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1 4 mutant, and (d) is lethal to the host when overproduced.
2 s its C-terminal domain (rSmCI-D3) were also overproduced.
3 Noise is not increased when eIF4E is overproduced.
4 ted through Pol12 to nontelomeric sites when overproduced.
5 and Cdt1 can induce its own degradation when overproduced.
6 romoting cell growth unless they were highly overproduced.
7 re activated four- to 15-fold when VirAG was overproduced.
8 ious -1 frameshift mutagenic phenotypes when overproduced.
9 inflammatory disorders in which TNF-alpha is overproduced.
10 n the histone H3-K9 trimethylase Suv39h1 was overproduced.
11 ere DeltaD is defective, secretory cells are overproduced.
12 hma and other lung diseases where it is also overproduced.
13 to complement an ftsN deletion unless it was overproduced.
14 s, and inhibiting cell division when DamX is overproduced.
15 omosome arms only when Cse4 (yeast cenH3) is overproduced.
17 630 and the thymidylate synthase and rTSbeta-overproducing, 5-FU-resistant H630-1 cell line as determ
18 overproduce wild type MtrA but not when they overproduce a nonphosphorylated MtrA, indicating that Mt
19 tion is unstable in mammalian cells, we have overproduced a recombinant hSNM1 protein in an insect ce
20 eractive phenotype relative to wild type and overproduces a number of compound families by 18- to 210
25 brains of two transgenic mouse models of AD overproducing Abeta peptides (Tg APPsw and Tg PS1/APPsw
26 in vivo, we treated Tg APPsw transgenic mice overproducing Abeta with EGCG and found decreased Abeta
27 fter injury observed both in transgenic mice overproducing Abeta, as well as in humans subjected to r
28 nic mice that express FAD mutant APP and PS1 overproduce Abeta42 and exhibit amyloid plaque pathology
29 oson mutants, we repeatedly isolated biofilm-overproducing acapsular mutants, suggesting that the cap
30 donovani NMT has been amplified and used to overproduce active recombinant enzyme in Escherichia col
31 s of acromegalic patients, in which IGF-1 is overproduced after aberrant synthesis of growth hormone.
37 ants with defects in the BYPASS1 (BPS1) gene overproduce an active mobile compound that moves from th
40 to which HetN inhibited differentiation when overproduced and altered the pattern of heterocysts in f
42 ransferase (EutT) of Salmonella enterica was overproduced and enriched to approximately 70% homogenei
43 stitutions are required to cause disease, we overproduced and purified WT, T251I, P587L, and T251I +
46 at the poles longer when ZapA and ZauP were overproduced, and frequently colocalized with MipZ, a ne
49 ypothesis, is that cortical interneurons are overproduced, and then after their migration into cortex
50 risingly, the expression of CsLAR in tobacco overproducing anthocyanin led to the accumulation of hig
56 o-4-(3-pyridyl)but-1-yl]guanine lesions were overproduced at the 3'-guanine bases within polypurine r
57 N7- and O(6)-guanine adducts of NNK are not overproduced at the endogenously methylated CG dinucleot
60 aceae) and Catharanthus roseus (Apocynaceae) overproduce benzophenanthridine alkaloids and monoterpen
62 ce mycothiol (MSH) and was found to markedly overproduce both ergothioneine and an ~15-kDa protein de
64 ration of the wild-type Perp levels in ErbB2-overproducing breast epithelial cells increases their an
66 ted by diacylglycerol, and diacylglycerol is overproduced by aberrant glucose metabolism in diabetic
67 r necrosis factor alpha (TNF-alpha), is also overproduced by FA mononuclear phagocytes in response to
68 suggest that multiple inflammatory cytokines overproduced by FANCA- and FANCC-deficient mononuclear p
69 lly rare myeloid-biased MPPs are transiently overproduced by HSCs in regenerating conditions, hence s
71 pha-melanocyte-stimulating hormone, which is overproduced by melanotroph tumors, attenuates neoplasti
72 med that the HIF targets IGBP3 and PAI-1 are overproduced by pVHL-defective renal carcinoma cells.
75 the surface as strongly as wild-type and EPS overproducing cells, and display a greater tendency to h
77 n extracellular matrix were diminished in HA-overproducing cells; however, motility was increased two
85 t vaccine comprised of strains that lack and overproduce DNA adenine methylase (Dam) conferred cross-
86 train yielded a small fraction of cells that overproduce DNA, as determined by flow cytometry after r
87 ain containing a second deletion in metE udp overproduced DNA at a high level during run-out replicat
88 with low levels of 5'-->3' exonuclease (exo) overproduced DNA while those with either high or normal
89 astidiosa rpfC mutants hyperexpress rpfF and overproduce DSF and are deficient in virulence and movem
95 dditionally, tumor growth in transgenic mice overproducing endostatin specifically in the endothelial
98 n Bacillus megaterium and using homologously overproduced enzymes, it has been possible to isolate al
99 proved yields by 10%, compared with a strain overproducing enzymes involved in only the first three s
103 ed, but not light grown, rcn1 seedlings also overproduce ethylene, and mutations conferring ethylene
106 nal experiments show that Delta hprK mutants overproduce exopolysaccharides and form nodules that do
107 g growth factor-beta also has the ability to overproduce extracellular matrix components in response
110 Spx concentration and activity in vivo when overproduced from an isopropyl-beta-D-thiogalactopyranos
111 by partial gene synthesis, and enzymes were overproduced from the cold-inducible cspD2 promoter in t
113 d expression system can easily be adapted to overproduce functional forms of all members of the vitam
114 hat leukemic myeloid cells stimulate MSCs to overproduce functionally altered OBCs, which accumulate
116 hat the heme of GlbN was covalently bound to overproduced GlbN apoprotein in cells grown under microo
118 while a syringafactin-producing strain that overproduced HAA exhibited slender swarming tendrils.
122 ires Hsp104 protein disaggregating activity, overproducing Hsp104 "cures" cells of [PSI(+)] prions.
124 ified human IL-15/IL-15Ralpha complexes from overproducing human cell lines and developed an ELISA sp
125 se models producing CAA mutants (Tg-SwDI) or overproducing human wild-type Abeta (Tg2576) to demonstr
126 or-activated T cells from TTP knock-out mice overproduced IFN-gamma mRNA and protein compared with ac
128 rived cells still produce Th2 cytokines, but overproduce IL-12p40, TNF, and IFN-gamma, fail to genera
129 showed that the LATY136F T cells could also overproduce IL-6 due to activated NF-kappaB, AKT, and p3
132 LPS-stimulated TTP-deficient macrophages overproduced IL-10, contained increased amounts of activ
133 null mutations of p50 to generate mice that overproduced IL-13 in the presence and absence of this N
139 w that prostaglandin E(2) (PGE(2)), a factor overproduced in chronic inflammation and cancer, induces
140 lytical and spectroscopic methods that RimO, overproduced in E. coli in the presence of iron-sulfur c
143 mH homolog from M. thermophila (Mt-CamH) was overproduced in Escherichia coli and characterized to va
144 rs, DesE, CchF, and CdtB, were recombinantly overproduced in Escherichia coli and purified to homogen
145 udy, the 10 uncharacterized GH9 enzymes were overproduced in Escherichia coli and purified, and their
153 (BMT), we previously reported that PGE(2) is overproduced in lungs of BMT mice, significantly impairi
154 isolated proteins that bound to proteasomes overproduced in M. tuberculosis and found a previously u
155 sed against S. aureus PBP2A, and was greatly overproduced in oxacillin-resistant clinical isolate S.
156 on and/or silencing reactive oxygen species (overproduced in oxidative stress) and other reactants.
163 imycin biosynthesis, VlmL and SvsR have been overproduced in soluble form in Escherichia coli, and th
165 ral cortex, administered intravascularly, or overproduced in the brain of transgenic mice expressing
167 id not inhibit Sir1-dependent silencing when overproduced in vivo, suggesting that other regions of S
168 observation that atr1D mutant plants, which overproduce indole glucosinolates, are more resistant to
169 plnMphi) from these genetically altered mice overproduce inflammatory cytokines following LPS stimula
170 the oxysterol 25-hydroxycholesterol (25-HC) overproduce inflammatory interleukin-1 (IL-1) family cyt
173 that transgenic Arabidopsis thaliana plants overproducing isoprenylcysteine methyltransferase (ICMT)
174 d us to discover that B. subtilis cells that overproduce KinA can bypass the salt-imposed block in sp
175 tana strains that can accumulate biomass and overproduce lipids have previously met with little succe
176 In these conditions, the liver and intestine overproduce lipoprotein particles, exacerbating the hype
177 binant Saccharomyces cerevisiae strain EKD13 overproducing mannoproteins has been used to obtain Alba
178 egulates p53 stability and many human tumors overproduce MDM2 as a mechanism to restrict p53 function
179 alysis revealed that a vast majority of MtrA overproducing merodiploids were associated with lysosoma
181 richment normalized the performance of Abeta-overproducing mice to the level of standard-housed nontr
186 A while those with either high or normal exo overproduce much less DNA in run-out assays in the wild-
187 ll length but not in cells that lack MukB or overproduce MukEF, suggesting that the clusters are form
190 wild type S. clavuligerus and in a holomycin-overproducing mutant resulted in decreased level of holo
191 ype, alginate-deficient mutant, and alginate-overproducing mutant) were used to cultivate three singl
192 images showed that, unlike the WT and curli-overproducing mutant, the curli-deficient mutant produce
194 g's moduli of both curli-deficient and curli-overproducing mutants were significantly lower than that
195 Arabidopsis thaliana) that the inducible NAD-overproducing nadC lines are more resistant to an avirul
198 ventually differentiate in excess number and overproduce neurons and BPs rostrally resulting in tange
199 The requirement for NeuE was suppressed by overproducing NeuS, suggesting that NeuE functions by st
201 over pcp1-18, but not pcp1-15, is rescued by overproducing nuclear pore components or advancing mitot
203 going extensive preclinical studies, melanin overproducing oncolytic virus strains might be used in c
205 ificance of MAM, M. arthritidis mutants that overproduced or failed to produce MAM were developed.
206 on occurs when mast cells are pathologically overproduced or if their activation is out of proportion
207 ound KD ICI, making it unlikely that ICI are overproduced or misfolded human protein aggregates.
208 normal 0.5% to 1%, either when flagella were overproduced or when expression of the FliL protein was
209 engineered to overproduce YvrI was found to overproduce oxalate decarboxylase (OxdC), and further an
210 wever, because the AGT-deficient hepatocytes overproduce oxalate, a large fraction of the mutant host
212 restore normal respiratory growth in strains overproducing Pet111p, suggesting that elevated Pet111p
214 ant of ppk1 is defective in social motility, overproduces pilin protein on the cell surface, is delay
217 ngineering of microbial farnesyl diphosphate-overproducing platforms for the production of biofuels.
219 the constituents of a B. cinerea mutant that overproduces polyketides gave sufficient quantities of 1
220 ion and increased network connectivity in SA-overproducing Populus, suggesting a previously undescrib
223 d orphan nuclear receptor beta lose rods but overproduce primitive S cones that lack outer segments.
225 t neutrophils isolated from patients with AT overproduce proinflammatory cytokines and have a prolong
226 T) neutrophils overexpress cyclooxygenase-2, overproduce prostaglandin E2 (PGE2), and exhibit defecti
227 e and together with BchM in Escherichia coli overproducing protoporphyrin IX suggests that the chelat
229 n a mutant carrying only a lon mutation, the overproduced pump mediated little, if any, increased mul
230 m the primary metabolite prephenate, we have overproduced, purified, and characterized the activity o
231 eltaPVL USA400 strains, while USA400 strains overproducing PVL caused increased bacterial burdens.
234 s observation has practical implications for overproducing recombinant vitamin K-dependent proteins f
235 nonglycosylated form (SmCI N23A mutant) were overproduced recombinantly in a Pichia pastoris system,
236 cell growth and may lead to cell death when overproduced, reminiscent of apoptotic genes in higher s
238 cates that the added drug drives the cell to overproduce ribosomes, keeping roughly constant the leve
241 nscripts are stabilized when RppH is absent, overproducing RppH does not accelerate their decay, nor
242 e to Agrobacterium infection, whereas plants overproducing SA were relatively recalcitrant to tumor f
243 ered to produce medium chain fatty acids and overproduce SAM, we obtain medium chain FAMEs at titers
244 olism in Sost(-/-) mice as well as mice that overproduce sclerostin as a result of adeno-associated v
245 hypersensitive to the TLR7/8 activator R848, overproducing SEAP and TNFalpha in response to all doses
248 bsent; this transcription can be restored by overproducing SlyA; (ii) in vivo dimerization and bindin
250 vely activate SoxR in an SOD(-) mutant, that overproduced SOD could not suppress activation by redox-
251 isolated neutrophils from mice engineered to overproduce soluble P-selectin (P-selectin(DeltaCT/Delta
252 dicted, females with high investment ability overproduced sons relative to those with lower ability.
253 The livers and heads of Insig-DKO embryos overproduced sterols, causing a marked buildup of sterol
255 ntly, immunization of mice with a native-Dam-overproducing strain at the same LD50 did not result in
257 activity in the culture supernatant of a Dam-overproducing strain were increased by 10-, 3-, and 2.4-
258 act gene expression in the A. hydrophila Dam-overproducing strain, and these data matched with Act pr
259 in murine macrophages infected with the Dam-overproducing strain, was diminished by 55% compared to
260 ached biofilm clusters, particularly the EPS overproducing strain, was significantly increased in the
262 autonomous replication in wild type and MtrA-overproducing strains, indicating that the integrity of
263 l actin cytoskeleton decrease aggregation of overproduced Sup35 and de novo prion induction and incre
264 nsferred T cells isolated from tumors stably overproduced supraphysiologic amounts of IL-12, and the
266 or gamma-irradiated Escherichia coli vectors overproducing tetanus and anthrax antigens, respectively
268 ic signs, stimulated IL-33/ST2 signaling and overproduced Th2 cytokine were observed in ocular surfac
269 plant alkaloids will enhance our ability to overproduce--that is, to metabolically engineer--these m
271 biosynthesis pathway in Escherichia coli to overproduce the industrially important isoprenoid lycope
273 ants have an overly responsive QS system and overproduce the secondary metabolite surfactin in the pr
282 cid-binding immunoglobulin-like lectin F and overproduced TNF and IL-6 through increased nuclear fact
284 ent sRNAs in E. coli for their ability, when overproduced, to inhibit or stimulate biofilm formation,
285 icago truncatula hairy roots and anthocyanin-overproducing tobacco (Nicotiana tabacum), but levels of
286 monas reinhardtii strains were engineered to overproduce tocopherols by chloroplast transformation wi
287 r, neither FtsA nor FtsA* protects FtsZ when overproduced together with ZipA mutants lacking the FZB
288 We studied the roles of RA in mice that overproduce tumor necrosis factor (TNF) and develop chro
290 Flt3-derived dendritic cells from these mice overproduced type 1 IFNs upon stimulation with ligands t
291 series of recombinant variants of JAK2 were overproduced using the baculoviral expression vector sys
292 in Mtb cells upon infection when these cells overproduce wild type MtrA but not when they overproduce
293 emical consequences of C10orf2 mutations, we overproduced wild type and 20 mutant forms of human mtDN
296 Our data imply that curing of [URE3] by overproduced Ydj1p does not involve direct interaction o
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