ライフサイエンスコーパス: overproduction

1 nd to examine underlying mechanisms of PTHrP overproduction.

2 therefore lead to hyperactive B cells and Ig overproduction.

3 ith AERD is associated with prostaglandin D2 overproduction.

4 icroglial neurotoxicity because of glutamate overproduction.

5 stress-related phenotype is not based on IAA overproduction.

6 prion propagation in a manner similar to Ssb overproduction.

7 promote tumour growth through sustained IL-6 overproduction.

8 ctive therapeutic agents that suppress mucus overproduction.

9 istent respiratory tract inflammation and LT overproduction.

10 ase (CYP11B2) is associated with aldosterone overproduction.

11 substantively according to degree of amylin overproduction.

12 ecruitment in BAL and lung and reduced mucus overproduction.

13 ith lung mast cell (MC) activation and cysLT overproduction.

14 gment Abeta-induced synaptotoxicity by Abeta overproduction.

15 e, retarded swarming motility, and pyocyanin overproduction.

16 s, is associated with intestinal lipoprotein overproduction.

17 , possibly by the infection of pDCs and IL10 overproduction.

18 entioned deleterious effects caused by Hsp90 overproduction.

19 c elimination of staphyloxanthin during AirR overproduction abolished the protective phenotype of inc

20 oped to investigate growth-coupled succinate overproduction, accounting for proteome constraints.

21 hin 4 (NT4) plays an essential role in mucus overproduction after early life allergen exposure by orc

22 Hsp42 overproduction also cures [URE3], and Hsp42p aids Btn2 o

23 In Pseudomonas aeruginosa, alginate overproduction, also known as mucoidy, is negatively reg

24 nd equally severe phenotype, namely, a large overproduction and aberrant placement of lateral root pr

25 e- and dose-dependent increase in superoxide overproduction and accumulation of free ferrous iron in

26 Pathway dysfunction leads to overproduction and accumulation of toxic, prooxidant com

27 e were protected from allergen-induced mucus overproduction and changes along the nerve-PNEC axis wit

28 Large-scale overproduction and elimination of exuberant widespread a

29 impaired SOD3 activity, resulting in O2(*-) overproduction and endothelial dysfunction in blood vess

30 Proinflammatory cytokine overproduction and excessive cell death, coupled with im

31 CB is caused by overproduction and hypersecretion of mucus by goblet cel

32 tes are associated with hepatic triglyceride overproduction and hypertriglyceridemia.

33 synaptogenesis, it is possible to study such overproduction and its role in speeding up development;

34 Alzheimer disease is caused in part by the overproduction and lack of clearance of Abeta protein.

35 promising targets to reduce BACE1 and Abeta overproduction and may ultimately serve as disease-modif

36 model characterized by amyloid beta (Abeta) overproduction and progressive amyloid pathology.

37 tly by ischemia-induced myocardial TNF-alpha overproduction and promotes the development of HF.

38 In this work we report the overproduction and purification of TsrM and the characte

39 can be constructed and tested for metabolite overproduction and secretion.

40 nflammatory milieu that in part drives CysLT overproduction and, in particular, the role of IFN-gamma

41 er to produce mitochondrial dysfunction, ROS overproduction, and calcium deregulation, which leads to

42 in both polycythemia, which is caused by Epo overproduction, and fatty livers.

43 Abeta-induced reactive oxygen species (ROS) overproduction, apoptosis, and calcium deregulation.

44 PGA overproduction appeared to be the result of an increase

45 chanism, the simulations reveal that synapse overproduction appears as an unavoidable concomitant of

46 oblet cell differentiation and related mucus overproduction are critical processes in the development

47 chronic antigenic stimulation, and cytokine overproduction are thought to be the main drivers of HIV

48 rotein (FADD), reactive oxygen species (ROS) overproduction, as well as mitochondrial dysfunction.

49 h in vivo platelet activation and serum TxB2 overproduction; aspirin 100 mg/day seems insufficient to

50 Consistent with sFlt1 overproduction being a significant driver of clinical sy

51 -encoded prg/pcf genes, or constitutive PrgU overproduction, block production of the Prg adhesins and

52 ht to establish the molecular basis of IL-13 overproduction by CD8(+) T cells from patients with SSc,

53 This, in turn, induced secondary IFN-gamma overproduction by colonic T cells, leading to prolonged

54 Here we examined acute effects of TGFbeta1 overproduction by keratinocytes on skin dendritic cells

55 could impair energy output and aggravate ROS overproduction by the damaged MRC.

56 in centriole assembly and promote centriole overproduction, Cetn2 and Cetn3 are not functionally int

57 locytosis, airway hyperresponsiveness, mucus overproduction, collagen deposition, and Th2/Th17 inflam

58 ], but neither Btn2p nor Cur1p is needed for overproduction curing by the other.

59 filaments to make new seeds, whereas Hsp104 overproduction curing occurs by a different mechanism.

60 proteins previously implicated in the Hsp104 overproduction curing of [PSI(+)].

61 Cur1p is needed for Hsp42 overproduction curing of [URE3], but neither Btn2p nor C

62 tion also cures [URE3], and Hsp42p aids Btn2 overproduction curing.

63 We show that YvcK T304A overproduction did not rescue the mreB mutant aberrant m

64 zed that dnaE915 cells would respond to DinB overproduction differently from dnaE(+) cells because th

65 In contrast, their overproduction enhanced the resistance to proteotoxic st

66 tify gene knockouts for targeted biochemical overproduction have been widely in use in modern metabol

67 between conjunctival intraepithelial melanin overproduction ("hyperpigmentation") and intraepithelial

68 eatment with PS (5 to 20 muM) suppressed ROS overproduction in a dose-dependent manner.

69 may be a valid treatment strategy for mucus overproduction in airway diseases, such as childhood ast

70 SA overproduction in Arabidopsis thaliana leads to dwarfism

71 activity, which we showed to underlie IL-13 overproduction in CD8(+)IL-13(+) cells from patients wit

72 A chromosome duplication implicated FtsA overproduction in Deltapbp2b suppression.

73 these no longer effect loss of survival upon overproduction in dnaE(+) strains.

74 In addition, the detection of IL-22 overproduction in HIV(NI) patients suggests that it migh

75 the previously described effects of ethylene overproduction in mature phytochrome-deficient plants.

76 Last, GABA installation restored mucus overproduction in NT4(-/-) mice after early life allerge

77 hese data demonstrate the mechanism for IL-6 overproduction in patients who develop postoperative SIR

78 Constitutive BH4 overproduction in sensory neurons increases pain sensiti

79 es to hepatic insulin resistance and glucose overproduction in the early adaptation to high-fat feedi

80 major cause of hepatic apoB100/triglyceride overproduction in type 2 diabetes.

81 oietic progenitors alleviates the neutrophil overproduction in vivo.

82 zed that the increased oxidative stress (ROS overproduction) in obese condition is a key contributor

83 However, the mechanism of mucin overproduction induced by M. pneumoniae remains unclear.

84 arkably, these cells are insensitive to Plk4 overproduction-induced ectopic centriole formation, yet

85 these results give insight into transposase overproduction inhibition by demonstrating that the appe

86 Its overproduction is a defining characteristic of several B

87 s immune and inflammatory responses, and its overproduction is a hallmark of inflammatory diseases.

88 Mucin overproduction is a hallmark of otitis media (OM).

89 This surfactin overproduction is associated with a strong fitness cost,

90 However, overproduction is associated with autoimmune disorders.

91 the post-transcriptional level and that FtsA overproduction is necessary and sufficient for suppressi

92 enses its environment and activates alginate overproduction is not fully understood.

93 ggest that APP overexpression, and not Abeta overproduction, is responsible for EEG abnormalities in

94 the mechanisms underlying the DinB-mediated overproduction loss-of-survival phenotype.

95 and suggest that Sac3 protein deficiency or overproduction may facilitate aggregation of aggregation

96 The IFN-beta overproduction observed in the absence of CdnP is due to

97 Induction of alginate overproduction occurs as a stress response to protect P.

98 c42 and exocytic function, we found that the overproduction of a regulator of exocytosis, Rab11, resc

99 ry known cellulose synthesis genes, leads to overproduction of a substance that binds the dyes Congo

100 t intercellular cross talk in which neuronal overproduction of Abeta activates astroglial NF-kappaB t

101 vacuolar protons and (2) elicitor-triggered overproduction of alkaloids.

102 In contrast, we discovered that overproduction of an artificial MinCc-MinD fusion protei

103 alifornica react to a fungal elicitor by the overproduction of antimicrobial benzophenanthridine alka

104 used by single-gene mutations that result in overproduction of beta-amyloid 42.

105 mmaturity of UGT1A1, in combination with the overproduction of bilirubin during the developmental sta

106 ne bioB-lacZ reporter was seen only upon the overproduction of BioR.

107 NCA- and FANCC-deficient macrophages induced overproduction of both TNF-alpha and IL-1beta in a p38-d

108 Lack of C1-INH leads to overproduction of bradykinin, a potent vasoactive peptid

109 iciency of C1 inhibitor (C1-INH), leading to overproduction of bradykinin.

110 Overproduction of Btn2p, involved in late endosome to Go

111 hese mutants collectively exhibited a strong overproduction of capsular polysaccharides, including al

112 Overproduction of catecholamines is the biochemical hall

113 esponse to defects in LPS core biosynthesis, overproduction of certain lipoproteins, and the global r

114 Heterologous overproduction of Chlorobaculum tepidum BchF revealed an

115 This transition coincides with the overproduction of collagen type I (COL1) and other extra

116 Collagen remodeling can lead to either an overproduction of collagen which can cause excessive col

117 g, we found that SigX is the missing link in overproduction of ComR.

118 Reduced expression of DUSP2 led to overproduction of COX-2-derived prostaglandin E2, which

119 ctions to aspirin, each involving the marked overproduction of cysLTs.

120 flammatory disorder of the airways, involves overproduction of cysteinyl leukotrienes (cysLTs), activ

121 haracterized by asthma, tissue eosinophilia, overproduction of cysteinyl leukotrienes (cysLTs), and r

122 ver indicated that neutrophils contribute to overproduction of cytokines and chemokines during fatal

123 revent pathological conditions deriving from overproduction of cytokines.

124 e idea that DapE strengthens the Ter signal, overproduction of DapE supports cell division with reduc

125 onsistent with this hypothesis, we find that overproduction of DDK leads to premature Eco1 degradatio

126 Although the overproduction of destructive factors promotes tissue da

127 e PgaA-dependent pathway was stimulated upon overproduction of DsrA, via negative regulation of H-NS,

128 Overproduction of E2 increased apoptosis-independent ext

129 eloping retina, Edn2 overexpression leads to overproduction of endothelial tip cells by both morpholo

130 helial dysregulation in patients with CRS is overproduction of eosinophil-promoting C-C chemokines by

131 ng EPS, while the Cheng report suggests that overproduction of EPS is a responsive mechanism for the

132 cts in this mechanism play a key role in the overproduction of erythrocytes in primary familial and c

133 Here we show that overproduction of Escherichia coli MraZ inhibited cell d

134 le for FeS cluster biosynthesis and that the overproduction of FeS clusters leads to a modified expre

135 Overproduction of FimY cannot alleviate the nonfimbriate

136 Overproduction of FtsA or FtsA* together with ZipA does

137 nalyses, such as in strain selection for the overproduction of fuels, chemicals and pharmaceuticals.

138 d features of normal development, an initial overproduction of functionally immature connections bein

139 Overproduction of FXIII-A by M2 macrophages might contri

140 In vivo, overproduction of FzlC causes cytokinesis defects wherea

141 anoids exhibit an accelerated cell cycle and overproduction of GABAergic inhibitory neurons.

142 cription factor FOXG1 is responsible for the overproduction of GABAergic neurons.

143 Overproduction of gain-of-function MtrAY102C advanced th

144 nal lamination, which is partially caused by overproduction of glia and subsequent disruption of the

145 excitatory neurotransmission associated with overproduction of glutamate has been implicated in the d

146 roduction (an energy-wasting state); and (4) overproduction of glutamate that caused NMDA receptor-de

147 myeloproliferative disorder characterized by overproduction of granulocytes and granulocytic infiltra

148 with the accumulation of oleic acid and the overproduction of growth hormone.

149 relationship between zinc deficiency and the overproduction of Hh ligand.

150 Deficiency or overproduction of Hsp104 cures the [PSI(+)] prion.

151 Overproduction of hydrogen peroxide (H2O2) causes oxidat

152 lacking Ezh2 were epigenetically primed for overproduction of IFN-gamma in Th2 and iTreg and IL-10 i

153 nction in limiting T cell overactivation and overproduction of IFN-gamma, a key lupus cytokine.

154 ort that loss of DBC1 results in spontaneous overproduction of Ig in mice after 10 mo of age.

155 0 promoters, causing a decrease in IL-10 and overproduction of IL-12 in Sb(R)LD-Mvarphis.

156 idered in pathologic states characterized by overproduction of IL-18 and/or IL-22.

157 y the p38 substrate MAPKAPK-2, p38-dependent overproduction of IL-1beta is controlled transcriptional

158 patients with Schnitzler syndrome, systemic overproduction of IL-1beta translates into a profound lo

159 egulated and hyperactive Th17 phenotype with overproduction of IL-22 and IL-17.

160 d4-family interacting protein 1 to show that overproduction of IL-4 in the periphery leads to an expa

161 preventing inflammatory response because of overproduction of IL-6.

162 ess cytokine production and can abrogate the overproduction of IL-8 in ROS-deficient cells.

163 owed higher MsgA and NanA activity, although overproduction of ILY in FBS was undetectable in mutants

164 Overproduction of immunoglobulin light chains leads to s

165 lead to insulin resistance characterized by overproduction of insulin acting as a growth factor.

166 e a systemic insulin resistance with chronic overproduction of insulin and localized field cancerizat

167 largely on epidemiological data that chronic overproduction of insulin is responsible for the increas

168 Furthermore, overproduction of Jac1 protected Isu from degradation in

169 sis that in this diabetic model, there is an overproduction of ketone-bodies within the vessels using

170 icular hydrocarbon profile, resulting in the overproduction of known queen pheromones as well as some

171 Application of k-OptForce to the overproduction of L-serine in E. coli and triacetic acid

172 he respiratory tract and is characterized by overproduction of leukotrienes (LT) and large numbers of

173 Overproduction of lipoproteins, a process that is depend

174 broth, and growth inhibition was relieved by overproduction of LppA or by metal ion titration.

175 at high efficiency, accompanied by a massive overproduction of LRV1-specific siRNAs, representing as

176 cIAPs and XIAP in the myeloid lineage caused overproduction of many proinflammatory cytokines, result

177 Hepatic fibrosis is associated with an overproduction of matrix proteins and a pathological inc

178 In addition, the extracellular overproduction of metabolites such as uric acid and chol

179 In contrast, overproduction of mitochondrial ROS was rarely observed.

180 These data suggest that overproduction of MMP-9 along with highly elevated level

181 hildhood that is clinically characterized by overproduction of monocytic cells that can infiltrate or

182 ve neoplasm in children characterized by the overproduction of monocytic cells that infiltrate the sp

183 Co-overproduction of MraW suppressed MraZ toxicity, and los

184 Furthermore, overproduction of Mre11 causes DNA damage sensitivity on

185 otic SPBs lost cohesion prematurely, whereas overproduction of Ndj1 delayed SPB separation.

186 ural circuit assembly is achieved by initial overproduction of neurons and synapses, followed by refi

187 s a plausible therapeutic strategy to combat overproduction of neurotoxic Abeta.

188 Overproduction of nitric oxide (NO) by inducible nitric-

189 Overproduction of nitric oxide (NO) can cause neuronal d

190 Overproduction of NO by nNOS is implicated in the pathog

191 However, overproduction of NO by the neuronal isoform of nitric o

192 and consequent inducible NOS (iNOS)-mediated overproduction of NO, which in combination with excess s

193 f the virus to escape neutralization through overproduction of non-infectious subviral particles, whi

194 Hes5 reveals an intact arterial program with overproduction of nonfunctional hematopoietic precursors

195 These data show that overproduction of NOX-derived ROS can promote the prolif

196 resulted in transient hyperproliferation and overproduction of OPCs but generation of normal numbers

197 In addition, overproduction of OspC in spirochetes also decreased the

198 ency for hypercalcaemia caused by autonomous overproduction of parathyroid hormone, is common, especi

199 The overproduction of polysaccharide alginate is responsible

200 Overproduction of PPM1A suppressed apoptosis of Mtb-infe

201 s that act to mitigate toxicity accompanying overproduction of PrgB-like adhesins in E. faecalis and

202 ranscriptional program and are biased toward overproduction of pro-B cells at the expense of T cell p

203 f the senescent phenotype, which involves an overproduction of pro-inflammatory and pro-oxidant signa

204 naling but rather is likely an effect of the overproduction of pro-inflammatory cytokines generated i

205 Older mice also showed overproduction of pro-inflammatory cytokines.

206 onse in obesity is unclear, it is known that overproduction of proinflammatory cytokines by innate im

207 er to prevent damaging consequences from the overproduction of proinflammatory cytokines by targeting

208 ophages causes intensified NLRP3 activation, overproduction of proinflammatory cytokines IL-1beta and

209 essive activation of glutamate receptors and overproduction of proinflammatory cytokines, including i

210 or lethality in F. novicida infection due to overproduction of proinflammatory effectors including pr

211 irectly invokes the activation and secondary overproduction of proinflammatory IL-6 from naive macrop

212 LPS, including NF-kappaB activation and the overproduction of proinflammatory mediators nitric oxide

213 kinase, IKKgamma (or NEMO), resulting in the overproduction of proteins that promote cellular surviva

214 low production, intermediate production, and overproduction of pyocyanin) in the presence or absence

215 associated with the primary injury, such as overproduction of reactive oxygen species (ROS) and infl

216 atrial fibrillation, which is accompanied by overproduction of reactive oxygen species (ROS).

217 Finally, Rab7 inhibition reduced overproduction of reactive oxygen species and increased

218 Oxidative stress (an overproduction of reactive oxygen species in relation to

219 gh glucose concentrations and the associated overproduction of reactive oxygen species.

220 T2440 is characterized by a slight catabolic overproduction of reducing power.

221 tion; early and late inactivation led to the overproduction of retinal ganglion cells (RGCs) and rod

222 the Notch signaling pathway, resulted in the overproduction of rod photoreceptors at the expense of M

223 tion of FA-CS-UA-NPs in mitochondria induced overproduction of ROS and destruction of mitochondrial m

224 t left shift, thereby normalizing persistent overproduction of ROS and its pathophysiologic consequen

225 photodriven NR system reduces the degrees of overproduction of ROS and pro-inflammatory cytokines bot

226 gulators of numerous cellular functions, and overproduction of ROS is a hallmark of various pathologi

227 portion of this defect could be bypassed by overproduction of RpoS.

228 Interestingly, both deletion and overproduction of Scy generated multiple polarity center

229 and Vps33 function are required to withstand overproduction of Sec17.

230 amage-response protein, caused age-dependent overproduction of secreted IgD resulting from increased

231 combinatorial metabolic engineering for the overproduction of secreted metabolites.

232 okines, particularly interleukin 6, leads to overproduction of serum amyloid A (SAA) by the liver.

233 rglycemia features increased bacterial load, overproduction of several cytokines, and increased immun

234 There is strong evidence that overproduction of soluble fms-like tyrosine kinase-1 (sF

235 The overproduction of specialized metabolites requires plant

236 our data suggest a strain-specific effect of overproduction of Sse1 - a nucleotide exchange factor of

237 pression and thereby leads to a phenotype of overproduction of stomatal lineage cells.

238 I(+) ] or [PIN(+) ] (prion form of Rnq1), or overproduction of Swi1 prion-domain (PrD) can considerab

239 evelopment of proper connections is an early overproduction of synapses.

240 olecular and biochemical events that lead to overproduction of TGF-beta, oxidative stress, and limite

241 Further analysis revealed that depletion or overproduction of the AirR response regulator resulted i

242 Strikingly, overproduction of the alternative sigma factor rpoS and

243 These include the overproduction of the exopolysaccharide alginate and the

244 Overproduction of the exopolysaccharide succinoglycan is

245 at abolish stator function also result in an overproduction of the extracellular polymer poly-gamma-g

246 The overproduction of the FtsZ-binding ZipA domain is suffic

247 ysis site in the nla6 transcript resulted in overproduction of the mRNA.

248 Overproduction of the mucin MUC5AC is an additional dise

249 Mutant IDH1 drives overproduction of the oncometabolite d-2-hydroxyglutarat

250 We report that overproduction of the peptide hormone Angiotensin II (An

251 lt in a hyperactive inflammasome that drives overproduction of the proinflammatory cytokines IL-1beta

252 Individual overproduction of the proto-ring component FtsA or its g

253 pressions impart flux changes that favor the overproduction of the target product thereby requiring f

254 Overproduction of the type I IFN family of cytokines is

255 Overproduction of the UA alarmin in the local microenvir

256 matopoietic progenitor cells associated with overproduction of the Vegf-a120 isoform.

257 We show that overproduction of the zorO gene is toxic to E. coli; co-

258 Depending on the cell type, overproduction of those mutant forms of Lyn could even u

259 IKKalpha(DeltaIEC) mice were associated with overproduction of thymic stromal lymphopoietin (TSLP) by

260 Both absence and overproduction of Toddler reduce the movement of mesendo

261 -dependent cleavage of APP, resulting in the overproduction of toxic Abeta isoforms.

262 nd NAP1 share some properties, including the overproduction of toxins, the binary toxin, and mutation

263 rogen-limited cells results in the transient overproduction of transcripts required for protein trans

264 he functional activity of TSLP in humans and overproduction of TSLP may be a key trigger for the ampl

265 genes on the GDAR system and the effects of overproduction of two of these genes were also studied.

266 elian disorders associated with constitutive overproduction of type I IFN has provided unique insight

267 d production of the antibiotic actinorhodin, overproduction of undecylprodigiosin, and diminished pro

268 o identify genes potentially involved in the overproduction of vascular tissues in central pedicels.

269 The recombinant overproduction of wild type and several site-directed mu

270 Overproduction of wild-type (MtrA+) or phosphorylation-d

271 Overproduction of wild-type or constitutively active Lyn

272 analyzed rescue of the mreB mutant strain by overproduction of YvcK in which the phosphorylation site

273 Overproduction of ZipA at levels that block septation is

274 Overproduction or deficiency of many chaperones and othe

275 Alginate overproduction, or mucoidy, plays an important role in t

276 nflammation through proinflammatory cytokine overproduction, oxidative stress, and intracellular Ca2+

277 Interleukin-10 (IL10) overproduction (P = .0003) was found in patients develop

278 In macrophages, the TNF-alpha overproduction phenotype depends on p38 mitogen-activate

279 The platelet overproduction phenotype was reversed by treatment with

280 In particular, IL-2 overproduction plays an important role in driving the ex

281 ocalizations are rarely seen during Swi1-PrD overproduction-promoted Swi1 prionogenesis.

282 ways produces the greatest amount of synapse overproduction, reduce adult performance by three measur

283 Early life allergen-induced mucus overproduction requires augmented neural stimulation of

284 Amazingly, its overproduction rescues growth and morphology defects of

285 Sclerostin overproduction results in the opposite metabolic phenoty

286 trast, variables that denote nocturnal urine overproduction sharply discriminate the risk of nocturia

287 Furthermore, IL-10 overproduction substantially reduced the immunopathology

288 etric localization of FtsZ during MinCc-MinD overproduction, suggesting that a downstream activity of

289 ds on ZapB to localize to the Z ring and its overproduction suppresses the division defect caused by

290 possible to study other outcomes of synapse overproduction that are seemingly new to the literature.

291 with LPS, because of microRNA-155 (miR-155) overproduction that excessively suppresses suppressor of

292 an propagate [PSI(+)], but cannot cure it by overproduction, thus separating filament cleavage from c

293 In contrast, ectopic Cyclin E overproduction uncouples short G1 from fast MCM loading.

294 We aimed to determine whether OmpA overproduction was a risk factor associated with pneumon

295 IgD overproduction was dependent on activation-induced cytid

296 Cutaneous IL-19 overproduction was reflected by elevated IL-19 blood lev

297 In each case, however, the overproduction was selective, occurring at the expense o

298 iprion systems curing [PSI+] without protein overproduction, we detected Siw14p as an antiprion eleme

299 ifferentiation with a 75% reduction in mucus overproduction while improving airway responsiveness to

300 tivity induces reactive oxygen species (ROS) overproduction within different MRC components upstream