ライフサイエンスコーパス: outer nuclear layer

1 ties of the RPE in the presence of an intact outer nuclear layer.

2 aic in both individuals, and thinning of the outer nuclear layer.

3 h low numbers of TUNEL-positive cells in the outer nuclear layer.

4 ses with photoreceptors at all levels of the outer nuclear layer.

5 lular structure and could integrate into the outer nuclear layer.

6 er-specific MRI detected degeneration of the outer nuclear layer.

7 s showed mislocalization of rhodopsin to the outer nuclear layer.

8 e-mediated visual losses and thinning of the outer nuclear layer.

9 ptic terminals are often observed within the outer nuclear layer.

10 d horizontal cells tha HJt extended into the outer nuclear layer.

11 lamination, and nearly complete loss of the outer nuclear layer.

12 ically increased TUNEL-positive cells in the outer nuclear layer.

13 l progenitors migrated from the inner to the outer nuclear layer.

14 the original 12 rows of nuclei remain in the outer nuclear layer.

15 tinal layers or cell number in the inner and outer nuclear layer.

16 inner and outer plexiform layers and in the outer nuclear layer.

17 ng of the external limiting membrane and the outer nuclear layer.

18 ent epithelium disruption and/or loss of the outer nuclear layer.

19 mically distinct and appropriately polarized outer nuclear layer.

20 outer plexiform, and to a lesser extent the outer nuclear layer.

21 with abnormal vasculature extending into the outer nuclear layer.

22 e outer plexiform layer (OPL) and invade the outer nuclear layer.

23 surrogate measure of INL thickness), and the outer nuclear layer.

24 tinas, but accurately detected the undamaged outer nuclear layer.

25 e presence of a single layer of cones in the outer nuclear layer.

26 rosensory retina between outer plexiform and outer nuclear layers.

27 ear layer and ferritin to both the inner and outer nuclear layers.

28 ficantly lower cell numbers in the inner and outer nuclear layers (85.1% +/- 4.6%, P < 0.05 and 81.4%

29 A population of proliferating cells in the outer nuclear layer accompanies photoreceptor death alon

30 subretinal deposits that extend through the outer nuclear layer, affect photoreceptor integrity, and

31 shows a retraction of rod spherules into the outer nuclear layer and a sprouting of rod bipolar cell

32 euronal progenitor cells that migrate to the outer nuclear layer and become rod precursor cells that

33 evidence of being able to integrate into the outer nuclear layer and differentiate into new photorece

34 s they showed focal areas of thinning of the outer nuclear layer and disruption of photoreceptors.

35 howed the presence of pyknotic nuclei in the outer nuclear layer and disruption of the normal organiz

36 eceptor outer segments extending through the outer nuclear layer and even beyond the outer limiting m

37 er plexiform layer, inner nuclear layer, and outer nuclear layer and in pericytes of postdevelopment

38 The outer nuclear layer and inner retinal thicknesses were n

39 Hsp70 immunoreactivity was restricted to the outer nuclear layer and inner segments of the retina.

40 Cfh(-/-) mice, and transgenics had a thicker outer nuclear layer and less sub-retinal pigment epithel

41 %) ERMs were associated with widening of the outer nuclear layer and loss of the foveal depression.

42 rhodopsin transgene lost the entire retinal outer nuclear layer and no longer responded to illuminat

43 lines showed focal areas of thinning of the outer nuclear layer and numerous photoreceptors with fra

44 difference in the thickness of the combined outer nuclear layer and outer plexiform layer when we co

45 o 21 days, all retinal layers apart from the outer nuclear layer and retinal pigment epithelium (RPE)

46 veola, especially the separation between the outer nuclear layer and the Henle fiber layer.

47 nuclear layer; the hypointense layer 2, the outer nuclear layer and the inner and outer segments; an

48 In addition, cone opsin mislocalized to the outer nuclear layer and the outer plexiform layer in the

49 one cells, with additional costaining in the outer nuclear layer and the synaptic region.

50 s bounding the retina, but not the avascular outer nuclear layer and the vitreous.

51 yclase (sGC), was in somata in the inner and outer nuclear layers and in both plexiform layers.

52 layer, inner plexiform layer, and inner and outer nuclear layers and within the spindle-shaped cell

53 w localized rosette-like arrangements in the outer nuclear layer, and develop abnormal vascularizatio

54 that continue to proliferate, migrate to the outer nuclear layer, and differentiate into photorecepto

55 x is expressed by both rods and cones in the outer nuclear layer, and in cells in the outer zone of t

56 tal cell and bipolar cell processes into the outer nuclear layer, and mislocalized synaptic complexes

57 r plexiform layer, loss of regularity of the outer nuclear layer, and shortening of the inner/outer s

58 tected in the ganglion cell layer, inner and outer nuclear layers, and inner segments of photorecepto

59 erties of reflections from ganglion cell and outer nuclear layers are indeterminate.

60 cell layer and subsequently in the inner and outer nuclear layer, associated with loss of RGCs and am

61 A spike in apoptosis was observed in KO outer nuclear layer at P25.

62 t of apoptotic activity in the photoreceptor outer nuclear layer at postnatal week 2 and highly disor

63 0 mutations trended to have retention of the outer nuclear layer at the fovea and macular thickening,

64 prior studies used hosts with a preexisting outer nuclear layer at the time of treatment.

65 After birth the foveal outer nuclear layer became much thicker as cone packing

66 t HCs form ectopic synapses with rods in the outer nuclear layer but lack bipolar dendrites.

67 zed with arrestin1 in the inner segments and outer nuclear layer, but remained in the inner segments

68 Reduction in outer nuclear layer cell counts and thickness were also

69 ment epithelial cell integrity and prevented outer nuclear layer cell death as examined by histopatho

70 sence of nearly all differentiated inner and outer nuclear layer cell types.

71 in the number of photoreceptor nuclei in the outer nuclear layer compared with WT controls.

72 matory cells progressively accumulate in the outer nuclear layer concurrently with photoreceptor dege

73 In Aipl1(-/-) retinas, the outer nuclear layer develops normally, but rods and cone

74 id lesions revealed hyperreflectivity of the outer nuclear layer; disruption of the external limiting

75 ei to migrate towards the apical side of the outer nuclear layer during early postnatal retinal devel

76 CT, acute retinal changes in PPM involve the outer nuclear layer, external limiting membrane, ellipso

77 immunoreactivity in the plexiform layers and outer nuclear layer fell into at least three patterns de

78 rm layer for Kv1.1, more concentrated in the outer nuclear layer for Kv2.1, and uniform throughout fo

79 When integrated into the host outer nuclear layer, grafted cells emanated elaborate, a

80 ptors, whose nuclei are scattered across the outer nuclear layer, had no effect on the positioning of

81 gy in the deeper retinal layers, such as the outer nuclear layer, has not been previously described i

82 r in 3 (19%), and loss of ellipsoid zone and outer nuclear layer in 3 (19%).

83 UDCA treatment preserved ERG b-waves and the outer nuclear layer in Bbs1(M390R/M390R) mice, and preve

84 opy showed a substantial preservation of the outer nuclear layer in most parts of the treated retina

85 he thickness or histologic appearance of the outer nuclear layer in retinas of mice with wild-type or

86 o mature and remain as immature cells in the outer nuclear layer in the adult.

87 The width of the outer nuclear layer in the area receiving RPE transplant

88 focal preservation of the ellipsoid zone and outer nuclear layer in the fovea.

89 arkers mislocalize to the inner segments and outer nuclear layer in the Nphp4(nmf192/nmf192) mutant r

90 UDCA treatment preserved ERG b-waves and the outer nuclear layer in the rd10 mice to P30.

91 of a population of stem cells located in the outer nuclear layer in the retina of the adult teleost H

92 eptor inner and outer segments and a thicker outer nuclear layer in the T17M mice but had no effect o

93 ckness of the whole retina and the inner and outer nuclear layers in mice that had been diabetic for

94 , evident in the loss of their somata in the outer nuclear layer, in their processes in the outer ple

95 event in CCDKO mice develops in the inferior outer nuclear layer independently of light around postna

96 g of horizontal and bipolar cells toward the outer nuclear layer indicating impaired rod transmitter

97 s expressed in the retina, especially in the outer nuclear layer, inner nuclear layer, and photorecep

98 rameric arrestin 1 (tet-ARR1), stored in the outer nuclear layer/inner segments in the dark, modulate

99 Significant retinal thinning and outer nuclear layer loss occurred in Rpe65(-)(/-)/Nrl(-)

100 acular outer plexiform layer (mOPL), macular outer nuclear layer (mONL), photoreceptors (PR), and ret

101 ayer (n = 1), outer plexiform layer (n = 4), outer nuclear layer (n = 12), or inner segment/outer seg

102 TUNEL-positive outer nuclear layer nuclei were most frequently observed

103 ayer, additional expression was noted in the outer nuclear layer of experimental animals.

104 otoreceptors nuclei at the outer edge of the outer nuclear layer of mammalian retinas.

105 tly known if a degenerate retina lacking the outer nuclear layer of photoreceptor cells would allow t

106 ranscription factor that is expressed in the outer nuclear layer of the embryonic retina.

107 Expression of NR2E3 was limited to the outer nuclear layer of the human retina.

108 rity of apoptotic cells were observed in the outer nuclear layer of the infected retina.

109 onstrated the presence of Plk1s1 mRNA in the outer nuclear layer of the mouse retina.

110 x-positive donor cells integrated within the outer nuclear layer of the recipient and differentiated

111 g of rd7 tissue shows that the whorls in the outer nuclear layer of the retina do not appear during e

112 man retinal lysates and was localized to the outer nuclear layer of the retina in me(v)/me(v) and con

113 The thickness of the outer nuclear layer of the retina was used as the quanti

114 e had significantly fewer cell bodies in the outer nuclear layer of the retina, a larger reduction in

115 , and human is expressed in the cells of the outer nuclear layer of the retina, one of the target tis

116 annel, is predominantly expressed within the outer nuclear layer of the retina.

117 ular, rosette-like structures located in the outer nuclear layer of the retinae of the 4 older patien

118 mRNA was expressed in cells in the inner and outer nuclear layers of diabetic retinas, but not in nor

119 No pathology was seen in the inner or outer nuclear layers of eyes with optic neuritis, sugges

120 became distributed throughout the inner and outer nuclear layers of the retina, and remained for at

121 s of RPE loss on the same day, and a reduced outer nuclear layer on day 7.

122 Abnormal cells were seen in the outer nuclear layer on P10 and among photoreceptors on P

123 f RPE loss occurred on day 14 with a reduced outer nuclear layer on the same day.

124 lly), inner plexiform layer (IPL) (nasally), outer nuclear layer (ONL) (nasally), and inner segment (

125 ologically by measuring the thickness of the outer nuclear layer (ONL) and functionally by electroret

126 -OCT acquisition, the boundaries between the outer nuclear layer (ONL) and Henle's fiber layer (HFL)

127 When the rats were 12 weeks of age, outer nuclear layer (ONL) and inner nuclear layer (INL)

128 Ellipsoid zone (EZ) width (EZW) and outer nuclear layer (ONL) and inner retinal layer (IRL)

129 Overall retinal thickness and outer nuclear layer (ONL) and inner retinal parameters a

130 ns, which were generally more intense in the outer nuclear layer (ONL) and less intense in the intern

131 .1 log cd-s/m2 flash, and morphometry of the outer nuclear layer (ONL) and rod outer segments (ROS).

132 light, the CD11b(+) microglial cells in the outer nuclear layer (ONL) and subretinal space in the mi

133 Electroretinograms were recorded, and the outer nuclear layer (ONL) and the choroidal thickness an

134 Measurements of the width of the outer nuclear layer (ONL) and the length of rod photorec

135 o or stimulated Muller cell migration to the outer nuclear layer (ONL) and to differentiate into phot

136 reduction in whole retinal thickness and the outer nuclear layer (ONL) at 3 and 8 weeks (P < 0.05), a

137 increased apoptotic nuclei in their retinal outer nuclear layer (ONL) at postnatal day (P) 22.

138 x35/36-positive plaques were detected in the outer nuclear layer (ONL) between neighboring rods, and

139 There were significant correlations between outer nuclear layer (ONL) cell counts and ERG contrast g

140 One month after separation, outer nuclear layer (ONL) cell counts were significantly

141 ssive rod outer segment (ROS) shortening and outer nuclear layer (ONL) cell loss with age.

142 on places donor cells beneath an intact host outer nuclear layer (ONL) containing host photoreceptors

143 g cells were virtually never detected in the outer nuclear layer (ONL) from ED 4 to postnatal day 2.

144 er segment (IS/OS) band, and thinning of the outer nuclear layer (ONL) have been identified in associ

145 uclear layer (INL) in all 11 eyes and in the outer nuclear layer (ONL) in 4 eyes.

146 on with disorganized POS and thinning of the outer nuclear layer (ONL) in addition to the anomaly at

147 of the outer plexiform layer (OPL) into the outer nuclear layer (ONL) in aged retinas.

148 With OCT there were small foveal islands of outer nuclear layer (ONL) in those with preserved acuity

149 Rod a-waves and rod and cone b-waves and outer nuclear layer (ONL) morphology were evaluated at 2

150 The outer nuclear layer (ONL) of 1-month-old Rs1h-KO mice wa

151 ded in the measurement, the thickness of the outer nuclear layer (ONL) of central horizontal B-scans

152 The outer nuclear layer (ONL) of KO retinas became 20% thinn

153 hT17M Rho was localized in the outer nuclear layer (ONL) of T17M(+/-)ERAI(+/-) photorec

154 TUNEL-positive cells were found within the outer nuclear layer (ONL) of the detached portions of th

155 bel a subpopulation of photoreceptors in the outer nuclear layer (ONL) of the mouse retina in additio

156 rites and horizontal cell processes into the outer nuclear layer (ONL) of the nob2 retina and to the

157 d precursors were able to integrate into the outer nuclear layer (ONL) of the Rd9 retina.

158 The outer nuclear layer (ONL) of the retina was no longer a

159 numerous immature rods were observed in the outer nuclear layer (ONL) of transgenic adults.

160 By postnatal day (PD)20, the outer nuclear layer (ONL) retained only 1 to 2 rows of n

161 , there were small foveal islands of thinned outer nuclear layer (ONL) surrounded by thick delaminate

162 OFL and OPL and in numerous processes in the outer nuclear layer (ONL) that ended at the outer limiti

163 ce was determined by measuring photoreceptor outer nuclear layer (ONL) thickness and electroretinogra

164 e taken for histology at each time point and outer nuclear layer (ONL) thickness determined.

165 6a-rd3/rd3 strains were measured for retinal outer nuclear layer (ONL) thickness from 5 to 12 weeks o

166 s in qAF, A2E bisretinoid concentration, and outer nuclear layer (ONL) thickness in mice of different

167 Outer nuclear layer (ONL) thickness in T(-/-) mice was -

168 litudes were recorded after OKT testing, and outer nuclear layer (ONL) thickness measurements were th

169 r death, one eye was fixed and processed for outer nuclear layer (ONL) thickness measurements.

170 s significant reduction of the photoreceptor outer nuclear layer (ONL) thickness overlying 92% of the

171 Outer nuclear layer (ONL) thickness was mapped topograph

172 Foveal and outer nuclear layer (ONL) thickness was measured and pre

173 Outer nuclear layer (ONL) thickness was measured from fl

174 To assess retinal damage, outer nuclear layer (ONL) thickness was measured on hema

175 tween cone photoreceptor packing density and outer nuclear layer (ONL) thickness within the central 1

176 nick-end labeling (TUNEL) and measurement of outer nuclear layer (ONL) thickness.

177 measurement of inner nuclear layer (INL) and outer nuclear layer (ONL) thickness.

178 uclear layer, inner nuclear layer (INL), and outer nuclear layer (ONL) thicknesses; and horizontal ex

179 The outer nuclear layer (ONL) thinned with eccentricity and

180 gnificantly blocked photoreceptor apoptosis, outer nuclear layer (ONL) thinning, and retinal gliosis.

181 jority of Muller glia nuclei migrated to the outer nuclear layer (ONL) to divide.

182 umber of rows of photoreceptor nuclei in the outer nuclear layer (ONL) was significantly higher in th

183 Finally, cells in the outer nuclear layer (ONL) were ChAT-IR during the embryo

184 o-/- hosts, there was rescue of cells in the outer nuclear layer (ONL), along with widespread integra

185 junction, external limiting membrane (ELM), outer nuclear layer (ONL), and outer plexiform layer (OP

186 cell layer (GCL), inner nuclear layer (INL), outer nuclear layer (ONL), and retinal vessels, after la

187 Photoreceptor nuclei were counted in the outer nuclear layer (ONL), and the thickness of the ONL

188 photoreceptor inner-outer segment junction), outer nuclear layer (ONL), and total retinal thickness w

189 rminal zone (CGZ); and rod precursors in the outer nuclear layer (ONL), both of which have been well

190 The internal limiting membrane, outer nuclear layer (ONL), external limiting membrane (E

191 Cell nuclei in the outer nuclear layer (ONL), inner nuclear layer (INL), an

192 ome PSD95 and mGluR6 was mislocalized in the outer nuclear layer (ONL).

193 performed by counting rows of nuclei in the outer nuclear layer (ONL).

194 layer (RGCL), inner nucleus layer (INL), and outer nuclear layer (ONL).

195 dpf; after 14 dpf, it was restricted to the outer nuclear layer (ONL).

196 inner nuclear layer and then migrate to the outer nuclear layer (ONL).

197 E16, nlacZ staining was also detected in the outer nuclear layer (ONL).

198 hotoreceptor cells and gross deficits in the outer nuclear layer (ONL).

199 he periphery of the mature retina and in the outer nuclear layer (ONL).

200 ong the cell bodies of photoreceptors in the outer nuclear layer (ONL).

201 progenitor cells which divide throughout the outer nuclear layer (ONL).

202 of the outer segments plus RPE (OS+) and the outer nuclear layer (ONL).

203 TUNEL-staining was positive in the outer nuclear layer only in the detached portions of the

204 lion cell complex (GCC), and some sectors of outer nuclear layer (P- values </=0.05) was found with n

205 Patients with inner and outer nuclear layer pathology have more rapid disability

206 layer (OPL), and outer retinal complex (ORC; outer nuclear layer + photoreceptor layer).

207 layer, and some plaques were observed in the outer nuclear layer, photoreceptor outer segment, and op

208 crine cells) and distal part of neuroblastic/outer nuclear layer (photoreceptors).

209 inal thickness, inner retinal thickness, and outer nuclear layer plus Henle fiber layer (ONL+HFL) thi

210 ocations at which the outer segment (OS) and outer nuclear layer plus outer plexiform layer (ONL+) th

211 The thicknesses of the outer nuclear layer plus outer plexiform layer (ONL+), o

212 knesses of the outer segment (OS) layer, the outer nuclear layer plus outer plexiform layer (ONL+), t

213 cal evaluation revealed complete loss of the outer nuclear layer, remodeling of the inner retina, los

214 Progressive thinning of the photoreceptor outer nuclear layer resulted from apoptotic cell death.

215 The lesions extended to the outer nuclear layer, resulting in focal retinal degenera

216 )Grk1(-/-) exhibit a progressive loss of the outer nuclear layer, retinal physiology deficits, and a

217 , then the inner nuclear layer, and then the outer nuclear layer, so cell birthday and cell fate were

218 slabs of choriocapillaris flow (CC-slab) or outer nuclear layer structure (ONL-slab) were generated

219 ld increase in FGFR1 immunoreactivity in the outer nuclear layer that persists for at least 7 days; a

220 Retinal damage was assessed by measuring outer nuclear layer thickness and by electroretinogram (

221 darkness was evaluated by quantification of outer nuclear layer thickness and by electroretinography

222 m LIRD, producing significant improvement in outer nuclear layer thickness and ERG activity.

223 HL+rho+/-, and GHL+rho-/-) were examined for outer nuclear layer thickness and outer segment formatio

224 Cell death peaked at 1 day, and outer nuclear layer thickness declined from 1 to 5 days.

225 uantified histologically by obtaining a mean outer nuclear layer thickness for each animal.

226 DGF1-326 significantly increased the retinal outer nuclear layer thickness from 6.34 +/- 1.6 to 11.7

227 Outer nuclear layer thickness in CNGA3-/- retina was red

228 sections were examined by TUNEL staining and outer nuclear layer thickness measurements.

229 Histological studies showed that the outer nuclear layer thickness was dramatically reduced i

230 er, after 2 weeks of exposure to 75% oxygen, outer nuclear layer thickness was significantly reduced

231 ut to 1040 mum allowed the quantification of outer nuclear layer thickness, a direct correlate of pho

232 otoreceptor cell layer with variable loss of outer nuclear layer thickness.

233 and USH2A shared the abnormality of loss of outer nuclear layer thickness.

234 was assessed by TUNEL and measurement of the outer nuclear layer thickness.

235 Inner and outer nuclear layer thicknesses in patients with non-mac

236 Mean outer segment lengths and outer nuclear layer thicknesses were analyzed as a funct

237 Amelioration of outer nuclear layer thinning indicated that vitamin E tr

238 fluorescence, decreased HPLC-quantified A2E, outer nuclear layer thinning, and increased methylglyoxa

239 An outer nuclear layer three to four profiles thick was pre

240 number of photoreceptor nuclei spanning the outer nuclear layer throughout postnatal retinal develop

241 outer retinal loss, generally involving the outer nuclear layer to photoreceptors, occasionally with

242 The identity of proliferating cells in the outer nuclear layer was established by double immunolabe

243 ths, the loss of photoreceptor nuclei in the outer nuclear layer was further accentuated and the numb

244 At P21, the outer nuclear layer was markedly reduced in rd mice or Q

245 The width of the outer nuclear layer was measured in the area of transpla

246 on day 21, but no significant damage to the outer nuclear layer was observed.

247 months, the number of photoreceptors in the outer nuclear layer was reduced by 50%.

248 At this age, the outer nuclear layer was reduced to a single row of photo

249 ally, outer segments were preserved, and the outer nuclear layer was significantly thicker in the tre

250 After 2 months, the outer nuclear layer was significantly thicker, and the p

251 tal schedule of opsin gene expression in the outer nuclear layer was similar to normal, and that it w

252 uter segments (ROS) and the thickness of the outer nuclear layer were determined histologically.

253 es (33.3%), and hyperreflective spots in the outer nuclear layer were observed in 5 eyes (16.7%).

254 receptor outer segments and reduction of the outer nuclear layer were present overlying areas of neov

255 d significant thinning of both the inner and outer nuclear layers, when compared with other patients

256 n the outer plexiform layer to innervate the outer nuclear layer where they appeared to form contacts

257 S length equals peripheral; on SDOCT, foveal outer nuclear layer (which includes HFL) and IS/OS thick

258 e disproportionate thinning of the inner and outer nuclear layers, which may be occurring as a primar

259 hs of age, resulting in a thinner but intact outer nuclear layer with residual cones expressing S- an

260 ho-GFP mislocalizes to the inner segment and outer nuclear layer, with only approximately 20% in rod