ライフサイエンスコーパス: overall yield

1 were prepared in four or five steps (33-50% overall yield).

2 seven steps and three purifications (24-28% overall yield).

3 o afford multifunctionalized molecules (>80% overall yield).

4 longest linear sequence and proceeds in 10% overall yield.

5 is of (-)-gephyrotoxin in nine steps and 14% overall yield.

6 e indole alkaloids in only four steps in 80% overall yield.

7 thiazino-, or thiazepino-2H-indazole in good overall yield.

8 accomplished in nine chemical steps and 13 % overall yield.

9 leted the synthesis of 3 in 12 steps and 13% overall yield.

10 dione alkaloids caulibugulones A-D in 24-57% overall yield.

11 nt amino acid residues in nine steps and 42% overall yield.

12 nse element (ERE) were synthesized in 12-17% overall yield.

13 l synthesis of tatanan A in 13 steps and 13% overall yield.

14 MgCl.LiCl and hydrolysis furnished 5 in good overall yield.

15 as it is prepared in just five steps and 23% overall yield.

16 propylidene-D-myo-inositol in 16 steps in 3% overall yield.

17 en accomplished in nine linear steps and 55% overall yield.

18 lavine was accomplished in 8 steps and 7.1 % overall yield.

19 and practical route involving 5 steps in 40% overall yield.

20 ve system was made in 21 steps and only 0.1% overall yield.

21 onogashira cross-coupling reactions with 62% overall yield.

22 nine steps from thiosalicylic acid in 14.5% overall yield.

23 s affords (+/-)-gamma-rubromycin (1) in 4.4% overall yield.

24 multiple catalytic reactions with excellent overall yield.

25 ge scale preparation, is accomplished in 23% overall yield.

26 ol required seven steps and proceeded in 18% overall yield.

27 drolysis gave beta-truxinic acid, 10, in 69% overall yield.

28 ized from seven to five steps, with a better overall yield.

29 ophenylboronic acid and 2-iodoaniline in 60% overall yield.

30 y-2-propyl)amine, 9, was achieved in 47- 51% overall yield.

31 eted in a 10 step linear sequence and 11-27% overall yield.

32 hybrubin A in three steps from 13 and 20.8% overall yield.

33 l ester, was achieved in eight steps and 48% overall yield.

34 ly delivers the desired silyltriflate in 66% overall yield.

35 f 8-epi-lucentamycin A in 15 steps with 2.2% overall yield.

36 esis of the clinical candidate VX-745 in 38% overall yield.

37 simiroa edulis, on a multigram scale in good overall yield.

38 ced from the Bamford-Stevens reactant in 82% overall yield.

39 ranose (6) and gives 3 in 11 steps with 9.7% overall yield.

40 om guanosine and gives 3 in 8 steps with 23% overall yield.

41 doline 1 was achieved in four stages and 32% overall yield.

42 cyclopentene ring, was accomplished in 13.5% overall yield.

43 was completed in nine chemical steps and 21% overall yield.

44 ized in three steps from phenanthrene in 44% overall yield.

45 near sequence of 24 steps, proceeded in 4.6% overall yield.

46 ies, has been achieved in 11 steps and 15.4% overall yield.

47 oped that proceeds in seven steps and 21-25% overall yield.

48 from commercially available materials in 42% overall yield.

49 butylaniline and 2-chlorobenzoic acid in 29% overall yield.

50 ired eight linear steps and proceeded in 37% overall yield.

51 eps (14 chromatographic separations) and 11% overall yield.

52 mercially available starting materials in 6% overall yield.

53 ute led to UT-39 in 19 steps with around 10% overall yield.

54 embled in 19 steps with a approximately 5.0% overall yield.

55 otent neurokinin 1 (NK1 ) antagonist in 60 % overall yield.

56 emical transformations and resulted in a 44% overall yield.

57 5R)-1a was accomplished in nine steps in 18% overall yield.

58 from ethyl 4-fluorobenzoylacetate (3) in 46% overall yield.

59 ith high stereocontrol (>20:1 d.r.) and 11 % overall yield.

60 g of a [2.2.1]dioxabicycloheptane core in 7% overall yield.

61 isobutyrylguanosine in nine steps with 10.2% overall yield.

62 rded a mixture of three stereoisomers in 61% overall yield.

63 ra has been synthesized in 12 steps and 28 % overall yield.

64 s single diastereoisomers (>99:1 dr) in good overall yield.

65 olo-fused heterocycles were obtained in good overall yields.

66 te the desired fused 1,2,3-triazoles in good overall yields.

67 mmercially available (R)-Roche ester in >10% overall yields.

68 ely, could be achieved in few steps and good overall yields.

69 ght halves of halichondrins A-C in excellent overall yields.

70 no-substituted indanes and tetralins in good overall yields.

71 veral polyfunctionalized derivatives in good overall yields.

72 dine systems as single diastereomers in good overall yields.

73 s were synthesized in four steps with 17-66% overall yields.

74 of 4-substituted chlorophthalazines in good overall yields.

75 TDs) with rare alicyclic scaffolding in high overall yields.

76 ocedure to give the target compounds in good overall yields.

77 in a regioselective manner and in excellent overall yields.

78 umn chromatography in very good to excellent overall yields.

79 were identified to be equally important for overall yields.

80 valent iodine reagents were prepared in good overall yields.

81 es C to form substituted 2-indanones in good overall yields.

82 ducts were obtained in moderate to excellent overall yields.

83 were synthesized in only 8 steps and 24-26% overall yields.

84 alogues 2 and 4 has been achieved with > 40% overall yields.

85 perature within minutes in good to excellent overall yields.

86 o give bicyclic oxazolidine products in good overall yields.

87 rom aldehyde 4, was developed with excellent overall yields.

88 generates aminophthalazin-1(2H)-ones in good overall yields.

89 yn-1-ols, respectively, in one-pot with good overall yields.

90 ,2-a]quinazolinones 4, respectively, in good overall yields.

91 methyl ketones, esters, and amides in 48-78% overall yields.

92 e by standard synthetic procedures with high overall yields.

93 ubstituted pyrroles in moderate to very good overall yields.

94 were synthesized in three steps with 86-91% overall yields.

95 ioselective syntheses of cladoacetals A (1a, overall yield: 16%) and B (1b, overall yield: 34%) from

96 cetals A (1a, overall yield: 16%) and B (1b, overall yield: 34%) from crotonaldehyde in nine and seve

97 itro esters and amides were obtained in good overall yields (53-84%).

98 ing environmentally benign conditions in 30% overall yield (6 steps) for the (S)-isomer, in 27% (7 st

99 he product materials to be generated in good overall yields (63-99%) and high enantioselectivities (7

100 y available Evans' chiral propionimide in 5% overall yield (8 steps from Evans' chiral dipropionate s

101 efficient six-step DTS that proceeded in 35% overall yield (83% average yield per step).

102 in 11 vessels and approximately 24% combined overall yield (A + C).

103 6)-carboxyfluorescein (JOE) is reported; the overall yield achieved starting from isovanillin is 10 t

104 eps from cyclopentenone and proceeded in 28% overall yield; adaptation of this route to an enantiosel

105 The macrocycles were isolated in 13-45% overall yield after HPLC purification and lyophilization

106 sis of 1 was accomplished in 7 steps and 38% overall yield aided by the development of an innovative,

107 In an overall yield analysis, pathogen yield was 57% (871 of 1

108 ed from readily available d-arabinose in 11% overall yield and >99.5/0.5 dr (diastereomeric ratio).

109 ocedure and isolated in approximately 50-60% overall yield and <99% enantiopurity, after diastereosel

110 The route proceeds in ten steps with an 8% overall yield and 92% ee.

111 e structure of yuremamine is reported in 39% overall yield and 96% ee over five steps.

112 urnishing the desired products in up to 77 % overall yield and 99:1 enantiomeric ratio.

113 synthetic route proceeds in 7 steps with 47% overall yield and begins from the abundant and inexpensi

114 rahydroquinolines 18 or indolines 14 in high overall yield and diastereoselectivity (19 examples each

115 with complete exo stereoselectivity in good overall yield and enantioselectivity (up to 99% and 166:

116 s been completed in 21% (TBZ) and 16% (DTBZ) overall yield and in >97% ee from the starting dihydrois

117 to non-glucose sugars often results in lower overall yield and productivity of ethanol.

118 t eucapsitrione, has been synthesized in 43% overall yield and six steps, including a key Suzuki-Miya

119 , 23d, and 23e were prepared in good to high overall yield and were selective for beta-alanyl aminope

120 ed C-H activation/Cope rearrangement in good overall yield and with good diastereo- and enantiocontro

121 Overall yields and results likely vary between studies d

122 d-based derivatives were synthesized in good overall yields and screened for their inverse agonist ac

123 3, and 14, respectively) were made in 13-17% overall yields and six to seven steps from oxazolidine b

124 (-)-(R,R,R)-hoprominol (in 10 steps and 4.0% overall yield) and (-)-(4'S,4''R,2'''R)-hopromalinol (in

125 acid 12 were synthesized in eight steps (44% overall yield) and three steps (55% overall yield), resp

126 shortest synthesis of codeine (13 steps, 20% overall yield) and, for the first time, allows access to

127 lphenyl)cyclopentyl)methanol in 7 steps, 11% overall yield, and >98% ee and de.

128 quence), affords the target molecule in 3.5% overall yield, and confirms the stereochemical assignmen

129 ,S)-homaline was achieved in 8 steps and 18% overall yield, and the asymmetric synthesis of (-)-(R,R)

130 ed photocatalyst 1a can be prepared in a 56% overall yield ( approximately 4.4 g).

131 photocatalyst 2a can be synthesized in a 78% overall yield ( approximately 8.1 g), and the iridium-ba

132 ly unstable but could be trapped in very low overall yield as the stable O(2)-benzyl derivative.

133 cedure afforded the target compound in a 68% overall yield based on the initial amount of the startin

134 atural products phidianidines A and B in 19% overall yield by a convergent route that will make analo

135 The oxidant was prepared in 87% overall yield by combining a fluorous amine with tosyl c

136 ative technique to produce nanosheets in 95% overall yield by cyclical monolayer compressions in a ro

137 i-A) systems have been synthesized in 58-66% overall yield, by a three-step synthesis sequence starti

138 total synthesis of (+)-scuteflorin A in 14% overall yield, employing a chiral iminium salt to effect

139 -d-ribose, the product is obtained in a 6.7% overall yield following an 11-step reaction sequence.

140 e the unstable hexacyclic parnafungin A (13% overall yield for 8 steps) and C (8% overall yield for 9

141 A (13% overall yield for 8 steps) and C (8% overall yield for 9 steps) models.

142 The overall yield for the 12-step synthesis is 34%.

143 The overall yield for the synthesis was 2.0%.

144 doubly substituted (DS) configurations which overall yield four electrons in four singly occupied orb

145 been accomplished in 12 linear steps and 18% overall yield from (-)-ethyl lactate.

146 hesis of (+)-petromyroxol in 9 steps and 20% overall yield from a readily accessible starting materia

147 of THL was accomplished in 10 steps and 31% overall yield from an achiral ynone.

148 (+/-)-actinophyllic acid is realized in 22% overall yield from commercially available di-tert-butyl

149 e synthesis proceeds in six steps and 59-70% overall yield from commercially available l-fucose, maki

150 lock 45 was synthesized in 11 steps and 6.5% overall yield from commercially available materials.

151 )-vincorine is achieved in nine steps and 9% overall yield from commercially available starting mater

152 liniketal B was obtained in 11 steps and 23% overall yield from commercially available starting mater

153 indanone was prepared in three steps and 48% overall yield from cyclohex-2-en-1-one.

154 ine (-)-31 was obtained in 16 steps and 3.6% overall yield from cyclohexan-1,3-dione.

155 fic fashion in seven reaction vessels in 27% overall yield from d-(+)-trytophan methyl ester (14) via

156 ps for the longest linear route, with a 1.7% overall yield from d-cellobiose and d-glucose.

157 has been achieved in 14 linear steps and 11% overall yield from ethyl glyoxalate.

158 ctical synthetic sequence furnished 1 in 11% overall yield from hydrocortisone in 15 linear steps.

159 /-)-streptonigrin in 14 linear steps and 11% overall yield from inexpensive ethyl glyoxalate.

160 id (+)-gliocladin C (11) in 10 steps and 11% overall yield from isatin is reported.

161 ne has been accomplished in 15 steps and 30% overall yield from known compounds.

162 icient and practical route with satisfactory overall yield from low-cost starting materials.

163 Previously, compound 1 was prepared in low overall yield from piperidinone 2 via the Strecker react

164 dalin was accomplished in five steps and 39% overall yield from readily available 4-bromo-2-triisopro

165 false positive hits and as such improve the overall yield from screening campaigns.

166 a multigram scale in three steps and in 44% overall yield from the corresponding benzylamines.

167 gion with a total of three HPLC events in 8% overall yield from the fragments.

168 /-)-9 was accomplished in four steps and 58% overall yield from the known pyrrolidinone 5.

169 In only five simple steps and 48% overall yield from the natural trioxane artemisinin, the

170 e corresponding galactose analogue in 66-78% overall yields from free sugars.

171 In only three steps and in 21-67% overall yields from the natural trioxane artemisinin, a

172 The overall yields (from phenylacetaldehyde) were 19% for 3-

173 in C has been established in four steps (31% overall yield) from a readily available compound without

174 Dinemasone C was prepared in three steps (8% overall yield) from cis-tetrahydro-4-hydroxy-6-methyl-2-

175 C acid was synthesized in eight steps (14.5% overall yield) from commercially available starting mate

176 aureol has been achieved in eight steps (14% overall yield) from epoxyfarnesol.

177 'R,2'''R)-hopromalinol (in 10 steps and 9.3% overall yield), from commercially available starting mat

178 R)-hopromine was achieved in 9 steps and 23% overall yield, from commercially available starting mate

179 = Ni, Pd, and Pt, respectively) in excellent overall yield (>95%) after three steps from commercially

180 ), which was synthesized in six steps in 52% overall yield, had low micromolar EC(50) for DeltaPhe508

181 +/-)-7-hydroxylycopodine that proceeds in 5% overall yield has been achieved.

182 These 2-nm DNA-Au NPs are obtained in a 46% overall yield, have a high surface coverage of DNA (64.8

183 s (PIN-acac complexes) were prepared in good overall yield in three steps from 2-iodo-1-naphthoic aci

184 tic route to pyrrolo[3,2,1-jk]carbazole (54% overall yield in two steps from indole).

185 dyads are designed and synthesized in 67-73% overall yields in 3 steps from commercially available st

186 g mixtures, and its potential for increasing overall yields in preparative mass spectrometry is explo

187 ed products are obtained in moderate to good overall yields irrespective of the strategy followed, in

188 N-acetylneuraminic acid in 15 steps and 17% overall yield is described.

189 The target tetrasaccharide, obtained in high overall yield, is amenable for conjugation to proteins.

190 from (R)-(+)-pulegone (3), proceeding in 44% overall yield, is described.

191 ccessible in essentially three steps and 34% overall yield, is stable as a solid when heated to 44 de

192 e and convergent synthesis (eight steps, 19% overall yield), its extension to the preparation of a se

193 of lipoprotein(a) levels >/=80th percentile overall yielded net reclassification indices of +16% (95

194 ghting optimization steps that increased the overall yield of 1 from 10.0% to 30.5%.

195 henolide was accomplished in 13 steps and an overall yield of 1.75% starting from commercially availa

196 without the use of phenolic protection in an overall yield of 13.4%.

197 phimedine in 8 steps from tryptamine with an overall yield of 14%.

198 ebrachidine (2), was then accomplished in an overall yield of 14.1% in 13 reaction vessels from d-(+)

199 seudoisocytidine (24), respectively, with an overall yield of 15.9% (six steps) and 37.9% (four steps

200 atographic purification, which results in an overall yield of 16-23% depending on the identity of the

201 2-methoxynaphthalene in 11 steps and with an overall yield of 2%.

202 ased on the starting purified A chain and an overall yield of 24 % based on the substitution of the r

203 selective synthesis of 1 in 10 steps with an overall yield of 24% from readily available benzyloxyace

204 d recrystallization significantly raises the overall yield of 2S.

205 olesterol was accomplished with an excellent overall yield of 3.5%.

206 from intermediate 11b in seven steps with an overall yield of 33.7%.

207 ackbone was successfully constructed with an overall yield of 37% from disaccharide building blocks.

208 as few as 15 linear steps (21 total) with an overall yield of 4.6%.

209 ble starting materials in five steps with an overall yield of 40% and without any column chromatograp

210 compound is prepared in seven steps with an overall yield of 41% starting from geraniol.

211 lidine-3,4-diol], prepared in 11 steps in an overall yield of 45% from d-lyxonolactone, is a potent s

212 ncisely achieved in four or five steps in an overall yield of 45, 33 and 44%, respectively, from a co

213 The overall yield of 46% in five steps was a significant imp

214 The overall yield of 50 % is a large improvement over the si

215 g group in 18 allowed preparation of 1 in an overall yield of 53% from 4 and eliminated the necessity

216 wing the synthesis of (R)-pantolactone in an overall yield of 55% (three steps) and high enantiomeric

217 ease-associated variants in 12 cases, for an overall yield of 6.3%.

218 With an overall yield of 6.4%, this pentacyclic compound has bee

219 stereoselective synthesis of morphine in an overall yield of 6.6 %.

220 15 linear steps from 4-bromotryptophol in an overall yield of 6.7%.

221 is synthesis proceeds in eight steps with an overall yield of 63%.

222 rs more than 99%; esters were isolated in an overall yield of 68% +/- 5% with radiochemical purity of

223 nvergent approach provides telmisartan in an overall yield of 72% while circumventing many issues ass

224 mol) from starting sugar 1 in 15 steps in an overall yield of 73%, with only 5 purification steps.

225 synthesis should take <4 d, resulting in an overall yield of 74% with a final step yield of 91%.

226 lt (1, Bobbitt's salt) in 88% yield, with an overall yield of 75%.

227 dispegatrine (1) has been accomplished in an overall yield of 8.3% (12 reaction vessels) from 5-metho

228 imidazole as elution buffer, which gave the overall yield of 80.3% and purity of 97.5%.

229 lethylamine at 65 degrees C for 1 h, with an overall yield of 96%.

230 bserved folding rates, resulting in a higher overall yield of active protein.

231 and IPr are isolated in four steps, with an overall yield of approximately 50%.

232 d three-step procedure and is isolated in an overall yield of approximately 55%.

233 The overall yield of bathorhodopsin is improved by using mon

234 ost deleterious stresses, affects growth and overall yield of crop plants.

235 progenitor cells enhanced the maturation and overall yield of in-vitro-derived RBCs.

236 U-34 and TT-35 in 18 steps with an excellent overall yield of more than 10% from d-xylose, while the

237 The overall yield of mutations among ARVC cases was 58% vers

238 The overall yield of our synthesis is 3.2% from 2-methylcycl

239 The overall yield of pathogenic mutations was higher among d

240 The overall yield of SL was 23.2% (95/409).

241 ) led to marked improvements in the isolated overall yield of the desired compound.

242 The overall yield of the eight-step sequence was 60 %.

243 e determine speed, product distribution, and overall yield of the photochemical process.

244 The overall yield of these radicals was measured to be 168-2

245 The overall yield of TRDN mutations was significantly greate

246 ino-5-bromopyridine (1b), respectively, with overall yields of 10.8% and 6.6%, respectively.

247 18 are obtained in nine and five steps with overall yields of 15% and 33%, respectively.

248 essible from the Inhoffen-Lythgoe diol) with overall yields of 15%, 6%, and 3% for 5a, 5b, and 5c, re

249 -dihydroxybenzoic acid with the satisfactory overall yields of 31% and 34%.

250 n, and protein conjugation, were prepared in overall yields of 40-97%.

251 ieno[3,2-b][1]benzothiophenes were formed in overall yields of 5-32%.

252 p procedure afforded the desired products in overall yields of 5-36%, and it tolerates structural div

253 11 steps from 4-methoxypyridines 6 and 7 in overall yields of 8 and 8%, respectively.

254 moted iodination (-40 to -60 degrees C) with overall yields of 80-90% and > 95% para selectivity foll

255 much higher asymmetric inductions and higher overall yields of aziridines.

256 oted dehydration and reduction provides good overall yields of the title compounds in three steps and

257 3'-phosphitylation give targets 1-4 in ~1-3% overall yield over 11 steps from 5.

258 Hapalindole J was prepared in 11% overall yield over 11 synthetic steps and hapalindole U

259 steps and hapalindole U was prepared in 25% overall yield over 13 synthetic steps from commercially

260 ach, (+)-esermethole was synthesized in good overall yield over 3 steps starting from the 1,4-additio

261 yl structures, synthesized in six steps with overall yields ranging from 11-64%.

262 (20 mol %) to give cyclopenta[b]indoles with overall yields ranging from 8 to 73% (for 2 steps).

263 eps (44% overall yield) and three steps (55% overall yield), respectively.

264 a total of 13 linear steps, and 7 % and 8 % overall yield, respectively (see scheme; (-)-sp= (-)-spa

265 c group differentiation (12 steps, 4% and 8% overall yield, respectively).

266 arins (MW = 1778.5 and 1816.5) in 45 and 37% overall yield, respectively, starting from a simple disa

267 nucleosides in seven steps with 24% and 12% overall yield, respectively.

268 s(4'-anilino)naphthalene, 21, in 65% and 90% overall yield, respectively.

269 NJ as single diastereoisomers in 16% and 24% overall yield, respectively.

270 ercial d-galactal in 13.4%, 21.1%, and 16.7% overall yield, respectively.

271 of uracil (U) and thymine (T) in 37 and 45% overall yields, respectively.

272 ccomplished in four steps and 25.6 and 37.4% overall yields, respectively.

273 Overall, yield-scaled GWP was minimized at optimal N rat

274 gin A has been achieved in six steps and 14% overall yield starting from commercially available tyros

275 ter afforded the target compounds in 16-21 % overall yield starting from D-glucose.

276 solution; such procedures proceed in 30-60% overall yield starting from inexpensive carbonyl compoun

277 en accomplished in five linear steps and 53% overall yield, starting from the readily available 3-chl

278 to a concise (13 steps) and efficient (14 % overall yield) synthesis of the macrolide (-)-clavosolid

279 Moreover, they are formed with speeds and overall yields that are significantly greater than those

280 of 1 has been previously reported in a poor overall yield, the total synthesis of the other seven st

281 nooxy amines have been synthesized in 60-95% overall yield using a common synthetic strategy from rea

282 phane was synthesized in three steps in good overall yield using mild conditions.

283 ion of F-BODIPYs to O- and C-BODIPYs in high overall yields using a mild one-pot procedure.

284 synthesized in 4 steps from d-ribose in 41% overall yield via an efficient intramolecular Baylis-Hil

285 no-1,2,4-triazoles (1) were prepared in good overall yield via two convergent routes.

286 uct was > or = 99.5% pure by GC and NMR, and overall yield was as high as 72%.

287 ree-step route that provides ketone 5 in 75% overall yield was developed.

288 aration of GSH bioconjugates in a satisfying overall yield was exemplified by the case of trypanothio

289 nitial contact and among pregnant women, the overall yield was lower than anticipated.

290 lichondrin B; 150 mg of halichondrin B (68 % overall yield) were obtained from 200 mg of the right-ha

291 ions, inexpensive reagents, step-counts, and overall yield when compared with previous synthetic atte

292 ch at least one pathogen was identified) and overall yield (which calculated the proportion of study

293 hese monomers is challenging (~20 steps, <3% overall yield), which has precluded full characterizatio

294 and C27-C38 aldehydes, respectively, in high overall yields with an excellent stereoselectivity.

295 ygrolines and pseudohygrolines in 30% to 56% overall yields with dr's > 95:5.

296 rcially available starting materials (61-75% overall yield) with minimal chromatographic purification

297 ced Winterfeldt spirocyclic precursor in 47% overall yield, with a longest linear sequence of five st

298 as achieved in 5 steps from galactose in 81% overall yield without any chromatographic separation ste

299 nthesis of the enantioenriched API in higher overall yield without the need for a resolution.

300 as completed in 14 steps from furan, in 9.5% overall yield, without the use of any protecting groups.