ライフサイエンスコーパス: overactivity

1 ion of autophagosomes as well as cathepsin B overactivity).

2 ing novel pathways thought to play a role in overactivity.

3 tially a function of VEGF receptor signaling overactivity.

4 ractivity and those with idiopathic detrusor overactivity.

5 mportance in the pathophysiology of detrusor overactivity.

6 ht play a role in the development of bladder overactivity.

7 sting bladder outlet obstruction and bladder overactivity.

8 ic and probably also non-neurogenic detrusor overactivity.

9 ting alternative pathways affecting detrusor overactivity.

10 ysregulation, predominantly with sympathetic overactivity.

11 r motor neurone syndrome, rather than muscle overactivity.

12 tem cells, to screen for suppressors of dCBP overactivity.

13 ent and not copy number that is the cause of overactivity.

14 ing, with a compensatory cardiac sympathetic overactivity.

15 eated mice, a commonly used model of bladder overactivity.

16 formed the management of neurogenic detrusor overactivity.

17 that Pirt deficiency in mice causes bladder overactivity.

18 signal leads to an equatorial band of myosin overactivity.

19 Neo-A damage resulted in central CRF systems overactivity.

20 s associated with sympathetic nervous system overactivity.

21 r hyperactivity as a feature of KATP channel overactivity.

22 oms/overactive bladder syndrome/and detrusor overactivity.

23 was characterized by disinhibition, restless overactivity, a fatuous affect, puerile behaviour and ve

24 gia following spinal cord injury and bladder overactivity after cerebral infarction.

25 This chronic mPFC overactivity also stably suppresses natural reward-motiv

26 Approximately half have detrusor overactivity and a smaller number have impaired detrusor

27 e mechanisms responsible for the sympathetic overactivity and blunted baroreflex control in chronic h

28 morphisms may contribute to Ca(v)3.2 channel overactivity and consequently to absence epilepsy and es

29 pressing this construct demonstrated TGFbeta overactivity and developed dermal and pulmonary fibrosis

30 (CIHH) during sleep that elicit sympathetic overactivity and diminished parasympathetic activity to

31 Since sympathetic overactivity and dysregulation of the renal-adrenal syst

32 failure (HF) is characterized by sympathetic overactivity and enhanced circulating catecholamines (CA

33 al muscle mass is associated with ergoreflex overactivity and exercise limitation in CHF, particularl

34 e (Fcgr3-rs), as a determinant of macrophage overactivity and glomerulonephritis in Wistar Kyoto rats

35 blunted glycogen synthase kinase (GSK)3beta overactivity and hyperactivation of its downstream mitog

36 is important in devising methods to regulate overactivity and hyperplasia of the parathyroid gland af

37 was observed, suggesting that ageing induces overactivity and hypersensitivity of the bladder.

38 flow pattern, voiding pressures, presence of overactivity and interpretation of findings on both urod

39 then leptin could contribute to sympathetic overactivity and its adverse consequences in human obesi

40 Moreover, in two mouse models of cholinergic overactivity and NMJ Ca(2+) overload, anti-cholinesteras

41 lly expressed GD is characterized by thyroid overactivity and orbital tissue inflammation and remodel

42 hed in the management of refractory detrusor overactivity and overactive bladder.

43 L225P underlies K(ATP) channel overactivity and PNDM by specifically increasing Mg-nucl

44 erapeutic alternatives for managing detrusor overactivity and possible future developments are discus

45 sulin resistance associated with sympathetic overactivity and regulation of brown fat metabolism.

46 rease cystometric capacity, inhibit detrusor overactivity and resolve overactive bladder symptoms acu

47 AA irritated the bladder, induced bladder overactivity and significantly (P < 0.001) reduced bladd

48 nsity of 3-4T, suppressed AA-induced bladder overactivity and significantly increased bladder capacit

49 t, both in patients with neurogenic detrusor overactivity and those with idiopathic detrusor overacti

50 The clinical significance of mild thyroid overactivity and underactivity is uncertain, which has l

51 deleterious effects of mutant L-type channel overactivity, and addressed potential effects of altered

52 ducing incontinence associated with detrusor overactivity, and repeated treatments appear safe and ef

53 ranscription, and therefore tandem duplicate overactivity appears to be a previously unidentified for

54 ntinence, overflow incontinence and detrusor overactivity are the major categories of urinary inconti

55 could contribute to the emergence of bladder overactivity as well as somal hypertrophy and hyperexcit

56 Bladders of DKO animals exhibited detrusor overactivity at an early stage: increased frequency of n

57 ree remissions had less evidence of HPA axis overactivity at entry than those who were not in remissi

58 ical status at 2-year follow-up and HPA axis overactivity at entry were examined.

59 , i.v.) suppressed PNS inhibition of bladder overactivity at low intensity (1T) but not at high inten

60 lure (CHF) and may contribute to sympathetic overactivity, attenuated baroreflex sensitivity (BRS), a

61 nnexin 43 plays an important role in bladder overactivity, but its localization has not been clearly

62 pses and decreased in axonal synapses during overactivity by veratridine.

63 Chronic sympathetic nervous system overactivity can also contribute to a further decline of

64 Further, this reflex overactivity can be partially normalized by antagonizing

65 The effects of C3G overactivity can be suppressed by reducing the gene dose

66 tical for maintenance of euglycemia and that overactivity can cause diabetes by inhibiting insulin se

67 n anesthetized pig model of myogenic bladder overactivity, compound 14 and (-)-cromakalim 1 were foun

68 n the genome that we tested, suggesting that overactivity could be a general property of tandem gene

69 harmacoresistance, overcoming P-glycoprotein overactivity could be investigated as a potential treatm

70 Whether sympathetic overactivity develops early during pregnancy, remaining

71 of autism spectrum disorder, inattention and overactivity, disinhibited social engagement, conduct or

72 tent with the conclusion that extreme B cell overactivity drives the initial stages of SLE leading to

73 s in PDGFRalpha(+) cells and prevent bladder overactivity during filling.

74 ole of CD154-CD40 interactions in the B cell overactivity exhibited by patients with active systemic

75 infections and tumours of immunodeficiency, overactivity in allergic and autoimmune disease.

76 Here we report that UNC-115 overactivity in C. elegans neurons promotes the formatio

77 disorder (MDD) raise the possibility that LC overactivity in depression may be secondary to reduced G

78 f thoracic aortic disease, and that TGF-beta overactivity in diseased aortas is a secondary, unproduc

79 Cholinergic overactivity in diseases of neuromuscular transmission e

80 mechanism for the development of sympathetic overactivity in experimental hypertension.

81 ng hypothalamic pituitary adrenal (HPA) axis overactivity in healthy controls (HCs) and patients with

82 r, these findings suggest that mechanoreflex overactivity in heart failure may be a compensatory resp

83 endocrine studies have demonstrated HPA axis overactivity in major depression, a relationship of HPA

84 Induced fluency decreased or eliminated the overactivity in most motor areas, and largely reversed t

85 e that simultaneous underactivity in OFC and overactivity in NAC can negatively impact behavioral con

86 eurone channelopathy induced by carotid body overactivity in neurogenic hypertension that may contrib

87 bladder DRG neurons and to alleviate bladder overactivity in Pirt(-/-) mice.

88 nce that supports the hypothesis of dopamine overactivity in schizophrenia is the psychomimetic poten

89 n relevant animal models have indicated that overactivity in selective hippocampal circuits contribut

90 ere is an association between P-glycoprotein overactivity in some regions of the brain and pharmacore

91 Overactivity in the detrusor is a common clinical proble

92 findings support the hypothesis of glutamate overactivity in the development of dyskinesias.

93 A novel finding was the presence of relative overactivity in the lateral premotor and inferolateral p

94 First, we found overactivity in the midbrain, which was at the level of

95 d touch' synesthetic experience is caused by overactivity in the neural system that responds to the o

96 Parkinson's disease patients showed relative overactivity in the precuneus, premotor and parietal cor

97 Overactivity in the subthalamic nucleus (STN) is believe

98 Indeed, Hh-deficient embryos showed Notch overactivity in their defective gut mesenchyme and expos

99 sure-flow urodynamics demonstrating detrusor overactivity, in the setting of a clinically relevant ne

100 children have substantial difficulties with overactivity, inattention, and impulsivity that are just

101 Sympathetic overactivity is a compensatory mechanism at first, but m

102 Detrusor overactivity is a relatively common yet embarrassing sym

103 Detrusor overactivity is a relatively common yet embarrassing sym

104 Chronic sympathetic overactivity is also known to be present in central obes

105 This overactivity is consistent with suggestions in previous

106 However, given that exercise pressor reflex overactivity is known to elicit enhanced circulatory res

107 The cause of this overactivity is not clear, but may be driven by certain

108 We have demonstrated that this overactivity is responsible for the exaggeration in the

109 nderstanding of the pathogenesis of detrusor overactivity is slow but steady.

110 Detrusor overactivity is the occurrence of abnormal increases in

111 Bladder overactivity is traditionally treated with anticholinerg

112 its endogenous ligand, angiotensin II, with overactivity leading to vascular remodeling and hyperten

113 Since the pathology of TGF-beta overactivity manifests primarily within the arterial med

114 This overactivity may be associated with the addictive scratc

115 This overactivity may be one of the underlying mechanisms of

116 nia" factor, in particular the subdimension "overactivity." Ncan(-/-) mice were hyperactive and showe

117 Neurogenic detrusor overactivity (NDO) is a well known consequence of spinal

118 Neurogenic detrusor overactivity (NDO) is among the most challenging complic

119 sclerosis often develop neurogenic detrusor overactivity (NDO), which currently lacks a universally

120 Overactivity occurs at the level of RNA transcription, a

121 iety-like behavior, our results suggest that overactivity of 5-HT(1B) autoreceptors in DRN neurons ma

122 se mutations of the Gs alpha gene leading to overactivity of adenylyl cyclase have been identified in

123 receptor binding, then causes inappropriate overactivity of basal ganglia-frontal projections, resul

124 al ganglia opioid transmission, resulting in overactivity of basal ganglia-frontal projections.

125 within the brain to another, as a result of overactivity of certain nerve cells.

126 latory lesions, suggesting that sprouting or overactivity of contralateral corticostriatal input cont

127 Overactivity of EGFR signaling, as achieved by heat-shoc

128 The overactivity of ergoreceptors (intramuscular afferents s

129 ersistent free heme overload in malaria, the overactivity of HO-1 resulted in continuous transient ge

130 Overactivity of immune responses at a systemic level is

131 We demonstrate overactivity of insulin-like growth factor (IGF) signali

132 p1 and Gasp2 have phenotypes consistent with overactivity of MSTN and GDF-11.

133 the brain may be caused by overexpression or overactivity of multidrug transporters, such as P-glycop

134 ssion and might be more appropriately termed overactivity of normal PRS.

135 roblasts and lymphoblasts from patients with overactivity of normal PRS.

136 e-feedback mechanism to protect neurons from overactivity of Pum.

137 ess of movement in PD has been attributed to overactivity of striatal projection neurons forming eith

138 Overactivity of subthalamic nucleus (STN) neurons is a c

139 lation and cell cycle arrest derive from the overactivity of TGF-beta receptor signaling, which is no

140 al actions of alcohol that may contribute to overactivity of the ACC during withdrawal and excessive

141 f sleep-wake regulation consisting of either overactivity of the arousal systems, hypoactivity of the

142 Overactivity of the brain renin-angiotensin system is a

143 enetic and epigenetic events cause universal overactivity of the cell cycle cdks in human cancer, and

144 ns and pathologies share the common theme of overactivity of the complement system's alternative path

145 in some electrophysiological studies showing overactivity of the corticostriatal glutamatergic system

146 ion in Alzheimer patients has been linked to overactivity of the cyclin-dependent kinase 5 (CDK5) and

147 Obesity is associated with overactivity of the endocannabinoid system, which is inv

148 major cause of end-stage kidney disease, and overactivity of the endocannabinoid/cannabinoid 1 recept

149 affected relatives, findings consistent with overactivity of the enzyme.

150 Overactivity of the hexosamine pathway mediates glucose-

151 activation of protein kinase C isoforms, and overactivity of the hexosamine pathway.

152 The E23K variant leads to overactivity of the K(ATP) channel, resulting in reduced

153 ic pathobiology in depression is a result of overactivity of the LC.

154 ate changes and overproliferation, mimicking overactivity of the RAS-MAPK pathway.

155 rtension, a genetic disease characterized by overactivity of the renal sodium chloride cotransporter

156 To establish that overactivity of the renal TGF-beta system mediates the f

157 Overactivity of the subcallosal cingulate has been assoc

158 buting to changes in insulin sensitivity and overactivity of the sympathetic nervous system.

159 e strongly in support of the hypothesis that overactivity of the TGF-beta system in the kidney is a c

160 Overactivity of these serotonergic sympatho-somatomotor

161 exogenous endothelin-1, possibly reflecting overactivity of this system and ET(A) receptor downregul

162 following chronic challenges may result from overactivity of this system.

163 se effects of chronic stress may result from overactivity of this system.

164 contractions during filling, and rescued the overactivity of Trpv4 (-/-) bladders.

165 s circulating atrial natriuretic peptide and overactivity of various intrarenal paracrine systems, in

166 ty mucocutaneous pigmentation, and endocrine overactivity (Ophthalmic Surg Lasers Imaging 39(6):514-6

167 al treatments like drug therapy for detrusor overactivity or sling procedures for female stress incon

168 ecation for patients with neurogenic bladder overactivity or spinal cord lesions.

169 modulin-dependent protein kinase II (CaMKII) overactivity plays a crucial role in the pathophysiology

170 Detrusor overactivity poses a major challenge to physicians from

171 These findings indicate that dopamine overactivity predates the onset of schizophrenia in indi

172 Because a state of adrenergic overactivity prevails when triiodothyronine (T3) concent

173 COMT genetic overactivity produced a selective overdrive of the endoc

174 function, especially for those with detrusor overactivity refractory to anticholinergics, is, however

175 ry feedback, the people who stuttered showed overactivity relative to controls in the anterior insula

176 We propose that detrusor overactivity results from exaggerated symptomatic expres

177 rams under an awake condition showed bladder overactivity revealed by time-dependent reductions in in

178 nerve stimulation in the management of both overactivity syndromes and nonobstructive voiding dysfun

179 s of medications aimed at targeting cytokine overactivity that act directly on brain function and/or

180 chanisms that are responsible for the B cell overactivity that is observed in patients with SLE, we h

181 nd pseudoephedrine might reduce the synaptic overactivity that occurs in the slow-channel myasthenic

182 n in the female LC could contribute to LC-NE overactivity that underlies the hyperarousal symptoms of

183 nsitivity as well as non-neurogenic detrusor overactivity, there is up-regulation of unmyelinated ner

184 bited social engagement, and inattention and overactivity through to young adulthood (pooled p<0.0001

185 ed as an important mediator inducing bladder overactivity under pathological conditions such as spina

186 Ergoreceptor overactivity was associated with a worse symptomatic sta

187 Hippocampal overactivity was due to a failure to deactivate during l

188 Foxo3a inhibits NF-kappaB activation, whose overactivity was responsible for T cell hyperactivity in

189 Focusing on hippocampal overactivity, which has emerged as a central feature of

190 cular the role of the various forms of motor overactivity, which might be amenable to botulinum toxin

191 on alternative pathways underlying detrusor overactivity with the intention of improving storage sym