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1 ity to CGI-17341 (and a related nitroimidazo-oxazole).
2 ng the distinguishing role of the activating oxazole.
3 is detailed, targeting the 5-position of the oxazole.
4 dration of which gave the desired indole bis-oxazole.
5 oxazole and gave the macrocyclic indole bis-oxazole.
6 e > thiazole > pyrrole > imidazole > furan > oxazole.
7 ine group into an oxazolone or (substituted) oxazole.
8 C-5 monosubstituted and C-4,5 disubstituted oxazoles.
9 ethylene position thereby affording extended oxazoles.
10 from novel aryl-substituted o-vinylstyryl-2-oxazoles.
11 n of enamides to afford 2,4,5-trisubstituted oxazoles.
12 to hydroperoxides bearing the heteroaromatic oxazoles.
13 des to 2-phenyl-5-(methylthio)-4-substituted oxazoles.
14 functionalities at 4-position of the product oxazoles.
15 eries of reversed amides and azoles, such as oxazole, 1,2,4-oxadiazole, and 1,3,4-oxadiazole, as well
16 ethylamine give 2-substituted condensed ring oxazoles 10, 16a-c, 18a-d, 20a-c, and 25 in a new genera
17 azines 7, pyrazolo-benzooxazines 9, pyrazolo-oxazoles 10, and its analogues 11a-c as potential COX-2
18 uorene 7, 2-(4-cyanophenyl)-5-(4-aminophenyl)oxazoles 14 and 20, 1,3,5-hexatrienes 24a-d and 26a-c, 1
19 eries of alpha-ketoheterocycles based on the oxazole 2 (OL-135) incorporating systematic changes in t
20 ent and DBU-assisted oxidation to form D-Ala-oxazole; (2) formation of D-Val-thiazole and D-Ala-thiaz
21 Intermolecular alkylation of the aziridinyl oxazole 20 using PhSO(2)CH(2)CH(2)OTf is possible despit
26 hange of the core heterocycle readily led to oxazoles 28 and 29, which were confirmed as highly poten
28 the proposed binding mode, and comparison of oxazoles 39 and 46 revealed interesting differences in o
30 One compound, 4-(benzyl-(2-[(2, 5-diphenyl-oxazole-4-carbonyl)-amino]-ethyl)-carbamoyl)-2-decanoyla
31 zol-1-yl)propyl)-5-(3-chloro-4-methoxyphenyl)oxazole-4-carboxa mide (PF-04802367 or PF-367) has been
35 ted dipeptide analogue (4) and a fluorescent oxazole (5) having amine and carboxyl groups approximate
37 4-(4-methylpiperazin-1-yl)phenyl]methyl]-1,2-oxazole-5-carboxamide} acts through a novel mechanism of
43 based on silver ion-assisted intramolecular oxazole alkylation and cyanide-induced ylide generation
44 tuents on the pyridine ring, implicating the oxazole alpha-hydroxy group as an active participant in
45 of pyridine at the C5 position of the 2-keto-oxazole and 2-keto-1,3,4-oxadiazole derivatives signific
47 and cyclodehydration incorporated the second oxazole and gave the macrocyclic indole bis-oxazole.
48 trategy focused on evaluating the effects of oxazole and phenyl ring replacements of the 2-(5-methyl-
49 iels-Alder reaction of an acetylene-tethered oxazole and the [4 + 3] cycloaddition of an oxyallyl.
52 iotic goadsporin contains six heteroaromatic oxazole and thiazole rings integrated into a linear arra
53 earing heterocycles of the different nature (oxazole and thiophene) as aromatic moieties have been de
55 d for the synthesis of highly functionalized oxazoles and benzofurans using an intramolecular Wittig
56 -catalyzed conditions to yield imidazo[1,2-c]oxazoles and imidazo[2,1-c][1,4]oxazine heterocycles.
57 rbier coupling reactions of alpha-iodomethyl oxazoles and related thiazoles are described with samari
58 ring dicyclizations to form 2,4-concatenated oxazoles and the mild synthesis of thiazoles from natura
59 -4-(3',4',5'-trimethoxyphenyl)-5-substituted oxazoles and their related 4-substituted-5-(3',4',5'-tri
60 ine residues in a polypeptide precursor into oxazoles and thiazoles during the maturation of the Esch
61 sphonium trifluoromethanesulfonate to afford oxazoles and thiazolines (oxidized to thiazoles) with hi
62 2,6-diethyl-4,8-diarylbenzo[1,2-d:4,5-d']bis(oxazoles) and four different 2,4,6,8-tetraarylbenzobisox
64 Quantum chemical analysis on the imidazole, oxazole, and thiazole derivatives of thiazole-2-amine in
66 aining two different heteroatoms (isoxazole, oxazole, and thiazole) and of the aromatic molecules con
67 thods for the synthesis of analogues of this oxazole- and thiazole-containing cyclic peptide have bee
68 Here we report the preparation of thiazole-, oxazole-, and oxadiazole-containing biarylhydroxamic aci
71 such as pyrroles, pyridines, thiazoles, and oxazoles, as well as other relevant organic derivatives,
73 rphyrinoid generates three pyrrole-modified, oxazole-based porphyrins: the known porpholactol (2-oxa-
74 ions with benzene and related substrates, an oxazole-based superelectrophile is found to be significa
78 bute the activity boost upon substitution of oxazole by oxadiazole to reduced steric interactions in
80 s are converted into four thiazoles and four oxazoles by the three subunit Microcin B17 synthetase.
81 side chain of 2 (OL-135) and representative oxazole C5 substituents were prepared and examined as in
85 ed method for the preparation of a series of oxazole-containing dual PPARalpha/gamma agonists is desc
88 general feature of the interactions between oxazole-containing macrocyclic ligands (including telome
90 ide analogues that contain variations in the oxazole-containing side chain and in the macrolide core
91 analysis of crystals of 4 and an acetylated oxazole derivative of 5 (6) confirm the proposed structu
93 es of furanone series containing benzene and oxazole derivatives as aryl residues has been carried ou
97 chanistic considerations rationalize kinetic oxazole formation over the more customary triazine or py
98 r rhodium carbene N-H insertion, followed by oxazole formation to give (S)-2-[1-tert-(butoxycarbonyla
99 ng three contiguous stereocenters, a modular oxazole formation, a flexible cross-metathesis approach
100 ymmetric ortholithiation strategy, a modular oxazole formation, and a late-stage Z,Z-selective Suzuki
103 ve, densely functionalized 2,4-disubstituted oxazole fragment was constructed using an efficient Negi
105 ated for the synthesis of highly substituted oxazoles from readily accessible ynamides in the presenc
106 acile preparation of mono- and disubstituted oxazoles from these TosMIC reagents and aldehydes is des
109 ne cluster for the synthesis of thiazole and oxazole heterocycles on ribosomally produced peptides.
111 A new set of end-cap heterocycle dimers, oxazole-hydroxybenzimidazole (No-Hz) and chlorothiophene
112 ibutions in the regions of space surrounding oxazole, imidazole, and thiazole are used to investigate
115 ecreases in the order thiazole > imidazole > oxazole; in combination with previous results on furan,
116 c 1,2,4-oxadiazoles 10, 1,3,4-thiadiazoles > oxazoles including 2 > 1,2-diazines > thiazoles > 1,3,4-
118 o-step synthesis of 2-phenyl-4,5-substituted oxazoles involving intramolecular copper-catalyzed cycli
123 convergent access to densely functionalized oxazoles is realized in a functional-group tolerant mann
124 idazo-oxazine) and CGI-17341 (a nitroimidazo-oxazole) is most commonly mediated by loss of a specific
125 such as thiophene, furan, pyridine, indole, oxazole, isoxazole, and benzoxazole, are effective in th
128 -2-yl)pyridine (L5), 2-(pyridin-2-yl)benzo[d]oxazole (L6), or 2,2'-dibenzo[d]thiazole (L7) are report
129 sis, and application of a novel bifunctional oxazole linchpin; and Stille coupling of a C(28) trimeth
130 rein we report the repurposing of a thiazole/oxazole-modified microcin (TOMM) cyclodehydratase to sit
131 of orthologous enzymes involved in thiazole/oxazole-modified microcin biosynthesis, a rapidly growin
134 rrole groups in meso-tetraphenylporphyrin by oxazole moieties is described, generating inter alia the
135 porphyrin-like chromophore) or (substituted) oxazole moiety (chlorin-like chromophore with, for the p
137 dification of the series revolved around the oxazole moiety to increase the hydrophilicity of the com
138 ure that involves the annelation of the [1,2]oxazole moiety to the isoindole ring, producing derivati
140 Bioassay-guided fractionation identified two oxazole natural products with selective activity against
142 n of an additional heteroatom at position 4 (oxazole numbering, N > O > CH) substantially increases a
143 arts: (1) Synthesis of functionalized alkyne oxazoles of type 5; (2) intramolecular Diels-Alder/retro
144 repared by the base-promoted ring-opening of oxazoles, offering an alternative to the conventional fo
147 Depending on the substitution pattern on the oxazole or oxazoline moieties, mono- and dioxabacterioch
148 ues, containing the heme-ligating imidazole, oxazole, or pyridine group instead of the thiazole moiet
149 roducts decorated with thiazoles and (methyl)oxazoles originating from cysteines, serines, and threon
151 al synthesis of galmic, the synthesis of its oxazole precursors, the coupling of the building blocks
153 iophene, furan, indole, imidazole, thiazole, oxazole, pyrazole) have been involved into this process,
155 l)carbodiimide hydrochloride (EDCI)-mediated oxazole rearrangement that affords quaternary 5,5-(aryl,
156 ysteine and serine residues to thiazoles and oxazoles, respectively, within the 69 aa McbA structural
160 moothly with the carboxamide en route to the oxazole ring by a P,N- or P,S-bidentate ligand such as M
161 ised that allows for the introduction of the oxazole ring either late in the synthetic sequence via a
162 que functional groups including a conjugated oxazole ring, a bromine substituent, and an alpha-hydrox
163 titution pattern at positions 4 and 5 of the oxazole ring, where the aryl group in position 5 deactiv
167 diazocarbonyl compounds to generate the four oxazole rings, which demonstrates the power of rhodium c
170 uted oxazole 24 was the best compound of the oxazole series in both the ex vivo (6 h pretreated rats)
171 of each other, neither the macrolide nor the oxazole side chain substituents of neopeltolide can inhi
174 with the formation of the 2,4-disubstituted oxazole, so this was synthesized via a modified approach
175 d C(1-28) macrocyclic iodide with a C(29-46) oxazole stannane side chain to establish the complete ph
176 onging to three different chemical families, oxazoles, strobilurins and triazoles, in water and fruit
177 Just as significantly, the nature of the C5 oxazole substituent substantially impacts the selectivit
181 group in five-position of the benzothiazole/oxazole system could achieve such a gain in selectivity
182 substituents on the 2-phenyl portion of the oxazole tail increased the ex vivo potency of these inhi
183 trate that a synthetic G4 ligand, Y2H2-6M(4)-oxazole telomestatin derivative (6OTD), limits the growt
185 ), also binds and activates another cyanine, oxazole thiazole blue (OTB), giving two well-resolved em
186 he design and synthesis of a novel series of oxazole-, thiazole-, and imidazole-based inhibitors of I
188 key steps, a diverse set of trifluoromethyl-oxazoles, -thiazoles, -imidazoles, -1,2,4-triazines, and
189 was coupled to another diazocarbonyl-derived oxazole to give the corresponding biaryl, deprotection a
190 lecular photocyclization in 2-(2-vinylstyryl)oxazoles to form benzo[f]quinoline derivatives proceeds
191 ion of propargylic stannanes with 5-iodo-1,3-oxazoles to produce 1,1-disubstituted allenes (11).
192 lized the binding site of the benzothiazoles/oxazoles to the CaM-BD/CaM interface and then used compu
194 modeling, we suggest that all benzothiazole/oxazole-type KCa activators bind relatively "deep" in th
195 a one-pot synthesis of 2,4,5-trisubstituted oxazoles via a Friedel-Crafts/Robinson-Gabriel synthesis
196 talyzed oxidative cyclization of enamides to oxazoles via vinylic C-H bond functionalization at room
200 d 5-aminothiazoles and 5-(trifluoroacetamido)oxazoles were all prepared by this improved methodology.
201 expected tripeptide product, 2,5-substituted oxazoles were isolated when O-tert-butyl protected N-hyd
202 he corresponding 2-alkyl-5-aryl- substituted oxazoles were obtained in up to 80% yield via a decarbox
204 t on its aromaticity, which is very minor in oxazole, when compared to furan, and small but noticeabl
206 tion generating cyclopenta[2,3]pyrrolo[2,1-b]oxazoles with good yields and excellent diastereoselecti
208 ing block by regiocontrolled "click-unclick" oxazole-ynone Diels-Alder cycloaddition/cycloreversion a
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