

254 g NFkappaB-mediated luciferase expression in outbred rats.

255 tterites, a founder population, and in three outbred replication populations.

256 icting class I allele from a large cohort of outbred rhesus macaques.

257 Outbred rhesus monkeys were used for renal transplantati

258 sive (LI) phenotypes were identified from an outbred rodent population with the 1-choice serial react

259 t the intestine of social wasps hosts highly outbred S. cerevisiae strains as well as a rare S. cerev

260 w substantially higher levels of LD than the outbred sample and many fewer regions of very low LD (te

261 e in the direction predicted on the basis of outbred source population.

262 These are outbred species exhibiting substantial levels of genetic

263 requent inbreeding, the number of inbred and outbred sporophytes was balanced, resulting in an averag

264 inction learning and retention compared with outbred Sprague Dawley rats, whereas bLRs show reduced e

265 resent study compared SHR, WKY and standard, outbred Sprague-Dawley (SD) rats on a delay discounting

266 Both selectively bred Crl:OP[CD] rats and outbred Sprague-Dawley rats fed an HE diet showing high

267 omotor activity in a novel environment among outbred Sprague-Dawley rats.

268 elements mapping to the peak linkage area in outbred spretus, Spret/EiJ, FVB/NJ, and NIH/Ola.

269 All inbred strains and outbred stocks of laboratory mice studied to date have b

270 Here we assess the most widely used outbred stocks of mice and present guidelines for their

271 analysis have capitalized on the genetics of outbred stocks to refine the identification of quantitat

272 2 on the C57BL/6 background) strain, and one outbred strain (CD1) of mice.

273 e was investigated in two mouse strains, the outbred strain CD1 and the inbred strain C57BL/6.

274 ype strains of mice like FVB/n, SJL, and the outbred strain Swiss Webster.

275 de (ODN) and was observed in both inbred and outbred strains of mice.

276 d intake of sucrose varies across inbred and outbred strains of mice.

277 lets was normal in Cc1(-/-) mice (inbred and outbred strains).

278 nditioning in male rats to determine whether outbred strains, Sprague Dawley and Long-Evans, and/or t

279 sensitivity when compared to other inbred or outbred strains.

280 iduals under consideration come from a large outbred subpopulation of the population for which allele

281 Outbred swine underwent in utero transplantation of full

282 One to 2 billion hepatocytes from outbred swine were transplanted into the spleens of cyno

283 is murine pathogen has been characterized in outbred Swiss Webster (SW) mice but not in the cognate i

284 egions (jejunum, ileum, cecum, and colon) of outbred Swiss Webster (SW) mice.

285 ng study relied upon mice backcrossed on the outbred Swiss Webster (SW) strain that were homozygous f

286 n liver, kidney and monocyte cell lines, and outbred Swiss Webster mice tolerate high doses of the co

287 tion (H268Q) in Jag1 (Jag1(+/Ndr) mice) were outbred to a C3H/C57bl6 background to generate a mouse m

288 differing ancestral histories (ranging from outbred to inbred) from the Dalmatian islands in Croatia

289 or mice; this may be the result of examining outbred versus captive populations.

290 information for rare, recent variants in the outbred Wellcome Trust Case-Control Consortium (WTCCC) d

291 ivation of sharp vision (DSV) was induced in outbred White Leghorn chicks aged 4 days.

292 Outbred Wistar rats experienced extended access methamph

293 the first study to examine simultaneously in outbred WT Drosophila pseudoobscura the lifetime costs a

294 However, five lines of outbred XY(d) females with Y chromosome deletions Y(Del(

295 ly documented for C57BL/6 inbred XY females, outbred XY(Sry-) and XO,Zfy2 females showed frequent fai

296 Outbred XY(Sry-) female mice that lack Sry due to the 11

297 Outbred Yorkshire sows and boars screening negative for

298 mes, we studied the induction of LTP in male outbred young and aged rats behaviorally characterized i

299 pment and population viability of inbred and outbred zebrafish (Danio rerio).

300 Eggs were obtained from WT outbred zebrafish and exposed to 0%, 0.1%, 0.2%, 0.4%, 0