ライフサイエンスコーパス: oxazolone

1 studying the humoral response to the hapten oxazolone.

2 by topical sensitization and challenge with oxazolone.

3 the time of sensitization or challenge with oxazolone.

4 osinophils developed upon repeat exposure to oxazolone.

5 in the responses to dinitrofluorobenzene and oxazolone.

6 ty responses to 2,4-dinitrofluorobenzene and oxazolone.

7 s of contact hypersensitivity in response to oxazolone.

8 ensitivity induced by topical application of oxazolone.

9 e exhibited less severe colitis induction by oxazolone.

10 show normal contact sensitivity responses to oxazolone.

11 The 2-oxazolone-4-carboxylates bear functionality that can be

12 New methods for the synthesis of 2-oxazolone-4-carboxylates from 3-nosyloxy- and 3-bromo-2-

13 AgOTf under similar conditions to provide 2-oxazolone-4-carboxylates in comparable yields (30-79%).

14 toluene in the presence of p-TSA provided 2-oxazolone-4-carboxylates in good yields (41-80%).

15 , a model of irritant contact dermatitis and oxazolone, a model of allergic contact dermatitis.

16 MLH1-deficient mice were immunized with oxazolone Ag, and splenic B cells were analyzed for muta

17 hose directed against the haptens 2-phenyl-5-oxazolone and (4-hydroxy-3-nitrophenyl)acetyl.

18 Oxazolone and croton oil were applied in a single sensit

19 e suppression of contact hypersensitivity to oxazolone and delayed-type hypersensitivity to herpes si

20 zolone-type structures, whereas a mixture of oxazolone and macrocycle b fragment structures are forme

21 ated pyrrole-modified chlorins incorporating oxazolone and morpholine moieties.

22 llergic contact hypersensitivity response to oxazolone and oxazolone-induced Langerhans cell migratio

23 ult from the local irritation seen with both oxazolone and phorbol ester.

24 ted an attenuated IgM response to the hapten oxazolone and produced no IgG antioxazolone antibodies.

25 ing behavior in mice exposed to the haptens, oxazolone and urushiol, the contact allergen of poison i

26 variety of heteroaryl- and aryl-substituted oxazolones and activated methylene isocyanides, yielding

27 for the synthesis of 1,2,4-triazolines using oxazolones and azodicarboxylates.

28 ermutation, Msh2-/- mice were immunized with oxazolone, and B cells were analyzed for mutation in the

29 ectal instillation of the haptenating agent, oxazolone, and is characterized by a rapidly developing

30 mice did not develop colitis in response to oxazolone, and their levels of IL-4, IL-13, and immunogl

31 ologic outcomes of treating BALB/c mice with oxazolone- and trinitrobenzene sulfonic acid (TNBS)-indu

32 ity of dinitrobenzene sulfonic acid (DNBS)-, oxazolone-, and dextran-sodium sulfate-induced colitis.

33 8-oxo-dG undergoes facile further oxidation, oxazolone appears to be a stable final product of guanin

34 hypersensitivity responses in BALB/c mice to oxazolone, but not irritant contact hypersensitivity res

35 nvolves initial nucleophilic ring opening of oxazolones by cupriomethylene isocyanides followed by se

36 The oxazolones can be converted in a one pot manner to funct

37 thro-pentofuranosyl)amino]-5(2H)-oxazolo ne (oxazolone), can be generated either directly by oxidatio

38 showed exacerbated dermatitis upon repeated oxazolone challenge when compared to their wild-type cou

39 from exacerbated ear swelling after repeated oxazolone challenge.

40 T cell mitogen IL-15, which was increased in oxazolone-challenged skin of Sash mice during the accumu

41 Oxazolone colitis (OC) is an experimental colitis that h

42 This feature of oxazolone colitis as well as its cytokine profile have i

43 Although oxazolone colitis has been reported as Th2 mediated, mic

44 The histologic features and distribution of oxazolone colitis have characteristics that resemble ulc

45 Oxazolone colitis is a T helper cell type 2 (Th2)-mediat

46 study, we investigated the role of STAT6 in oxazolone colitis, a murine model of UC, by inducing col

47 In this study we describe oxazolone colitis, a new form of experimental colitis.

48 Nicotine attenuated oxazolone colitis, which was associated with an increase

49 kappaB decoy ODNs also prevented and treated oxazolone-colitis and thus affect a Th2-mediated inflamm

50 utaneous application of the haptens FITC and oxazolone confirmed that topically applied cFLIP antisen

51 n both fluorescein isothiocyanate (FITC) and oxazolone contact hypersensitivity models, WASp-null Lan

52 While the amounts of oxazolone continued to increase with the duration of irr

53 hydantoin (dSp), 5-guanidinohydantoin (dGh), oxazolone (dZ), 5-carboxamido-5-formamido-2-iminohydanto

54 ymph nodes draining the skin sensitized with oxazolone, especially activated T cells.

55 s of biologically relevant 3,5-disubstituted oxazolone frameworks.

56 report that mice sensitized with the hapten oxazolone had increased numbers of CCR6+ T cells in the

57 responses (e.g., contact hypersensitivity to oxazolone, IgM response to Pneumovax, IgG response to ke

58 characteristic of the inflammatory milieu in oxazolone (IL-4) and TNBS (IL-12) colitis, respectively.

59 0 expression, indicating the ability of some oxazolone-immune CD4+ T cells to mediate IP-10 expressio

60 e quantitative analysis of both 8-oxo-dG and oxazolone in DNA from biological sources.

61 itive and specific detection of 8-oxo-dG and oxazolone in enzymatic DNA hydrolysates was achieved by

62 d that contact hypersensitivity reactions to oxazolone in mice were associated with significant incre

63 ing PCR to analyze the Ab response to phenyl-oxazolone in the mouse, we show that the Ab repertoire o

64 a delayed-type hypersensitivity response to oxazolone in vivo.

65 We studied induction of colitis with oxazolone in wild-type mice and those with CD4(+) T cell

66 ht increased (approximately 1.5-fold) in the oxazolone-induced allergic dermatitis model, and 22ROH a

67 challenge phase inhibited the development of oxazolone-induced atopic dermatitis (AD).

68 ng allergic contact dermatitis, we evaluated oxazolone-induced changes in cell populations and cytoki

69 his study, we report that the development of oxazolone-induced chronic allergic dermatitis, in a mous

70 ression reduced production of TGF-beta(1) in oxazolone-induced colitis and that prevention of IL-13Ra

71 cell numbers and confers protection against oxazolone-induced colitis in adulthood.

72 cells to produce IgE, which together mediate oxazolone-induced colitis in mice.

73 induction of immunopathology associated with oxazolone-induced colitis, a colitis model mediated prim

74 deletion reduced dextran sodium sulfate- and oxazolone-induced colitis.

75 9-expressing mucosal T cells in experimental oxazolone-induced colitis.

76 ted against experimental iNKT cell-mediated, oxazolone-induced colitis.

77 rmines their effector functions and mediates oxazolone-induced colitis.

78 not produce IgE, were also protected against oxazolone-induced colitis.

79 l cell apoptosis and chronic inflammation in oxazolone-induced colitis.

80 In this issue, Lehtimaki et al. use an oxazolone-induced contact hypersensitivity (CHS) model t

81 se activation in the epidermis of mice in an oxazolone-induced contact hypersensitivity model.

82 macodynamic effects on ITK, which reduces an oxazolone-induced delayed type hypersensitivity reaction

83 hibit thioglycollate-induced peritonitis and oxazolone-induced delayed-type hypersensitivity.

84 Our findings show that oxazolone-induced dermatitis caused a marked increase in

85 Oxazolone-induced increases in ear thickness and ear wei

86 mpair sensitization, but potently suppressed oxazolone-induced inflammation by inhibiting the infiltr

87 t hypersensitivity response to oxazolone and oxazolone-induced Langerhans cell migration from epiderm

88 e-specific mutagenesis studies indicate that oxazolone is a strongly mispairing lesion, inducing appr

89 tion of colitis in mice by administration of oxazolone is mediated by T-helper (Th) 2 cells and has f

90 At the end of 4 wk of chronic exposure to oxazolone, it was found that serum IgE levels had signif

91 Continued exposure to oxazolone led to a downregulation of interferon-gamma an

92 The formation of oxazolone lesions in rat liver DNA, their relative stabi

93 tent mispairing characteristics suggest that oxazolone may play a role in oxidative stress-mediated m

94 tion in the trinitrobenzenesulfonic acid and oxazolone models by reducing the trafficking of Ly6C(+)

95 olactone N-oxide carrying the N-oxide on the oxazolone moiety is reported.

96 p replacement of a pyrrole moiety in 1 by an oxazolone moiety.

97 droxy-functionalized pyrroline group into an oxazolone or (substituted) oxazole.

98 Colitis was induced by administration of oxazolone or 2,4,6-trinitrobenzenesulfonic acid to contr

99 not develop colitis after administration of oxazolone or 2,4,6-trinitrobenzenesulfonic acid; lamina

100 type mice, with or without sensitization to oxazolone or croton oil, we observed mixed Th1/Th2 cytok

101 ery mild dermatitis when treated with either oxazolone or croton oil.

102 Peptide fragmentation can lead to an oxazolone or diketopiperazine b(2)(+) ion structure.

103 rrent with HEV reversion, at day 4 following oxazolone or OVA immunization, reduced accumulation of E

104 ically stable, fused isoxazolone, isoxazole, oxazolone, or cyano substituents on the aromatic rings.

105 mice with 2,4-dinitrofluorobenzene (DNFB) or oxazolone (Ox) resulted in increased and prolonged CHS r

106 Here, 9-10 challenges with oxazolone (Ox) to hairless mice also produced a chronic

107 tact sensitizer 2-phenyl-4-ethoxymethylene-5-oxazolone (oxazolone) to stimulate the skin and draining

108 igh in animal fat contained 2-6 molecules of oxazolone per 10(7) guanines, while 8-oxo-dG amounts in

109 the isotype in a splenic response to phenyl-oxazolone (phOx) on a chicken serum albumin carrier.

110 the formal replacement of a pyrrole with an oxazolone (porphyrin-like chromophore) or (substituted)

111 Oxazolones possessing benzylic-type substituents were fo

112 methylthio)hetero(aryl)methylene]-2-phenyl-5-oxazolone precursors by alkoxides, amines, amino acid es

113 T cells from E-/P-deficient mice transferred oxazolone reactivity into naive wild-type mice.

114 of interferon-gamma and interleukin-4 in the oxazolone response may be the infiltrating lymphocytes;

115 previously shown to predominate in the anti-oxazolone response).

116 oiminodihydantoin, 5-guanidinohydantoin, and oxazolone resulting from H2O as the nucleophile.

117 in linear fragment ions with a five-membered oxazolone ring on their C-terminal side.

118 ransfer kinetics from the b ion's C-terminal oxazolone ring to the N-terminus.

119 Our data also indicate that oxazolone rings instead of hydroxyimidazolate rings form

120 For example, the oxazolone rings make methanobactin structurally more sim

121 ytokine profile and inflammatory response in oxazolone sensitized mouse skin.

122 ing Langerhans cells from the lymph nodes of oxazolone-sensitized mice and transfer to naive mice res

123 ve COX-2 inhibitor within the thiazolone and oxazolone series of di-tert-butylphenols.

124 cate a second population corresponding to an oxazolone species.

125 ion has been obtained and, for this ion, the oxazolone structure proposed based on prior calculations

126 ches best to the theoretical spectrum for an oxazolone structure protonated on the ring nitrogen.

127 n for b(6)-b(7), while the "fast"-exchanging oxazolone structure represents the remainder (70%).

128 e-Gly-Leu-Met), is confirmed not to adopt an oxazolone structure, even upon collisional activation.

129 oscopy confirms that smaller fragments adopt oxazolone structures.

130 mixture of b(2)(+) ion diketopiperazine and oxazolone structures.

131 Treatment of the oxazolone template with a range of aromatic nucleophiles

132 s/Robinson-Gabriel synthesis using a general oxazolone template.

133 developed more severe colitis in response to oxazolone than control mice.

134 those seen in the class-switched response to oxazolone that we have also analyzed.

135 Following exposure to oxazolone, the intralesional production of inflammatory

136 In the contact hypersensitivity induced by oxazolone, the OGG-1(-/-) mice showed reduced neutrophil

137 alpha-substituted 2-oxindoles, cyanoesters, oxazolones, thiazolones, and azlactones) to alpha'-oxy e

138 izer 2-phenyl-4-ethoxymethylene-5-oxazolone (oxazolone) to stimulate the skin and draining prescapula

139 e oxysterol-treated sites from both TPA- and oxazolone-treated animals.

140 r Diels-Alder cycloaddition of N-substituted oxazolone triene I allows direct entry to the functional

141 b(n) fragments (n = 2, 3) exclusively adopt oxazolone-type structures, whereas a mixture of oxazolon

142 parison to the known lesions imidazolone and oxazolone using primer extension and pyrosequencing expe

143 N-(Boc)-Ynamides are converted to oxazolones via a cyclization reaction.

144 sticity of PLN HEVs during immunization with oxazolone was apparent as a reversion to an immature phe

145 as injected intravenously, and within 30 min oxazolone was painted on injected skin sites.

146 sensitivity reaction of mAb-treated mice to oxazolone was the same as that of normal rat IgG-treated

147 (-/-) ) mice, sensitized and challenged with oxazolone, was used as a criterion to assess the relevan

148 y fragment recognising the hapten 2-phenyl-5-oxazolone were grown in a mutator strain of bacteria (Es

149 topical application of a contact sensitizer, oxazolone, which also induced markedly elevated IL-1beta

150 (2-thienyl)-4-[(aryl/heteroaryl)methylene]-5-oxazolones with activated methylene isocyanides has been