ライフサイエンスコーパス: overlapping function

1 line mutation that arises in characters with overlapping function.

2 (1) contributed to primary adhesion, showing overlapping function.

3 ctivate MAPK isoforms that have redundant or overlapping function.

4 ng that the two proteins have some essential overlapping function.

5 and a complete cytokinetic block, suggesting overlapping function.

6 ene's function can be obscured by genes with overlapping function.

7 le biological process with both distinct and overlapping functions.

8 ptor might couple to multiple effectors with overlapping functions.

9 ike kinases that appear to have redundant or overlapping functions.

10 ions of type III effectors that likely share overlapping functions.

11 ng that AtSPO11-1 and AtSPO11-2 have largely overlapping functions.

12 erent laminin isoforms exhibit specific, non-overlapping functions.

13 and include numerous analogous enzymes with overlapping functions.

14 ic aspects of organizer function, suggesting overlapping functions.

15 suggesting that CACNG subunits have in vivo overlapping functions.

16 n (pRB) tumor suppressor family members have overlapping functions.

17 l a similar set of target genes and may have overlapping functions.

18 um has maintained four plasmepsin genes with overlapping functions.

19 otic, suggesting that the two syntaxins have overlapping functions.

20 and, although structurally similar, have non-overlapping functions.

21 mutants, indicating that these homologs have overlapping functions.

22 y controlled by at least two genes that have overlapping functions.

23 s are responsible for distinct and sometimes overlapping functions.

24 gests that delta- and eta-tubulin could have overlapping functions.

25 m expression of a related gene (AtSMC2) with overlapping functions.

26 ation pathway either as a complex or through overlapping functions.

27 ther gene, echidna hedgehog, that could have overlapping functions.

28 sely related molecules in the L1 family have overlapping functions.

29 r studies whether these sites have unique or overlapping functions.

30 dicate that Glc7p, Ppz1p, and Ppz2p may have overlapping functions.

31 ns, treacle and Nopp140 exhibit distinct but overlapping functions.

32 ops (SL1-SL4) that have both independent and overlapping functions.

33 of Rpb1 CTD mutations on H3K36me, suggesting overlapping functions.

34 to the periphery, they have pleotrophic and overlapping functions.

35 cess, and many kinesins are proposed to have overlapping functions.

36 ens vs. parasitoid wasps) and symbionts with overlapping functions.

37 ynthetic enzymes have similar and, at times, overlapping functions.

38 on proteins, but yet are ascribed unique and overlapping functions.

39 , HTP-1, HTP-2, and HTP-3) have distinct but overlapping functions.

40 fected the FgSRP1 function, suggesting their overlapping functions.

41 two functional isoforms of DRP5B have highly overlapping functions.

42 urine membrane C3 complement regulators with overlapping functions.

43 the identification of homologous genes with overlapping functions.

44 y for which each isoform serves distinct but overlapping functions.

45 ested that PHYB1 and PHYB2 have distinct yet overlapping functions.

46 accessory systems that perform distinct and overlapping functions.

47 erved among duplicated genes (paralogs) with overlapping functions.

48 edly, often occurs between reactions without overlapping functions.

49 d GAGA-581 perform different, albeit largely overlapping, functions.

50 Because zyxin family members may have overlapping functions, a comprehensive understanding of

51 To establish whether AFT1 and AFT2 have overlapping functions, a mutant containing a double aft1

52 inct steps in transcriptional activation and overlapping functions among BET family members.

53 rate the in vivo function of SRCs due to the overlapping functions among different members of SRCs.

54 has proved elusive, a likely consequence of overlapping function and expression among various homeob

55 results indicate that MYB108 and MYB24 have overlapping functions and act downstream of MYB21 in a t

56 Thus, CI and CII sHSPs have both unique and overlapping functions and act either directly or indirec

57 The overlapping functions and activities of BCP and AhpC pro

58 mutants, indicating that Smads 1 and 5 have overlapping functions and are more important than Smad8

59 ations in integrin alpha5 and alphav and for overlapping functions and compensation between these int

60 Genetic interactions define overlapping functions and compensatory pathways.

61 natural protein engineering are obscured by overlapping functions and complexity accumulated through

62 ganogenesis are poorly delineated because of overlapping functions and expression profiles.

63 These elegant studies highlight overlapping functions and interdependent roles of mitoch

64 is greatly confounded by their large number, overlapping functions and interspersed shared enhancers.

65 Given that NRL and NR2E3 have overlapping functions and NR2E3 expression is abolished

66 tional protolanguage that remains evident in overlapping functions and shared neural circuitry.

67 th positive growth regulators with partially overlapping functions and that FlbA has an important rol

68 suggest that Rad52 and Rad59 have partially overlapping functions and that Rad59 can substitute for

69 These data suggest that PE and CL have overlapping functions and that the absence of both lipid

70 ate that the tails contribute to similar and overlapping functions, and cross-linking assays show tha

71 In the first, genes have overlapping functions, and loss-of-function mutations in

72 We have shown previously that CL and PE have overlapping functions, and the loss of both is synthetic

73 degradation uses dual protease families with overlapping function; and (v) hemoglobin-degrading plasm

74 ree isoforms of Dvl with specific as well as overlapping functions are found in mammals.

75 Although overlapping functions are inevitable, studies over the p

76 e mechanisms explaining their divergent, non-overlapping functions are unclear.

77 occludin, and tricellulin have distinct but overlapping functions at the tight junction.

78 While the members of this family may perform overlapping functions at these sites, the unique structu

79 -associated Ag to CD8(+) T cells, suggesting overlapping function between Treml4 and other receptors

80 Hence, there is no evidence for overlapping functions between Ras1 and Rhb1.

81 To analyze potential overlapping functions between Sac1p and other homologous

82 d from each cross, indicating that potential overlapping functions between these genes in other organ

83 vegetative growth and reproduction and have overlapping functions but that AAPT1 contributes more th

84 ates that ASC and these NLRs also elicit non-overlapping functions, but the molecular basis for this

85 eir mammalian counterparts, yet they perform overlapping functions by binding and inhibiting BH3 (Bcl

86 MSH4 and hMSH4sv can carry out different but overlapping functions by differential protein interactio

87 Consistent with important complementary and overlapping functions, combined antagonism of these inte

88 ed that fibrillins 1 and 2 perform partially overlapping functions during aortic development.

89 and alphaN-catenin suggest both distinct and overlapping functions during cortical development.

90 To determine whether Nrf1 and Nrf2 have overlapping functions during early development and in th

91 esting that these integrin genes do not have overlapping functions during early embryonic development

92 gest that Hmx2 and Hmx3 have both unique and overlapping functions during embryogenesis.

93 g that these histone acetyltransferases have overlapping functions during embryogenesis.

94 signaling pathways execute both specific and overlapping functions during mammalian development.

95 Dmc1 and Rad51 have unique and overlapping functions during meiotic recombination.

96 ow distinct expression patterns and have non-overlapping functions during mesendoderm and asymmetric

97 Here we show that Bim and Bmf have overlapping functions during mouse development and coreg

98 atal lethality, suggesting that they perform overlapping functions during mouse development.

99 us, NET25 and emerin have at least partially overlapping functions during myogenic differentiation, w

100 emodeling activities perform independent and overlapping functions during transcriptional activation.

101 oncomitant loss of three E2F activators with overlapping functions (E2F1, E2F2, and E2F3) triggered t

102 d theta contribute to T-cell activation with overlapping functions essential for GVHD induction while

103 s we show that these three copine genes have overlapping functions essential for the viability of pla

104 Further, the overlapping functions exist despite striking differences

105 Although these systems regulate overlapping functions, few studies have investigated whe

106 Despite overlapping functions, FGF19 and FGF21 have many discret

107 Here we establish a novel overlapping function for PSO2 with MutS mismatch repair

108 We demonstrate an overlapping function for Reh1 and Rei1 in the cytoplasmi

109 unfolding and translocation and indicate an overlapping function for the N-domain and NBD-1 pore tyr

110 These studies also suggested overlapping functions for ADF and n-cofilin.

111 ingly, AKT activity inhibits mGluR-LTD, with overlapping functions for AKT1 and AKT3.

112 parable to EAE in wild-type mice, indicating overlapping functions for B7-1 and B7-2.

113 ant motor nerve terminals, suggesting widely overlapping functions for each isoform.

114 lammation these data thus identify novel non-overlapping functions for ERK1 and ERK2 that are biologi

115 These results establish essential and overlapping functions for Ets1 and Ets2 in coordinating

116 during or after DNA replication, and reveal overlapping functions for NHEJ and Rad54-dependent HR in

117 These findings demonstrate novel, overlapping functions for pRb and p107 in numerous murin

118 Our data reveal overlapping functions for Snf1 and Rad23 in UV-responsiv

119 sis, and protein interaction assays, we find overlapping functions for the two SWI/SNF ATPases.

120 A deficiency, thus demonstrating largely non-overlapping functions for these enzymes in retinoid meta

121 rrhagic phenotype, consistent with partially overlapping functions for these two orthologs.

122 ents, many with isoforms that have partially overlapping functions; from the connections among compon

123 ations, it is much less clear why genes with overlapping functions have been retained, in some cases

124 in which both protein-coding and additional overlapping functions have evolved under purifying selec

125 regulators of cell cycle and have extensive overlapping functions; however, only Rb has been shown t

126 upport of the idea that Hoxa1 and Hoxb1 have overlapping functions, Hoxa1/Hoxb1 double mutant homozyg

127 d than in the single mutants, supporting the overlapping function hypothesis.

128 Our data show that TBX-35 and CEH-51 have overlapping function in MS lineage development.

129 auses similar phenotypic changes, suggesting overlapping function in the DVL gene family.

130 tor LHY and the related protein CCA1 perform overlapping functions in a regulatory feedback loop that

131 ackground, shows that these two enzymes have overlapping functions in amino acid biosynthesis.

132 the brain and show that Abcg1 and Abcg4 have overlapping functions in astrocytes, promoting efflux of

133 rved increased expression of nine genes with overlapping functions in bacterial invasion of its host,

134 B, and -C (biofilm maturation protein), with overlapping functions in biofilm maturation.

135 rs, are microtubule-associated proteins with overlapping functions in both neuronal migration and axo

136 e effects indicate that LACS1 and LACS2 have overlapping functions in both wax and cutin synthesis.

137 sults suggest that Bmi-1 and Mel-18 may have overlapping functions in cancer cell growth.

138 Finally, we show that TRAF2 and TRAF6 have overlapping functions in CD40-mediated NF-kappaB activat

139 osing functions in cancer cell migration but overlapping functions in cell growth.

140 y, indicating that these proteins contribute overlapping functions in cell polarization.

141 of transcription factor partners, and exert overlapping functions in cells.

142 g that the RAG proteins and DNA-PKcs perform overlapping functions in coding joint formation.

143 c transglycosylases in DC3000 appear to have overlapping functions in contributing to T3SS functions

144 r demonstrate that Rpd3, Hos2, and Hda1 have overlapping functions in deacetylating histones and supp

145 the regulation of hematopoiesis and may have overlapping functions in determining hematopoietic and e

146 tic analyses reveal that Lhx4 and Prop1 have overlapping functions in early pituitary development.

147 ls, and ontogenically distinct MSCs have non-overlapping functions in endochondrogenesis and HSC nich

148 Thus, Adh1 and Adh4 demonstrate overlapping functions in ethanol and retinol metabolism

149 (Box1 and Box2) between these segments have overlapping functions in forming native eIF4G*mRNA*PABP

150 ll three host proteins, suggesting partially overlapping functions in infected cells.

151 PD-L1 and PD-L2 have overlapping functions in inhibiting interleukin-2 and in

152 Therefore, FgSKN7 and FgATF1 must have overlapping functions in intracellular ROS signalling fo

153 ins and their associated HDAC complexes have overlapping functions in limiting Pol II occupancy acros

154 Here, we show that ATM and DNA-PKcs have overlapping functions in lymphocytes.

155 t tubulin glycylation and glutamylation have overlapping functions in maintaining cilia structure and

156 2 are broadly expressed and may have certain overlapping functions in mammals, as deletions of both M

157 ophil recruitment, suggesting that they have overlapping functions in mediating this critical biologi

158 in tubular mitochondrial morphology and have overlapping functions in mitochondrial fusion.

159 eptor substrate specificities with partially overlapping functions in N-glycosylation.

160 thermore, each En gene has unique as well as overlapping functions in patterning the ML molecular cod

161 nd bone metastases and regulate distinct and overlapping functions in PCa progression.

162 ant tissues, suggesting non-redundant or non-overlapping functions in plants.

163 IDP2, when expressed, and ZWF1 have critical overlapping functions in provision of reducing equivalen

164 and CrkL, suggesting that Crk and CrkL play overlapping functions in regulating fibroblast growth.

165 trxG genes ULTRAPETALA1 (ULT1) and ULT2 have overlapping functions in regulating shoot and floral ste

166 five proteins that display distinct but also overlapping functions in repressing GA responses.

167 , Wag1p and CnjBp are two novel players with overlapping functions in RNA interference-mediated genom

168 suggest, however, that they might also have overlapping functions in setting the thresholds for thym

169 mpound mutants revealed that Pbx genes share overlapping functions in shoulder development and that P

170 egrees C than the single mutants, suggesting overlapping functions in stress response.

171 Thus, Lin28a and Lin28b have overlapping functions in temporally regulating NPC proli

172 emonstrate that B7-1 and B7-2 have critical, overlapping functions in the antibody and CTL responses

173 imilar, the molecules have both distinct and overlapping functions in the cell.

174 trains to examine whether these myosins have overlapping functions in the cell.

175 eins, which may serve both complementary and overlapping functions in the cell.

176 In contrast, En1 and En2 have overlapping functions in the cells derived from each pro

177 each protein has distinct as well as partly overlapping functions in the downregulation of inflammat

178 Pitx1 and Pitx2 have overlapping functions in the expansion of Rathke's pouch

179 The chaperones Trigger factor and HSP70 have overlapping functions in the folding process, but both o

180 st that the two Asf1 homologs have partially overlapping functions in the germline, while UNC-85 is p

181 helial selectins and FucTs have distinct but overlapping functions in the immunosurveillance of the s

182 hat Uch-L1 and Uch-L3 have both separate and overlapping functions in the maintenance of neurons of t

183 that MnSOD and CuZnSOD have both unique and overlapping functions in the mitochondrion.

184 at both helicases have essential but largely overlapping functions in the processing and export of ma

185 stream of Crk and CrkL, which play essential overlapping functions in the Reelin signaling pathway.

186 n somatic gonadal precursors (SGPs) and have overlapping functions in their development.

187 The consequences of the overlapping functions in this eEF1A domain and its uniqu

188 ly due to the presence of other systems with overlapping functions in this pathogen.

189 is plausible that both OMPs have similar or overlapping functions in this pathogenic spirochete.

190 silencing, and individual Agos have largely overlapping functions in this process.

191 sults suggested that myogenin and MRF4 share overlapping functions in thoracic skeletal formation.

192 In vivo, the two Isw1 complexes have overlapping functions in transcriptional regulation of s

193 uch as Fli1 and TEL1 display distinct and/or overlapping functions in vasculo/angiogenesis, hemostasi

194 MP phosphodiesterase genes PDE1 and PDE2 had overlapping functions in vegetative growth, conidiation,

195 tal defects, and that myogenin and MRF4 have overlapping functions in ventral myotome differentiation

196 e conclude that E2f3a and E2f3b have largely overlapping functions in vivo and that E2f3a can fully s

197 e 5' UTR, but whether they perform unique or overlapping functions in vivo is poorly understood.

198 h the idea that Nhp6, Gcn5, and Swi/Snf have overlapping functions in vivo, nhp6a nhp6b gcn5 mutants

199 ndicating that these isoforms have partially overlapping functions in vivo.

200 ese data suggest that NPFs have distinct and overlapping functions in vivo.

201 t-osteoclast cocultures, which mirrors their overlapping functions in vivo.

202 tiator and the +24 to +29 region could serve overlapping functions in vivo.

203 erase complex may account for their apparent overlapping functions in vivo.

204 We hypothesize that Cntnap2 has overlapping functions in vocal learning species, and exp

205 Wnt pathway has independent, albeit possibly overlapping, functions in early intestinal villi and adu

206 ic regulator, Boule, to assume distinct, yet overlapping, functions in germ cell development.

207 e receptors have been described to stimulate overlapping functions, including enhanced proliferation

208 ies in dendritic arbor development, but also overlapping functions, indicating a requirement for both

209 , redundancy in which multiple genes fulfill overlapping functions is often maintained.

210 redundant, interact, or serve only partially overlapping functions is unknown.

211 A network of adhesion molecules with overlapping functions mediate the capture, rolling and f

212 pment, indicating an essential and partially overlapping function of PIPKIalpha and PIPKIgamma during

213 Genetic studies here reveal an overlapping function of the BAP1 and BAP2 genes in cell

214 the development of seizures, possibly due to overlapping function of the chemokines.

215 Our data provides the first evidence of overlapping function of the Lmx1 genes during embryonic

216 However, despite the partially overlapping function of the residues in the 40's loop in

217 rovide molecular insight into the unique and overlapping functions of ARF gene family members in Arab

218 To investigate the overlapping functions of Bcrp1, Mdr1a/b, and Mrp2 in viv

219 emplate strand of the telomere requires some overlapping functions of BLM and WRN helicase for leadin

220 Our results suggest that the partially overlapping functions of FHY3 and FAR1 entail divergence

221 Our data reveal important overlapping functions of Hes1 and Prop1 in cell differen

222 ween those of the single mutants, suggesting overlapping functions of HIFs in bone.

223 e analyses of mutant lines revealed strongly overlapping functions of LACS4 and LACS9 in lipid traffi

224 To differentiate the unique and overlapping functions of LFA-1 and Mac-1, LFA-1-deficien

225 To investigate the divergent and potentially overlapping functions of MDC1 and 53BP1 in the ATM respo

226 am processes modulated by the independent or overlapping functions of MEcPP and SA in adaptive respon

227 ell lines.Taken together, these studies show overlapping functions of PD-L1 and PD-L2 and indicate a

228 ess in our understanding of the distinct and overlapping functions of SFKs in platelets, and new aven

229 To explore the overlapping functions of Src kinases, we have targeted C

230 te chemical probes to examine the unique and overlapping functions of the ALDH1/2 isoenzymes.

231 stomach or other organs, possibly because of overlapping functions of the other two epsins.

232 To address the individual and overlapping functions of the three Arabidopsis carotenoi

233 ngle and multiple mutants unmasks unique but overlapping functions of the various ACS members in plan

234 AS analysis, we demonstrate distinct and non-overlapping functions of these chromatin modifiers on tr

235 Overlapping functions of these enzymes have hampered gen

236 genetic analyses have demonstrated partially overlapping functions of these regulators, the underlyin

237 ng site were used to dissect the potentially overlapping functions of these residues.

238 These results suggest an overlapping functions of tocopherols and carotenoids in

239 The results demonstrate both independent and overlapping functions of two FGF8 homologues in mesoderm

240 n between members and also suggests that the overlapping functions of ZAD proteins are the result of

241 In concert, these data reveal disparate, but overlapping, functions of Ets transcription factors at d

242 gral member of the piRNA pathway, but has an overlapping function, possibly competing with Maelstrom

243 y that Sro7p and the exocyst share partially overlapping functions, possibly in SNARE regulation.

244 t that Cdc42 (ModA) and Rac1 (RacA) share an overlapping function required for polarity establishment

245 CatM, a paralog with overlapping function, responds only to muconate.

246 ng germline mutations is often confounded by overlapping function resulting in compensation.

247 With overlapping function retained on an evolutionary time-sc

248 Therefore, the two B7 molecules have overlapping functions, since either B7-1 or B7-2 alone c

249 Consistent with such overlapping functions, single deletions of spoIIIJ or yq

250 Since different connexins could have overlapping functions, some developmental phenotypes may

251 contrast with these examples of redundant or overlapping function, stationary-phase survival is decre

252 Closely related molecules with overlapping functions, such as the Syk kinases, SYK, and

253 roviding a new approach to circumventing the overlapping function that is a common feature of the cyt

254 xpressed in mammals, Cks1 and Cks2, share an overlapping function that is essential for early develop

255 phenotype suggesting that Crk and CrkL have overlapping functions that are critical for maintaining

256 ymes, and indicate that PDAT1 and DGAT1 have overlapping functions that are essential for normal poll

257 ovide evidence that AtIRE1A and AtIRE1B have overlapping functions that are essential for the plant U

258 Gli2, but not Gli1 and Gli3, have extensive overlapping functions that are likely downstream of SHH

259 ude that while Yap1p and Yap2p may have some overlapping functions they are clearly not redundant and

260 wever, although the suf and isc operons have overlapping functions, they act as distinct complexes be

261 While the SoxB1s have overlapping functions, they are not strictly redundant a

262 Different PP1c isoforms have pleiotropic and overlapping functions; this has complicated the analysis

263 Reflecting overlapping functions, three desaturases share a common

264 Thus, Smad1 and Smad5 have overlapping functions to govern hepcidin transcription.

265 Kos and Sir1 proteins contributed partially overlapping functions to silencing of both cryptic matin

266 e results suggest that MoMCM1 and MST12 have overlapping functions to suppress appressorium formation

267 and activated Notch appear to have partially overlapping functions, we now report that activated Notc

268 ter mtTFB1 and mtTFB2 do not have completely overlapping functions, we propose a model for human mtDN

269 Even though these two motors have overlapping functions, we show that Ncd is primarily res

270 s mainly between nonessential reactions with overlapping functions, whereas positive epistasis usuall

271 AN1 share at least one and possibly multiple overlapping functions, which may be relevant to Emery-Dr

272 ly arrested dauer larva stage, indicating no overlapping function with another C. elegans TGFbeta sig

273 Rcf1 displays overlapping function with another Hig1-related protein,

274 ed Arabidopsis HAM homolog, AtHAM4, exhibits overlapping function with AtHAM1 and AtHAM2 in promoting

275 However, AtLYK5 shares overlapping function with AtLYK4 and, therefore, Atlyk4/

276 es ATM phosphorylation of Chk2, which has an overlapping function with Chk1 in regulating G2/M checkp

277 SGS3-like proteins FDM3, FDM4 and FDM5 have overlapping function with FDM1 in RdDM.

278 sis thaliana MERISTEM LAYER1 (AtML1), shares overlapping function with HDG2: AtML1 overexpression als

279 nd AIP1 gene, aipl-1 (AIP1-like gene-1), has overlapping function with unc-78, and that depletion of

280 etration and invasive growth, and MoMsb2 has overlapping functions with Cbp1 in recognizing environme

281 Foxc1 has overlapping functions with Foxc2.

282 n factors expressed in the floor plate share overlapping functions with Foxj1.

283 r data suggest that Ppz1p and Ppz2p may have overlapping functions with Glc7p and that all three phos

284 sary for barrier activity at HMR and to have overlapping functions with histone regulators (Asf1 and

285 ery of two genes, ehn-1 and ehn-3, that have overlapping functions with hnd-1 in embryogenesis and go

286 regulates histone gene transcription and has overlapping functions with known histone chaperones.

287 ble mutants suggested that SFC has partially overlapping functions with MP in patterning of both prim

288 han having a unique role, BMPRIB has broadly overlapping functions with other BMP receptors during sk

289 while at least two flp genes appear to have overlapping functions with other flp genes.

290 ucted in order to examine whether BMPRIB has overlapping functions with other type I BMP receptors.

291 ese results demonstrate that p27 carries out overlapping functions with p107 in controlling cell cycl

292 RAPETALA acts independently of ERA1, but has overlapping functions with PERIANTHIA and the CLAVATA si

293 107 showing that they have both specific and overlapping functions with RB gene.

294 Ptc1 has overlapping functions with Reg1-Glc7 and Sit4 in glucose

295 wed that the EKI1 and CKI1 gene products had overlapping functions with respect to phospholipid synth

296 ave unique biological roles, they also share overlapping functions with their paralogues.

297 These results suggest that Tom72p possesses overlapping functions with Tom70p and that the pleiotrop

298 SopB exhibits overlapping functions with two other effectors of bacter

299 ressed in skeletal muscle, have distinct and overlapping functions, with AKT2 more important for insu

300 Bol1-Bol3 perform largely overlapping functions, yet cannot replace the ISC protei