ライフサイエンスコーパス: outer surface protein A

1 from the single-layer beta-sheet of Borrelia outer surface protein A.

2 d on the single-layer beta-sheet of Borrelia outer surface protein A.

3 eratin 10 and a prominent B. burgdorferi Ag, outer surface protein A.

4 and the prototypic spirochetal lipoprotein, outer surface protein A.

5 Furthermore, we demonstrate that anti-outer surface protein A Abs develop in these mice only a

6 ve been identified for Borrelia burgdorferi, outer surface protein A and a 70-kDa protein (BPBP).

7 a dominant T-cell epitope of B. burgdorferi outer surface protein A and an adhesion molecule, human

8 s the 49-kb linear plasmid and expression of outer surface proteins A and B (OspA and OspB).

9 luorescence assays that combined monoclonal (outer surface protein A) and polyclonal antibodies were

10 B. burgdorferi, purified native outer surface protein A, and a synthetic outer surface p

11 as LPS, the Borrelia burgdorferi lipoprotein outer surface protein A, and PMA.

12 ocytes with B. burgdorferi lysate, lipidated outer surface protein A, and triacylated lipopeptide Pam

13 D14 confers responsiveness to LPS but not to outer surface protein A, B. burgdorferi failed to stimul

14 ive outer surface protein A, and a synthetic outer surface protein A hexalipopeptide stimulated human

15 cated B. burgdorferi or with the lipoprotein outer surface protein A in the presence of increasing co

16 OspA (outer surface protein A) is an abundant immunogenic lipo

17 eze-thawed, live, or sonicated) or lipidated outer surface protein A (L-OspA) augmented their SOCS1/S

18 rrelia burgdorferi spirochetes and lipidated outer surface protein A (L-OspA) stimulated the in vitro

19 losis factor (STF), and Borrelia burgdorferi outer surface protein A lipoprotein (OspA-L).

20 arthritis resolved, had serum antibodies to outer surface protein A of B burgdorferi.

21 ver an extended time period, as well as anti-outer surface protein A of Bb serum titers.

22 Finally, we identify Th1 cells specific for outer surface protein A of Borrelia burgdorferi, the age

23 ained fully virulent, did not express either outer surface protein A or Lp6.6, lipoproteins known to

24 primer-probe sets that target genes encoding outer surface proteins A or B or a flagellar protein (P4

25 ither a recombinant antigen of the pathogen, outer surface protein A, or a negative control antigen i

26 ally infected mice produced no antibodies to outer surface protein A (OSP A).

27 h T cell recognition of Borrelia burgdorferi outer surface protein A (OspA(161-175)) and with HLA-DR

28 clonal antibodies to B. burgdorferi-specific outer surface protein A (OspA) (antibodies H3TS and H533

29 clonal antibodies to B. burgdorferi-specific outer surface protein A (OspA) (antibodies H5332 and H3T

30 f flagellin (fla), 66-kDa protein (p66), and outer surface protein A (ospA) alleles were examined in

31 mediated by two B. burgdorferi lipoproteins, outer surface protein A (OspA) and OspC, was determined.

32 rotective antigens, including B. burgdorferi outer surface protein A (OspA) and OspC.

33 ulator (BosR), is required for repression of outer surface protein A (OspA) and OspD in the mammal.

34 spect to the production of two lipoproteins [outer surface protein A (OspA) and outer surface protein

35 orrelation between antibody to an epitope on outer surface protein A (OspA) and protection against in

36 Here we used purified B. burgdorferi outer surface protein A (OspA) and synthetic lipopeptide

37 elia burgdorferi sensu stricto downregulates outer surface protein A (OspA) and upregulates outer sur

38 were able to initiate the production of anti-outer surface protein A (OspA) antibody in vitro with no

39 s demonstrated that B. burgdorferi expresses outer surface protein A (OspA) but not OspC when residin

40 arval ticks, characterized the production of outer surface protein A (OspA) by spirochetes entering l

41 peptide self-assembly mimic (PSAM) from the outer surface protein A (OspA) can form highly stable bu

42 Outer surface protein A (OspA) coats the spirochetes fro

43 Borrelia outer surface protein A (OspA) contains a unique single-

44 attempt to investigate the possible role of outer surface protein A (OspA) escape mutants of Borreli

45 Outer surface protein A (OspA) from Borrelia burgdorferi

46 Outer surface protein A (OspA) from the Lyme disease spi

47 Outer surface protein A (OspA) from the Lyme disease spi

48 Outer surface protein A (OspA) from the Lyme disease spi

49 sgenic mice tolerant to Borrelia burgdorferi outer surface protein A (OspA) from the weakly virulent

50 flagellin (flaB), 66-kDa protein (p66), and outer surface protein A (ospA) gene sequences from DNAs

51 e vaccines based on purified preparations of outer surface protein A (OspA) have been shown to be eff

52 LuIII, which expresses Borrelia burgdorferi outer surface protein A (OspA) instead of its coat prote

53 Outer surface protein A (OspA) is a borrelial protein im

54 Outer surface protein A (OspA) is a major lipoprotein of

55 inant Lyme borreliosis vaccine consisting of outer surface protein A (OspA) is commercially available

56 Antibodies directed against outer surface protein A (OspA) of B. burgdorferi kill sp

57 Abs to the outer surface protein A (OspA) of B. burgdorferi provide

58 hypothesis that cross-reactivity between the outer surface protein A (OspA) of Borellia burgdorferi a

59 Antibody responses to outer surface protein A (OspA) of Borrelia burgdorferi m

60 itis is associated with immune reactivity to outer surface protein A (OspA) of Borrelia burgdorferi,

61 Outer surface protein A (OspA) of the Lyme disease spiro

62 A marked Ab and T cell response to BB: outer surface protein A (OspA) often develops during pro

63 se of DR4-Tg mice after immunization with Bb outer surface protein A (OspA) or infection with live Bb

64 r the predominantly vector-stage lipoprotein outer surface protein A (OspA) or the in vivo-expressed

65 sponding to the N terminus of B. burgdorferi outer surface protein A (OspA) to activate human umbilic

66 The Borrelia burgdorferi outer surface protein A (OspA) vaccine induces antibodie

67 The Lyme disease outer surface protein A (OspA) vaccine is a transmission

68 he administration of a lipidated recombinant outer surface protein A (OspA) vaccine presently undergo

69 Serum concentrations of antibodies against outer surface protein A (OspA) were shown to correlate w

70 ntramolecular dynamics and thermodynamics of outer surface protein A (OspA), a key protein in the lif

71 In this study, outer surface protein A (OspA), a model B. burgdorferi l

72 Similar results were obtained using outer surface protein A (OspA), a naturally occurring tr

73 ferentially expressed in the tick, including outer surface protein A (OspA), Borrelia iron and copper

74 Purified lipidated outer surface protein A (OspA), but not its unlipidated

75 eferentially recognized Borrelia burgdorferi outer surface protein A (OspA), but TCL from four patien

76 irect evidence that a major surface protein, outer surface protein A (OspA), can induce arthritis.

77 cal immunofluorescence microscopy to express outer surface protein A (OspA), compared to only 5% of s

78 t Arp, an unrelated 37-kDa protein (P37-42), outer surface protein A (OspA), or glutathione S-transfe

79 reparations of recombinant antigens included outer surface protein A (OspA), OspB, OspC, OspE, OspF,

80 iacidal antibody, directed primarily against outer surface protein A (OspA), was readily produced by

81 i, the agent of Lyme disease, down-regulates outer surface protein A (OspA), which is abundantly expr

82 single-layer beta-sheet segment of Borrelia outer surface protein A (OspA).

83 ne response to the Borrelia burgdorferi (Bb) outer surface protein A (OspA).

84 ed from Borrelia burgdorferi and recombinant outer surface protein A (OspA).

85 ere shown to lack the 49-kb plasmid encoding outer surface protein A (OspA).

86 lpha/beta/alpha-sandwich) and another within outer surface protein A (OspA, beta-sheet) to have high

87 icacy of a recombinant vaccine consisting of outer-surface protein A (OspA) without adjuvant in subje

88 nition of an epitope of Borrelia burgdorferi outer-surface protein A (OspA163-175).

89 a common Lyme disease vaccine is recombinant outer surface protein A (rOspA) of Borrelia burgdorferi

90 tion with high concentrations of recombinant outer surface protein A (rOspA).

91 nation of wild white-footed mice resulted in outer surface protein A-specific seropositivity that led

92 urred 24 h after LPS stimulation, 18 h after outer surface protein A stimulation, and 3 h after PMA s

93 Outer surface protein A vaccination significantly reduce

94 d Drug Administration approved a recombinant outer surface protein A vaccine against Lyme disease (LY

95 B. burgdorferi outer surface protein A, which is abundantly expressed o

96 rferi, and 15 animals vaccinated with either outer surface protein A, whole-spirochete vaccines, or t