ライフサイエンスコーパス: oxazine

1 salicylanilides and 3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dione derivatives as potential antiosteo

2 salicylanilides and 3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-diones could be potential lead compounds

3 providing access to diastereomerically pure oxazine-2-carboxylic acids which were readily converted

4 enzyloxy-5,6-diphenyl-2,3,5,6-tetrahydro-4 H-oxazine-2-one (10) was synthesized from ethyl [1,2-(13)C

5 l-substituted 6-aryl-1,4-dihydrobenzo[d][1,3]oxazine-2-thiones, analogues of Tanaproget.

6 lysis has an unusual 3H-benzo[d]pyrrolo][1,3]oxazine-3,5-dione core.

7 nation to generate the corresponding all-syn oxazine 4 with excellent diastereoselectivity.

8 esponding 2-oxo-1,2-dihydrospirobenzo[d][1,3]oxazine-4,3'-piperidine series of spirocycles (e.g., 42)

9 ss to the 2-oxo-1,2-dihydrospirobenzo[d][1,3]oxazine-4,3'-pyrrolidines (III), the method is applicabl

10 bstituted 2-oxo-1,2-dihydrospirobenzo[d][1,3]oxazine-4,3'-pyrrolidines), and VI (2-(4,5-dihydro-1H-py

11 that the N-oxide (7, 9, 11, 13, 15) and 1,2-oxazine (6, 8, 10, 12, 14) structures possessed similar

12 everal classes of compounds such as pyrazolo-oxazines 7, pyrazolo-benzooxazines 9, pyrazolo-oxazoles

13 e 6 H,8 H -3, 4-dihydropyrimido[4,5- c ][1,2]oxazine-7-one (Q6) base at 3'-ends were used in three cy

14 The CF3 substituted oxazine 89, a potent and highly brain penetrant BACE1 in

15 e 7, bisthiazoline 8, and 5,6-dihydro-4H-1,3-oxazines 9 or 10 have also been prepared in 82-96% yield

16 particularly fast for the methyl-substituted oxazine and can be exploited to detect micromolar concen

17 the formation of the corresponding bicyclic oxazine and five-membered cyclic nitrone, respectively.

18 the high-yielding preparation of widely used oxazine and xanthene fluorophores from a common diaryl e

19 7 fully restored sensitivity to nitroimidazo-oxazines and restored the ability of Mtb to metabolize P

20 ed that resistance to PA-824 (a nitroimidazo-oxazine) and CGI-17341 (a nitroimidazo-oxazole) is most

21 1,4-Oxazines are presented, which show good in vitro inhibit

22 ss to dipolar intermediates, 3,6-dihydro-1,2-oxazines are produced in high yields by dirhodium(II) ca

23 ha-enaminone synthones yields an assembly of oxazines, azaspirones, quinolinones, and quinolinols in

24 -theoretical investigation has revealed that oxazine-based compounds are multiaddressable, multistate

25 allowed for the synthesis of tetrahydro-1,2-oxazines bearing alkyl, aryl, and heteroaromatic substit

26 mily of 3-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazines bearing different pattern substitutions in the

27 With respect to acceptor groups, oxazines bearing donor groups are characterized not only

28 proach for the silver-catalyzed synthesis of oxazine/benzoxazine-fused isoquinolines 5a-q and naphthy

29 ituted 2-nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazine class was further explored, seeking efficacious

30 e C-O bond at the junction of the indole and oxazine cycles (of the closed a forms) is acido-triggere

31 provides the rare 2-imino-5,6-dihydro-4H-1,3-oxazine derivative 32, rather than a pyrimidine as the m

32 es, followed by addition of alkynes to yield oxazine derivatives, is presented.

33 Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretor

34 ssed by excitation at the 650-nm band of the oxazine dye component, causing the dye to fluoresce.

35 ide, and the other is a strongly fluorescing oxazine dye.

36 employing correlation analysis of extrinsic oxazine fluorescence fluctuations.

37 ere, we describe the synthesis of a near-IR, oxazine fluorescent K(+) sensor (KNIR-1) with a dissocia

38 nd is coated with approximately 400 quenched oxazine fluorophores that are released by reaction with

39 at pyrrole, or furan, formation proceeds via oxazine formation, followed by a boryl rearrangement and

40 endly synthesis of highly functionalized 1,2-oxazines from phosphinyl- and phosphonyl-nitroso alkenes

41 nthesis of cis-3,6-disubstituted dihydro-1,2-oxazines has been accomplished through the one-pot oxida

42 ubstituted 6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines have been extensively explored for their potent

43 The parent 5H-indazolo[3,2-b]benzo[d]-1,3-oxazine heterocycle as well as a series of novel analogu

44 midazo[1,2-c]oxazoles and imidazo[2,1-c][1,4]oxazine heterocycles.

45 m having a 5,6-dihydro-8H-imidazo[2,1-c][1,4]oxazine heterocyclic substituent at the C6 position with

46 gives various 3,6-disubstituted dihydro-1,2-oxazines in excellent regio-, diastereo-, and enantiosel

47 s afforded cis-3,6-disubstituted dihydro-1,2-oxazines in high yields with excellent regio-, diastereo

48 ylamino)-5-octadecanoylimino-5H-benzo[a]phen-oxazine) in plasticized poly(vinyl chloride).

49 eeds through o-quinone methide (o-QM) and an oxazine intermediate via tandem Knoevenagel condensation

50 ile solvent in the formation of a 5-halo-1,3-oxazine intermediate.

51 ate a small degree of flexibility around the oxazine linkage, which may be a consequence of the antia

52 layed a approximately 20 degrees bend at the oxazine linkage.

53 five-membered thiazolidine, six-membered 1,4-oxazines (morpholines) and tetrahydro-2H-1,4-thiazines (

54 se intermediates for the synthesis of 2H-1,4-oxazine N-oxides has been developed for a variety of alp

55 f the new method for the synthesis of 2H-1,4-oxazine N-oxides is discussed, in addition to initial st

56 nzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1, 3]oxazine (PA-824), in which the OCH(2) linkage was replac

57 The synthesis of 4-vinyl-5,6-dihydro-1,3-oxazines, precursors of 1,3-amino alcohols, using the pa

58 (1)H and (11)B NMR studies on two boro-oxazine regioisomers showed that selective deprotection

59 amino alcohols that can be converted to 1,3-oxazines, representing the tetracyclic core of alkaloids

60 An extensive fluorine scan of 1,3-oxazines revealed the power of fluorine(s) to lower the

61 e cycloadditions followed by cleavage of the oxazine ring afford azepin-2-ones or azocin-2-ones.

62 at an appropriate activation wavelength, the oxazine ring cleaves irreversibly to bring the adjacent

63 es cleaves a [C-O] bond and opens their [1,3]oxazine ring in less than 6 ns with quantum yields of 0.

64 th compounds induces the opening of the [1,3]oxazine ring in less than 6 ns with quantum yields up to

65 roscopy demonstrates that their central [1,3]oxazine ring opens thermally with free energy barriers r

66 olve the stereoselective construction of the oxazine ring via an intramolecular epoxide ring opening

67 ity of the condensation reaction, forming an oxazine ring, allows for implementation of silica gel ca

68 Diels-Alder cycloaddition and acid catalyzed oxazine ring-opening.

69 nduced opening and thermal closing of a [1,3]oxazine ring.

70 nm upon the photoinduced opening of the [1,3]oxazine ring.

71 The oxazine rings formed by the corresponding hetero-Diels-A

72 on silica gel-catalyzed formation of two 3,1-oxazine rings, is reported.

73 hiles based on poly(2-oxazoline)s and poly(2-oxazine)s with respect to their solubilization capacity

74 1) inhibitors based on a pyrimido[4,5-b][1,4]oxazine scaffold is described.

75 undergo tautomerism between N-oxide and 1,2-oxazine structures in a pH- and time-dependent manner.

76 elated ketones react to furnish benzo[e][1,3]oxazine structures in generally good yields.

77 n the 4-nitroimidazoles include the bicyclic oxazine, the lipophilic tail, and the 2-position oxygen.

78 sistance to PA-824 (and another nitroimidazo-oxazine), they retained sensitivity to CGI-17341 (and a

79 hydrolysis of the resulting 5,6-dihydro-1,3-oxazines was also investigated.

80 fluoro-3-methyl-3,4-dihydro-2H-benzo-[b][1,4]oxazine, which is a key precursor of the antimicrobial a

81 t yields of the corresponding tetrahydro-1,2-oxazines with high levels of diastereoselectivity.

82 stituent led to the formation of stable boro-oxazines with high regioselectivity in most of the cases

83 1,6-Cyclization into 2H-1,4-oxazines with participation of the oxygen of ester or am

84 nyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H -1,4-oxazines with trimethylsilyl cyanide.

85 ne (BODIPY) chromophore and a photocleavable oxazine within their covalent skeleton.