ライフサイエンスコーパス: overactive

1 hereas the mechanically sensitive fibres are overactive.

2 , regulatory components upstream of WspR are overactive.

3 orders in which CRF neurotransmission may be overactive.

4 other disorders in which CaRs are under- or overactive.

5 other pathologies in which FAAH and Cox are overactive.

6 n of an unrelated synthetic reporter gene is overactive (2.3- to 5.1-fold) at all sites in the genome

7 t that, in C, the mirror system for touch is overactive, above the threshold for conscious tactile pe

8 domain-binding motif of Crumbs die due to an overactive actomyosin network associated with disrupted

9 miR-146a-deficient mice, leading to both an overactive acute inflammatory response and chronic infla

10 variety of clinical outcome measures (e.g. 'Overactive, aggressive behaviour'), symptoms proved supe

11 thy with severe renal injury secondary to an overactive alternative complement pathway (AP).

12 In sprouty mutants, the FGF pathway is overactive and ectopic branches are induced on the stalk

13 Female subjects exposed to ethanol were overactive and exhibited spatial learning deficits, effe

14 eoclasts that are large, multinucleated, and overactive and that contain paramyxovirus-like nuclear i

15 -associated neurodegeneration accompanied an overactive anterior cingulate cortex, which in turn resu

16 In aHUS patients with an underlying overactive AP, additional stimulation of the AP and inhi

17 estrogen production within the breast due to overactive aromatase.

18 We hypothesized that in the presence of overactive ATP-insensitive KATP channels, a reduction in

19 emic lupus erythematosus is characterized by overactive B cells that differentiate into autoantibody-

20 e, in late-gestation upper-layer precursors, overactive beta-catenin signaling was able to partially

21 OCD in the form of poor frontal control over overactive BG, and a frontostriatoinsular maldevelopment

22 As overactive bladder (OAB) is a prevalent and chronic medi

23 human beta3-AR agonist for the treatment of overactive bladder (OAB), is described.

24 tor agonists (beta3-AR) for the treatment of overactive bladder (OAB).

25 Overactive bladder affects 10-12% of men, of which 13% a

26 Overactive bladder affects 10-27% of men, a significant

27 -five urine specimens (from 41 patients with overactive bladder and 24 controls) were examined using

28 drugs remain the first-line treatment of the overactive bladder and a favorable efficacy/tolerability

29 dysfunctional voiding, Botox injections for overactive bladder and an adult anticholinergic for over

30 Overactive bladder and benign prostatic hyperplasia comm

31 Control patients did not have overactive bladder and did not have a clinically relevan

32 cantly less likely to receive a diagnosis of overactive bladder and more likely to receive a diagnosi

33 Men with overactive bladder and other lower urinary tract symptom

34 nation with an alpha-blocker, in men with an overactive bladder and summarize the efficacy and safety

35 d clinical trials, to establish the cause of overactive bladder and to determine the best method of m

36 ndicate that BK channel dysfunction leads to overactive bladder and urinary incontinence.

37 ure drug targets for effective management of overactive bladder are discussed.

38 may be a viable target for the treatment of overactive bladder disorders.

39 from urothelium results in incontinence and overactive bladder due to abnormal mechanotransduction;

40 New theories and modified definitions of overactive bladder have been proposed, structured eviden

41 r existing anticholinergics, in treating the overactive bladder in children need closer scrutiny.

42 l nerve neuromodulation for the treatment of overactive bladder in patients who do not respond to opt

43 The overactive bladder is a common and distressing condition

44 Overactive bladder is an important lower urinary tract s

45 Overactive bladder is now recognized as a chronic debili

46 ur understanding of the basic science of the overactive bladder it is becoming clear that the control

47 However, coexisting overactive bladder may be responsible for storage sympto

48 al treatment of men with incontinence due to overactive bladder or to stress urinary incontinence pub

49 on the Urogenital Distress Inventory and the Overactive Bladder Questionnaire (both P <0.001) at both

50 both before and after RTx as measured by the Overactive Bladder Questionnaire and International Prost

51 nd 2010 were asked to complete the validated Overactive Bladder Questionnaire based on patient sympto

52 inumtoxinA showed greater improvement in the Overactive Bladder Questionnaire SF for symptom bother (

53 om baseline in urinary symptom scores in the Overactive Bladder Questionnaire Short Form (SF); range,

54 00, higher scores indicating worse symptoms; Overactive Bladder Satisfaction questionnaire; range, 0-

55 rusor instability with subsequent obstructed/overactive bladder symptom complexes not dissimilar to t

56 y, inhibit detrusor overactivity and resolve overactive bladder symptoms acutely.

57 Men with enlarged prostates experience overactive bladder symptoms of urgency and frequency.

58 hat in men with persistent storage symptoms (overactive bladder symptoms), clinically meaningful impr

59 ht be useful clinically for the treatment of overactive bladder symptoms.

60 ection and a control group the prevalence of overactive bladder syndrome (OAB), and how it was associ

61 Lower urinary tract disorders such as overactive bladder syndrome (OABS) and interstitial cyst

62 Overactive bladder syndrome (OBS) results from disturban

63 gastroesophageal reflux disease (GERD), and overactive bladder syndrome (OBS), as well as other gast

64 apy of lower urinary tract disorders such as overactive bladder syndrome and cystitis.

65 ower urinary tract storage disorders such as overactive bladder syndrome and urinary incontinence sig

66 lower urinary tract symptoms, including the overactive bladder syndrome, and that combination of the

67 tment of nonobstructed urinary retention and overactive bladder syndrome, especially when accompanied

68 treatment of obstructive airway disease and overactive bladder syndrome.

69 ifenacin, as a treatment alternative of male overactive bladder syndrome.

70 he treatment of lower urinary tract symptoms/overactive bladder syndrome/and detrusor overactivity.

71 ive bladder and an adult anticholinergic for overactive bladder that underwent testing in children; e

72 tion and therefore are candidate targets for overactive bladder therapy.

73 oms and nonobstructive pattern recognized as overactive bladder type has also been successfully evalu

74 Treatment options for the overactive bladder were recently discussed at the 4th In

75 This mix of obstructed, overactive bladder with hidden stress incontinence incre

76 ere are persistent urinary storage symptoms (overactive bladder) following therapy with an alpha-bloc

77 on is required to identify the true cause of overactive bladder, allowing new targeted treatments to

78 veral potential targets for treatment of the overactive bladder, particularly within the mechanosenso

79 actions is pivotal to the disease process in overactive bladder, urge incontinence, and spinal cord i

80 involved in the management of patients with overactive bladder.

81 ecent developments in pharmacotherapy of the overactive bladder.

82 ted pig bladder strips, an in vitro model of overactive bladder.

83 evere lower urinary tract symptoms including overactive bladder.

84 and are obvious targets for treatment of the overactive bladder.

85 openers may have utility in the treatment of overactive bladder.

86 sorders of urine storage and voiding such as overactive bladder.

87 ment of refractory detrusor overactivity and overactive bladder.

88 Present treatments for overactive bladders have significant non-compliance rate

89 dies using anticholinergics in patients with overactive bladders supports these findings.

90 his suggests a role for BMPR-IA in mediating overactive BMP signaling in the absence of Noggin.

91 Loss of Noggin function leads to overactive BMP signaling, particularly in the palatal ep

92 This may be due to an overactive bowel, as suggested by previous studies.

93 c C3 complexes, and promoted formation of an overactive C3/C5 convertase.

94 Overactive Cdc42 has been implicated in the pathology of

95 Most human cancers contain overactive CDK4/6-cyclin D, and CDK4/6-specific inhibito

96 The inhibition of overactive CDKs during cancer remains an important strat

97 tween circuits, probably by calming down the overactive cells.

98 These overactive channels remained sensitive to sulfonylurea,

99 An overactive complement system is associated with AMD path

100 ase-relevant mutations that formed either an overactive convertase (M433I) or a convertase resistant

101 tic cell uptake is essential for suppressing overactive dendritic cell-mediated inflammatory response

102 ults from low cAMP due to a misregulated and overactive DhkC phosphorelay in the amtC null strain.

103 ess, nausea, sweating, and being restless or overactive) did not differ between the groups.

104 or depressive disorder is associated with an overactive dorsal raphe nucleus with overactive projecti

105 resting periods and single units in KO were overactive during SWR events.

106 provide a checkpoint function to inactivate overactive E2F-1, but the association may also inactivat

107 Therefore, overactive EC signaling elicits an increase in plasma tr

108 rovements in dyslipidemia, direct effects of overactive EC signaling on plasma lipoprotein metabolism

109 Obesity is associated with an overactive endocannabinoid (EC) system.

110 01) and baroreflex sensitivity (P=0.03), and overactive ergoreceptors (P=0.003) compared with patient

111 We conclude that a population of overactive, excessively synchronized iSPNs could orchest

112 diovascular responsiveness is mediated by an overactive exercise pressor reflex (EPR).

113 o exercise in hypertension is mediated by an overactive exercise pressor reflex.

114 o exercise in hypertension is mediated by an overactive exercise pressor reflex.

115 ontainment of the inflammatory response, and overactive fibrosis may cause adverse remodeling in pati

116 s of function, suggesting that it encodes an overactive form of Cdc20p.

117 and hyperactive behaviors of mutants with an overactive Galpha(q) pathway.

118 iatal AA release in HD is consistent with an overactive glutamate system and diminished glutamate tra

119 r phosphorylation and excessive signaling by overactive GPCR mutants result in a wide variety of dise

120 Ptc(+/-) mice, which have an overactive Hh pathway, exhibited sustained overinduction

121 interaction in mutated GATA1s converges with overactive IGF signaling to promote cellular transformat

122 tissues from excessive collateral damage by overactive immune cells and their proinflammatory cytoki

123 triggers of the emergency downregulation of overactive immune cells.

124 e-protecting negative feedback inhibition of overactive immune cells.

125 However, an overactive immune response can cause tissue damage and s

126 reventing uncontrolled tissue destruction by overactive immune responses, but also for protecting tum

127 We propose that an overactive immune system, including the "metabolic syndr

128 It is abnormally overactive in almost all human cancers.

129 The ergoreflex was particularly overactive in cachectics (P<0.05), accompanied by marked

130 e first evidence that neddylation pathway is overactive in ccRCC and that MLN4924 induces dose-depend

131 These processes are often overactive in diseased cells, leading to unregulated cel

132 e results suggest the muscle metaboreflex is overactive in hypertension.

133 y prefrontal-striatal circuits, which may be overactive in individuals suffering from trauma-related

134 he midbrain and hippocampus were found to be overactive in major depressive disorder during unsuccess

135 by distal cues predictive of threats and is overactive in major depressive disorder.

136 We find that STAT3, a transcription factor overactive in many cancers, regulates PCBP2, a protein i

137 factor receptor (EGFR) signaling pathway is overactive in more than half of human cancers and mediat

138 Several proteases are overactive in NS, including kallikrein-related peptidase

139 dy weight, and systemic metabolism, which is overactive in obesity and type 2 diabetes.

140 pathways were significantly upregulated and overactive in patients who developed SIRS (P < 0.0001).

141 inhibitors targeted against driver kinases, overactive in selected subsets of solid tumors, elicit i

142 STEP is overactive in several neuropsychiatric and neurodegenera

143 The orexin system is overactive in SHRs and contributes to the augmented CO2

144 mGluR5-ERK1/2 pathway is not constitutively overactive in the Fmr1 KO, however, suggesting that mRNA

145 Similarly, ethanol-exposed subjects were overactive in the open field, an effect attenuated with

146 e formation of signaling complexes that stay overactive in the presence of the attractant.

147 xpression and function in CD8(+) T cells, is overactive in these cells in patients with lymphoma, and

148 The same frontomesial network was overactive in TS patients compared with healthy subjects

149 a gain-of-functionNlrp3allele and subsequent overactive inflammasome activity displayed abnormal sacc

150 or managing genetic diseases associated with overactive inflammasomes, but also for treating common m

151 Following myocardial infarction (MI), overactive inflammation remodels the left ventricle (LV)

152 cance due to the attractiveness of targeting overactive inflammation without significant adverse effe

153 a key negative regulator to tightly control overactive inflammation.

154 actions, how glucocorticoids tightly control overactive inflammatory response is not fully understood

155 rt by delayed vascularization accompanied by overactive inflammatory responses following surgery.

156 OM characterized by the presence of overactive inflammatory responses is due to the aberrant

157 understanding of the role factors such as an overactive innate immune response play in the pathogenes

158 These mutant HPs contain increased ROS, overactive intracellular signalling through the AKT/mamm

159 arises from suppressed insulin secretion by overactive KATP channels in pancreatic beta-cells, but t

160 tion circuits bilaterally, together with an "overactive" left-sided ventral striatal-ventrolateral an

161 ochemical studies have provided evidence for overactive mAChR signaling in the fragile X knock-out (F

162 itro, a condition that is secondary to their overactive metabolic state.

163 leotide drugs are being developed to inhibit overactive miRNAs linked to disease.

164 ciated increase in glucose metabolism and an overactive mitochondrial electron transport chain and is

165 Pals1 deficiency as a potential inhibitor of overactive mitogenic signaling.

166 icating that each defect is a consequence of overactive myosin.

167 a great level of enthusiasm to downregulate overactive N-methyl-D-aspartate (NMDA) receptors to prot

168 differentiation and function as a result of overactive NF-kappaB and reduced Wnt/beta-catenin signal

169 Our findings suggest that an overactive NHEJ system and, specifically, aberrant Ku70/

170 However, overactive NMDARs can trigger cell death signalling path

171 mor suppressor is excessively degraded by an overactive oncogenic E3 ligase.

172 e inhibition and may be a strategy to target overactive oncogenic kinase cascades in cancer.

173 These include agents that either block overactive or enhance underresponsive cellular pathways.

174 iological evidence indicating this system is overactive or hyperresponsive in depression and with gen

175 a(2+) release, rather than the expression of overactive or leaky SR Ca(2+) release channels.

176 rest in defining cellular factors that limit overactive or misdirected Th17-type inflammation.

177 iety disorder (SAD), are characterized by an overactive or underactive serotonin system has not been

178 TRPpathies, disease states that result from overactive or underactive TRP channels?

179 sured samples, in which these regulators are overactive or underactive, respectively.

180 Overactive or unresolved inflammation is the primary det

181 esized that an augmented CO2 chemoreflex and overactive orexin system are linked with high ABP in bot

182 We suggest that an overactive orexin system may play an important role in t

183 FAK KO keratinocytes exhibited overactive p38 and MMP9 signaling in vitro, findings rec

184 Cell Stem Cell, Ceccaldi et al. identify an overactive p53/p21 stress response and cell cycle arrest

185 oregulation, and survival, and targeting the overactive parasympathetic system may be a useful therap

186 diac arrhythmias in mutant mice, implicating overactive parasympathetic tone.

187 rative glomerulonephritis is associated with overactive PDGF receptor signal transduction.

188 It supports the hypothesis that overactive performance monitoring is an endophenotype th

189 Overactive performance monitoring, as measured by the er

190 nitrogen stress, resulting in precocious and overactive PHG.

191 ion in Atg5(-)/(-) cells does not occur from overactive phosphatases.

192 These results suggest that overactive phosphorylation of cytoplasmic residues of be

193 els are increased in HD cells as a result of overactive positive feedback loop.

194 reduces BR only when the blink generator is overactive, possibly influencing tear film retention.

195 rotransmission in SAD is characterized by an overactive presynaptic serotonin system, with increased

196 with an overactive dorsal raphe nucleus with overactive projections to the amygdala, periaqueductal g

197 The presumed role of an overactive protein arginine deiminase 4 (PAD4) in the pa

198 Overactive pyramidal cells, notably those in the hippoca

199 nsgenic expression suppressed the effects of overactive Rac, including ectopic lamellipodia and filop

200 Overactive RAS signaling is prevalent in juvenile myelom

201 A core abnormality in both tumor groups is overactive RAS/ERK signaling, a pro-proliferative signal

202 These overactive reflexes may also contribute to the chronic s

203 on is critical for host defense; however, an overactive response is detrimental to the host.

204 Overactive responses by interleukin 17 (IL-17)-producing

205 aking, which is postulated to result from an overactive reward system in the brain.

206 ar-IR laser irradiation to thermally disrupt overactive sebaceous glands in the skin which define the

207 nd indicate that ODA is likely the result of overactive SHH signaling in humans harboring mutations i

208 Previous work has suggested that overactive signaling by group I metabotropic glutamate r

209 Selective modulation of overactive SMA-STN projection pathways may underlie the

210 ion may counteract the inhibitory effects of overactive sphincter afferents on the detrusor, and dete

211 cent hypotheses suggest an involvement of an overactive stress axis.

212 idiopathic torsion dystonia (ITD) have shown overactive striatum and frontal accessory areas and unde

213 es have suggested that PTSD patients have an overactive sympathetic nervous system (SNS) that could c

214 However, an overactive T(H)17 response results in tissue inflammatio

215 erable evidence supports the hypothesis that overactive T-channels may contribute to thalamocortical

216 The PD-L1-PD-1 axis protects the host from overactive T-effector cells not only in cancer but also

217 oint is achieved through competition between overactive telomerase and TRD.

218 e ECM of Bgn(-/0) Fmod(-/-) MCCs, leading to overactive TGF-beta1 signal transduction.

219 ing an explant culture system, we found that overactive TGF-beta1 signals induced chondrogenesis and

220 ound that cells that underwent EMT exhibited overactive transforming growth factor beta (TGFbeta) sig

221 n cancer because of increased expression and overactive transport.

222 enuating invasiveness and metastasis of Her2 overactive tumors.

223 ecently been introduced for the treatment of overactive urinary bladder syndrome.

224 the normal function of T(reg) cells, because overactive variants of some target genes are known to be

225 dolescence results in part from a relatively overactive ventral striatal (VS) motivational circuit th

226 c2 +/- ASD mice where mTOR is constitutively overactive, we observed postnatal spine pruning defects,

227 ventral epidermis, and double mutants mimic overactive Wg signaling in this tissue.

228 lays a role in disease such as cancer, where overactive Wnt signaling drives LEF/TCFs to transform ce

229 xpression at the cell surface contributes to overactive Wnt signaling in subsets of pancreatic, ovari