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1 ic diagnosis was made in 56 families (36.8%) owing to 57 (likely) pathogenic variants in 50 genes alr
2 a durable effect on long-term graft survival owing to a combination of drug toxicities and the emerge
5 good combination of strength and plasticity owing to a dual-hierarchy in eutectic length-scales in t
6 uded, 1052 (39%) were defined as higher risk owing to a family history of melanoma, multiple primary
7 was similar between 1- and 2-muscle surgery, owing to a greater number of less symptomatic undercorre
9 absence of RAS pathway mutations (P=0.004), owing to a high risk of relapse, and the presence of JAK
10 asibility is currently unproven, potentially owing to a lack of compatible donors, and is associated
11 period is rare and lacks robust chronologies owing to a lack of direct dating applications, poor pres
13 fluence oxidants may change with climate and owing to a lack of palaeo-records with which to constrai
17 the therapy after only 4 cycles of treatment owing to a life-threatening progression of the disease.
19 ion of the data and safety monitoring board, owing to a low likelihood of benefit and evidence of the
20 tructure and find that habitat fragmentation owing to a natural barrier has resulted in strong geneti
22 rly evolution of termitophily is challenging owing to a scarcity of fossil termitophiles, with all kn
23 phene are perfect one-dimensional conductors owing to a set of gapless states that are topologically
24 issibility of L. donovani by infected hosts, owing to a systemic effect that exposure to bites has on
25 Most patients stopped or used no opioids owing to adequate pain control, and 16% to 29% of patien
28 hdrew consent or discontinued prematurely, 6 owing to adverse events attributed to X-82 including leg
31 though 17% of participants discontinued X-82 owing to AEs, those who completed the study had lower th
33 sarcoplasmic reticulum Ca(2+) levels, likely owing to altered cellular excitability as a result of BP
35 ive capacity to targeted molecular therapies owing to an established network of signalling cascades w
36 this hypothesis has not been formally tested owing to an inability to purify or track these progenito
38 egative regulatory proteins (CRPs), possibly owing to bisretinoid accumulation, may be responsible fo
40 th a high probability of sharing specificity owing to both conserved motifs and global similarity of
43 ating HSP72 inhibitors in cells is difficult owing to competition with the high affinity and abundanc
44 etween DOC and free copper ion concentration owing to complexation by predominantly organic ligands.
46 nts aged >/=6 years with ocular misalignment owing to congenital or acquired paralytic or comitant st
47 s fail to converge to form glomeruli, likely owing to contact-mediated repulsion between axons expres
49 irst incident myocardial infarction or death owing to coronary heart disease, and stroke, defined as
55 ased studies have been conflicting, possibly owing to different methods to assess SDB or cognitive do
56 ndels to cancer has been largely unexplored, owing to difficulties in detecting them in short-read se
57 er ecological niche models are still lacking owing to difficulties in evaluating forecasts using real
58 this hypothesis remains inadequately tested owing to difficulties in reconstructing terrestrial pale
61 ivity in the western North Pacific, which is owing to enhanced subtropical deep convection and favora
63 t glutamine is often depleted at tumor sites owing to excessive cellular consumption and poor vascula
64 cing response time of electricity generation owing to fast mass transport through pressure-driven flo
66 euro2348) than in the heparin arm (euro6744) owing to fewer admission days related to treating CVC-re
68 learance pathways varies between individuals owing to genetic differences and similarities and differ
69 -damage response (DDR) are often tumor prone owing to genome instability caused by oncogenic challeng
70 y have the best diagnostic potential, partly owing to having no areas excluded for being larger than
72 c and idiolectal variation-genetic variation owing to heterogeneity in ancestry within admixed groups
73 risk of cardiovascular disease (CVD) in part owing to hypertriglyceridemia and low high-density lipop
75 the outer retina associated with papilledema owing to idiopathic intracranial hypertension (IIH) at p
76 as a smaller contributor to total cost (24%) owing to increased costs from room and board (mean [SD]
77 significantly reduced number of HSCs, likely owing to increased differentiation of HSCs toward myeloi
78 e and patients, hepatic S1P levels increased owing to increased hepatic sphingosine kinase-1 expressi
80 r to document eating times may be misleading owing to individual differences in circadian timing rela
83 thods can introduce systematic errors (e.g., owing to interconversion among metabolites) and how prop
84 sources of anxiety were fear of going blind owing to intravitreal injections and concerns about trea
85 al challenge of the mutant viruses, possibly owing to its ability to mediate antibody-dependent cellu
87 logy practices, MIPS may be more appropriate owing to its broader applicability and the current pauci
88 onformational change upon adsorption to NPs, owing to its capability to label the primary amines expo
91 e measurement technique for this application owing to its dependence on the diffusional potentials of
92 e with an unprecedented selectivity of 100, owing to its distinctive pore topology with large heart-
93 the metabolism and survival of all organisms owing to its function as a cofactor of enzymes collectiv
95 lectrolyte exhibits great promise for SSLiBs owing to its high Li-ion conductivity, wide potential wi
96 capacity anode, but faces several challenges owing to its high reactivity and uncontrolled dendrite g
97 of nitric oxide, is a significant challenge owing to its high reactivity with biological thiols (wit
100 resource in the signal transduction pathway owing to its low abundance relative to its binding partn
101 protein is an attractive therapeutic target, owing to its multifunctionality in virus replication and
102 has recently received significant attention owing to its remarkable capability of enabling subwavele
103 hus, although this study has inherent biases owing to its retrospective nature, concern regarding an
104 ike breast cancer (BLBC) with poor prognosis owing to its role in promoting epithelial-to-mesenchymal
107 aphy is the quintessential imaging technique owing to its unique ability to provide real-time images
108 ants to climate change is poorly constrained owing to large uncertainties in the degree to which proc
111 ze of the different members of the Ln series owing to lattice strain effects induced by changing the
114 us mutations have been ineffectively purged, owing to limited recombination in the cassava genome; (i
116 fite-sequencing poses statistical challenges owing to low and uneven sequencing depth, as well as the
122 FDG was greatest and continuously increasing owing to metabolic trapping through phosphorylation by h
123 parison with previous estimates is not ideal owing to methodological differences, our results are con
125 ced increase in cytosolic calcium is blunted owing to mitochondrial calcium sequestration, and calciu
127 uroendocrine tumours (PanNETs) is increasing owing to more sensitive detection methods, and this incr
128 toms reach a very high degree of ionization, owing to multiphoton absorption, which in a heteronuclea
129 n thus frequently exhibits a transformation, owing to multiple possibilities caused by incompatible i
131 ed in scale and susceptible to contamination owing to nonspecific adsorption and desorption on the su
132 than in HC group (16.9 +/- 5.8), especially owing to number of missing teeth (RA = 6.0 +/- 5.4, HC =
134 ow that GMP clusters are constantly produced owing to persistent activation of the self-renewal netwo
135 on beta-cells, wherein continued DNA damage owing to persistent oxidative stress results in p53 acti
137 causes adverse pregnancy and birth outcomes owing to Plasmodium falciparum accumulation in the place
138 reatment response to binocular treatment was owing to poor treatment adherence or lack of treatment e
139 ow greater infection in provisioned habitats owing to population growth and food-borne exposure to co
140 blanking period" (when arrhythmias may occur owing to postablation inflammation), there were 680 epis
141 y 3A4 is often a concern in drug development owing to potential drug-drug interactions and the variab
142 the percentage of postintervention SICU days owing to potentially avoidable admissions (152 of 1168 d
143 to Candida albicans in patients with EoE is owing to pre-existing disease and its underlying abnorma
146 ersons compared with white persons, possibly owing to racial differences in the glycation of hemoglob
147 did not start tuberculosis treatment, mostly owing to rapidly deteriorating clinical conditions or lo
148 xed groups [25, 26] and idiolectal variation owing to recent language formation from differentiated s
149 2-year-old girl was referred to our hospital owing to repeated anaphylactic reactions induced by exer
153 arate architecture and substrate specificity owing to several potential target bonds within the react
155 okers differed in whole-brain SUVs (P=0.006) owing to smokers having 16.8% lower values than non-smok
159 ut they diverged in their chemical evolution owing to subsequent fractionation by nebular and planeta
161 yes) with PE, 11 children (19 eyes) with PPE owing to suspected buried optic disc drusen (ODD), and 3
162 ell-appearing infants who presented for care owing to symptoms that placed them at increased risk of
163 ificial systems typically lack applicability owing to synthetic challenges and structural complexity.
164 rn preterm are expressed prior to birth, but owing to technical limitations, this has been difficult
166 anthropogenic-driven mass mortality events, owing to the ability to account for uncertainty in the a
167 gy of highly heterogeneous cell populations, owing to the ability to collect highly parametric proteo
168 ism of action of GDF15 are poorly understood owing to the absence of a clearly identified cognate rec
169 recognition by DASS remain obscure, largely owing to the absence of any substrate-bound DASS structu
170 efficacy is significantly variable in clinic owing to the absence of proper drugs and the lack of und
172 ionality over multiple cycles of actuations, owing to the anti-fatigue property of the hydrogel under
173 rds for assessing phototoxicity cannot exist owing to the breadth of samples and experimental questio
174 y trapped waves, the Kelvin and Yanai modes, owing to the breaking of time-reversal symmetry by Earth
175 of a stratosphere remains open to question, owing to the challenges posed by the highly variable hos
177 ocal Universe, the systematic uncertainties (owing to the chosen stellar initial-mass function and th
178 ring disasters could challenge pediatricians owing to the close follow-up likely to be required.
179 interesting applications as food ingredient, owing to the coloring capacity and the presence of healt
181 which has been more challenging to implement owing to the complexity of molecular structures, has now
182 network enables larger property enhancement owing to the cooperative effects of both the increased c
184 cost of MP $12330 (MP $2500), predominantly owing to the cost of surgical care (mean [SD] cost, MP $
186 nes possessing an aryl carbamate substituent owing to the direct attachment of an C(O)OSiR3 group to
187 bout the ancient origin of retroviruses, but owing to the discovery of their ancient endogenous viral
189 nsiderable scientific inquiry, most recently owing to the dramatic collapse of juvenile recruitment [
191 l DFT calculations reveal that the receptor, owing to the enhanced H-bonding ability of thiourea grou
193 uired to decipher the course of the reaction owing to the fact that the IR responses are perturbed by
195 n lesions using images is a challenging task owing to the fine-grained variability in the appearance
196 as no effect on tetramerization of RXRalpha, owing to the head-tail interaction that is absent in tRX
198 etals have not been reported to date, likely owing to the highly reactive nature of low-valent niobiu
201 ite antagonist results in bleeding, possibly owing to the important role of PAR1 activation on cells
202 nd balance are often irreversible in mammals owing to the inability of cells in the inner ear to prol
206 escence microscopy faces a 'colour barrier', owing to the intrinsically broad (about 1,500 inverse ce
208 e amide nonisolable at 35 degrees C and pH 4 owing to the joint presence of carboxy and carboxylate g
209 t this hypothesis has been difficult to test owing to the lack of a permissive in vivo model of HAdV
212 ally from that in crystalline semiconductors owing to the lack of long-range order and high defect de
213 gth (826 MPa) and Young's modulus (65.7 GPa) owing to the large length and the alignment of nanofiber
214 % CI: 0.15, 3.2) for the 2009 H1N1 pandemic, owing to the late timing of the vaccination program in r
215 mains challenging to scale up these circuits owing to the limited number of designable, orthogonal, h
216 fficult to discern patterns of dissemination owing to the limited number of patients and available me
218 e velocity or optical depth of the outflows, owing to the long timescales of quasar variability.
221 on may proceed on molten salt state surfaces owing to the lower melting point of the used Na salts co
223 physics in fractional quantum Hall systems, owing to the microscopic control and precision that is a
225 ation and aggregation has proven a challenge owing to the multiple potential phosphorylation sites an
226 trics scales proportionally with V cr(-2.2), owing to the one-dimensional structural constraint on la
229 he adult mammalian heart is non-regenerative owing to the post-mitotic nature of cardiomyocytes.
230 , fitness is at best a derived quantity, and owing to the potential complexity of such processes, the
231 ty of dynamical scenarios and instabilities, owing to the properties of the incoherent excitonic rese
233 velopment of synthetically useful reactions, owing to the proximity-induced reactivity and selectivit
238 ch a wide spectral range remains a challenge owing to the rigidity of the resonator for the generatio
241 terpretation of NGS data remains challenging owing to the size and complexity of the genome and the t
242 Despite the limited power of the analysis owing to the small sample size of those with impaired vi
243 se a major concern to public health, largely owing to the steadily increasing prevalence of drug resi
246 f stable isotope patterns in mammalian cells owing to the superimposition of different pathways contr
248 batteries has received increasing attention owing to the unique benefits of Mg metal electrodes, nam
250 al breast cancer rates are declining as well owing to the widespread use of adjuvant systemic therapy
251 monooxygenases have attracted vast attention owing to their abilities to disrupt glycosidic bonds via
252 ultaneous depletion of both Satb1 and Satb2, owing to their antagonistic effect on the pluripotency r
253 olecular tags for magnetic resonance imaging owing to their biocompatibility and ease of incorporatio
254 tractive solution for practical applications owing to their biocompatibility and sustainability.
255 robeam have attracted considerable attention owing to their capability to grab and separate a single
259 ce are a predictive TB drug development tool owing to their consistent development of human-like path
260 d an increasing importance in nanotechnology owing to their contributions to both fundamental and app
261 they avoided adhesive trapping in the brain owing to their dense PEG coating, which was critical to
262 s are at the frontiers of modern electronics owing to their discrete voltage regulated operational le
263 significant attention as cancer biomarkers, owing to their ease of access (circulating miRNA in the
264 oteases are highly sought-after drug targets owing to their essential roles in apoptosis, proliferati
265 sfully implemented using inorganic materials owing to their excellent electrical properties, however,
267 ging findings demonstrating that TSCM cells, owing to their extreme longevity and robust potential fo
268 cted the tremendous attention of researchers owing to their fascinating electrical, thermal and physi
270 onately large influence on colloidal systems owing to their greater surface area; however, the challe
271 I)-are key tracers of accretionary processes owing to their high volatility and incompatibility, but
272 s, which have attracted significant interest owing to their integration with everyday life activities
281 d candidates as photoanode materials, mainly owing to their resistance to photocorrosion, non-toxicit
282 carrying biological entities are attractive owing to their sensitivity, selectivity, and minimally d
283 herapeutics including macromolecules is that owing to their size they are subject to cellular uptake
285 tractive motifs for bioorthogonal chemistry, owing to their small size and unique modes of reactivity
286 ties for next-generation implantable devices owing to their soft mechanical nature that leads to mini
288 neffective for photochemical internalisation owing to their sub-optimal intracellular localisation.
290 mising materials for a range of applications owing to their unique crystal structure and optoelectron
291 t are distinct from other tissue macrophages owing to their unique homeostatic phenotype and tight re
292 omising lightweight EMI shielding materials, owing to their unique nanostructures and extraordinary e
293 l have received tremendous research interest owing to their unique structural features, fascinating p
294 us applications, but has had limited success owing to thermodynamic favorability of sphere formation.
297 s vary sharply over short distances (<<1 km) owing to unevenly distributed emission sources, dilution
299 ock hours of corneoscleral limbal dissection owing to wide tumor excision (8 vs 7; P = .12), were com
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