ライフサイエンスコーパス: overcome

1 ies the ER stress that is elicited cannot be overcome.

2 chieve this, the identified barriers must be overcome.

3 r, these factors affecting production can be overcome.

4 lutionary hurdle relatively few species have overcome.

5 epending on whether biases were successfully overcome.

6 enemase-producing Enterobacteriaeceae can be overcome.

7 ehaviour is lost when external perturbations overcome a critical threshold, i.e. above a critical mag

8 A two-photon process is employed to overcome a first order forbidden transition and the firs

9 l systems identification, AMA may be able to overcome a fundamental limitation of standard subunit mo

10 e the mechanisms via which these CAR T cells overcome a hostile tumor microenvironment.

11 ng, S-shaped Atg17 complexes are required to overcome a substantial kinetic barrier in the transition

12 , the RNA ligand-centric approach taken here overcomes a problematic molecular redundancy of CspC and

13 pproach to directly impede transcription and overcome aberrant pathways in aggressive malignancies.

14 Overcoming acquired drug resistance remains a core chall

15 es within the first few minutes of injection overcomes adverse reactions in pigs using two independen

16 ic processes have been optimized in order to overcome all the issues of the technological integration

17 he use of optical excitation would allow for overcoming all these limitations.

18 research, potential challenges that must be overcome along the way, and a literature review of the c

19 n induced by XPC expression in somatic cells overcomes an early epigenetic barrier in cellular reprog

20 Microbial populations can withstand, overcome and persist in the face of environmental fluctu

21 The depletion effects are overcome and protein capture rates are enhanced by apply

22 ient reaches deep into the tissue, it likely overcomes antioxidant barriers only within approximately

23 ich mediates the cognitive control needed to overcome anxiety and differentiate between old and alter

24 g of the energy barrier that the system must overcome at the stage of membrane budding by an assembli

25 ic regulation of viral functions required to overcome barriers to infection.RNA viruses, such as poli

26 g of markers within a single cell promise to overcome barriers to T-cell discovery in human asthmatic

27 However, major challenges still have to be overcome before commercialization can be achieved.

28 to grow, but several challenges remain to be overcome before LVADs will be considered as the therapy

29 ly quantifies individual allelic effects and overcomes bias from hitchhiking mutations and context-de

30 crease in RUNX1 expression; the blockade was overcome by a RUNX1 inhibitor.

31 ransmembrane and cytoplasmic domains must be overcome by cellular energy input to stabilize extension

32 utant tumor cells, the effects of which were overcome by combined treatment with osimertinib and SFK

33 tion of infection via apical inoculation was overcome by disruption of intercellular junctions.

34 During S-phase, minor DNA damage may be overcome by DNA damage tolerance (DDT) pathways that byp

35 Nonetheless, these defects could be overcome by early or prolonged exposure to IL-2, or by a

36 e negative effect on HGF-mediated growth was overcome by expression of CD44v4-10, but not by CD44s.

37 The GC-MS component co-elution was overcome by GCxGC-qMS.

38 therapeutic treatment of cancer and might be overcome by inhibition of the transporter.

39 serving as a mechanical barrier that can be overcome by mechanical force as well as disruption of th

40 signal transduction pathway, and that can be overcome by miR-7 overexpression.

41 ment due to short plasma stability; this was overcome by reversing the amide bond and changing the he

42 The latter was overcome by selection of BCL-2 overexpressing cells unde

43 acid but had slight interference, which was overcome by specific ion selective electrode.

44 of anxiety or motor impairment and could be overcome by strong motivational drive.

45 h mortality at the seedling stage, which was overcome by the addition of an exogenous carbon source.

46 The effort to simplify diagnosis could be overcome by the risk of undiagnosed HBP.

47 state occurs when this activation strain is overcome by the stabilizing interaction energy.

48 We suggest that this failure can be overcome by using chemically and geometrically accurate

49 epressive effect of FOF2 in flowering can be overcome by vernalization.

50 ts an effective species barrier that must be overcome by zoonotic viruses.

51 fold: it enables "ate" complex formation and overcomes catalytic inhibition by halide ions.

52 cleus challenge the resident genome and must overcome cellular responses, including the DDR.

53 nique working principle allows the system to overcome challenges faced by previously reported reusabl

54 e efficacy of multiscale flux measurement to overcome challenges of wetland heterogeneity.

55 M may serve as a novel therapeutic target to overcome chemoresistance in SCLC.

56 notypes, but optimal treatment strategies to overcome chemotherapeutic resistance and eliminate metas

57 xperiments showed that RAD6 is necessary for overcoming cisplatin-induced replication fork stalling,

58 Reversible mutagenesis overcomes clonal variance by permitting functional annot

59 lized immunoengineering with optogenetics to overcome critical hurdles in cancer immunotherapy.

60 g education and research in palliative care, overcoming disparities, and innovating palliative care d

61 entification of apoptotic vulnerabilities to overcome drug resistance in ovarian and other cancers.Hi

62 P90 inhibition may be explored to prevent or overcome drug resistance to single targeting agents.

63 Successful drug delivery and overcoming drug resistance are the primary clinical chal

64 mes, but there are many design challenges to overcome (e.g., cost, comparability, standardization).

65 a challenge for developing new treatments to overcome EGFR tyrosine kinase inhibitor resistance.

66 This unique combination is able to overcome existing challenges in remediating low permeabi

67 are expected to become stronger and possibly overcome fire prevention efforts.

68 These results show that it is possible to overcome fluorescence quenching when functionalizing dia

69 s context, we discuss the caveats we need to overcome for automated causal discovery to become a part

70 we propose, serves as a barrier that must be overcome for tumor formation.BRCA2 mutations promote tum

71 ach to supporting conventional therapies and overcoming GC resistance in pediatric T-ALL patients.

72 ocal focus as the most effective approach to overcome global-scale conservation challenges.

73 230 nanometers transport distance that could overcome grain boundaries.

74 olved in many organic conversions but has to overcome high free-energy barriers in water.

75 Here, we overcame historical technical limitations and non-invasi

76 oteins have evolved different strategies for overcoming host APOBEC3.

77 ies have helped clarify these relationships, overcoming hurdles to provide a range of potential model

78 e substantial obstacles that will need to be overcome if CRISPR-Cas9 is to be used in the practice of

79 ystem functions in the brain and can readily overcome immune privilege.

80 microenvironment (TME) is a major barrier to overcoming immune escape.

81 ogress to identify suitable target antigens, overcome immunosuppressive tumour microenvironments, red

82 of the significant challenges which must be overcome in realizing a practical magnesium battery.

83 propose that this "fundamental" limit can be overcome in systems where Lorentz reciprocity is broken.

84 ration rather than a complete block, and was overcome in the presence of neutrophils.

85 ect of musicianship on listeners' ability to overcome informational versus energetic masking of speec

86 To overcome inherent hydrophobicity and improve their bioco

87 In these structures, folding overcomes intramolecular electrostatic repulsions and fo

88 However, a key challenge that has yet to be overcome is the inferior reversibility of Li plating and

89 One of the largest barriers to overcome is to achieve a stable PEC reaction in either s

90 ure climate in New England, United States to overcome issues of extrapolation in novel environments.

91 t on cancer therapy due to the potential for overcoming issues such as drug resistance.

92 acteroides to survive thymine starvation and overcome it through the exchange of genetic material.

93 hosphorylated hnRNP L sequesters miR-574-3p, overcoming its decoy activity and seed sequence-dependen

94 arming oncolytic adenoviruses with BiTE can overcome key limitations in oncolytic virotherapy.

95 t transmission, sharing positive messages to overcome key rumours, and strengthening community suppor

96 r-specific disruption of Notch signaling may overcome legitimate concerns associated with the tumor s

97 of implant placement has been introduced to overcome limitations of dis/reconnection of healing/prov

98 d has suitable pharmacokinetic properties to overcome limitations of previous approaches.

99 ffective under varying operating conditions, overcoming limitations faced by previous healing agents

100 We further discuss perspectives on overcoming limitations of current organoid systems for t

101 V diagnosis in infants have the potential to overcome logistical challenges that delay treatment init

102 e that leverages increased taxon sampling to overcome long evolutionary distances and identify putati

103 t of a general catalytic Chan-Lam amination, overcoming long-standing and unsolved amine and organobo

104 onal solvent systems that are well suited to overcoming low mass fractions of nanoparticles, producin

105 escribe a method - Freestyle Fluidics - that overcomes many key limitations.

106 nal multiparameter single cell analysis that overcomes many limitations of fluorescence-based flow cy

107 e potential function of nitric oxide (NO) to overcome MDR.

108 s review will discuss the mechanism of NO in overcoming MDR and recent progress of combined NO and dr

109 completely different process, autophagy, can overcome multiple BRAF inhibitor resistance mechanisms i

110 nt thermodynamic disadvantages, SIBs have to overcome multiple kinetic problems, such as fast capacit

111 ceptors and uncover how cytokine stimulation overcomes NK cell education.

112 man intestinal pathogen Vibrio cholerae must overcome noxious compounds that damage the bacterial out

113 ing better susceptibility testing tools, and overcoming obstacles in discovery and research of new an

114 on of steroid hormones in the uterus, and to overcome P4 resistance in human reproductive diseases, s

115 nd 3) a "performance bundle" to identify and overcome perceived barriers to the pursuit of best pract

116 results for the design of therapies that can overcome persistence and, indirectly, drug resistance.

117 that engineered expression of alphaLNNd can overcome polymerization deficits to increase laminin, st

118 The use of a one-pot reaction allowed us to overcome potential problems with individual steps during

119 ully understood, and effective solutions for overcoming preexisting neutralizing antibodies are still

120 covery of new streptogramin antibiotics that overcome previous limitations of the class.

121 To overcome problems in their determination, an evaporation

122 ion and the tOPV-bOPV switch were related to overcoming regulatory policies and challenges with vacci

123 tool to boost maturation of resident OPCs to overcome remyelination failure and halt disease progress

124 A-ZIP53 electrostatically mimics DNA and can overcome repulsion between basic DNA binding regions of

125 d at restoring lysosomal functionality might overcome resistance to ADC-based therapies and improve t

126 iangiogenesis drugs may be a new strategy to overcome resistance to antiangiogenesis therapy.

127 ential utility of broad-spectrum aptamers to overcome resistance, and molecular interactions that occ

128 t only provide improved treatment options to overcome resistance, but, in the future, will also be th

129 inhibitors as potential therapeutic means to overcome resistance.

130 anisms to BCL-2-selective therapy and how to overcome resistance.

131 function, induces apoptosis in MM cells and overcomes resistance to proteasome inhibitor bortezomib.

132 calation batteries offers a promising way to overcome safety, cost, and energy density limitations of

133 These findings provide a strategy to overcome several key limitations of CED that have been p

134 Tetracene-based materials can overcome significant challenges, as the tetracene triple

135 is absorption spectroelectrochemistry should overcome some difficulties related to direct measurement

136 odels based on these principles will help to overcome some of the obstacles on the road from basic ne

137 le recent policies in the UK offers scope to overcome some of these challenges there is a risk that s

138 Next-generation sequencing (NGS) can overcome some of these problems but has limited applicat

139 he feasibility of dual RAF/MEK inhibition to overcome sorafenib treatment escape in HCC.

140 side chains and backbone are coordinated to overcome steric constraints, and the degradation involve

141 ment of age-specific vaccine formulations to overcome suboptimal immunization.

142 udies using a similar approach should aim to overcome such issues.

143 To overcome such limitations, protein transduction domains

144 The development of clean label options to overcome such quality problems is currently of high inte

145 requires barriers to their development to be overcome, such as their chemical instability under opera

146 riple quadrupole instrument more efficiently overcame the problem of ArCl(+) interference, from the n

147 r' metaplastic models that can substantially overcome the adaptability-precision tradeoff.

148 Its overexpression can overcome the antitumor effects of miR-1 and promote andr

149 ion or microinjection have been developed to overcome the cellular plasma membrane, but they all resu

150 To overcome the challenge of using two-dimensional material

151 ges; however, how particular in vivo systems overcome the challenge remains unclear.

152 les (NPs) have demonstrated the potential to overcome the challenges and limitations associated with

153 Still, computational approaches to overcome the challenges that affect both assembly-based

154 er ultraviolet-light irradiation in order to overcome the competition of facile geometric isomerizati

155 all the above-mentioned strategies will help overcome the correlation era in microbiome research and

156 the extrinsic apoptotic pathway which could overcome the cytoprotective autophagic mechanism.

157 the recessive k1 mutation can epistatically overcome the dominant I and i(i) alleles, which inhibit

158 offering a potential "green alternative" to overcome the drawbacks associated with conventional chem

159 DNA molecules are imaged as they attempt to overcome the entropic barrier to nanochannel entry throu

160 onditions that permit replicating systems to overcome the fundamental limits imposed on selection pro

161 e been considered as a promising solution to overcome the fundamental speed limit of the current elec

162 d biosynthesis pathway manipulation can help overcome the gemcitabine resistance in pancreatic cancer

163 borations and novel approaches are needed to overcome the genetic heterogeneity of pancreatic cancer

164 genetic engineering may make it possible to overcome the humoral immune barrier that prevents xenotr

165 cused on the synthesis of catalysts that can overcome the inherent thermodynamic preference of an ole

166 is placed on describing research efforts to overcome the inherent weaknesses of peptide drugs, in pa

167 tial of DNA nanotechnology, it is crucial to overcome the lack of robust analytical techniques that c

168 A2 M(I) M(III) X6 , is a promising route to overcome the lead toxicity issue confronting the current

169 To overcome the limitation of the 'flat world' we construct

170 t can both perform rapid sample analysis and overcome the limitations of conventional analysis proced

171 hybrid functionalities, which may be used to overcome the limitations of current nanoparticle-based t

172 Molecular or cellular imaging helps to overcome the limitations of morphological imaging in imp

173 nal (3D) electrodes are successfully used to overcome the limitations of the low space - time yield a

174 nting the Fourier transform optically we can overcome the limiting O(nlogn) complexity of fast Fourie

175 We developed a new MALS methodology that has overcome the long-standing, stubborn barrier to microlit

176 Compensation must therefore occur to overcome the loss of K(ATP) channels in K(ATP) knockout

177 in nanotechnology that could be exploited to overcome the major obstacles in the prevention of and th

178 -Ala-d-Ala/d-Ala-d-Lac binding that directly overcome the molecular basis of vancomycin resistance, p

179 design of multifunctional, elastic SEIs that overcome the most serious limitations of spontaneously f

180 d by us earlier, are more likely to grow and overcome the nucleation barrier.

181 Thus, ATR inhibition is a unique strategy to overcome the PARPi resistance of BRCA-deficient cancers.

182 ntial pathways employed by microorganisms to overcome the placental barrier and prospects for the fut

183 by pathogens to target these compartments to overcome the plant's defense barrier.

184 efficient degradation of benzene, which can overcome the potential risk of leakage commonly found in

185 Cancer stem-like cells (CSC) evolve to overcome the pressures of reduced oxygen, nutrients or c

186 sk representations might even be enhanced to overcome the previous task.

187 ination chemistry, these species may help to overcome the problem of lethal resistance.

188 enhancement by the GNR array can efficiently overcome the quenching effect of the gold nanoparticle e

189 To overcome the recent outbreaks of hepatotoxicity-related

190 plet excitons (T1), could provide a means to overcome the Shockley-Queisser limit in photovoltaics.

191 It was designed to overcome the spectral congestion and line broadening tha

192 successful synthetic strategies allowing to overcome the still "unpredictable" reactivity of titaniu

193 ractable approach to RNA-ligand kinetics, we overcome the two main difficulties by applying a gradien

194 meaningful interaction patterns but can also overcome the unstable nature of interaction patterns.

195 Long-read sequencing can overcome the weaknesses of short reads in the assembly o

196 rop poplar, we have identified a mutant that overcomes the block of lateral root (LR) formation under

197 multispectral image acquisition method that overcomes the challenge of spectral overlap in the fluor

198 kpLogo also overcomes the limitations of conventional motif-visualiz

199 pting critical protein-protein interactions, overcomes the limitations of current therapies and may b

200 with secondary free amines and anilines also overcomes the limitations of palladium(II)-catalyzed C-H

201 to TORC1 inactivation, and deletion of pab1 overcomes the repression of differentiation genes in cel

202 emonstrate a travelling source approach that overcomes the sub-luminal propagation limits.

203 ro, this change can be reversibly induced by overcoming the energy barrier through mild heating of th

204 Treg-recruiting microspheres are capable of overcoming the immunological imbalance of Tregs and CD4(

205 Overcoming the lipid bilayer to deliver RNA into cells h

206 ent the beneficial effects of MSC therapy by overcoming the low homing efficiency of MSCs systemicall

207 We report a method for overcoming the low stability of nitroalkynes through the

208 f L. interrogans spirochetes that succeed in overcoming the natural defenses of the ocular conjunctiv

209 ies, or plasmid DNA to living cells requires overcoming the plasma membrane barrier without harming t

210 This work paves the way for overcoming the structural and functional limitations of

211 mous variety of strategies used by phages to overcome their hosts, one can expect that the efficiency

212 tions with the oligonucleotide, and helps to overcome their intrinsic biopharmaceutical shortcomings,

213 angiogenic therapy and develop strategies to overcome them.

214 poptosis that inhibits a ubiquitin ligase to overcome therapy resistance in tumors.

215 ors within glioblastomas may be effective in overcoming therapy resistance caused by intratumoral het

216 Here, we overcame these limitations by acquiring high-resolution

217 To overcome these barriers, we developed a strategy to macr

218 Herein, we overcome these challenges and obtain single crystals of

219 icate that germline-targeting immunogens can overcome these challenges with high-affinity multimeric

220 To overcome these challenges, we developed an albumin-coate

221 gest novel epitopes that can be exploited to overcome these challenges.

222 In an effort to overcome these difficulties, a previous study proposed a

223 have now devised a new scaling technique to overcome these difficulties, and make accurate measureme

224 To overcome these drawbacks, we proposed to filter decay cu

225 rats (F = 2%) and was therefore modified to overcome these drawbacks.

226 potential of targeting HIFs as a strategy to overcome these instances of AA therapy resistance.

227 To overcome these issues, we provide techniques and algorit

228 super-resolution microscopy methods help to overcome these limitations and have led to new and refin

229 ve in vitro Proarrhythmia Assay) proposes to overcome these limitations by evaluating drug effects on

230 ECTs with vertically stacked contacts, which overcome these limitations, is reported.

231 In order to overcome these limitations, we present MEGARes, a hand-c

232 voltages offers an energy efficient route to overcome these limitations.

233 y to induce antigen-specific tolerance might overcome these obstacles.

234 for coherent quantum interpolation that can overcome these problems.

235 izing antibodies (bNAbs) against HIV-1 could overcome these shortcomings.

236 nization (PSI) technique coupled to MS might overcome these steps by direct analysis of complex mixtu

237 trophoretic and hydrodynamic shear forces to overcome these thermodynamic limitations with irreversib

238 To overcome these voltage-clamp errors, we developed an app

239 modular hybridization probes (M-Probes) that overcomes these challenges.

240 Biosensing approach overcomes these disadvantages, as these are highly speci

241 Here we demonstrate a new technique which overcomes these limitations by directly drawing micropil

242 re increasingly important in confronting and overcoming these challenges.

243 LAB spectral imaging toolbox with the aim of overcoming these limitations.

244 However, multi-dimensional statistics overcame this extreme intra-group variability for each i

245 One strategy to overcome this barrier is to use latency-reversing agents

246 To overcome this barrier, we developed a synthetic-biology

247 To overcome this barrier, we have developed Omicseq, a nove

248 To overcome this barrier, we studied a natural experiment i

249 Mechanisms that overcome this challenge have been previously proposed, i

250 To overcome this challenge, we propose the utilization of t

251 To overcome this challenge, we used end-to-end annealing to

252 industrial partners has been established to overcome this challenge.

253 To help overcome this complexity, systems biology mathematical m

254 Here, we overcome this constraint with an electrically insulating

255 We show that it is possible to overcome this limitation and train networks that can mai

256 BIDS Apps overcome this limitation by taking advantage of the Sing

257 To overcome this limitation of partition density, we sugges

258 of enhancing tumor penetration by drugs, can overcome this limitation to a substantial degree when ad

259 variety of strategies are being employed to overcome this limitation, including conjugation to carri

260 n ozonide, artefenomel (OZ439, 2), which has overcome this limitation, maintaining the rapid onset of

261 To overcome this limitation, we develop new, compact expres

262 To overcome this limitation, we developed a self-inactivati

263 To overcome this limitation, we developed an ex vivo cultur

264 To overcome this limitation, we present a hierarchical hidd

265 e-smaller nanodiscs (6- to 8-nm diameter) to overcome this limitation.

266 We set out to develop a method to overcome this obstacle by utilizing the 6-amino-acid (CC

267 One strategy to overcome this obstacle is to remove the methyl group on

268 To overcome this obstacle, we constructed AAV vectors carry

269 Previous efforts were not able to fully overcome this phenotype without settling in sugar yield

270 A new study seeks to overcome this problem by sampling more species and data

271 To overcome this problem, rock phosphate fertilisers are he

272 To overcome this problem, we have developed a novel Single

273 To overcome this problem, we have introduced the Trainable

274 To overcome this temperature distribution, a copper flange

275 To overcome this, entanglement swapping may be used to gene

276 Natural structures provide blueprints to overcome this, however this approach introduces another

277 To overcome this, we hosted a kaggle.com competition to cro

278 gement excision circles (sj/beta-TREC ratio) overcomes this limitation but has only been assayed in s

279 orithm with a two-phase sampling method that overcomes this limitation.

280 We devised a protocol that overcomes this problem, and were thus able to discover a

281 fluidics-assisted cell screening (MACS) that overcomes this trade-off by temporarily immobilizing sus

282 a mixture of 2',5'- and 3',5'-linkages, and overcoming this backbone heterogeneity has long been con

283 prohibitive toward chemical reaction, may be overcome through multiple RETs facilitating an otherwise

284 ibution of nanocarriers and that this can be overcome through the use of a fibrinolytic enzyme such a

285 phage escape from the type I-F system can be overcome through use of type I-F spacers by a horizontal

286 ctors is a nontrivial challenge that must be overcome to establish soil magnetism as a trusted paleoe

287 NDs, as well as the challenges that must be overcome to successfully translate the reviewed technolo

288 To overcome treatment evasion and reduce systemic effects,

289 on chemotherapies that have the potential to overcome treatment resistance, but is also a valuable re

290 erapy and radiotherapy, and the potential to overcome tumor microenvironment-driven immunosuppression

291 Our results demonstrate that ToxDock can overcome two fundamental challenges of docking large tox

292 Insects often overcome unfavorable seasons in a hormonally regulated s

293 ts, yet must be low enough to allow it to be overcome upon demand by specific fusion proteins [such a

294 We hypothesized this could be overcome using a cysteine-targeted irreversible inhibito

295 ic analogues rationally designed to not only overcome vancomycin resistance but provide the foundatio

296 This overcomes various sources of noise and variability, subs

297 d sterility due to epistasis, which breeders overcame with suppressors.

298 y our prediction that this resistance can be overcome with AKT1/2 inhibition.

299 These obstacles can be overcome with thoughtful study design to ensure maximal

300 e to their feedback mechanisms(9), which, if overcome, would enable high-density nanomechanical probi