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1 inner leaflet and sphingomyelin (SM) in the outer leaflet.
2 phipathic LPS molecules across the OM to the outer leaflet.
3 r translocation of MPD from the inner to the outer leaflet.
4 nd defective redistribution of sterol to the outer leaflet.
5 he induction of inner leaflet domains by the outer leaflet.
6 ria contains lipopolysaccharide (LPS) in the outer leaflet.
7 a unique lipid bilayer containing LPS in its outer leaflet.
8 ation of ceramide within the plasma membrane outer leaflet.
9 cellular envelope and is assembled at the OM outer leaflet.
10 f diblock copolymer and an independent lipid outer leaflet.
11 ation of phospholipids from the inner to the outer leaflet.
12 ted galactosylceramide from the inner to the outer leaflet.
13 ry, with only 2% of the total present in the outer leaflet.
14 f the membrane leading to PS exposure on the outer leaflet.
15 ent NBD-labeled phospholipids exposed to the outer leaflet.
16 leaflet and lipopolysaccharides (LPS) in the outer leaflet.
17 osition mimics the mammalian plasma membrane outer leaflet.
18 end into the hydrocarbon chain region of the outer leaflet.
19 n the inner leaflet and a single site in the outer leaflet.
20 ing a majority of lipopolysaccharides in its outer leaflet.
21 d GM3 (monosialodihexosylganglioside) in the outer leaflet.
22 lipid bilayer with lipopolysaccharide in the outer leaflet.
23 dylcholine (PC) family from the inner to the outer leaflet.
24 formation of nano-clusters of GM3 within the outer leaflet.
25 between the physical states of the inner and outer leaflets.
26 ral perturbation moved through the inner and outer leaflets.
28 ent for PS appearance in the plasma membrane outer leaflet, aminophospholipid translocase activity ul
30 observe an enrichment of cholesterol in the outer leaflet and a general non-ideal lateral mixing of
31 line (POPC) as the predominant lipids in the outer leaflet and dioleoylphosphatidylcholine (DOPC), PO
32 tive pressure in the headgroup region of the outer leaflet and increasing the positive pressure throu
33 distribution with lipopolysaccharides at the outer leaflet and phospholipids (PLs) at the inner leafl
34 composed of lipopolysaccharide (LPS) in the outer leaflet and phospholipids in the inner leaflet.
35 ne, with lipopolysaccharide molecules in the outer leaflet and phospholipids in the inner leaflet.
36 FFA into vesicles containing both FPE in the outer leaflet and pyranine trapped in the inside aqueous
37 species including the glycolipid GM3 in the outer leaflet and the anionic lipid, phosphatidylinosito
40 usion intermediates are shown to have merged outer leaflets and distinct inner leaflets prior to form
43 ght to pass through hemifusion, in which the outer leaflets are fused while the inner leaflets engage
44 and thereby stress small unilamellar vesicle outer leaflets as well as the periphery of intermediate
46 only the outer leaflet of the bilayer, this outer leaflet becomes more ordered, and thus more solid-
50 mbrane of gram-negative bacteria contains an outer leaflet composed of lipopolysaccharide (LPS) that
51 mentioned nonextractable cardiolipin and its outer leaflet composed of trehalose dimycolates, phospha
54 UVs, lateral diffusion in the bSM-containing outer leaflet decreased, whereas that in the DOPC-contai
55 ance of endogenous PS in the plasma membrane outer leaflet detected with fluorescein isothiocyanate-l
60 osphatidylserine (PS) in the plasma membrane outer leaflet during apoptosis, a cell surface change th
61 lasma membrane inner leaflet, appears in the outer leaflet during apoptosis, where it triggers non-in
63 distinct waves, presumably hemifusion of the outer leaflet followed by inner leaflet (core) fusion.
66 y flipped across the liposome bilayer to the outer leaflet in the presence of Mg(2+)-ATP, whereas no
67 The presence of phosphatidylcholine in the outer leaflet increased the cholesterol concentration re
68 At room temperature, SM exchange into the outer leaflet increased the inner leaflet lipid order, s
69 veral assays showed that the ordering of the outer leaflet induced by the presence of SM was not refl
70 osphatidylserine (PS) to the plasma membrane outer leaflet is a nearly universal marker of apoptosis
71 unique asymmetric lipid bilayer in which the outer leaflet is composed of lipopolysaccharide (LPS) an
73 ta-thalassemic RBCs indicates that PS on the outer leaflet is distributed either over the entire memb
76 e outer leaflet of brain SM, which decreased outer-leaflet lateral diffusion, had little effect upon
78 ously defined for erythrocytes, as judged by outer leaflet lipid composition; and plasma membrane out
81 le neutral or cationic lipid was used as the outer leaflet lipid to form an asymmetric lipid bilayer
82 rically perturbed by hydrolyzing 2.5% of the outer leaflet lipid with phospholipase A(2) and removing
83 envelope protein induced mixing of membrane outer leaflet lipids but did not lead to content mixing,
85 stant rafts exhibited a balance of inner and outer leaflet lipids, whereas the Triton X-100 rafts con
92 For asymmetric vesicles containing egg SM, outer-leaflet Lo domains were also depleted in a saturat
93 on-enhanced coupling resulting in inner- and outer-leaflet Lo domains with similar physical propertie
94 t the two populations of cells have distinct outer leaflet membrane compositions with the membranes o
96 nes, communication between inner leaflet and outer leaflet, membrane adhesion, and raft mobility.
97 ted at the cell surface mediated hemifusion (outer leaflet merger) upon low-pH treatment, but only th
98 outer-leaflet diffusion upon introduction of outer-leaflet milk SM or a synthetic C24:0 SM, both of w
99 contrast, in asymmetric vesicles containing outer-leaflet milk SM, which has long acyl chains capabl
100 ed in vesicle fusion is shown here to be (1) outer leaflet mixing accompanied by (2) transient pore f
101 never before been shown to be distinct from outer leaflet mixing, begins simultaneously with, but is
102 and TMA-DPH) were used to detect changes in outer leaflet molecular packing between nonfusing and fu
104 the wedging of its long alpha-helix into the outer leaflet of a membrane may cause curvature and an a
105 ptor, phosphatidylserine translocated to the outer leaflet of apoptotic cell membranes, and CD14 (LPS
106 sequesters cell wall precursors found in the outer leaflet of bacterial plasma membranes, Lipid II an
108 aberrant lipid composition presented on the outer leaflet of cancer cell membranes, which makes the
109 bined enrichment of both these lipids in the outer leaflet of cancer cells is highly significant for
111 1% of the human proteome is anchored to the outer leaflet of cell membranes via a class of glycolipi
112 amine, two aminophospholipids exposed on the outer leaflet of dead and activated cells, has shed new
113 Finally, DMPC-d54 incorporated into the outer leaflet of echinocytic erythrocytes exhibited a ph
114 In contrast, DMPS-d54 incorporated into the outer leaflet of echinocytic erythrocytes was conformati
115 hosphatidylcholine, which is enriched in the outer leaflet of eukaryotic cells, are not well understo
121 phiphile that spontaneously inserts into the outer leaflet of lipid bilayers to bury its hydrophobic
122 atidylethanolamine (FPE) introduced into the outer leaflet of lipid vesicles was used to monitor FFA
124 A(2) rapidly hydrolyzed phospholipids in the outer leaflet of liposomes and proteoliposomes with a ha
125 ing the fraction of NBD-lipid exposed to the outer leaflet of membranes that are impermeant to dithio
127 n, glucose 6-phosphate releases HKI from the outer leaflet of mitochondria; however, the site of gluc
129 eaflet showed that PS already existed in the outer leaflet of null spermatozoa before sperm capacitat
130 ngle layer of WT annexin IV, attached to the outer leaflet of one vesicle, would undergo face-to-face
131 nction in preventing appearance of PS in the outer leaflet of plasma membrane, and ectopic exposure o
132 th lipid compositions typically found in the outer leaflet of plasma membranes induce liquid-ordered
133 containing glycosphingolipids present in the outer leaflet of plasma membranes, are produced at high
134 cyanine lipid analogs in the plasma membrane outer leaflet of RBL mast cells was used to investigate
136 This glycolipid is found exclusively in the outer leaflet of the asymmetric outer membrane (OM), whe
139 increase in the amount of PS exposed on the outer leaflet of the bilayer, and (4) a transient channe
140 g of wt20, which is known to affect only the outer leaflet of the bilayer, this outer leaflet becomes
141 syn penetrates approximately 9-14 A into the outer leaflet of the bilayer, with a substantial portion
145 nzyme from intracellular compartments to the outer leaflet of the cell membrane, where hydrolysis of
146 osphocholine and DiI have been imaged on the outer leaflet of the cell membrane, while phosphocholine
152 dases of prokaryotic organisms reside in the outer leaflet of the cytoplasmic membrane and catalyze t
153 ught to power the extraction of LPS from the outer leaflet of the cytoplasmic membrane and its transp
154 d within a coiled-coil domain of Rz near the outer leaflet of the cytoplasmic membrane and were not a
157 l wall dd-carboxypeptidase, localized in the outer leaflet of the cytosolic membrane of this Gram-neg
159 Kdo) is an essential component of LPS in the outer leaflet of the Gram-negative bacterial outer membr
161 huttling hopanoid virulence factors from the outer leaflet of the inner membrane to the periplasm.
162 e faces, RS is associated primarily with the outer leaflet of the inner segment plasma membrane throu
163 ng conformation with two portals open to the outer leaflet of the membrane and a unique topology of t
165 of phosphatidylserine from the inner to the outer leaflet of the membrane bilayer during platelet ac
166 PS) externalization has been observed on the outer leaflet of the membrane shortly after nsPEF exposu
167 geranyl-geranyl lipid tail of Cdc42 from the outer leaflet of the membrane to the isoprenyl binding s
168 bstrates, phosphatidylserine exposure on the outer leaflet of the membrane, and loss of viability.
169 , translocation of aminophospholipids to the outer leaflet of the membrane, and release of microvesic
170 lipooligosaccharide (LOS) exclusively in the outer leaflet of the membrane, establishes an impermeabl
172 lipid droplets are thought to form from the outer leaflet of the microsomal membrane, the reduction
174 sh chemical treatments accumulate PLs in the outer leaflet of the OM and this disrupts lipopolysaccha
175 oprotein that removes phospholipids from the outer leaflet of the OM of Escherichia coli, increases O
176 ert LPS from the periplasm directly into the outer leaflet of the OM to establish the asymmetry of th
177 assembled with divalent metal cations in the outer leaflet of the OM to form an impervious layer that
178 ransport of misplaced phospholipids from the outer leaflet of the OM to the cytoplasmic membrane (4)
184 Lipid A species comprise the bulk of the outer leaflet of the outer membrane and are produced thr
186 s of lipopolysaccharides that constitute the outer leaflet of the outer membrane in Gram-negative bac
187 e (LPS), a glycolipid that forms most of the outer leaflet of the outer membrane in Gram-negative bac
188 endotoxin) is an essential component of the outer leaflet of the outer membrane of gram-negative bac
189 k, anchors lipopolysaccharide (LPS) into the outer leaflet of the outer membrane of gram-negative bac
190 lipid anchor of a lipopolysaccharide in the outer leaflet of the outer membrane of Gram-negative bac
191 highly acylated saccharolipid located on the outer leaflet of the outer membrane of Gram-negative bac
192 antigen (ECA), a glycolipid situated on the outer leaflet of the outer membrane of members of the fa
194 Similar to most Gram-negative bacteria, the outer leaflet of the outer membrane of Vibrio cholerae i
195 lipid A of the LPS may be inserted into the outer leaflet of the outer membrane through a lateral op
196 ase subunits reveals that they reside on the outer leaflet of the outer membrane under anaerobic cond
197 slocated lipoprotein that is anchored in the outer leaflet of the outer membrane, with its C-terminal
201 lucosamine-based phospholipids that form the outer leaflet of the outer membranes of Gram-negative ba
203 lasma membrane induced exposure of PS on the outer leaflet of the plasma membrane at sites of egress,
204 X2 or tNOX), associated exclusively with the outer leaflet of the plasma membrane at the surface of c
205 ect traversing of CPPs through the uncharged outer leaflet of the plasma membrane bilayer is unlikely
206 ion, we show that coupling may extend to the outer leaflet of the plasma membrane by examining the fl
207 ion with the GM1 ganglioside receptor in the outer leaflet of the plasma membrane in intestinal (HT-2
208 quid disorder heterogeneity of lipids in the outer leaflet of the plasma membrane in live cells.
209 imited exposure of aminophospholipids on the outer leaflet of the plasma membrane is a fundamental fe
210 ellular pool of sphingomyelin present on the outer leaflet of the plasma membrane is not involved in
211 monstrated that the lipid composition of the outer leaflet of the plasma membrane is sufficient for t
212 hatidylethanolamine, that are exposed on the outer leaflet of the plasma membrane of dead and activat
213 PS), 2 phospholipids that translocate to the outer leaflet of the plasma membrane of dead cells, as t
214 agged annexin V to phosphatidylserine in the outer leaflet of the plasma membrane of degranulated mas
215 e the sphingolipids and phospholipids in the outer leaflet of the plasma membrane of living mammalian
217 o remove FM1-43 nonspecifically bound to the outer leaflet of the plasma membrane or extracellular mo
218 d signaling molecules typically float in the outer leaflet of the plasma membrane or freely diffuse a
220 and phosphatidylserine (PS) exposure on the outer leaflet of the plasma membrane preceded loss of PM
221 of unknown function that is retained on the outer leaflet of the plasma membrane when MCs are activa
222 by this flippase causing PS exposure on the outer leaflet of the plasma membrane without disrupting
223 livery of acid sphingomyelinase (ASM) to the outer leaflet of the plasma membrane, and a rapid form o
224 id not interact with liposomes mimicking the outer leaflet of the plasma membrane, but it did induce
225 from the inner (cytoplasmic) leaflet to the outer leaflet of the plasma membrane, delivering Glc2-DA
227 membranes and, most interestingly, with the outer leaflet of the plasma membrane, suggesting a role
235 to selectively oxidize MPD molecules in the outer leaflet of the reconstituted vesicles, we demonstr
237 n of the midspan Arg (694) "snorkels" to the outer leaflet of the viral membrane, the MSD assumes a m
238 ed viruses display phosphatidylserine on the outer leaflet of their membranes, enabling TAM receptor
239 phosphatidylserine (PtdSer) exposure on the outer leaflet of transduced cells triggers their engulfm
240 l-phosphatidylcholine was exchanged into the outer leaflet of vesicles composed of 1,2-dioleoyl-phosp
241 ich the physical properties of the inner and outer leaflets of a bilayer are coupled to one another.
244 hat both vesicle systems fused only when the outer leaflets of both contacting vesicles were perturbe
246 proximately 1:1 if only the PG lipids in the outer leaflets of membranes are accessible to daptomycin
248 through hemifusion, a condition in which the outer leaflets of the bilayers are mixed, but the inner
250 differences in tension between the inner and outer leaflets of the membrane contribute to this proces
251 l cases the solid domains span the inner and outer leaflets of the membrane, suggesting a strong coup
252 In all cases the domains span the inner and outer leaflets of the membrane, suggesting a strong coup
253 ns may even cause the fusion of at least the outer leaflets of the membranes, contributing to the abi
254 nthesizing major components of the inner and outer leaflets of the mycobacterial outer membrane.
255 species are segregated between the inner and outer leaflets of the plasma membrane by ATP-dependent l
256 the context of lipid rafts at the inner and outer leaflets of the plasma membrane, respectively, for
260 ried as glycoproteins and glycolipids on the outer leaflets of their plasma membranes and constitute
261 usion intermediate, a condition in which the outer leaflets of two bilayers are combined and the inne
262 ially binds to mammalian cell membranes, the outer leaflets of which are enriched in sphingomyelin, c
264 s also significantly lower than the D in the outer leaflet or in giant unilamellar vesicles and the d
265 ster, indicative of coupling between SM-rich outer-leaflet-ordered domains and inner-leaflet-ordered
267 gesting that fusion is dependent not only on outer leaflet packing but also on the properties of the
270 aflet lipid composition; and plasma membrane outer leaflet phosphatidylcholine had a significantly lo
272 Furthermore, in all raft preparations, the outer leaflet phospholipid species were significantly di
273 eaflet phospholipids to the pore, but allows outer leaflet phospholipids to bind to a pronounced ridg
274 d transport protein that selectively removes outer leaflet phospholipids to help maintain the essenti
276 asymmetric in labeled lipid by reduction of outer leaflet probe with externally added sodium dithion
278 oon as FPE detects adsorption of FA into the outer leaflet, pyranine detects its movement to the inne
279 eaflet components with IgE-Fc(epsilon)RI and outer leaflet raft components, ganglioside GD1b and glyc
281 ol POPE:POPS inside (SMo/2:1 POPE:POPSi) the outer leaflet SM formed an ordered state with a thermal
282 In other words, ordered state formation by outer-leaflet SM in asymmetric vesicles was not destabil
283 anoparticles was held at a distance from the outer leaflet-solution interface of bilayers containing
286 within the TMD region spanning the vesicle's outer leaflet strongly impairs exocytosis and decelerate
287 characteristic time of lipid mixing between outer leaflets (tau approximately equal to 24 s) was com
288 redistributes lysosomal-derived PS to the PM outer leaflet that leads to membrane expansion and the f
289 ect phospholipid packing modification in the outer leaflet, that is promoted by protonation of cardio
290 e bilayer: upon hemifusion and mixing of the outer leaflets, the DNA-lipid is free to diffuse into th
291 sphingomyelin resided in the plasma membrane outer leaflet; the asymmetry of metabolically active cel
293 ethanolamine and phosphatidylserine from the outer leaflet to the cytosolic leaflet of the plasma mem
294 luorescent PtdIns(3,4)P(2) can flip from the outer leaflet to the inner leaflet of the membrane.
295 diffusion of annular lipids in the inner and outer leaflets was observed and correlated with an asymm
296 (asymmetric) compositions in their inner and outer leaflets were deposited at surface pressures of 20
298 the sum of the molar ratios of the inner and outer leaflets), were characterized before and after bet
299 rom the plasma membrane inner leaflet to the outer leaflet where it triggers recognition and phagocyt
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