ライフサイエンスコーパス: outer segment

1 ide of the inner segment, directly below the outer segment.

2 ble for blocking the movement of PDE6 to the outer segment.

3 but had little efficacy when applied to the outer segment.

4 accumulates either in the cone cell body or outer segment.

5 e sensory cilium of photoreceptor cells, the outer segment.

6 y can be sorted for specific delivery to the outer segment.

7 t and GDP-locked mutants concentrated in the outer segment.

8 or cells shed approximately a tenth of their outer segment.

9 on surrounding the base of the photoreceptor outer segment.

10 d inner retina but an abnormal photoreceptor outer segment.

11 ostasis in the vicinity of the photoreceptor outer segment.

12 lding and trafficking to the photoreceptor's outer segment.

13 ing their transport to the rod photoreceptor outer segment.

14 ly through phagocytosis of the photoreceptor outer segments.

15 s responsible for removing Ca(2+) from their outer segments.

16 did not prevent rhodopsin trafficking to rod outer segments.

17 iated proteasomal degradation at the base of outer segments.

18 necessary for the formation of rod and cone outer segments.

19 ncodes a protein localizing to photoreceptor outer segments.

20 able to traffic effectively to the Rp2h(-/-) outer segments.

21 GRK1 to their destination, the photoreceptor outer segments.

22 under some circumstances, of generating new outer segments.

23 eptor cell death, and reduced lengths of rod outer segments.

24 hyporeflective spaces at the level of absent outer segments.

25 n addition to its normal localization to the outer segments.

26 nal defects in phagocytosis of photoreceptor outer segments.

27 peared dim, suggesting loss of photoreceptor outer segments.

28 rs is contained within the membrane discs of outer segments.

29 , photoreceptor terminals, and photoreceptor outer segments.

30 with peanut agglutinin to the Irbp(-/-) cone outer segments.

31 ht exposure quickly translocates them to the outer segments.

32 axonemes and basal bodies characteristic of outer segments.

33 lly active despite having lost most of their outer segments.

34 increased structural instability of the rod outer segments.

35 uorescent annuli surrounding individual cone outer segments.

36 e for the ABCA4 transporter in photoreceptor outer segments.

37 itating rhodopsin transport to photoreceptor outer segments.

38 function and abnormally shaped photoreceptor outer segments.

39 interface between the RPE and photoreceptor outer segments.

40 glycolytic pathway impacted the size of the outer segments.

41 for normal trafficking of cone opsins to the outer segments.

42 te previous reports of diffuse photoreceptor outer segment abnormalities in BVMD, our data reveal nor

43 yer corresponding to photoreceptor inner and outer segments above drusen was also reduced, and the re

44 ansion of Abca4(-/-)Rdh8(-/-) mouse rod cell outer segments accompanied by macrophage infiltration af

45 ween RPE apical microvilli and photoreceptor outer segments also declined during peak adhesion in all

46 AOSLO imaging showed repopulation of cone outer segments, although their density remained below no

47 that acts as a diffusion barrier between the outer segment and cell body.

48 s, including disruption of the inner segment/outer segment and outer segment/retinal pigment epitheli

49 ever, S-opsin trafficked normally to the rod outer segment and produced functional S-pigment upon sub

50 geting information that excludes it from the outer segment and that this information is overridden by

51 acute vision loss to the cone photoreceptor outer segment and will refocus the search for the cause

52 eonatal retina leads to defects in inner and outer segments and axon terminals of photoreceptors.

53 structures that distorted rod photoreceptor outer segments and became more prominent with age.

54 Rpgrip1homozygous mutants do not form rod outer segments and display mislocalization of rhodopsin,

55 e shown that RDH8 localizes to photoreceptor outer segments and is a strong candidate for performing

56 -one match between sites of formerly missing outer segments and new outer segments that had appeared

57 knockdown of rab11a in rods led to shortened outer segments and retinal degeneration.

58 the retinal nerve fiber layer, photoreceptor outer segments and retinal pigment epithelium show promi

59 nerve fiber layer's features, photoreceptor outer segments and retinal pigment epithelium when 23 di

60 usen complex includes the interdigitation of outer segments and RPE apical processes and SDD in eyes

61 rmal retinal histology, normal morphology of outer segments and RPE cells, and no evidence of photore

62 PDE6H in murine eyes was restricted to both outer segments and synaptic terminals of short and long/

63 livered M-opsin localizes in the dorsal cone outer segments, and co-localizes with S-opsin in the ven

64 end transition zones (connecting cilia) with outer segments, and visual pigments mistrafficked.

65 , reduced levels of rhodopsin, disrupted rod outer segments, and widespread accumulation of the typic

66 Outer segments appeared rapidly at postnatal day six and

67 the optical path length of the photoreceptor outer segment as a response to an optical stimulus in th

68 in protein trafficking across the CC to the outer segments, as we identified that rhodopsin accumula

69 st, their anchor protein R9AP remains in the outer segment at all times.

70 nstate phagocytosis of labeled photoreceptor outer segments at a reduced, but significant level.

71 nd that tagged KIF17 localized along the rod outer segment axoneme when expressed in mouse and X. lae

72 microvillus-like calyceal processes and the outer segment basolateral region in rods and cones.

73 nerate retinas of adult mice and mature into outer segment-bearing photoreceptors.

74 Defects in outer segment biogenesis were evident with Dnmt1 exon ex

75 ceptors in mice rely on glycolysis for their outer segment biogenesis.

76 inner segment ellipsoid zone (EZ; ie, inner/outer segment border) in the context of short-term varia

77 vision from being a visual pigment and major outer segment building block to directing trafficking of

78 rinsic instability and long half-life in the outer segment, but also highlights the potential of alte

79 uccessfully enhanced P23H traffic to the rod outer segment, but this led to reduced photoreceptor fun

80 oreceptors developed more distinct inner and outer segments, but these were longer on peripheral than

81 s, all-trans-retinal, is released in the rod outer segment by photoactivated rhodopsin after light ex

82 Ca(2+) ions have distinct roles in the outer segment, cell body, and synaptic terminal of photo

83 tion, leading to the positioning of the cone outer segment closer to the retinal pigment epithelium.

84 ce of CNGB3, CNGA3 was able to travel to the outer segments, co-localize with cone opsin, and form te

85 ptor layer and better targeting of opsins to outer segments compared with sham-treated eyes.

86 transducin undergoes translocation from the outer segment compartment, which results in the uncoupli

87 Outer segment components are transported from the site o

88 wever, all-trans-retinal can also react with outer segment components, sometimes forming lipofuscin p

89 at a rate approximately proportional to its outer segment concentration, and that activation of phos

90 que, right circular conical geometry of cone outer segments (COSs) in Xenopus laevis and other lower

91 Rod outer segments could be identified by the CARS signal fr

92 Photoreceptor outer segment degeneration was evident, with a significa

93 es rhodopsin for intracellular stability and outer segment delivery.

94 hat visual pigments transport to the retinal outer segment despite removal of KIF3 and IFT88, and KIF

95 owever, the photoreceptors completely lacked outer segments despite near normal expression of phototr

96 Loss in the photoreceptor outer segment detected by SD-OCT co-localized with an ar

97 ion in homozygotes with a loss of proper rod outer segment development and improper disc formation.

98 r data indicate RPGRIP1 is necessary for rod outer segment development through regulating ciliary pro

99 transduction, the retinoid cycle, cilia, and outer segment development.

100 dvanced maturation, showing the beginning of outer-segment disc formation and photosensitivity.

101 rticular the presence of photoreceptors with outer-segment discs and light sensitivity.

102 Rod outer-segment discs were not essential and developed aft

103 shape the high-curvature rim domains of the outer segment disk and suggests that the protein's C ter

104 eceptors does not affect the localization of outer segment disk membrane proteins, such as rhodopsin,

105 ization at the high-curvature rim domains of outer segment disk membranes suggests that it may act to

106 letion of NCKX1 in mice results in malformed outer segment disks, suppressed expression and function

107 into account the spatial organization of the outer segment divided into compartments, together with m

108 nsory cilium is subdivided into an inner and outer segment, each containing specific proteins essenti

109 The intensity of inner segment/outer segment (ellipsoid zone line) reflectivity was red

110 at disruption of photoreceptor inner segment-outer segment (ellipsoid) layer on SD-OCT and reduced ER

111 of key photoreceptor genes underlies delayed outer segment elongation and possibly mispositioning of

112 ubjects, there was a significant decrease in outer segment equivalent length (OSEL) of -2.14 mum (95%

113 en were deposits juxtaposed to photoreceptor outer segments extending through the outer nuclear layer

114 omes in building the elaborate photoreceptor outer segment filled with hundreds of tightly packed "di

115 vels of all-trans-retinal and retinol in rod outer segments following light exposure.

116 mulates a reduction via translocation to the outer segments for terminating G-protein coupled phototr

117 ephrocystin-5 is essential for photoreceptor outer segment formation but is dispensable for kidney an

118 Prph2 cannot form the complexes required for outer segment formation, and in cones cannot interact wi

119 protein is required for mouse photoreceptor outer segment formation.

120 diurnal phagocytosis of spent photoreceptor outer segment fragments.

121 were macular hole size, FAF patterns, retina outer segment from OCT, and BCVA before and after operat

122 mistry required by such large differences in outer segment geometry, we developed a computational app

123 ess, presence of the inner nuclear layer and outer segment, gestational age at birth, sex, spherical

124 processes from the early embryonic stages of outer segment growth onwards.

125 when added to metabolically compromised rod outer segments; however, it was only 11-cis-retinal that

126 eported to translocate from the inner to the outer segment in bright light, but we saw effects on res

127 the basolateral region of the photoreceptor outer segment in humans, and that defects in this struct

128 information and instead is delivered to the outer segment in the same post-Golgi vesicles as rhodops

129 The lack of outer segments in mutant cones indicates a ciliary dysfu

130 embrane interfaces (i) between the inner and outer segments in rods and (ii) between the microvillus-

131 thalmoscope (AOSLO) showed depletion of cone outer segments in the affected retina.

132 G protein-coupled receptor found in the rod outer segments in the retina, which triggers a visual re

133 tofluorescence of phagocytosed photoreceptor outer segments increased by lysosomal alkalinization was

134 tol-3-phosphate (PI(3)P) levels in rod inner/outer segments increased more than 30-fold after light e

135 cesses and had no USH1 proteins at the inner-outer segment interface.

136 an 2 weeks, a time interval during which the outer segment is completely renewed.

137 umulation of transducin alpha subunit in the outer segment is driven by its re-binding to the transdu

138 Phagocytosis of daily shed photoreceptor outer segments is an important function of the retinal p

139 ught that the concentration of Ca(2+) in rod outer segments is controlled by a dynamic balance betwee

140 s, the mechanism for its extrusion from cone outer segments is not well understood.

141 d location of cystoid changes, inner segment-outer segment (IS-OS) continuity, quantity and location

142 ivity over lesions with intact inner segment-outer segment (IS-OS) junction was 13.35 +/- 3.75 dB and

143 hy (SD-OCT), disruption of the inner segment/outer segment (IS/OS) band, and thinning of the outer nu

144 egardless of the photoreceptor inner segment/outer segment (IS/OS) condition.

145 the integrity of photoreceptor inner segment/outer segment (IS/OS) junction and external limiting mem

146 025), initial BCVA (P = .002), and inner and outer segment (IS/OS) junction disruption on spectral-do

147 OCT scans showed disruption of inner segment/outer segment (IS/OS) junction in 54.6% of eyes, a sligh

148 ed a loss of the photoreceptor inner segment/outer segment (IS/OS) junction in the central retina, wh

149 demonstrated visibility of the inner segment/outer segment (IS/OS) junction, external limiting membra

150 ment epithelium (RPE), and inner segment and outer segment (IS/OS) junction.

151 d parafoveal loss of the photoreceptor inner/outer segment (IS/OS) junction.

152 of examples in which the photoreceptor inner/outer segment (IS/OS) junctions lost reflectivity at the

153 for the formation of their light sensor, the outer segment, is not well understood.

154 8%), photoreceptor loss (43%), inner segment-outer segment junction (IS-OS) irregularity (37%), IS-OS

155 ter nuclear layer (n = 12), or inner segment/outer segment junction (n = 1).

156 Preoperative features of the inner/outer segment junction correlate well with improvement o

157 ERM (P = .003), and foveal inner segment and outer segment junction disruption (P = .006) were associ

158 The inner segment-outer segment junction or the inner segment ellipsoid ba

159 ized loss of the photoreceptor inner segment/outer segment junction was seen more frequently on extra

160 Focal loss of the inner segment/outer segment junction was seen most commonly on inferio

161 valuation of the photoreceptor inner segment/outer segment junction, using this approach, may be of v

162 in the IPL (P = 0.004), OPL (P < 0.003), and outer segment layer (P </= 0.02), and severe ganglion ce

163 an inflammatory lesion in the photoreceptor outer segment layer displacing ELM.

164 hyper-reflective lesion at the photoreceptor outer segment layer disrupting the ellipsoid zone (EZ) a

165 ers was comparable with those of adults, the outer segment layer was 36% thinner in children than in

166 ith concomitant defects of the inner segment/outer segment layer.

167 grees of the fovea, and the foveal inner and outer segment layers were significantly thinner than nor

168 Foveal inner and outer segment length matched peripheral cones by 15 mont

169 ure retina, including exuberant outgrowth of outer segment-like structures and synaptic ribbons, phot

170 The advanced outer segment-like structures reported here support the

171 In all patients, a disrupted inner segment/outer segment line and the external limiting membrane we

172 midperipheral retina, the rod inner segment/outer segment line was disrupted and blurry, and the rod

173 subretinal drusenoid deposits, photoreceptor outer segment loss, RPE drusen complex volume, and RPE d

174 autonomous role of the glycolytic pathway in outer segment maintenance and provide evidence that aero

175 d the unglycosylated RDS binding partner rod outer segment membrane protein 1 (ROM-1) were found in N

176 cannot interact with its binding partner rod outer segment membrane protein 1.

177 icalis, these processes are connected to the outer-segment membrane by links composed of protocadheri

178 RGS9Gbeta5 is tethered to the outer segment membranes by its membrane anchor, R9AP.

179 1gamma1 The complex was formed on native rod outer segment membranes upon light activation, solubiliz

180 of Ca(2+) regulate phototransduction in the outer segment, metabolism in the cell body, and neurotra

181 Rbpr2 loss resulted in shorter photoreceptor outer segments, mislocalization and decrease in visual p

182 data show that both mislocalization and rod outer segment morphogenesis are likely associated with t

183 s that guide the modulation of photoreceptor outer segment morphogenesis by RPE during retinal develo

184 We also observed disorganized photoreceptor outer-segment morphology and defective trafficking of op

185 As a consequence, in the small outer segment of a mouse rod only a few activated PDEs a

186 ein Numb localizes to the inner, but not the outer segment of mouse photoreceptor cilia.

187 layers and reduced rhodopsin content in the outer segment of mutant retina prior to the onset of pho

188 in the RPE, and impaired phagocytosis of the outer segment of the photoreceptors.

189 rt defects between the inner segment and the outer segment of the photoreceptors.

190 hich seem to be rods and cones; however, the outer segments of both have an identical cone-like morph

191 ast, RHBDD2H seems to be present only in the outer segments of cone photoreceptors and may correspond

192 , arrestin, is effectively excluded from the outer segments of dark-adapted rods and cones.

193 found that PTPRG and CNTN3 associate in the outer segments of mouse rod photoreceptor cells.

194 In the eyes, the outer segments of photoreceptor cells appeared shortened

195 These structures interdigitate with the outer segments of rod and cone photoreceptor cells.

196 Rhodopsin, the light-sensing molecule in the outer segments of rod photoreceptors, is responsible for

197 Outer segments of rods deficient in Rdh8 failed to reduc

198 The bipolar synapse and the inner and outer segments of the photoreceptor may serve as critica

199 We observed similar vacuolization in outer segments of transgenic mice expressing human rhodo

200 The outer segments of vertebrate rod photoreceptors are rene

201 ating complex located in the light-sensitive outer segment organelle.

202 d for biogenesis of vertebrate photoreceptor outer segment organelles.

203 Rod photoreceptors consist of an outer segment (OS) and an inner segment.

204 -cone degeneration (PRCD) is a photoreceptor outer segment (OS) disc-specific protein with unknown fu

205 0-fold intensity range caused correlated rod outer segment (OS) elongation and increased light scatte

206 The photoreceptor outer segment (OS) is a sensory compartment specialized

207 The photoreceptor outer segment (OS) is a unique modification of the prima

208 The photoreceptor outer segment (OS) is comprised of two compartments: pla

209 (CMZ) cell death and decreased photoreceptor outer segment (OS) length, as well as gross morphologica

210 ion of biosynthetic intermediates, improving outer segment (OS) length, enhancing photoreceptor survi

211 Structural parameters included outer segment (OS) length, thickness and elevation of th

212 protein and the key RDS-binding partner, rod outer segment (OS) membrane protein 1 (ROM-1), were prop

213 PRPH2 oligomerizes with its homologue rod outer segment (OS) membrane protein 1 (ROM1), and non-pa

214 The outer segment (OS) of the rod photoreceptor is a light-s

215 linked complexes which were localized to the outer segment (OS) where they impaired the formation of

216 specialized for phototransduction called the outer segment (OS).

217 ing compartment of photoreceptors called the outer segment (OS).

218 (IS) of photoreceptor cells, as well as the outer segments (OS) of cone cells.

219 L13b is located exclusively in photoreceptor outer segments (OS) presumably anchored to discs by palm

220 light exposure and have significantly longer outer segments (OS) than age-matched controls.

221 ne for ABCA4, a transporter in photoreceptor outer segments (OS) that clears retinaldehyde and preven

222 lterations at the level of the photoreceptor outer segments (OS) to choroidal neovascularization.

223 In cultured RPE-J cells incubated with rod outer segments (OS), siRNA knockdown of Grb2 had no effe

224 rated by and accumulate in the photoreceptor outer segments (OS), which is the retinal layer with the

225 in in the form of phagocytized photoreceptor outer segments (OS).

226 ed progressive degeneration of photoreceptor outer segments (OSs) and increased apoptosis of retinal

227 Photoreceptor outer segments (OSs) are essential for our visual percep

228 The degeneration of rods' outer segments (OSs) is predominant, followed by the deg

229 ion of the disc/lamella rim in photoreceptor outer segments (OSs), but plays a different role in rods

230 ptors did exhibit long-term defects in their outer segments (OSs), which were less severe when more p

231 ltage was considerably less than that of the outer segment photocurrent following equivalent pigment

232 Measurements of the rod outer segment photocurrent in transgenic mice, which hav

233 of the rod photovoltage with respect to the outer segment photocurrent, which is eliminated upon int

234 ubstantial as the desensitization of the rod outer segment photocurrent.

235 s difference in desensitization with the rod outer segment photocurrent.

236 hotovoltages and with suction electrodes the outer segment photocurrents of Lampetra fluviatilis reti

237 a change in current at the rod photoreceptor outer segment plasma membrane.

238 derived from the ingestion of photoreceptor outer segment (POS) disk membranes, is a major role of t

239 ntal extent of the ONL and the photoreceptor outer segment (POS) interdigitation zone (IZ).

240 cells by macrophages and spent photoreceptor outer segments (POS) by retinal pigment epithelial (RPE)

241 hagocytosis and degradation of photoreceptor outer segments (POS) by retinal pigment epithelium (RPE)

242 ong renewal of light-sensitive photoreceptor outer segments (POS) involves circadian shedding of dist

243 e daily phagocytic turnover of photoreceptor outer segments (POS) required for maintenance of vision.

244 (RPE) is the clearance of shed photoreceptor outer segments (POS) through a multistep process resembl

245 promotes its targeting to the photoreceptor outer segments (POS).

246 s that the iPS-RPE phagocytose photoreceptor outer segments (POS).

247 Phagocytosis of shed photoreceptor outer segments (POSs) by retinal pigment epithelial (RPE

248 scent waste products from shed photoreceptor outer segments (POSs).

249 ndicated that axonemes gradually shorten and outer segments progressively degenerate.

250 Rhodopsin is the most abundant outer segment protein and its proper transport is essent

251 afish also showed mislocalisation of certain outer segment proteins (rhodopsin, opn1lw, opn1sw1, GNB3

252 re absent, thereby preventing trafficking of outer segment proteins to their destination.

253 n implicated in trafficking of photoreceptor outer segment proteins.

254 opment, most likely by trafficking cilia and outer-segment proteins.

255 e to become mature rods with light-sensitive outer segments, reconnecting with host neurons downstrea

256 The R838S RetGC1 expression in rod outer segments reduced inhibition of cGMP production in

257 rphogenesis and maintenance of photoreceptor outer segments, regions that collect light stimuli.

258 ed to the rod for rhodopsin regeneration and outer segment renewal.

259 Daily renewal of 10% of photoreceptor outer segments requires stringent control of gene expres

260 although it is associated with photoreceptor outer segments, retbindin's expression is not dependent

261 ption of the inner segment/outer segment and outer segment/retinal pigment epithelium bands, whereas

262 Rs1-KO rod outer segment (ROS) length was significantly shorter tha

263 with TM1, TM2, TM4, and TM5 peptides in rod outer segment (ROS) membranes shifted the resulting dete

264 have double membrane discs located in their outer segments (ROS) that are continuously formed proxim

265 accumulation of all-trans-retinal in the rod outer segments (ROS).

266 n affecting rhodopsin's stabilization of rod outer segments (ROS).

267 hic analyses of the basal-most region of the outer segment show changes in shape of the ciliary plasm

268 Our findings explain how the outer segment structure evolved from the primary cilium

269 r-specific knock-out mice, the photoreceptor outer segment structure was severely impaired at 4 weeks

270 ration of active monomeric arrestin-1 in the outer segment, suggesting that P-Rh generated by high-ga

271 ice trafficked normally to the photoreceptor outer segment, suggesting that the failure to remove the

272 idden by association with R9AP, which allows outer segment targeting of the entire complex.

273 s of formerly missing outer segments and new outer segments that had appeared over the course of the

274 ots appeared to originate from photoreceptor outer segments that were arranged within retinal folds a

275 its partners, because in the Gnb3(-/-) cone outer segments, the levels of Galphat2 and Ggammat2 are

276 ptimal levels of transducin heteromer in the outer segment, thereby indirectly contributing to robust

277 ss, the continuous current entering the cone outer segment through cGMP-gated (CNG) channels is carri

278 cilium, regulates rhodopsin transport to the outer segment through its effect on the turnover of acti

279 t line was disrupted and blurry, and the rod outer segment tip line was absent.

280 urry line at the central fovea, and the cone outer segment tip line was absent.

281 , hyperreflective foci, microaneurysms, cone outer segment tip visibility, and external limiting memb

282 xternal limiting membrane (ELM) and the cone outer segment tips (COST) line were least frequently ide

283 e G protein transducin translocates from rod outer segments to inner segments/spherules in bright lig

284 utes .15% of all lipids in the photoreceptor outer segment, to produce beta-HB.

285 Outer segment transmembrane protein accumulation in Nphp

286 odopsin is transported from the inner to the outer segment via the ciliary plasma membrane, subsequen

287 ers corresponding to photoreceptor inner and outer segments was measured using SD-OCT.

288 ng and internalization of shed photoreceptor outer segments was subjected to changes in localization.

289 the reduction in Galphat2 level in the cone outer segment, we conclude that activation of Galphat2 i

290 al retina at postnatal day 6 (P6) and older, outer segments were absent, thereby preventing trafficki

291 the return of the transducin subunits to the outer segments were compared in transgenic mouse models

292 isks displayed excessive outgrowth, and cone outer segments were curved, with lamellae of heterogeneo

293 endent fluorescent compounds produced in rod outer segments were not transferred to the RPE of mice g

294 f a specialized membrane-rich organelle, the outer segment, which is the primary site of phototransdu

295 ls phagocytize and digest shed photoreceptor outer segment, which provides a rich source of fatty aci

296 epends upon the formation and maintenance of outer segments, which are lost in degenerative diseases.

297 en agnatha and gnathostomata, and a rod-like outer segment with cytosolic disks surrounded by a plasm

298 alpha and betagamma subunits returned to the outer segments with a half-time (t(1/2)) of approximatel

299 Vision begins in photoreceptor outer segments with light captured by opsins in continua

300 he identification of small fragments of cone outer segments within the RPE led us to characterize the