ライフサイエンスコーパス: oval

1 nly weak emission away from the main auroral oval.

2 The oval 14.3 +/- 1.5 mm x 6.7 +/- 1.6 mm x 1.0 +/- 0.2 mm S

3 MFFs were oval (62%, 15 of 24) or linear (38%, nine of 24) and inv

4 onstrated by double immunofluorescence using oval- (A6 and EpCam) and hepatocyte-specific (i.e. hepat

5 ed, flagellated trypomastigotes remodel into oval amastigotes with no external flagellum.

6 essing axonal plexuses were prominent in the oval and juxtacapsular subregions.

7 The proximity of the hook region to the oval and round windows, combined with it having the bigg

8 roximately 25 per cent as bright as the main oval, and we show this to be caused by interaction with

9 Overall, the pelvises had transverse oval appearance in inlet and size of the female pelvis.

10 w southern mid-latitude region in which dark ovals are observed both to merge with each other and to

11 Here we report the discovery of a secondary oval at Saturn that is approximately 25 per cent as brig

12 direction, curved in two dimensions with an oval base and a round tip.

13 of overlapping bundles that matures into an oval base by the asymmetric addition of bundles on the d

14 Likewise, in vivo intra-oval bed nucleus of the stria terminalis DRD1 pharmacolo

15 entiation of GABAA-IPSCs (D1-LTPGABA) in the oval bed nucleus of the stria terminalis that was positi

16 exert opposite effects on the anxious state: oval BNST activity promoted several independent anxious

17 2,551 laryngeal, 3,693 pharyngeal, and 3,116 oval cavity cancers, with over 8,000 controls.

18 Hepatic progenitor/oval cell (OC) activation occurs when hepatocyte prolife

19 3b, is crucial in the ductular reaction (DR)/oval cell (OC) response for generating new hepatocyte li

20 essing cells proliferate in the liver during oval cell (OC)-mediated liver regeneration.

21 taminophen injury was followed by periportal oval cell accumulation displaying a moderate degree of m

22 CTGF and integrin alphavbeta6 regulate oval cell activation and fibrosis, probably through inte

23 Extensive oval cell activation and proliferation were observed at

24 ified a novel function of RAGE in regulating oval cell activation and tumor development in inflammati

25 or (CTGF), has been shown to be critical for oval cell activation during liver regeneration following

26 In conclusion, our studies indicate a marked oval cell activation during the height of hepatic injury

27 acologic blockade of RAGE signaling impaired oval cell activation in an independent mouse model of ov

28 ha-fetoprotein expression, implying impaired oval cell activation in these animals.

29 e ability to self-renew in all classic mouse oval cell activation injuries.

30 mediated liver regeneration does not require oval cell activation or proliferation.

31 pericentral hepatocytes during liver injury, oval cell activation, and hepatocyte regeneration.

32 Oval cell activation, as part of the regenerative proces

33 Hepatic expression of genes indicative of oval cell activation, as well as the number of cells exp

34 orted by NF-kappaB and STAT3 is required for oval cell activation, expansion, and differentiation.

35 ormal liver cells and at different stages of oval cell activation, indicating potential utility for p

36 activation in an independent mouse model of oval cell activation, the choline deficient ethionine-su

37 d integrin alphavbeta6 in hepatic progenitor/oval cell activation, which often occurs in the form of

38 adhesion and migration, thereby facilitating oval cell activation.

39 thoxycarbonyl-1,4-dihydrocollidine to induce oval cell activation.

40 we assessed the involvement of G-CSF during oval cell activation.

41 up B received the 2-AAF/PHx required for the oval cell activation.

42 hat SDF-1 is an essential molecule needed in oval cell activation.

43 nchyma cells in prototypical mouse models of oval cell activation.

44 and fibrosis, in association with decreased oval cell activation.

45 rin alphavbeta6 could bind to CTGF mediating oval cell adhesion to CTGF and fibronection substrata an

46 regeneration, and induces NK cell-sensitive oval cell and hematopoietic-like cell expansion followin

47 firm colocalization of beta-catenin with the oval cell antigen A-6.

48 ary injury, atypical ductular proliferation, oval cell appearance, and limited fibrosis.

49 Also, there were smaller oval cell areas, fewer proliferating ductular epithelial

50 onstrated a critical role of beta-catenin in oval cell biology.

51 ly, TWEAK stimulated the proliferation of an oval cell culture model.

52 ved at this time, which was localized to the oval cell cytoplasm and nuclei by immunohistochemistry a

53 novel findings implicating Wnt1 in directing oval cell differentiation during the rat 2-acetylaminofl

54 Oval cell expansion induced by 3,5-diethoxycarbonyl-1,4-

55 A group of novel differentially expressed oval cell genes is also presented.

56 Tgfa, and Tweak) for proteins that maintain oval cell growth and differentiation.

57 s, lymphocytic inflammation, focal necrosis, oval cell hyperplasia, and fibrosis.

58 sing TWEAK in hepatocytes exhibit periportal oval cell hyperplasia.

59 physiological requirement of Wnt1 during the oval cell induction.

60 uency of one of 34 or one of 25 in normal or oval cell injury livers, respectively.

61 Sox9(+) cells were traced in multiple oval cell injury models using both histology and fluores

62 <1%) to the hepatocyte pool, even in classic oval cell injury models.

63 e of hepatocyte-driven regeneration in mouse oval cell injury models.

64 Two oval cell lines, LE/2 and LE/6, were less responsive.

65 in vivo exposure to Wnt1 shRNA inhibited rat oval cell liver regeneration.

66 s the number of cells expressing A6, a mouse oval cell marker, was greater in egr-1(-/-) mice.

67 EpCAM(+) cells express the classical oval cell markers (alpha-fetoprotein, cytokeratin-19, OV

68 and by low expression of hepatocyte markers, oval cell markers, and stellate cell markers.

69 nt two different populations of cells in the oval cell niche.

70 essage increased coinciding with the rise in oval cell number, whereas protein levels peaked immediat

71 A dramatic decrease in the A6-positive oval cell numbers in the absence of beta-catenin demonst

72 ty of oval cells in vitro as well as reduced oval cell pool, impaired migration, and decreased hepato

73 Group B showed that approximately 20% of the oval cell population expressed both donor marker (DPPIV)

74 pecific for regenerating livers with massive oval cell presence.

75 as associated with a significant decrease in oval cell proliferation and a lower level of alpha-fetop

76 ductal progenitor cells give rise to clonal oval cell proliferation and bipotential organoids, but r

77 of age demonstrated a robust and widespread oval cell proliferation followed by cholangiofibrosis an

78 l cycle arrest in hepatocytes but stimulates oval cell proliferation in cultured cells.

79 F-like weak inducer of apoptosis) stimulates oval cell proliferation in mouse liver through its recep

80 HMGB1 promoted an ERK1/2-Cyclin D1-dependent oval cell proliferation in vitro.

81 The regulation of oval cell proliferation is incompletely understood.

82 sibility through the targeted elimination of oval cell proliferation secondary to bile duct destructi

83 remained virtually unaffected, with minimal oval cell proliferation, only occasional and small foci

84 evels peaked immediately after the height of oval cell proliferation.

85 ne (DDC)-enriched diet was used to stimulate oval cell proliferation.

86 al cells and hepatocytes in serial sections, oval cell proliferations with CK-19(+)/laminin(+) and OV

87 The timing of the two peaks of the oval cell reaction also changed with increasing dose, th

88 The oval cell reaction was quantified, on immunostaining for

89 ficantly increased both the magnitude of the oval cell reaction, and the contribution of BM to liver

90 The magnitude of oval cell reaction, the entity of BM contribution to liv

91 e liver, as well as enhancing the endogenous oval cell reaction.

92 n through the generation of NO and stimulate oval cell replication.

93 that CTGF induction is important for robust oval cell response after 2-AAF/PHx treatment in rats.

94 The age dependence of the oval cell response and bile duct carcinomas of male F344

95 ed beginning at 8 weeks of age had much less oval cell response and cholangiofibrosis with only 1 of

96 osed to cyclic CDE diet display a diminished oval cell response and fewer CCAs.

97 rom normal adult mice or those undergoing an oval cell response and tested their capacity to form bil

98 Extensive elimination of oval cell response by repeated administration of 4,4'-me

99 odies to support investigation of the murine oval cell response has been developed.

100 Oval cell response was biphasic, not temporally correlat

101 The oval cell response was compromised in these animals, as

102 as accompanied by a robust activation of the oval cell response, suggesting more severe liver injury

103 face reactive reagents more specific for the oval cell response, we generated a new collection of mon

104 the role of the Wnt/beta-catenin pathway in oval cell response, which was initiated in male Fisher r

105 both CCl(4)-induced hepatic fibrosis and the oval cell response.

106 ats to investigate the effect of Iloprost on oval cell response.

107 the damaged rat liver by contributing to the oval cell response.

108 mma) increases in liver injury that involves oval cell responses, but it is not upregulated during li

109 In this work, we studied progenitor/oval cell surface markers in the liver of rats subjected

110 The specificity of progenitor/oval cell surface markers was confirmed by ISH and doubl

111 an FN-concentrated provisional matrix during oval cell-aided liver regeneration.

112 ithin the liver, implying a possible role in oval cell-aided liver regeneration.

113 etreatment increased the numbers of separate oval cell-like CD117(+) cells and hematopoietic-like Sca

114 rogenitors within 1 week through a transient oval cell-like stage.

115 ylaminofluorene/partial hepatectomy model of oval cell-mediated liver regeneration, followed by admin

116 Progenitor ("oval") cell expansion accompanies many forms of liver in

117 liver triggers activation of the progenitor (oval) cell compartment and a severe fibrogenic response.

118 Progenitor (oval) cell mitogen tumor necrosis factor-like weak induc

119 During hepatic stem, or oval, cell activation, SDF-1 has been reported to be up-

120 SNS signaling affects hepatic progenitor/oval cells (HPCs) and beta-adrenoceptor agonism will exp

121 ized lines of hepatocytes (AML-12 cells) and oval cells (LE-6 cells) to investigate the potential mec

122 intrahepatic biliary tree, identification of oval cells (presumed progeny of hepatic stem cells) in a

123 Ductular reactions are primarily composed of oval cells also known as "intermediate hepatobiliary cel

124 h reduced periductal accumulation of CD24(+) oval cells and abrogation of fibrosis.

125 rescent protein reporter mice suggested that oval cells and cholangiocytes were the main sources of C

126 ce staining for markers specific for hepatic oval cells and hepatocytes in serial sections, oval cell

127 ween TGF-beta signaling and proliferation in oval cells and hepatocytes, we examined TGF-beta signali

128 termediate or transitional cell type between oval cells and mature hepatocytes, rather than a distinc

129 through atypical ductular proliferation and oval cells and their subsequent differentiation to bile

130 Oval cells appear and expand in the liver when hepatocyt

131 Hepatic progenitor/oval cells appear in injured livers when hepatocyte prol

132 Oval cells appear to be resistant to acetaminophen injur

133 We have shown that EpCAM(+) oval cells are bipotential adult hepatic epithelial prog

134 Oval cells are considered liver stem cells, a portion of

135 Adult hepatic stem cells or oval cells are facultative stem cells in the liver that

136 Oval cells are hepatocytic precursors that proliferate i

137 roliferation, and differentiation of hepatic oval cells are not fully understood.

138 Oval cells are postnatal hepatic progenitors with high p

139 ls are elevated in chronic liver injury when oval cells arise, we hypothesized that oval cells may be

140 The oval cells at the proximal tips of the ductules have a m

141 These findings highly suggest the hepatic oval cells but not mature hepatocytes as the origin of S

142 g evidence that SHPCs are not the progeny of oval cells but represent a distinct population of liver

143 t to produce hepatocytes, cholangiocytes, or oval cells by way of mesenchymal-epithelial transition i

144 Oval cells can potentially become either hepatocytes or

145 Oval cells constitute a reserve compartment that is acti

146 Oval cells do not express previously reported hematopoie

147 r the efficient regeneration of the liver by oval cells during massive hepatic injury.

148 However, oval cells express a number of mesenchymal markers inclu

149 Sorted Thy-1+ oval cells expressed a high level of CTGF gene in a quan

150 Oval cells expressed high RAGE levels and displayed redu

151 Oval cells expressed low levels of albumin and thereby e

152 In the absence of Wnt1 signaling, oval cells failed to differentiate into hepatocytes and

153 nderlying mechanism for the proliferation of oval cells in an environment inhibitory to hepatocytic p

154 neration of hepatocytes, cholangiocytes, and oval cells in immune-deficient adult animals after neona

155 liferation were compensated by a response of oval cells in Nemo(Deltahepa) mice.

156 ation of adult facultative stem cells termed oval cells in periductal regions.

157 a expression was augmented in bile ducts and oval cells in retrorsine/partial hepatectomy-treated liv

158 e recently, recognition of the role of small oval cells in the carcinogenic process led to a new hypo

159 tor decreased the sphere-forming capacity of oval cells in vitro as well as reduced oval cell pool, i

160 acted as a chemoattractant and a mitogen for oval cells in vitro.

161 Because oval cells induction is commonly associated with liver i

162 he bone marrow cells are a source of hepatic oval cells involved in rat liver regeneration induced by

163 Recruitment and proliferation of Thy-1+ oval cells is a hallmark of liver regeneration after 2-a

164 The precursor to oval cells is considered to be a facultative liver stem

165 Oval cells isolated from DDC-fed mouse livers showed the

166 when oval cells arise, we hypothesized that oval cells may be less responsive to the growth inhibito

167 enitor cells, is also expressed in activated oval cells of rat liver.

168 cytokeratins, as both number and density of oval cells per portal tract, analyzed by size of portal

169 le, and triple staining to study lineages of oval cells present in DRs.

170 se and generated NO, while similarly treated oval cells produced little if any NO.

171 through replication of existing hepatocytes, oval cells proliferate only when hepatocyte proliferatio

172 The adhesion of these two modules on Thy1(+) oval cells required heparan sulfate proteoglycan and int

173 From these data, we conclude that oval cells respond to Wnt ligands (Wnt3a) in vitro with

174 n contrast, was significantly more common in oval cells than hepatocytes.

175 knockout (KO) mice led to fewer A6-positive oval cells than wildtype (WT) littermates.

176 K has a selective mitogenic effect for liver oval cells that distinguishes it from other previously d

177 Repopulation of the liver with oval cells that expressed NEMO reversed liver damage in

178 nuclear translocation of beta-catenin within oval cells throughout the 2AAF/PHx protocol.

179 The response of hepatocytes and oval cells to cytokine combinations may contribute to th

180 y, inhibition of Wnt1 resulted in failure of oval cells to differentiate into hepatocytes and alterna

181 ion, we studied the role of Wnt signaling in oval cells using a mouse model of chronic liver injury.

182 Deletion of c-met in oval cells was confirmed in both models by polymerase ch

183 ion of the mesodermal mesenchymal cells into oval cells was not observed.

184 g with increased expression of Frizzled-2 in oval cells was observed.

185 hybridization further confirmed that Thy-1+ oval cells were a source of CTGF.

186 Oval cells were activated in 2-acetylaminofluorene-treat

187 rare clones containing both hepatocytes and oval cells were found in any experiment.

188 Oval cells were found to express G-CSF receptor and G-CS

189 Increases in oval cells were largely confined to the smallest portal

190 Oval cells were never seen in the livers of DAPM-treated

191 n appearance or numbers of total A6-positive oval cells were observed after DDC administration.

192 Moreover, stimulation of oval cells with HMGB1 promoted an ERK1/2-Cyclin D1-depen

193 ysaccharide content, more round cells versus oval cells with OG1RF, decreased biofilm formation, atte

194 ls in group C failed to significantly induce oval cells with the donor DPPIV antigen.

195 catenin signal transduction in proliferating oval cells within atypical ductal proliferations (ADPs).

196 ilize facultative stem cells, also known as "oval cells" or "atypical ductal cells" (ADCs), for regen

197 patocytes and intrahepatic progenitor cells (oval cells) have similar responses to most growth factor

198 iation of hepatic stem cell progenies (i.e., oval cells) sustain liver regeneration when the replicat

199 Our results indicate that oval cells, both in vivo and in vitro, are less sensitiv

200 ate genes differentially expressed in Thy-1+ oval cells, in this liver injury model.

201 tential lineage relationship between hepatic oval cells, small hepatocyte-like progenitor cells (SHPC

202 to thymus cell antigen 1-positive (Thy1(+)) oval cells, stellate cells, and sinusoidal endothelial c

203 her types of HCC included markers of hepatic oval cells, suggesting that HCC of this subtype may aris

204 We examined the response of murine oval cells, that is, the putative liver progenitor cells

205 To activate oval cells, the hepatic stem cell (HSC) progeny, we used

206 giocytes, and progenitor cell types known as oval cells, thereby acting as stem cells in the liver.

207 To examine TGF-beta signaling in vivo in oval cells, we analyzed livers of rats fed a choline-def

208 ls, which share phenotypic similarities with oval cells, were previously reported to be capable of fo

209 face markers specific for hepatic progenitor/oval cells, which offers powerful tool for their identif

210 Proliferating ducts, termed "oval cells," have long been thought to be bipotential, t

211 h is attributed to the specific expansion of oval cells.

212 resident stellate cells, myofibroblasts, and oval cells.

213 ogenitor cells, most likely endoderm-derived oval cells.

214 t migration but not proliferation on Thy1(+) oval cells.

215 ributing to differentiation of donor-derived oval cells.

216 on assays were performed on freshly isolated oval cells.

217 placement of hepatocytes, cholangiocytes, or oval cells.

218 s, but staining was substantially reduced in oval cells.

219 denced by a decreased number of OV6-positive oval cells.

220 xpression and localization of CTGF in Thy-1+ oval cells.

221 tocytes and thus appears to be selective for oval cells.

222 erential growth responses in hepatocytes and oval cells.

223 pes such as hepatocytes, cholangiocytes, and oval cells.

224 cytoplasmic EpCAM(+)/HNF-4alpha(-) ductular oval cells.

225 initiated by the proliferation of so-called oval cells.

226 and compensatory hyperplasia of progenitor (oval) cells as a reaction to chronic injury due to ongoi

227 ion is impaired is thought to be mediated by oval/dedifferentiated progenitor cells, which replenish

228 The specimen features two large oval depressions on the dorsal surface, accompanied by n

229 central nucleus of the amygdala (CEAl/c) and oval division of the bed nucleus of the stria terminalis

230 pseudodrusen appeared as yellowish round to oval (dot subtype; n = 5) or confluent, wriggled (ribbon

231 mesenchymal origin as the progenitor for the oval/ductular response in the rat.

232 ltifocal, coarse, raised, punctate, round to oval epithelial lesions in the cornea in slit-lamp exami

233 nated, sharply outlined, contrast-enhancing, oval foci with persistent restriction of diffusion.

234 Genotype CS 1418 had big size and oval form so it could be destined to potato chips indust

235 able with time, and disappears when the main oval has a spiral morphology; this suggests that althoug

236 At Saturn, only the main auroral oval has previously been observed and there remains much

237 l up into larger fibers, and also to develop oval holes to form fiber networks that were "pre-attache

238 ence, and generating a new cold anticyclonic oval in the center of the disturbance at 41 degrees N.

239 White Ovals, the disappearance of two White Ovals in 1997-2000 was unexpected.

240 Earth's main auroral oval is formed through interactions with the solar wind,

241 This is a weak equivalent of Jupiter's main oval, its relative dimness being due to the lack of as l

242 re defined as irregular networks of round to oval lesions that appear hyporeflective on near-infrared

243 tion with ODRS included a well-circumscribed oval mass (P = .024) at mammography, vascularity (P = .0

244 ogeneous, predominantly hypoechoic, round-to-oval masses in both testes.

245 hat mitochondrial numbers, typical size, and oval morphology were evident after 12 h of imbibition in

246 septohypothalamic nucleus, anteromedial and oval nuclei of the bed nucleus of the stria terminalis,

247 us, the central nucleus of the amygdala, the oval nucleus of the bed nuclei of the stria terminalis,

248 selectively expressed in CRF neurons in the oval nucleus of the BNSTALG.

249 ispheric, bi-layered optic cup forms from an oval optic vesicle during early vertebrate eye developme

250 phology noted was the common and distinctive oval or ovoid perisomatic staining in macaque cortices.

251 s calretinin immunoreactive large cells with oval or polygonal cell bodies.

252 The mental foramen may be oval or round and is usually located apical to the secon

253 Plastoglobules (PGs) are oval or tubular lipid-rich structures present in all pla

254 We show that a mutation of the zebrafish oval (ovl) locus affects a component of the ciliary tran

255 ebrafish, we generated maternal-zygotic (MZ) oval (ovl; ift88) mutants that lack all cilia.

256 the obex was activated and projected to the oval paracentral nucleus (OPC) of the intralaminar thala

257 controls the presence vs absence of a brown oval pattern on the ventral hind wing.

258 Patent foramen ovales (PFOs) are common congenital cardiac defects that

259 in radiation dose or noise between round and oval phantoms (P = .604 and P = .06, respectively), but

260 image noise, and image contrast in round and oval phantoms were determined by fitting second-degree p

261 rid domicile shape (crescentic pit, circular-oval pit, or a true gall) shows that species within crab

262 o give informed consent, and had circular or oval postoperative defects larger than 8 mm on the trunk

263 ently, reports have questioned whether these oval/progenitor cells truly serve as the facultative ste

264 bands that probe Titan's surface occur in an oval region of about 60 x 40 km(2), which has been obser

265 the contralateral eye was conspicuous as an oval region without ocular dominance columns.

266 xpression of the CB(1) cannabinoid receptor, oval/round soma, apical nucleus, a variable number of ci

267 on both poleward and equatorward of the main oval (separated by a region of low emission).

268 h and division to achieve its characteristic oval shape is poorly understood.

269 ion) is a direct consequence of the extended oval shape of the compound.

270 uroretinal rim width conforms to the overall oval shape of the disc, which is usually greatest in ver

271 Oval shape on SW elastographic images and quantitative m

272 n the absence of inducer, did not attain the oval shape or characteristic core structure of mature vi

273 anged to a more compact conformation with an oval shape.

274 s the neomain pulmonary artery was typically oval shaped with decreased anteroposterior and normal la

275 ure adipocytes, intermingled with spindle or oval-shaped cells, and accompanied by thick-walled blood

276 display a round but a horizontal or vertical oval-shaped dome and could be missed on a single OCT sca

277 round dome in 10/48 (20.8%) eyes; horizontal oval-shaped dome in 30/48 (62.5%) eyes; and vertical ova

278 ped dome in 30/48 (62.5%) eyes; and vertical oval-shaped dome in 8/48 (16.7%) eyes.

279 0) and was significantly greater in vertical oval-shaped domes.

280 aman spectroscopy (SERS) optical ruler using oval-shaped gold nanoparticles and Rh6G dye-modified rig

281 roximately 18 nm by choosing the size of the oval-shaped gold nanoparticles.

282 nce imagining and angiography, identified an oval-shaped mass on the medial rectus of the right orbit

283 The structure reveals an oblong, oval-shaped molecule with a unique globular N-terminal d

284 ages of 21 tumors showed a solid, frequently oval-shaped, and hyperechoic mass in 13 tumors and rando

285 n in the right parietal bone, filled with an oval-shaped, large, extra-axial, extradural, intracrania

286 treptococcus pneumoniae (pneumococcus) is an oval-shaped, symmetrically dividing opportunistic human

287 xed to the solar wind direction; the auroral oval shifts quickly in latitude; and the aurora is often

288 e the neural basis of body patterning in the oval squid, Sepioteuthis lessoniana Most areas in the op

289 ectrically stimulating the optic lobe of the oval squids and observing their body pattern changes, su

290 ies between the Great Red Spot and the White Ovals, the disappearance of two White Ovals in 1997-2000

291 Light microscopy demonstrated pale pink, oval to crescentic intracytoplasmic inclusions with a pr

292 en development switches metamorphically from oval to larval stages.

293 s--consistent with observations of the White Ovals-until they disappear and the cycle begins again.

294 sition of large epithelioid melanocytes with oval vesicular nuclei, distinct nucleoli, and abundant c

295 propose that the disappearance of the White Ovals was not an isolated event, but part of a recurring

296 All patent foramen ovales were completely closed in the first group.

297 RVOT geometry was not generally circular but oval with 2 different types.

298 The BMO was predominantly vertically oval with a median area of 1.74 mm(2) (range, 1.05-3.40

299 In transverse sections, PMD is oval with its long axis aligned with the dorsal border o

300 ith second intention healing for circular or oval wounds on the trunk and extremities.