ライフサイエンスコーパス: overwhelm

1 d proteasomal degradation are compromised or overwhelmed.

2 ories of individuals in need too emotionally overwhelming.

3 or the remains being those of Richard III is overwhelming.

4 However, the resulting deluge of data can be overwhelming.

5 of highly active viral promoter elements may overwhelm a cell's post-transcriptional regulatory machi

6 proposed for addressing the challenge of the overwhelming abundance of genomic sequence and other bio

7 However, overwhelming activation and accumulation of neutrophils

8 One patient died from an overwhelming adenoviral infection before reconstitution

9 Owing to the overwhelming advantage in energy density, lithium-sulfur

10 tA or equivalent mutations that conferred an overwhelming advantage.

11 , the default IgG response at age 1 year was overwhelmed after age 2 years by an "pre-atopic" IgG res

12 ethylated CpGs at other gene regions, and by overwhelming age-related methylation in CpG islands and

13 pled algorithmic approaches to deal with the overwhelming amount of data generated by modern mass spe

14 r technological solutions able to manage the overwhelming amount of high throughput genomic data need

15 f pathogen transcripts is complicated by the overwhelming amount of host RNA isolated from an infecte

16 Sensory environments often contain an overwhelming amount of information, with both relevant a

17 ing machines, these must be selected from an overwhelming amount of raw data.

18 es displayed by humans in making sense of an overwhelming amount of sensory information cannot be exp

19 s for a target antibody in the context of an overwhelming amount of unrelated immunoglobins present i

20 mponents of the immune system as well as the overwhelming amounts of data can make it difficult to in

21 The presence of overwhelming amounts of information in our big-data era

22 Our brains operate on overwhelming amounts of information, and thus their effi

23 cation, the product multiplicity and novelty overwhelmed analytical efforts by MS methods.

24 n in such a capricious environment can prove overwhelming and compromise one's ability to effectively

25 ice with HOXA10 gene disruption exhibited an overwhelming and fatal emergency granulopoiesis response

26 edoxin-thioredoxin antioxidant chain becomes overwhelmed, and H2O2 degradation stalls or ceases.

27 ress, the cell's folding capacity can become overwhelmed, and misfolded proteins can accumulate in al

28 synthetic methodology toward heterocycles is overwhelming, and catalysis, in particular, as one of th

29 The literature on this subject is overwhelming, and no consensus has been reached, with a

30 ssively and express phenotypes indicative of overwhelming antigenic stimulus and tissue homing/cytoto

31 ased susceptibility to frost damage that can overwhelm any benefit of flowering early.

32 nce of some calcifying herbivores, which can overwhelm any direct negative effects.

33 P generated by remineralization should have overwhelmed any pore water and/or bottom water because o

34 ond which internal resistance mechanisms are overwhelmed are uncommon.

35 Although we also confirmed overwhelming association at the LOXL1 locus, the key SNP

36 Pines use defensive resin to overwhelm attackers, creating an Allee effect requiring

37 forementioned confounding factors can easily overwhelm attempts to extract relevant information.

38 SSA measurements are typically dominated by overwhelming background aerosol concentrations even in r

39 s where small features are masked by a broad overwhelming background.

40 ponses employed by the host to deal with the overwhelming bacterial presence of the microbiota.

41 that glutamate clearance mechanisms must be overwhelmed before spillover can occur.

42 up of 27 months, because the boundary for an overwhelming benefit with LCZ696 had been crossed.

43 Despite the overwhelming benefits of antiretroviral therapy (ART) in

44 Overwhelming, bipartisan support by voters exists for en

45 However, an overwhelming body of knowledge has accumulated in the fi

46 The overwhelming body of research on T regulatory cells (Tre

47 hich physical effects of habitat-formers can overwhelm broad-scale thermal trends, suggesting a need

48 ed intercellular communications may place an overwhelming burden on the nervous system and account fo

49 s of the emerging economies of Asia could be overwhelmed by an increase of dust emissions due to chan

50 ecause existing software solutions are often overwhelmed by error correction tasks.

51 versity, but weak or asymmetric mutualism is overwhelmed by genetic drift even when mutualism is stil

52 suggests that these direct responses can be overwhelmed by indirect effects mediated via other inter

53 urodegeneration renders hippocampal circuits overwhelmed by internal information and therefore preven

54 other small Pt(n) on GCE, any ORR signal is overwhelmed by large oxidative currents attributed to ca

55 ate recognition and because authorities were overwhelmed by many patients and poor community involvem

56 r the last three decades, the field has been overwhelmed by nanotechnology, nanomedicine, and many na

57 ic conditions, they are susceptible to being overwhelmed by patient influxes.

58 conditions, estrogen effects were partially overwhelmed by pro-inflammatory cytokines.

59 which stimulus-driven cortical excitation is overwhelmed by spontaneous neuronal excitation through t

60 icial effect of high CO2 on Trichodesmium is overwhelmed by the deleterious effect of the concomitant

61 Providers are often overwhelmed by the heterogeneity in clinical features an

62 hange resulting from emission mitigation are overwhelmed by the increased water stress from the emiss

63 olecule, but this minor enzyme inhibition is overwhelmed by the marked enhancement of membrane recrui

64 ith this system, weak acoustic pulse signals overwhelmed by the noise are successfully recovered.

65 ular encounters are random, short-lived, and overwhelmed by the solvent.

66 limited information-processing resources are overwhelmed by the total concurrent processing demands i

67 er of these diseases, a clinician may become overwhelmed by the volume of data, making it difficult t

68 drug-induced error-prone polymerase Pol IV, overwhelms cells with toxic DNA breaks.

69 Considering the overwhelming changes that occurred during primate evolut

70 hylmercury inputs to the estuary by 25-200%, overwhelming climate-driven changes over the next decade

71 hes enable rapid reconstruction of TRNs, the overwhelming combinatorics of possible networks limits i

72 y assuming a tame solution and inaction from overwhelming complexity.

73 of the finite difference method can have an overwhelming computational cost in models with a high-di

74 erficial zone (SZ) due to the presence of an overwhelming concentration of nonspecific TGF-beta bindi

75 The overwhelming contribution of diesel compared to gasoline

76 Overwhelming data in both humans and mice reveal a clear

77 Overwhelming data suggest that oncogenic and neurodegene

78 Overwhelming data support the use of medical therapy as

79 However, mCRPC showed overwhelming de novo resistance to immune checkpoint blo

80 To survive overwhelming demands on the proteasome arising during en

81 le this may be thought of as secondary to an overwhelming desire for drugs, it could equally well ref

82 differ greatly, ranging from asymptomatic to overwhelming disease and death, having available both an

83 disorder was related to helpless/inadequate, overwhelmed/disorganized, and special/overinvolved count

84 Issues are discussed as related to the overwhelming dominance of social determinants on oral di

85 ndation of this model is the theory that the overwhelming driver of cancer risk is mutations.

86 If mitochondrial antioxidant enzymes are overwhelmed during severe infections, mitochondrial dysf

87 small number (<3) action potentials, but is overwhelmed during sustained or theta-like activity whic

88 ee densities at finer scales, as well as the overwhelming effect of humans across most of the world.

89 We also observe an overwhelming effect of the established TCF4 locus.

90 count after therapy initiation highlight the overwhelming effectiveness of antiretroviral therapy in

91 he data and safety monitoring board owing to overwhelming efficacy.

92 o acid mutations, hypoxia, or infection, can overwhelm ER protein quality control, leading to misfold

93 utational analysis of a large dataset can be overwhelming, especially for novices.

94 Considering the overwhelming evidence about the effectiveness of primary

95 There is overwhelming evidence both in vivo and in vitro that tra

96 Despite overwhelming evidence for D2 receptors (D2Rs) in maintai

97 moma, although there was significant but not overwhelming evidence for thyroid, parathyroid, lung, an

98 Overwhelming evidence indicates that an ultrasonography-

99 Overwhelming evidence now supports the presence of a dee

100 ived comparatively little attention, despite overwhelming evidence of a pivotal role for the PAG in c

101 With overwhelming evidence of change in habitats, biologists

102 This is despite overwhelming evidence of its unique role in causing a wo

103 Recent genetic studies have provided overwhelming evidence of the involvement of microglia-re

104 However, the overwhelming evidence shows that the quality of reportin

105 Overwhelming evidence shows the critical role of glycoly

106 Overwhelming evidence supports the endosymbiosis theory

107 There is overwhelming evidence that G-protein-coupled receptors (

108 There is overwhelming evidence that ions are present near the vap

109 There is overwhelming evidence that leaf-internal isoprene increa

110 In disease states, there is overwhelming evidence that stress hyperlactataemia is a

111 There is now overwhelming evidence that the innate and adaptive branc

112 or analyzing the SOP fail to account for the overwhelming evidence that the wake/sleep transition is

113 timulate the immune system, and there is now overwhelming evidence that this drives chronic immune ac

114 Despite overwhelming evidence that transcriptional activation by

115 For example, their large strengths typically overwhelm externally applied forces, which makes it chal

116 d by clinical homogeneity among patients, an overwhelming female predominance, production of a multil

117 Finally, the complex nature of plasma was overwhelming for HD1, but we define conditions for the t

118 ions based on molecular profiling results is overwhelming for many oncology clinicians and researcher

119 cant.] Upper-bound estimates suggest that an overwhelming fraction (90%) of these losses is due to th

120 Finally, we demonstrate that RecBCD always overwhelms FtsK when these two motor proteins collide wh

121 The present findings indicate that the overwhelming GABAergic drive present at the DMV is prima

122 ola epidemic in parts of west Africa largely overwhelmed health-care systems in 2014, making adequate

123 ts exciting scientific challenges as well as overwhelming health, equity, and economic benefits.

124 s such as transcription and replication that overwhelm high-fidelity DNA repair.

125 The pace and extent to which GCM projections overwhelm historical trends will play a key role in defi

126 ontrol of an illegal trade in which there is overwhelming historical evidence of its complicity.

127 This overwhelming historical success makes it very difficult

128 , but in the clinical setting are limited by overwhelming host material and ultra-low target frequenc

129 es a novel function of the H4R preventing an overwhelming immune reaction by engagement of a negative

130 plication fidelity functions are impaired or overwhelmed in pJlacS, with results analogous to those o

131 Notably, the UPS was overwhelmed in podocytes during experimental glomerular

132 Future warming may overwhelm increases in precipitation leading to similar

133 An overwhelming infection of hepatocytes was a major conseq

134 In contrast to the overwhelming infection seen in the mice challenged with

135 ighly susceptible to fatal ehrlichiosis, had overwhelming infection, and developed extensive tissue i

136 of STAT1 mutation is ultimately fatal due to overwhelming infection.

137 nia, a condition linked to increased risk of overwhelming infections, remain largely unknown.

138 ages, leading to early onset, recurrent, and overwhelming infections.

139 nvading pathogens is essential to preventing overwhelming inflammation and sepsis that are symptomati

140 vation syndrome (MAS) is an acute episode of overwhelming inflammation characterized by activation an

141 his might be important to avoid sustained or overwhelming inflammation, our data suggest that a negat

142 Here, we show that VML injury incites an overwhelming inflammatory and fibrotic response that lea

143 Controlling the overwhelming inflammatory reaction associated with polym

144 induces organ failure and is accompanied by overwhelming inflammatory response and impairment of mic

145 eroxia, but this effect is less prominent if overwhelming injury is induced by the combination of hyp

146 ous models of abdominal sepsis because of an overwhelming innate immune response, leading to prematur

147 and attractive target for modulation of the overwhelming innate immune response.

148 cts alters microbial community structure and overwhelms inter-individual differences in microbial gen

149 red to simulate cellular crowding, introduce overwhelming interferences to mass spectrometry (MS) ana

150 ons for fluorescent dye molecules due to the overwhelming isoenergetic fluorescence signal.

151 groups rather than one is clearly unable to overwhelm it.

152 tive correlated response in the humerus that overwhelmed its own trait-specific response to selection

153 pond to bacterial siderophores that evade or overwhelm Lcn2 binding by increasing proinflammatory cyt

154 zed mutants, the capacity of this network is overwhelmed, leading to the observed increase in phenoty

155 e parasite species, resulting in potentially overwhelming levels of complexity.

156 sence of adequate compensatory regeneration, overwhelming liver damage can cause acute liver failure

157 olving hundreds of introns and genes with an overwhelming loss of IR in erythroid cells and MKs compa

158 Overwhelming lung inflammation frequently occurs followi

159 zero positive end-expiratory pressure caused overwhelming lung injury, subsequently shown by others t

160 The overwhelming majority (97%) of alpha-satellite DNA is fo

161 ch incorrect candidate locations consumes an overwhelming majority of a modern read mapper's executio

162 rved as the archetypal organism on which the overwhelming majority of biochemical characterizations o

163 asive and metastatic stages accounts for the overwhelming majority of cancer deaths.

164 An acceptable formation model for the overwhelming majority of chondrules, however, has not be

165 To date, however, the overwhelming majority of experimentally realized single-

166 Furthermore, an overwhelming majority of genetic variants within or near

167 oss-comparison of assemblies showed that the overwhelming majority of HGT candidates in the Boothby e

168 From 2006 to 2009, the overwhelming majority of hospitalizations or ED presenta

169 hed active variants up to 2,800-fold from an overwhelming majority of inactive ones at approximately

170 stablished that aerobactin accounted for the overwhelming majority of increased siderophore productio

171 Although the overwhelming majority of intertwines between the parenta

172 nto the human genome, we discovered that the overwhelming majority of intronic and exonic RE are expr

173 emerged in all 3 serovars and is seen in the overwhelming majority of isolates, while resistance to t

174 However, an overwhelming majority of liquids possess anisotropy in p

175 Unfortunately, spectral selectivity of the overwhelming majority of metamaterials that are made of

176 The overwhelming majority of Msp2 variants expressed during

177 Though the overwhelming majority of natural processes occur far fro

178 low, supporting a nonstroke etiology to the overwhelming majority of original events.

179 sequencing (NGS) technologies, results in an overwhelming majority of partial-length protein predicti

180 al-regulated kinase inhibitor treatment, the overwhelming majority of patients eventually acquire res

181 conclusion, COL7A1 harbored mutations in the overwhelming majority of patients with dystrophic epider

182 g and MNase HS regions) may give rise to the overwhelming majority of phenotypic variation, greatly n

183 However, the overwhelming majority of previously reported temperature

184 mber of sequenced genomes rapidly grows, the overwhelming majority of protein products can only be an

185 The overwhelming majority of pseudoviruses fully released GF

186 e acetylation marks have been described, the overwhelming majority of regulatory genomics studies foc

187 s electric activity/asystole is growing, the overwhelming majority of research in risk stratification

188 irect response to metabolic deficit, yet the overwhelming majority of research on the biology of food

189 The overwhelming majority of respondents thought that incide

190 y the male population, which constitutes the overwhelming majority of smokers in China.

191 The overwhelming majority of sports-related sudden deaths oc

192 The overwhelming majority of studies aiming to understand ub

193 However, the overwhelming majority of studies demonstrate the presenc

194 However, the overwhelming majority of studies examining this relation

195 the active sites of oxidoreductases, yet the overwhelming majority of studies on small-molecule mimic

196 The overwhelming majority of UTIs are caused by uropathogeni

197 Because the overwhelming majority of variants are present in only a

198 Moreover, the overwhelming majority of variants, both somatic and germ

199 s and assemble into homomeric complexes, the overwhelming majority of which (>96%) are symmetric.

200 ustry products are made using catalysts, the overwhelming majority of which are heterogeneous catalys

201 Foods contain microorganisms, the overwhelming majority of which are nonpathogenic, some a

202 ated in patients with advanced fibrosis, the overwhelming majority of whom had NASH.

203 LAC was absent in an overwhelming majority of women with exclusively early re

204 ng variants identified per individual can be overwhelming, making it prudent to focus on noncoding re

205 injury coexist, providing the basis for the overwhelming morphologic and clinical heterogeneity of A

206 In order to make sense of the overwhelming mutational data and capitalize on this clin

207 Alternatively, land-use change might overwhelm natural buffering and amplify latent climate s

208 e development of new technologies, which now overwhelm natural REE anomalies.

209 Anthropogenic emissions completely overwhelmed natural marine lead (Pb) sources during the

210 n seeds arrived in extremely high densities, overwhelming niche-based mortality factors.

211 clinicians and scientists now have access to overwhelming number of available databases capturing pat

212 In the last decade, an overwhelming number of genetic aberrations have been dis

213 The overwhelming number of genetic alterations identified th

214 Despite the overwhelming number of human long non-coding RNAs (lncRN

215 The overwhelming number of new catalysts and conditions rece

216 Due to the overwhelming number of passenger mutations in the human

217 This financial burden is an overwhelming obstacle for Haiti's poorest citizens, and

218 ses, including HIV and hepatitis C virus, to overwhelm or subvert host immune responses contributes t

219 Sometimes, cancer researchers can feel overwhelmed or confused when faced with such a corpus of

220 A appears to be a suicidal event when BER is overwhelmed or disrupted.

221 s the major contributor to Pb contamination, overwhelming other potential local and transboundary sou

222 s opioids works to close this gate, reducing overwhelming pain generated by parallel pathways.

223 erior population survival during a simulated overwhelming pandemic.

224 e essential, but the scale of the task risks overwhelming parliament and the civil service.

225 etween giving explicit information while not overwhelming patients and being realistic while remainin

226 rdingly, exogenous activation of neutrophils overwhelmed Pce-mediated phagocyte disruption.

227 stal thickening at the base of the ice shell overwhelm positive gravity anomalies (mass excesses) pro

228 s and clinical presentation of patients with overwhelming postsplenectomy infection (OPSI).

229 dity and mortality in these patients are the overwhelming postsplenectomy sepsis and development of l

230 k were IgA isotype, in stark contrast to the overwhelming predominance of IgG isotype Env-specific B

231 standing feature of these assemblages is the overwhelming predominance of monothalamids, a group ofte

232 conditions where ER chaperoning capacity is overwhelmed, preemptively providing extracellular chaper

233 Experienced divers had an overwhelming preference for natural reefs.

234 f prokaryotic type were characterized by the overwhelming presence of omega-3 C18 polyunsaturated fat

235 the search for novel approaches to blunt the overwhelming pro-allergic Th2 response, we evaluated the

236 evidence that complement activation provokes overwhelming pro-inflammatory responses, whether or not

237 that most septic patients do not die from an overwhelming proinflammatory immune response but in an i

238 Aggregation does not arise because of overwhelming proteasome-mediated degradation but because

239 Given the overwhelming quantity of information available from the

240 O2 and water availability are likely to have overwhelmed reduced nitrogen availability.

241 Also notable was the overwhelming reduction in mast cell transcripts, potenti

242 poisoning may be related to interrupting or overwhelming relevant regulatory or signaling process(es

243 ttempts at repair by continued proliferation overwhelm reparative capacity, causing loss of specialis

244 Although the results revealed overwhelming satisfaction with the IACUC administrative

245 med 'masts', are thought to be a strategy to overwhelm seed predators or to maximise pollination rate

246 is that natural selection for cheating could overwhelm selection for cooperation.

247 also hyperactivates myosin-II, which locally overwhelms self-signaling at a phagocytic synapse.

248 unoglobulins, the patient ultimately died of overwhelming sepsis.

249 mmunomodulating therapy, the patient died of overwhelming sepsis.

250 also affect leading-edge sex ratios, perhaps overwhelming sex-biased dispersal.

251 HIV disease could affect healthy ageing and overwhelm some health-care systems, particularly those i

252 ior is often conceptualized as a response to overwhelming stress.

253 If the ER response is overwhelmed, substantial amounts of calcium are released

254 elationship can be established because of an overwhelming success in ablation.

255 s an intriguing feature and critical for the overwhelming success of higher plants.

256 ecently, 5 major randomized trials showed an overwhelming superior benefit of combining endovascular

257 We find overwhelming support for a long-term decline across all

258 ral snakes in both space and time, providing overwhelming support for Batesian mimicry.

259 42(fl/fl) mice died at 3 weeks of age due to overwhelming suppurative upper airway infections that we

260 In severe trauma, overwhelming systemic inflammation can result in additio

261 Overwhelming systemic inflammatory responses may suppres

262 educed Treg recruitment to the kidney and an overwhelming TH1 immune response, with an aggravated cou

263 The evidence is now overwhelming that partially assembled nucleosome states

264 icularly at axon terminals, ultimately might overwhelm the capacity of intracellular disposal mechani

265 m (ER) stress occurs when misfolded proteins overwhelm the capacity of the ER, resulting in activatio

266 vents arising from surface inhomogeneity can overwhelm the correlation measurement and mask the surfa

267 However, nonnative invasion may overwhelm the effect of immigration timing on community

268 Interhost dispersal was strong enough to overwhelm the effects of host factors, largely eliminati

269 ally to microbiome variation, and is able to overwhelm the effects of individual host factors, in an

270 ic state, increased insulin biosynthesis can overwhelm the ER antioxidative and folding capacity, cau

271 assembly/disassembly will potentially act to overwhelm the spatial information that controls microtub

272 ated sediment-water diffusive fluxes greatly overwhelmed the atmospheric depositional flux to the riv

273 or numbers of patients with EVD that quickly overwhelmed the capacity for safe management.

274 , mixture LD from a two-locus Wahlund effect overwhelmed the reduction in drift LD from incorporating

275 nts in a dose- and motor-dependent manner by overwhelming the ability of Aurora B to mediate error co

276 ific variation in these responses was large, overwhelming the average community response.

277 ting condensation level (LCL) with elevation overwhelming the effects of decreasing total column wate

278 g the lowest LUMO level recorded for an NDI, overwhelming the formative tetracyanoquinodimethane (TCN

279 ce 2009, the economic recovery increased TF, overwhelming the influence of improved emissions intensi

280 , and complexity of environmental change are overwhelming the intrinsic capacity of corals to adapt a

281 rate of expansion is so great that it often overwhelms the capacity of environmental planners and ma

282 me (d < ~2 nm) the effect of the yellow band overwhelms the effect of quantum confinement with distin

283 olved oxalate and the mineral surface for Ni overwhelms the enhancement in adsorption associated with

284 isfolded/unfolded proteins when protein load overwhelms the ER folding capacity, which activates the

285 lux of HOCs bioaccumulated from natural prey overwhelms the flux from ingested microplastic for most

286 dden loss of cardiomyocytes after infarction overwhelms the limited regenerative capacity of the myoc

287 ind that the size of the pro-tobacco network overwhelms the others, which suggests a huge number of u

288 production of reactive oxygen species (ROS) overwhelms the scavenging ability of an organism.

289 Depletion of PTF1A causes an imbalance that overwhelms the UPR, induces cellular injury, and provoke

290 een sometimes described as "compelling" and "overwhelming", there are limitations that existing studi

291 obial community structure, but that diet can overwhelm these genetic effects.

292 Exposure to imidacloprid at >/= 4.0 mg/L overwhelmed this adaptive response and reduced reproduct

293 mmunosuppressive mediators that help prevent overwhelming tissue damage.

294 ntations of significant sequence hits can be overwhelming to the user.

295 late detoxification mechanisms may have been overwhelmed under elevated CO2 forcing slowed consumptio

296 scovery of new phages and help interpret the overwhelming unknown sequences in the viral metagenomics

297 the tumor promoting activity of AID when it overwhelms uracil excision repair.

298 associated with death at an early age due to overwhelming viral infection (complete STAT1 deficiency)

299 Therefore, a single dietary modification overwhelms vital host antimicrobial strategies, leading

300 e full spectrum of research grapple with the overwhelming volume of data being generated daily and a