ライフサイエンスコーパス: overt

1 With regard to off-target accumulation, overt (124)I activity was seen in the thyroid, as expect

2 ild amacrine and ganglion cell death, but no overt abnormalities in photoreceptors and synaptic struc

3 O2 and might benefit from oral alkali before overt acidosis develops.

4 at airway opening, to a greater extent than overt acinar wall destruction.

5 t these incorrect impulses from turning into overt action errors.

6 LAG3 upregulation is required to control overt activation and prevent the onset of autoimmunity.

7 tent with perturbations of calcium preceding overt acute toxicity.

8 aptic plasticity defects without evoking the overt adverse effects commonly associated with potentiat

9 In vivo PET scans revealed an overt age-dependent elevation in whole-brain uptake of (

10 A substantial proportion of subjects without overt airflow obstruction have significant respiratory m

11 urprisingly, this effect was observed before overt amyloid deposition.

12 r perceptual/cognitive preservation and both overt and covert markers of awareness.

13 Analyzing both overt and covert response tendencies enables to gauge th

14 inhibition of DNA replication abolished both overt and molecular rhythmicities by repressing frequenc

15 In 45/0, pulmonary edema was overt and rapid, with survival less than 30 minutes.

16 tors or investigate the relationship between overt- and covert-attention-defined centers.

17 Despite handedness being among the most overt aspects of human lateralization, studies of this h

18 e (HD) model mice at ages not accompanied by overt astrogliosis (at approximately postnatal days 70-8

19 Moreover, since the mutation did not promote overt aSyn aggregation, we conclude that E46K toxicity w

20 However, the pups develop overt ataxia by postnatal day 8-10 and die shortly there

21 n, observed in patients with CKD but without overt atherosclerotic disease and with few traditional r

22 The site of overt attention (fixation point) defines a spatial refer

23 Top-down influences on observers' overt attention and how they interact with the features

24 ms a visual-to-motor transformation vital to overt attention, but existing SC models cannot predict s

25 the saccade programs underlying movements of overt attention.

26 We conclude that both covert- and overt-attention sites define visual reference centers th

27 ert-attention SRC effect disappeared and the overt-attention SRC effect retained full strength, exclu

28 rrent reduction, but not elimination, of the overt-attention SRC effect.

29 pulations in normal numbers and exhibited no overt autoimmune manifestations.

30 se activity in vivo, which is different from overt BBB breakdown.

31 ming cardiac crescent (stage E7.75) prior to overt beating.

32 e abilities beyond those apparent from their overt behavior.

33 oding can occur in the absence of changes in overt behavior.

34 n difficult to link synaptic modification to overt behavioral changes.

35 The mice showed no overt behavioral phenotype but recapitulated distinctive

36 This was true for both overt behavioral reports (immediate button presses) and

37 k, is required for circadian timekeeping and overt behavioral rhythms.

38 in brain function in the first year of life, overt behavioral symptoms do not emerge until the second

39 the unfolded protein response at 8 weeks and overt beta cell endoplasmic reticulum stress at 12-16 we

40 t associated with any difference in rates of overt bleeding (6 vs 3; p = 0.50) or daily hemoglobin co

41 difficile infection; minor outcomes included overt bleeding, hemoglobin concentration profiles, and m

42 ail bleeding assays, but did not demonstrate overt bleeding.

43 ecisely timed pause response that drives the overt blink response.

44 therapy and lay dormant or progress to cause overt bone and visceral metastases.

45 In patients without overt CAD, impaired CFR was independently associated wit

46 ble lesions with reduced macrophage content, overt cap thinning, and necrotic core expansion as the m

47 The prevalence of overt cardiac abnormalities among V122I TTR carriers was

48 s (2 male, 3 female), with no history of any overt cardiac disease.

49 16492 outpatients with type 2 diabetes with overt cardiovascular disease (CVD) or multiple risk fact

50 Atherosclerosis), a cohort initially free of overt cardiovascular disease (CVD).

51 with type 1 diabetes mellitus (T1DM) without overt cardiovascular disease and stable glycemic control

52 n for primary prevention in patients with no overt cardiovascular disease is more controversial.

53 e randomized patients with severe OSA and no overt cardiovascular disease to receive 2 months of trea

54 ts with nonelevated clinic BP, no history of overt cardiovascular disease, and no use of antihyperten

55 f microglia, retinal neurons did not undergo overt cell death or become structurally disorganized in

56 sleep regulation were responsible for these overt changes in activity.

57 Although no overt changes in corneal opacity were detected by slit-l

58 Untreated SerpinB2(-/-) mice showed no overt changes in epithelial structure, and we were unabl

59 Loss of EZH2 did not result in overt changes in genome-wide and gene-specific H3K27me3

60 The absence of any overt changes in the expression of podocyte proteins at

61 In the human microbiome, we find no overt changes in the richness or composition induced by

62 ailable alternatives affect neural activity, overt choice, and the timing of choice responses.

63 and caused uterine inflammation, but without overt chorioamnionitis.

64 is inhibitory action was not associated with overt circadian rhythmicity in GHT output, indicating mo

65 ome families carrying susceptibility to both overt clefts and dental anomalies.

66 allinacea-infected chickens remained without overt clinical disease, but showed body weight gains sig

67 olvement in acute rheumatic fever, even when overt clinical findings are not apparent, was undertaken

68 marrow stromal cells, which peaked prior to overt clinical relapse and detection of resistance mutat

69 to an initial IgA deposition step preceding overt clinical symptoms in patients.

70 tic samples (79%): 2 of 2 from patients with overt CNS disease and 21 of 27 from patients thought to

71 ed de novo inflammation even in mice without overt colitis, after the administration of low-dose DSS.

72 However, overt compliance is not necessarily accompanied by a cha

73 that oppositely affects internalization and overt compliance.

74 After adjustments, pressure to eat and overt control at 4 y of age were associated with a lower

75 elderly, community-based population free of overt coronary artery disease and heart failure.

76 We studied 4580 participants free of overt coronary artery disease, heart failure, and signif

77 al cohort of older adults free of clinically overt coronary heart disease or heart failure, obesity w

78 ning the Child Feeding Questionnaire and the Overt/Covert Control scale and then adapting it to Portu

79 In the overt-criterion task, observers adjusted the orientation

80 with hepatitis C virus (HCV) infection, and overt cryoglobulinemia vasculitis (CryoVas) develops in

81 We show that by introducing overt cues to the illumination, we can flip the dress co

82 -presenting cell stimulation, and priming of overt cutaneous disease.

83 A virus that caused overt cytopathic effects was isolated, but it did not in

84 nited States, and numbers needed to treat to overt death were obtained from published sources.

85 t most die within 3 d after birth showing no overt defects in anatomy.

86 levels of Cas9 in the heart, but display no overt defects.

87 ced mitochondrial function did not result in overt deficits in basal glutamatergic synaptic transmiss

88 es and neuronal synchronization occur before overt deficits in place fields in these mice.

89 he loss of TSPO in the CNS did not result in overt developmental defects or phenotypes.

90 ocytotic machinery sensitizing beta-cells to overt diabetes after unfolded protein stress.

91 time risk of progression from prediabetes to overt diabetes and from diabetes free of insulin treatme

92 resistance per se, however, does not provoke overt diabetes as long as compensatory beta-cell functio

93 nd 49.1% (38.2-60.0) of the individuals with overt diabetes at this age started insulin treatment.

94 ucose intolerance that rapidly progresses to overt diabetes.

95 dently results in insulin resistance but not overt diabetes.

96 transition of impaired glucose tolerance to overt diabetes; endoplasmic reticulum (ER) stress expedi

97 e <30 mL/min per 1.73m(2), or development of overt diabetic nephropathy), eye events (a composite of

98 at delaying or preventing the progression to overt disease and its many complications-could be most b

99 ancer, one "big-hit" might be sufficient for overt disease and supports a key contribution of epigene

100 f diabetes and its complications long before overt disease develops.

101 guished high-risk subjects who progressed to overt disease from those who did not.

102 Progression of malignancy to overt disease requires multiple genetic hits.

103 myosuroides; Am) populations, displaying no overt disease symptoms, contained three previously undes

104 restingly, BACHD-DeltaN17 mice manifest more overt disease-like phenotypes than the original BACHD mi

105 syndromes, allergic manifestations, and even overt disease.

106 e of asymptomatic nasopharyngeal carriage to overt disease.

107 patients had a 13 times higher prevalence of overt disseminated intravascular coagulation at admissio

108 rom the intention-to-treat population (3 had overt distant metastases at the time of randomization; 2

109 In basal conditions, no overt dystonic movements or postures or change in locomo

110 tic deletion of Pak1 and Pak2 in mice has no overt effect on skeletal muscle development or regenerat

111 r accumulation and activation of YAP without overt effects on Scrib localization and vice versa.

112 Lesions with overt endoscopic evidence of SMIC are referred for surge

113 ated with SMIC, and examined lesions without overt endoscopic high-risk signs to determine factors as

114 weeks of adult age, the R6/2 mouse developed overt endothelial dysfunction due to an inability to inc

115 a that, even in absence of hyperglycaemia or overt endotoxaemia, synergistically induce TLR4-mediated

116 acity and sodium sieving before the onset of overt EPS.

117 used mitochondrial network in the absence of overt ER stress.

118 fic CD8(+) T cell transcription preceded the overt establishment of T cell exhaustion, making this si

119 s aggression and courtship, and controls the overt expression of these social behaviors in a threshol

120 ion has tended to focus on the perception of overt expressions of at most five or six basic emotions.

121 hether command following was evident through overt external behavior, or through covert functional ne

122 double-homozygous mutant embryos exhibit an overt facial clefting phenotype more severe than that ob

123 rosis (PMF): prefibrotic/early (pre-PMF) and overt fibrotic (overt PMF) phase.

124 ion contributes to H. pylori persistence and overt gastric disease.

125 In patients with overt gastrointestinal bleeding, and negative findings o

126 ained standing for several stops, or made an overt gesture such as waving his hand toward the seat?

127 ghtened levels of proinflammatory cytokines, overt granulocyte/monocyte progenitor cell apoptosis, an

128 nization-related benefit of markedly reduced overt HBV infection.

129 isolated anti-HBs positive, and 3.4% had an overt HBV infection.

130 red with controls, the SIC was 61% higher in overt HCM and 47% higher in subclinical HCM (P<0.001 for

131 uantitatively different across subjects with overt HCM, subclinical HCM, and healthy controls (P<0.00

132 th a reduction in mortality in patients with overt HE (RR = 0.36, 95% CI 0.14-0.94, NNT = 20), althou

133 rognostic value regarding the 1-year risk of overt HE and death.

134 were followed up regarding the occurrence of overt HE and death.

135 The HR for overt HE was higher (adjusted HR = 1.88; 95% CI, 1.21-1.

136 se with hypertension (n=734), and those with overt heart failure (HF; n=207).

137 , transforming subclinical cardiac injury to overt heart failure.

138 t isolated Ash1l or Mll1 deficiency, induced overt hematopoietic failure.

139 OLA) in patients with cirrhosis and bouts of overt hepatic encephalopathy (OHE) are missing.

140 Post-TIPS overt hepatic encephalopathy was present in 14 patients

141 failure (HF), only to return much later with overt HF syndrome, mainly caused by chronic remodeling o

142 d with progression from subclinical stage to overt HF.

143 The transition from asymptomatic to overt HFpEF is linked to diastolic, systolic, and chrono

144 vast majority of drowning patients develops overt hyperfibrinolytic disseminated intravascular coagu

145 Overt hyperglycemia (>250 mg/dL) manifested 6 weeks afte

146 Characterization of overt hyperglycemia in insulin receptor mutant (Insr(P11

147 and treatment of subclinical and undiagnosed overt hypothyroidism and hyperthyroidism in adults witho

148 -), and Mavs(-/-) knockout mice exhibited no overt illness.

149 d myeloid cell function shows no evidence of overt immune deficiency in HED mutant mice.

150 study confirms that adjuvant imatinib has an overt impact on RFS.

151 ansmission cycle to start, an outbreak of an overt infection must first occur within the host.

152 e innate immune activation in the absence of overt infection.

153 is context parallels and differences between overt inflammation and para-inflammation in the eye.

154 not induce advanced liver disease (i.e., no overt inflammation or fibrosis) in adult Brown Norway ra

155 constitutively expressed, in the absence of overt inflammation, with a specific tissue distribution

156 Unexpectedly, this occurs in the absence of overt inflammation.

157 on and remyelination, even in the absence of overt inflammation.

158 Sudden death, where no end point illness is overt, is observed at a median age of 6.5 and 4.8 months

159 A second allograft is recommended if overt JMML relapse occurs after transplantation.

160 r (APV) >0.23 diopter (D) yielded a test for overt Kc with sensitivity and specificity rates of, resp

161 egorized as forme fruste (FFKc, n = 212) and overt keratoconus (Kc, n = 222).

162 PE was not associated with overt left or right ventricular systolic dysfunction (ej

163 ymptomatic for years before progressing into overt lesions.

164 um from asymptomatic clonal hematopoiesis to overt leukemia and exhibit substantial clonal heterogene

165 When antibody therapy was initiated in overt leukemia, antibody CD19-DE was still efficient in

166 mutations then drive clonal evolution toward overt leukemia.

167 e early stages of NAFLD development prior to overt liver inflammation and advanced liver disease.

168 creased transepidermal water loss, increased overt loss of stratum corneum in inflammatory lesions, a

169 -positive, early-stage breast cancer without overt lymph node metastases.

170 lecular and cellular responses that included overt lymphoid as well as myeloid contributions.

171 of endogenous dTau proteins did not lead to overt, macroscopic phenotypes in flies.

172 Although overt manifestations of cardiovascular disease (CVD) rar

173 intraepithelial T cell activation offers an overt means to promote the innate antiviral potential of

174 lls (ECs) lining the vein, in the absence of overt mechanical disruption of the EC layer.

175 mice have alkaline urine but do not exhibit overt metabolic acidosis, a renal phenotype similar to t

176 nies as well as their subsequent growth into overt metastases.

177 raction of these cells is capable of forming overt metastases.

178 These conduction defects were accompanied by overt mislocalization of the gap junction protein connex

179 could be an alternative; however, even if no overt mitochondrial toxicity is detected, widespread cha

180 the mental simulation of a motor act without overt motor output.

181 firing rate) is associated with the lack of overt movement, when a stable posture is maintained by s

182 t exclusively investigated in the context of overt movements.

183 ion induces cardiomyocyte dedifferentiation, overt muscle hyperplasia, epicardial activation, increas

184 sive peribiliary fibrosis, in the absence of overt necroinflammation.

185 on that may foreshadow the development of an overt neoplasm.

186 Finally, overt nephropathy is characterized by proteins involved

187 f subjects with type 2 diabetes mellitus and overt nephropathy receiving angiotensin converting enzym

188 t OL differentiation but only FrCasE induces overt neurodegeneration, restriction of OL maturation al

189 However, no overt neuronal loss was observed, though significant abn

190 reas 5 (18%) patients experienced clinically overt obstructive THV thrombosis.

191 he bees, activate a covert infection into an overt one.

192 robability that a decision or a proposition, overt or covert, is correct given the evidence, a critic

193 ividuals before neurological disease becomes overt or serious.IMPORTANCE The detection of highly comp

194 ncidence is particularly high in people with overt or un(der)diagnosed psychiatric disorders.

195 rity of the human population without causing overt pathogenesis in healthy individuals.

196 ul parasites form chronic infections without overt pathology, we are gaining additional insights into

197 ients with lower mPAP and frequently develop overt PH and to identify clinical correlates of borderli

198 Our secondary outcome was the diagnosis of overt PH in patients initially diagnosed with borderline

199 th significant comorbidities, progression to overt PH, and decreased survival.

200 rwent a repeated RHC, 43 (61%) had developed overt PH, with a median increase in mPAP of 5 mm Hg (int

201 k(-/-)Bok(-/-) mice were reported to have no overt phenotype or apoptotic defects in response to a ho

202 Animals lacking Neil3 had no overt phenotype, but were predisposed to autoantibody pr

203 Although null dhtt mutants display no overt phenotype, we found that dhtt acts as a suppressor

204 elial and non-epithelial tissues, causing no overt phenotype.

205 , NEIL1, and NEIL3), Neil2-null mice show no overt phenotype.

206 The mice are viable and show no overt phenotype.

207 es for disease processes before the onset of overt phenotypes.

208 Engraftment of CMML and JMML resulted in overt phenotypic abnormalities and lethality in recipien

209 reas aapt1 or aapt2 single KO plants show no overt phenotypic alterations.

210 gely on the transfer from mental practice to overt physical performance.

211 ncreased and associated with synapses before overt plaque deposition.

212 dian survival was significantly shortened in overt PMF (7.2 vs 17.6 years), with triple negativity fo

213 Compared with pre-PMF, overt PMF was enriched in patients with anemia, thromboc

214 More patients with overt PMF were in higher International Prognostic Scorin

215 fibrotic/early (pre-PMF) and overt fibrotic (overt PMF) phase.

216 RSF2, IDH1/2, EZH2) were more represented in overt PMF.

217 In addition, we did not find any overt positive or negative effect of dTau removal on hum

218 vides an immediate and simple solution to an overt problem.

219 it the damaging inflammation associated with overt production of proinflammatory IL-1beta.

220 did not otherwise appreciably change ALP and overt proof-of-concept was not established as per prespe

221 pertension (AASK) Cohort Study who exhibited overt proteinuria have been reported to show high nonalb

222 (oxLDL) particles, a process that induces an overt prothrombotic phenotype.

223 n of SMN in postnatal motoneurons results in overt proximal weakness, fibrillations on electromyograp

224 xaggerated chemokine production in vitro and overt psoriasis-like inflammation in vivo.

225 t of skeletal muscle dysfunction even before overt pulmonary pathology.

226 activation of latent infection, resulting in overt pulmonary, pleural, and extrapulmonary tuberculosi

227 ness, and macular volume; (3) development of overt PVR recurrence; (4) complete and posterior retinal

228 We obtained no evidence for overt radial or tangential neuronal migrations.

229 Driven by the overt recognition of such a potential obstacle, a panel

230 to intentionally induce a placebo effect via overt recruitment in an effort to evaluate the role of p

231 ific Lrp6-knockout mice consistently exhibit overt reduction of Cx43 gap junction plaques without any

232 novel strategy to prevent dissemination and overt relapse in multiple myeloma.

233 n, but neither family A nor family B men had overt renal disease.

234 obtaining food even when he/she did not make overt requests for help.

235 We also found that overt rhythmic movements improved the quality of tempora

236 s to understand how they interact to control overt rhythms, remaining plastic enough to respond and a

237 to drive rhythmic transcription required for overt rhythms.

238 th postinfection follow-up did not detect an overt right ventricular (RV) phenotype in nonexercised (

239 ences can be observed also in the absence of overt sensory stimulation.

240 arrier and virus clearance in the absence of overt sequelae.

241 onally conserved enhancers in the absence of overt sequence homologies and over extensive evolutionar

242 A cohort of 40 children with clinically overt severe sepsis syndrome and 30 children immediately

243 The clinically overt severe sepsis syndrome children had confirmed or h

244 Postcardiopulmonary bypass versus clinically overt severe sepsis syndrome descriptors included the fo

245 us postcardiopulmonary bypass and clinically overt severe sepsis syndrome groups in children.

246 fully for 35 of 40 (87.5%) of the clinically overt severe sepsis syndrome patients and 29 of 30 (96.7

247 ed postcardiopulmonary bypass and clinically overt severe sepsis syndrome patients by receiver operat

248 count and low fertility in C/C males, but no overt sex organ phenotype in C/C females.

249 scular-blocking agents may be used to manage overt shivering in therapeutic hypothermia.

250 me and is being extended to patients without overt shock.

251 ges from the normal breast of a patient with overt signs of cancer only in the other breast.

252 hat B6.Htt(Q111/+) mice are healthy, show no overt signs of central or peripheral inflammation, and n

253 he maturation stages was unaffected, with no overt signs of developmental blocks.

254 ulin levels are normal, and individuals lack overt signs of immunodeficiency.

255 In the absence of overt signs of infection or fetal compromise, a policy o

256 early adulthood, yet aged animals display no overt signs of kidney failure.

257 Although retinal terminals lacked overt signs of neurodegeneration, transport-intact areas

258 ytic activity, and does so in the absence of overt signs of neuroinflammation, suggesting that like m

259 ERX-11 is orally bioavailable, with no overt signs of toxicity and potent activity in both muri

260 ans health, and neuronal counts, revealed no overt signs of toxicity.

261 m of the disease and present with few if any overt signs or symptoms.

262 le skin irritation, in sharp contrast to the overt skin irritation caused by intradermal injections.

263 s immune responses elicited by cGAMP with no overt skin irritation was attributable to its stay in th

264 Vaccination with BCG-MNA caused no overt skin irritation, in marked contrast to intradermal

265 sification accuracy between imagined speech, overt speech and listening.

266 n accuracy was obtained in the listening and overt speech conditions (mean = 89% and 86%, respectivel

267 n related to language production (sentential overt speech production-Speech task) and activation rela

268 ech may ultimately reflect a special type of overt speech.

269 Pax8-Cre/GR(fl/fl) mice did not exhibit an overt spontaneous phenotype.

270 In this study, mice that developed an overt squeaky (sqk) phenotype were identified with obstr

271 odynamic signals in the absence of a task or overt stimulation are used to infer neural activity.

272 ers for metabolic studies in rodents without overt stress is challenging.

273 st Huntington's disease (HD) subjects before overt striatal neuronal loss, but whether the white matt

274 ion therapy, has decreased the prevalence of overt stroke from approximately 11% to 1%.

275 ograms, resulted in successful prevention of overt strokes, but a high cumulative risk of silent cere

276 knockout mouse model of Alix, we identified overt structural changes in the epithelium of the choroi

277 gested that electrical abnormalities precede overt structural disease in arrhythmogenic right ventric

278 This model does not display overt symptoms of HD but has circadian rhythm alteration

279 ction and survival, even if they produce few overt symptoms.

280 Despite overt T-cell expansion and neutrophilia, a reduction in

281 from cord blood of newborns who progress to overt T1D suggests that the DVPs likely emerge after bir

282 Overt task performance was maintained across the lifespa

283 Overt tau pathology in the aged mice was accompanied by

284 h CD45 on CD8(+) T cells may protect against overt TCR auto-MHC reactivity, while enhanced sensitivit

285 related with nephrotic disease severity, but overt thrombosis may require an initiating insult, such

286 In contrast, overt thymus deletion and functionally impaired TEIPP T

287 develop normally, and adult mice exhibit no overt tissue abnormalities.

288 sitized CRPC tumors to enzalutamide, without overt toxicity, in mice.

289 Although the plants did not exhibit overt toxicity, the major seed proteins primarily associ

290 nhibited by RK-33 treatment in mice, without overt toxicity.

291 mpletely suppressed the tumor growth without overt toxicity.

292 mentation, clearance from circulation and no overt toxicity.

293 increased hepatic lipid metabolism prior to overt tumor development.

294 that local p53 activation in TME comprising overt tumor-infiltrating leukocytes (TILeus) induces sys

295 to promote progression from autoimmunity to overt type 1 diabetes.

296 r neuron disease phenotypes, with clinically overt upper motor neuron involvement.

297 wild-type MCMV, lacking HEL, did not induce overt uveitis, suggesting that disease is mediated by an

298 g mutations of ISG15 do not present with any overt viral phenotype, but are highly susceptible to env

299 Overt vitamin B-12 deficiency causes neurologic disturba

300 ons and suggest a more nuanced definition of overt vs. covert attention.