ライフサイエンスコーパス: outer hair cell

1 t constant along the length of an individual outer hair cell.

2 t prestin function and functionally tune the outer hair cell.

3 rgan of Corti MOR was expressed in inner and outer hair cells.

4 duction currents and sensitivity in cochlear outer hair cells.

5 tory currents in apical developing inner and outer hair cells.

6 frequencies, the shift is larger in shorter outer hair cells.

7 ently expanded to the entire lateral wall in outer hair cells.

8 were mostly contracted and detached from the outer hair cells.

9 stological alterations and cell apoptosis of outer hair cells.

10 aluating the function of prestin in cochlear outer hair cells.

11 arker, Endo G, translocated to the nuclei of outer hair cells.

12 lls and is augmented in inner hair cells vs. outer hair cells.

13 nt in the stria vascularis and the inner and outer hair cells.

14 e shifts of electromotility were observed in outer hair cells.

15 inned by electromechanical feedback from the outer hair cells.

16 hair cells and spiral ganglion cells but not outer hair cells.

17 inner hair cells, but not in Myo15(sh2/sh2) outer hair cells.

18 anti-Foxo3 immunofluorescence in adult human outer hair cells.

19 dependence in adult rodent IHCs and immature outer hair cells.

20 voltage-driven electromotility of mammalian outer hair cells.

21 potentials, drive somatic electromotility of outer hair cells.

22 to active electro-mechanical feedback of the outer hair cells.

23 d to the homeostasis of inner hair cells and outer hair cells.

24 dye transfer between supporting cells around outer hair cells.

25 reciprocal gradient found between inner and outer hair cells.

26 is expressed in the basolateral membrane of outer hair cells.

27 ed hearing thresholds, and extensive loss of outer hair cells.

28 s in maximal vibration at the apical ends of outer hair cells.

29 loss of inner hair cell synaptic ribbons and outer hair cells.

30 Prestin is the motor protein of cochlear outer hair cells.

31 rons along the cochlear duct to contact many outer hair cells.

32 ment of voltage-dependent electromotility of outer hair cells.

33 Recent studies have demonstrated that outer hair cells actively generate force using somatic e

34 l studies showed preserved cochlear receptor outer hair cell activities (otoacoustic emissions) and a

35 restin, a terminal differentiation marker of outer hair cells, although many new hair cells eventuall

36 h decreased density of efferent terminals on outer hair cells: although the onset of this degeneratio

37 otoacoustic emissions, suggesting defects in outer hair cell amplification, their endocochlear potent

38 in mice with relatively little reduction in outer hair cell amplification.

39 Outer hair cells amplify and improve the frequency selec

40 Outer hair cells amplify the traveling wave within the m

41 without the push-pull action provided by the outer hair cell and Deiters cell phalangeal process.

42 co-evolved with a novel hair cell type, the outer hair cell and its constituent membrane protein, pr

43 we study a mouse model without alteration to outer hair cell and organ of Corti mechanics or to mecha

44 In summary, we suggest that these defects in outer hair cell and strial cell function are important c

45 harmacological inhibitor compound C, reduced outer hair cell and synaptic ribbon loss as well as nois

46 olivocochlear morphology and innervation to outer hair cells and a highly disorganized efferent inne

47 ss associated with increased degeneration of outer hair cells and diminution of DPOAE amplitudes but

48 m the reticular lamina at the apical ends of outer hair cells and from the basilar membrane using a c

49 expressed in the plasma membrane of cochlear outer hair cells and functions as a unique voltage-depen

50 ected in the entire lateral wall of cochlear outer hair cells and had an intermediary distribution (b

51 s mechanoelectrical transduction currents in outer hair cells and hence cochlear amplification is gre

52 In the mouse cochlea, Ocm is found only in outer hair cells and is localized preferentially to the

53 his observation accords with the function of outer hair cells and lends support to the recent hypothe

54 26a5), is responsible for electromotility of outer hair cells and mammalian cochlear amplification, a

55 positively shifted nonlinear capacitance of outer hair cells and prestin-transfected cells by approx

56 educed TRPV1 expression, decreased damage to outer hair cells and reduced cisplatin-induced hearing l

57 elium is required for the differentiation of outer hair cells and SCs, while mesenchymal FGFRs regula

58 ngly reduced, with complete loss of cochlear outer hair cells and some groups of vestibular hair cell

59 It appears to lack outer hair cells and some supporting cells are either ab

60 tions between ABR thresholds and the loss of outer hair cells and spiral ganglion cells, but not with

61 ormalities, there was an accelerated loss of outer hair cells and the progressive appearance of large

62 These include the cochlear outer hair cells and their singular feature, somatic ele

63 sent in Prph((-/-)) mice, demonstrating that outer hair cells and their type II afferents constitute

64 Cochlear outer hair cells and vestibular type I cells that expres

65 ession and current levels in Pit1(dw) mutant outer hair cells, and (3) sensory and strial cell deteri

66 in cDNA libraries of rat cochlear inner and outer hair cells, and HCN1 protein was immunolocalized t

67 ner ear and is composed of inner hair cells, outer hair cells, and highly specialized supporting cell

68 ow that type II afferents are activated when outer hair cells are damaged.

69 function as afferent sensory cells, whereas outer hair cells are electromotile amplifiers of auditor

70 The sensory hair bundles of the outer hair cells are imbedded in the tectorial membrane,

71 Absent Foxo3, outer hair cells are lost throughout the middle and high

72 Cylindrical outer hair cells are motile and their somatic length cha

73 logically observed shapes of hair bundles of outer hair cells are near-optimal in this regard.

74 s that regulate differentiation of inner and outer hair cells are not known.

75 ne row of inner hair cells and three rows of outer hair cells are surrounded by specialized supportin

76 esidual alpha9 homomeric nAChRs expressed by outer hair cells are unable to transduce efferent signal

77 POAEs, suggesting a role for dopamine in the outer hair cell area.

78 ysis of the de-efferentation in inner versus outer hair cell areas suggested that outer hair cell eff

79 The ability of Anc80L65 to target outer hair cells at high rates, a requirement for restor

80 ortion product amplitude and massive loss of outer hair cells at the basal turn of the cochlea was ob

81 Among other striking features, outer hair cell bodies were extremely small and were str

82 eedback: voltage-driven contractility of the outer hair cell body and active motion of the hair bundl

83 Outer hair cells boost auditory performance in mammals.

84 tions, we used a finite-element model of the outer hair cell bundle incorporating previously measured

85 tnatal days 10-13) spiral ganglion cells and outer hair cells but not inner hair cells.

86 y affects the level of mitochondrial NADH in outer hair cells, but not inner hair cells, within minut

87 utant mice exhibit a total loss of inner and outer hair cells, but supporting cells remain relatively

88 Our results indicate that outer hair cells can generate sufficient force to drive

89 Furthermore, depolarization of one outer hair cell caused motion of neighboring hair bundle

90 Depolarization of solitary outer hair cells caused cell-length changes whose voltag

91 signaling and (ii) suggest that the loss of outer hair cells causes the majority of the hearing loss

92 The motile activity of outer hair cells' cell body is associated with large non

93 The lateral membrane of mammalian cochlear outer hair cells contains prestin, a protein which can a

94 nt movement, or electromotility, of cochlear outer hair cells contributes to cochlear amplification i

95 instem: one pathway provides gain control on outer hair cells' contribution to cochlear amplification

96 nario where the singular organization of the outer hair cells' cortical cytoskeleton may have emerged

97 taV giant spectrin, a major component of the outer hair cells' cortical cytoskeleton.

98 re introduces a premature stop codon, causes outer hair cell defects, and leads to progressive hearin

99 differentiation is unaffected in mambo mice, outer hair cells degenerate rapidly after the first post

100 and Csb(-/-) mice lose hearing and manifest outer hair cell degeneration after systemic cisplatin tr

101 The polygenic basis of outer hair cell degeneration in Beethoven mice provides

102 henotypes, such as presbycusis, that involve outer hair cell degeneration in humans.

103 in neurons, causes profound hearing loss and outer hair cell degeneration in mice.

104 inhibitory synapses can be found on inner or outer hair cells, depending on developmental age, both c

105 some function is preserved in low frequency outer hair cells, despite concomitant profound hearing l

106 In addition, there was excess outer hair cell development in the apical region.

107 through activation of MEKK4 is necessary for outer hair cell differentiation.

108 These results indicate that outer hair cells do not amplify the basilar membrane vib

109 The outer hair cell-driven reticular lamina vibration collab

110 3) showed threshold elevations indicative of outer hair cell dysfunction.

111 versus outer hair cell areas suggested that outer hair cell efferents are the most important in mini

112 red explicitly-organ of Corti mechanics, and outer hair cell electro-mechanics.

113 active cochlear mechanics, which arises from outer hair cell electromotility and hair bundle movement

114 e organ of Corti suggests that regulation of outer hair cell electromotility may be the primary funct

115 basilar membrane, causes a leftward shift in outer hair cell electromotility towards hyperpolarizatio

116 es may contribute to processes as diverse as outer hair cell electromotility, ion channel gating, and

117 Outer hair-cell electromotility involves a membrane-base

118 ner hair cells are of linear shape, those of outer hair cells exhibit a distinctive V-shape.

119 Surprisingly, only outer hair cells exhibit fast adaptation and sensitivity

120 Singly isolated cochlear inner and outer hair cells express HCN1 transcript, and HCN1 and H

121 electromotility, in which the cell bodies of outer hair cells extend and contract as the protein pres

122 ults suggest that the mechanical feedback of outer hair cells, facilitated by the organ of Corti micr

123 The outer hair cell from Corti's organ possesses voltage-dep

124 rocesses resulting from the disappearance of outer hair cells from the epithelium.

125 tory brainstem response (ABR) wave 1] and in outer hair cell function [distortion product otoacoustic

126 docochlear potentials, suggesting defects in outer hair cell function and potassium recycling.

127 ted auditory thresholds combined with normal outer hair cell function.

128 tory brainstem response with preservation of outer hair cell function.

129 issions were not impaired pointing to normal outer hair cell function.

130 e origin of mechanical amplification whereby outer hair cells generate force to augment the sensitivi

131 y selectivity of mammalian hearing depend on outer hair cell-generated force, which amplifies sound-i

132 The mechanical stimulation of the outer hair cell hair bundle (HB) is a key step in nonlin

133 , which is associated with the elongation of outer hair cells, has a conformation with a shorter hydr

134 pplied by the tectorial membrane (TM) on the outer hair cell HB.

135 t otoacoustic emissions, suggesting cochlear outer hair cell impairment.

136 of all inner hair cells and the majority of outer hair cells in an adult cochlea via virus injection

137 e motion during depolarization of individual outer hair cells in isolated rat cochleas.

138 n highly efficient transduction of inner and outer hair cells in mice, a substantial improvement over

139 eins, is expressed predominantly by cochlear outer hair cells in subcellular regions associated with

140 efferent synapses that form later (P6-P8) on outer hair cells in the basal cochlea.

141 electron microscopy revealed degeneration of outer hair cells in the basal region of baringo, nice, a

142 Outer hair cells in the cochlea have a unique motility i

143 associated with progressive degeneration of outer hair cells in the cochlea, whereas cochlear deleti

144 tes Rho GTPase pathways, leading to death of outer hair cells in the cochlea.

145 ear positioning specifically to the death of outer hair cells in the organ of Corti and ultimately to

146 hearing loss is caused by loss or damage to outer hair cells in the organ of Corti.

147 to lipid peroxidation and damage or death of outer hair cells in the organ of Corti.

148 ion between medial olivocochlear neurons and outer hair cells, in a two-choice visual discrimination

149 The effects of acetylcholine on outer hair cells include cell hyperpolarization and a de

150 rane area and linear membrane capacitance of outer hair cells increases exponentially with the electr

151 The outer hair cell is electromotile, its membrane motor ide

152 Prestin in the lateral membrane of outer hair cells, is responsible for electromotility (EM

153 dulin (Ocm), which is predominately found in outer hair cells, leads to a progressive hearing loss af

154 owed the progressive threshold elevation and outer hair cell loss characteristic of the age-related h

155 xpression correlated with ABR amplitudes and outer hair cell loss in the cochlea, but NADPHd did not.

156 uced endocochlear potential, (2) significant outer hair cell loss in the mutants, which may result fr

157 Outer hair cell losses were exacerbated in the same time

158 noelectric transduction (MET) in rat cochlea outer hair cells maintained in organotypic cultures.

159 it the auditory stimulus to the brain, while outer hair cells mechanically modulate the stimulus thro

160 l5 null mutation, the unitary conductance of outer hair cell mechanotransducer (MT) channels was redu

161 localized preferentially to the basolateral outer hair cell membrane and to the base of the hair bun

162 s of age in a basal-to-apical gradient, with outer hair cells more severely affected than inner hair

163 udies found that salicylate not only affects outer hair cell motility in the cochlea, but also blocks

164 rotyrosine and Lmo4 was particularly high in outer hair cell nuclei after cisplatin treatment.

165 Outer hair cell numbers and efferent function measures (

166 However, outer hair cells of knockout mice have significantly alt

167 sduction and tip-link formation, we examined outer hair cells of mouse cochleas during development an

168 Although stereocilia of both inner and outer hair cells of Myo15(sh2/sh2) mice lack myosin-XVa

169 In both inner and outer hair cells of Myo15(sh2/sh2) mice, we found mechan

170 -4 and Sun1, another LINC complex component, outer hair cells of the cochlea form normally during dev

171 ma membranes of the stereocilia of inner and outer hair cells of the inner ear.

172 attached to the electromotile, sensorimotor outer hair cells of the organ of Corti, and that the amp

173 ochlea, with highest levels in the inner and outer hair cells of the organ of Corti, cells lining the

174 Outer hair cells of Va(J)/Va(J) mice additionally had de

175 lea induce transmembrane potential along the outer hair cell (OHC) but its distribution along the cel

176 membrane-based yeast two-hybrid screen of an outer hair cell (OHC) cDNA library was performed.

177 Outer hair cell (OHC) electromotility enables frequency

178 Mammalian hearing is powered by outer hair cell (OHC) electromotility, a membrane-based

179 in is the membrane motor protein that drives outer hair cell (OHC) electromotility, a process that is

180 Outer hair cell (OHC) electromotility, a response consis

181 f anion transporters that is responsible for outer hair cell (OHC) electromotility.

182 dentified as a motor protein responsible for outer hair cell (OHC) electromotility.

183 Outer hair cell (OHC) function was measured with the cub

184 The lateral membrane of the cochlear outer hair cell (OHC) is the site of a membrane-based mo

185 e the discovery of otoacoustic emissions and outer hair cell (OHC) motility, the fundamental question

186 n hypothesized to interact with the membrane outer hair cell (OHC) motor protein, prestin on its intr

187 The cylindrical outer hair cell (OHC) of Corti's organ drives cochlear a

188 The outer hair cell (OHC) of the mammalian inner ear exhibit

189 r NO-GC2 did not influence electromechanical outer hair cell (OHC) properties, as measured by distort

190 system plays a role in suppressing cochlear outer hair cell (OHC) responses, particularly for backgr

191 The outer hair cell (OHC) somatic electromotility is a poten

192 Outer hair cell (OHC) somatic motility plays a key role

193 In the outer hair cell (OHC), the extracisternal space (ECiS) i

194 at is enhanced in amplitude and sharpness by outer hair cell (OHC)-based forces.

195 different proportions of prestin-containing outer hair cells (OHC) have on cochlear amplification.

196 Outer hair cells (OHC) possess voltage-dependent membran

197 secreted protein found in mammalian cochlear outer hair cells (OHC) that is a member of the carcinoem

198 Because mammals possess differentiated outer hair cells (OHC), they also benefit from a novel e

199 ctrical potentials in the cochlear ducts and outer hair cells (OHC).

200 he cochlear organ of Corti, particularly the outer hair cells (OHCs) [1]; however, this epithelium is

201 Using both isolated murine outer hair cells (OHCs) and a heterologous expression sy

202 ner pillar cells, and synaptic region of the outer hair cells (OHCs) and Deiters' cells (DCs) by post

203 transport is investigated both in guinea-pig outer hair cells (OHCs) and in an expression system wher

204 tion was observed around postnatal day 14 in outer hair cells (OHCs) and supporting cells surrounding

205 s type II neurons arborize extensively among outer hair cells (OHCs) and supporting cells.

206 compound C attenuated noise-induced loss of outer hair cells (OHCs) and synaptic ribbons, and preser

207 Outer hair cells (OHCs) are a mammalian innovation for m

208 Because outer hair cells (OHCs) are the only cochlear cells affe

209 how that Np55 is expressed in stereocilia of outer hair cells (OHCs) but not inner hair cells and aff

210 hanical activity termed electromotility: its outer hair cells (OHCs) change length upon electrical st

211 Outer hair cells (OHCs) drive cochlear amplification tha

212 Electromotility of outer hair cells (OHCs) has been extensively studied wit

213 In contrast, cochlear outer hair cells (OHCs) have a far weaker effect on thei

214 opy was used to examine efferent synapses of outer hair cells (OHCs) in mice with diminished or enhan

215 nounced reduction of efferent innervation to outer hair cells (OHCs) in the knockout cochleas.

216 ceive glutamatergic synaptic excitation from outer hair cells (OHCs) in the rat cochlea.

217 ermore, the role of afferent transmission in outer hair cells (OHCs) is not understood.

218 s evolved, now serving as a motor protein in outer hair cells (OHCs) of the mammalian inner ear and i

219 aring relies on the mechanosensory inner and outer hair cells (OHCs) of the organ of Corti, which con

220 Outer hair cells (OHCs) power the amplification of sound

221 in mammals depends on sound amplification by outer hair cells (OHCs) presumably by their somatic moti

222 The mammalian outer hair cells (OHCs) provide a positive mechanical fe

223 Outer hair cells (OHCs) provide amplification in the mam

224 ctin/spectrin-based cortical cytoskeleton of outer hair cells (OHCs) regulate their motile responses

225 neurons, with its expression being higher in outer hair cells (OHCs) than inner hair cells.

226 This requires force generation by cochlear outer hair cells (OHCs) to amplify the basilar membrane

227 cochlea is due to active forces delivered by outer hair cells (OHCs) to the cochlear partition.

228 Active force generation by outer hair cells (OHCs) underlies amplification and freq

229 bility and conductance of the MET channel of outer hair cells (OHCs) were reduced.

230 Prestin is the motor protein of cochlear outer hair cells (OHCs) with the unique capability of pe

231 ation stems from the somatic motility of the outer hair cells (OHCs), changes in their length impelle

232 cisplatin toxicity in the inner ear, mainly outer hair cells (OHCs), inner hair cells, stria vascula

233 nstem olivary complex project to and inhibit outer hair cells (OHCs), refining acoustic sensitivity o

234 iverge to contact inner hair cells (IHCs) or outer hair cells (OHCs), respectively.

235 c stimulation, displaces the hair bundles of outer hair cells (OHCs), thereby initiating sensory tran

236 osted by electromechanical forces in sensory outer hair cells (OHCs).

237 s along the cochlear spiral, contacting many outer hair cells (OHCs).

238 mplex required for cochlear amplification in outer hair cells (OHCs).

239 unique amplification process that resides in outer hair cells (OHCs).

240 le row of inner hair cells and three rows of outer hair cells (OHCs).

241 part, through the electromotile response of outer hair cells (OHCs).

242 Mechanosensory outer hair cells play an essential role in the amplifica

243 In its native cochlear outer hair cell, prestin is crucial to the amplification

244 ed high-frequency regions, where the sensory outer hair cells produce force that greatly increases th

245 LC-PK1-CL4 epithelial cells (CL4 cells), the outer hair cell protein prestin showed faithful domain-s

246 Outer hair cells provide amplification within the mammal

247 While it is generally agreed that outer hair cells provide the amplification, two mechanis

248 ctive degeneration of inner hair cells while outer hair cells remain structurally and functionally in

249 Myo15(sh2/sh2) outer hair cells retain a staircase arrangement of the a

250 t kilohertz rates, which is required for the outer hair cells' role as a cochlear amplifier.

251 orm the approximately 11-nM particles in the outer hair cell's basolateral membrane.

252 viable mechanism as it is not limited by the outer hair cell's membrane time constant as previously s

253 First, the phase of the outer hair cell's somatic force with respect to its elon

254 asilar membrane and active feedback from the outer hair cells, sensory-effector cells that detect and

255 In St3gal5(-/-) mice, stereocilia of outer hair cells showed signs of degeneration as early a

256 In contrast, a proportion of alpha10(-/-) outer hair cells showed small ACh-evoked currents.

257 ner hair cell, there are approximately three outer hair cells, so only one-quarter of the hair cells

258 his protein provides the molecular basis for outer hair cell somatic electromotility, which is crucia

259 Prestin drives outer hair cell somatic motility and amplifies mechanica

260 ells and outer pillar cells, which constrain outer hair cells standing on the basilar membrane, cause

261 ea are attributed to amplification involving outer hair cell stereocilia and/or somatic motility.

262 found that the structures that stimulate the outer hair cell stereocilia, the tectorial membrane and

263 stereocilia and progressive degeneration of outer hair cell stereocilia.

264 reveals persistent damage to some surviving outer hair cell stereocilia.

265 ethods, we modeled an inner hair-cell and an outer hair-cell stereocilia bundle and simulated the eff

266 iliary growth and differentiation as well as outer hair cell stereociliary rigidity and organization

267 es ago and derives from the observation that outer hair cell surface area is voltage-dependent.

268 ate Foxo3 and its transcriptional targets in outer hair cell survival after noise damage.

269 ical, stemming from active mechanisms within outer hair cells that amplify the basilar membrane trave

270 rgeted inactivation of prestin, a protein of outer hair cells that generates forces on the basilar me

271 Prestin is the membrane protein in outer hair cells that harnesses electrical energy by cha

272 omechanical transduction process in cochlear outer hair cells that increases hearing sensitivity and

273 logy revealed a significant loss of SGNs and outer hair cells that strongly correlated to the level o

274 tructure in the organ of Corti formed by the outer hair cell, the Deiters cell, and the Deiters cell

275 rs and is responsible for electromotility in outer hair cells, the basis of cochlear amplification in

276 ents have shown a much larger conductance in outer hair cells, the central components of the mammalia

277 iffer gating springs, such as those from rat outer hair cells, the channel must be tethered for all b

278 ity range, depends on mechanical coupling of outer hair cells to the tectorial membrane.

279 n product otoacoustic emissions derived from outer hair cell transduction and decreased suprathreshol

280 cell-type-specific markers revealed that the outer hair cells transiently express Prox1.

281 gests that the high-frequency cut-off of the outer hair cell transmembrane potential in vivo may be n

282 r, type II afferents are weakly activated by outer hair cell transmitter release and are insensitive

283 and hair-bundle motility of the thousands of outer hair cells uniquely found in mammalian cochleae.

284 Thus, the RC corner of a short outer hair cell used for high-frequency amplification do

285 he organ of Corti complex felt by individual outer hair cells varies along the cochlear length.

286 Loss of outer hair cells was evident 1 h after noise exposure in

287 r cells were absent and by P16 all inner and outer hair cells were absent in DTR mice.

288 Physiological properties for the outer hair cells were incorporated, such as the active f

289 The cochleae outer hair cells were reduced from 5-10% at one month to

290 cells and the classic efferent inhibition of outer hair cells were unaffected.

291 expressed in the basal membrane of cochlear outer hair cells where it may mediate K(+) efflux.

292 II spiral ganglion neuron innervation of the outer hair cells, whereas innervation of the inner hair

293 anically active auditory receptor cells, the outer hair cells which amplify the actions of incoming s

294 sensitivity of mammalian hearing depends on outer hair cells which generate forces for amplifying so

295 Outer hair cells, which are thought to mediate the activ

296 onfers electromotility on mammalian cochlear outer hair cells, which is essential for normal hearing

297 sensitivity stems from the active process of outer hair cells, which possess two force-generating mec

298 ical to maintain a stable mechanical link of outer hair cells with the tectorial membrane.

299 de-diuretic combination produced loss of all outer hair cells within 48 hours in both strains.

300 In this case, the absence of outer hair cells would be compatible with overexposure t