ライフサイエンスコーパス: oxidative burst

1 iveness to flg22, as indicated by a stronger oxidative burst.

2 loxanthin production, and sensitivity to the oxidative burst.

3 one marrow with a quantitative defect in the oxidative burst.

4 s essential for EC-K1-mediated inhibition of oxidative burst.

5 mal cytokine production and generation of an oxidative burst.

6 phox) promoter, thereby diminishing the host oxidative burst.

7 east partially susceptible to the neutrophil oxidative burst.

8 on, integrin activation, or induction of the oxidative burst.

9 om PCD that requires the early mitochondrial oxidative burst.

10 3 and Rac1 and Rac2 in the FcgammaR-mediated oxidative burst.

11 reducing associated chemokine production and oxidative burst.

12 ated with decreased chemokine production and oxidative burst.

13 ing the plant cell wall and/or triggering an oxidative burst.

14 Monocytes were studied for phagocytosis and oxidative burst.

15 hway leading to programmed cell death and an oxidative burst.

16 was most efficient in inducing a macrophage oxidative burst.

17 gether completely abrogated the ANCA-induced oxidative burst.

18 process may contribute to the potency of the oxidative burst.

19 ronary dilation and inhibition of neutrophil oxidative burst.

20 ation, including adhesion, phagocytosis, and oxidative burst.

21 ures which might account for its role in the oxidative burst.

22 g was accompanied by an increased macrophage oxidative burst.

23 is correlated with an impaired immature cell oxidative burst.

24 R, placing calcium elevation upstream of the oxidative burst.

25 all middle dot) and ONOO(-) modulate the PMN oxidative burst.

26 human blood via increased sensitivity to the oxidative burst.

27 vement of Ca2+ in signal transduction of the oxidative burst.

28 th cross-linking mechanisms produced a rapid oxidative burst.

29 la protects itself from damage likely due to oxidative burst.

30 cytosed L. monocytogenes, and have decreased oxidative burst.

31 the site of infection, and displayed blunted oxidative burst.

32 e holoenzyme, resulting in an absence of the oxidative burst.

33 erating cAMP and consequently inhibiting the oxidative burst.

34 c bacterial killing, a process also known as oxidative burst.

35 pathway could be operative in the absence of oxidative burst.

36 y preventing phagocytosis and the associated oxidative burst.

37 acity to prime polymorfonuclear cells for an oxidative burst.

38 which abolishes the NADPH oxidase 2 complex oxidative burst.

39 lly increase iron levels to activate a toxic oxidative burst.

40 neurodegeneration together with inflammatory oxidative burst.

41 phoid Salmonella by impairing the neutrophil oxidative burst.

42 Oxidative burst, a critical antimicrobial mechanism of n

43 such as activation of CD11b/CD18 integrins, oxidative burst, actin polymerization, and interaction w

44 ted to those responsible for the respiratory oxidative burst activated in mammalian neutrophils durin

45 ood granulocyte and monocyte phagocytosis or oxidative burst activity after 2.5 h of intensive runnin

46 dose-related increase in neutrophil oxidative burst activity as the result of dilution follo

47 a minor JNK2 dependence but phagocytosis and oxidative burst activity did not require this MAPK.

48 Neutrophil activation (intracellular oxidative burst activity with dichlorofluorescin diaceta

49 inant population of neutrophils with reduced oxidative burst activity, which gradually normalized ove

50 However, monocyte oxidative burst after stimulation increased significantl

51 to primary human PMNs and suppressed the PMN oxidative burst akin to parental, Opa(-) bacteria.

52 Furthermore, the magnitude of the host oxidative burst alone does not stress the pathogen suffi

53 evels of SA also potentiate activation of an oxidative burst and a cell death pathway that results in

54 rminal kinase (JNK) ameliorated heme-induced oxidative burst and blocked macrophage cell death.

55 etr1 plants suggested that engagement of the oxidative burst and cognate redox signalling functioned

56 dopsis (Arabidopsis thaliana) leaves induced oxidative burst and expression of PTI early marker genes

57 disrupt other responses, such as the initial oxidative burst and expression of some early defense-ass

58 tant plants display progressively diminished oxidative burst and gene activation induced by the 22-am

59 crobe-associated molecular pattern-triggered oxidative burst and gene expression across four soybean

60 TIPE2 sets the strengths of phagocytosis and oxidative burst and may be targeted to effectively contr

61 antioxidant enzymes that inhibit neutrophil oxidative burst and negatively modulate platelet aggrega

62 ant (VU-3, Lys to Arg115) to investigate the oxidative burst and nicotinamide co-enzyme fluxes after

63 ges to kill bacteria by complement-dependent oxidative burst and opsonophagocytic mechanisms.

64 We analyzed neutrophil oxidative burst and phagocytosis in whole blood by fluor

65 ole of ABCA1, ABCG1 and HDL in dampening the oxidative burst and preserving viability of macrophages

66 ver, recombinant CD40L stimulated neutrophil oxidative burst and release of matrix metalloproteinase-

67 il the impact of HopM1 on the PAMP-triggered oxidative burst and stomatal immunity in an AtMIN7-indep

68 -3-3 proteins is required for PAMP-triggered oxidative burst and stomatal immunity, and chemical-medi

69 sses two early PAMP-triggered responses, the oxidative burst and stomatal immunity, both of which see

70 are basally activated, and exhibit aberrant oxidative burst and survival responses.

71 HR is preceded by an oxidative burst and the generation of both reactive oxyg

72 also required for both the elicitor-induced oxidative burst and the transduction of the hydrogen per

73 espectively), to modulate human neutrophils' oxidative burst and to protect Caco-2 cells against oxid

74 roxidase type 1 (FBP1) exhibited an impaired oxidative burst and were more susceptible than wild-type

75 acrophages have an independent defect in the oxidative burst and whether Burkholderia contributes to

76 salicylic-acid-dependent activation of micro-oxidative bursts and various defense-related genes.

77 s responsible for IgA-mediated phagocytosis, oxidative burst, and antibody-dependent cellular cytotox

78 rial internalization, intracellular killing, oxidative burst, and cytokine release during phagocytosi

79 ons, including transmigration, phagocytosis, oxidative burst, and cytokine secretion.

80 ions to impair human leukocyte phagocytosis, oxidative burst, and extracellular trap production, prom

81 of l-selectin, CD11b upregulation, increased oxidative burst, and faster progression to apoptosis.

82 n-dependent ligand binding, activation of an oxidative burst, and Fc receptor-mediated phagocytosis.

83 They can kill Borrelia via phagocytosis, oxidative burst, and hydrolytic enzymes.

84 nto Opaless Gc, the bacteria induced the PMN oxidative burst, and OpaD(+) Gc survived less well after

85 anule membranes, generating the bactericidal oxidative burst, and releasing lytic enzymes, specific p

86 nonuclear phagocytes including phagocytosis, oxidative burst, and secretion.

87 ype and Ncf1 mutant mice that lack phagocyte oxidative burst, and stimulated with LPS and other agent

88 myristate acetate (PMA), a known promoter of oxidative burst, and the production of superoxide was me

89 enhance significantly PICD by increasing the oxidative burst, and this is Mac-1-dependent.

90 Furthermore, modulation of autophagy and oxidative burst appeared to be one of the mechanisms by

91 ROIs derived from this oxidative burst are generated by plasma membrane NADPH o

92 Phagocytosis and oxidative burst are two major effector arms of innate im

93 ascular rolling and adhesion, migration, and oxidative bursting, are better measured in seconds or mi

94 The early component of the oxidative burst, arising primarily from chloroplasts, re

95 impaired FcgammaR-mediated phagocytosis and oxidative burst, as well as defective activation of Cdc4

96 RA101295 reduced the E. coli-induced "oxidative burst," as well as leukocyte activation, witho

97 Neutrophil functions were assessed using an oxidative burst assay as well as a degranulation assay.

98 study confirms previous reports of a higher oxidative burst associated with AgP and presented prelim

99 nd these macrophages effectively elicited an oxidative burst associated with clearance of Pneumocysti

100 ignificantly decreased the non-mitochondrial oxidative burst associated with inflammatory response in

101 ed defective fungicidal activity and reduced oxidative burst, both of which improved in the presence

102 th 17beta-estradiol demonstrated an enhanced oxidative burst but decreased P. aeruginosa killing and

103 d the ability to phagocytose and generate an oxidative burst, but exhibited defective killing of inte

104 cally in FcgammaR-mediated activation of the oxidative burst, but not in phagocytosis.

105 uce a marked transcriptional response and an oxidative burst, but not to cause substantial tissue dam

106 n dictates the strengths of phagocytosis and oxidative burst by binding to and blocking Rac GTPases.

107 Infection of PMNs with EC-K1 suppresses oxidative burst by downregulating rac1, rac2 and gp91(ph

108 P levels, and the inhibition of adhesion and oxidative burst by dPGJ2 was enhanced in the presence of

109 yzed in a masked manner for phagocytosis and oxidative burst by flow cytometry in response to Escheri

110 he discovery of regulatory nodes controlling oxidative burst by functional screening of genes within

111 sitive bacteria by macrophages, induction of oxidative burst by Gram-positive bacteria in neutrophils

112 Thus, alterations in the oxidative burst can profoundly impact host defense, yet

113 Unexpectedly, the subsequent oxidative burst can suppress cell death in cells surroun

114 m TK-/- mice exhibited decreased spontaneous oxidative burst capacity ex vivo, and by intravital micr

115 signaling of CyaA-generated cAMP blocks the oxidative burst capacity of neutrophils by two convergin

116 Neutrophil phagocytosis, oxidative burst capacity, and neutrophil extracellular t

117 respect to lymphocyte subsets, phagocytosis, oxidative burst capacity, and T cell proliferation upon

118 Furthermore, we show that the oxidative burst, catalyzed by nicotinamide adenine dinuc

119 e for inherent deficits in the CF macrophage oxidative burst caused by decreased phosphorylation of N

120 itro, including reduced l-selectin shedding, oxidative burst, chemotaxis, neutrophil extracellular tr

121 ired phagocytosis, and increased spontaneous oxidative burst compared to controls.

122 the development of drugs that generate high oxidative burst could be of great use in tuberculosis tr

123 ells, sustained accumulation of H2O2 from an oxidative burst cues localized host cell death.

124 We analyzed the killing activity, oxidative burst, cytokine production, and in vitro effec

125 The FcgammaR-mediated oxidative burst defect in Vav-deficient cells was linked

126 ients had sustained correction of neutrophil oxidative burst defect.

127 nhances bacterial clearance, and rescues the oxidative burst defects associated with Ncf4 haploinsuff

128 ently contributes to and worsens the overall oxidative burst deficits in CF MDMs compared with non-CF

129 d maintains functional PMN responses such as oxidative burst, degranulation, and phagocytosis.

130 as Fc-mediated phagocytosis, BCR signaling, oxidative burst, degranulation, cytokine secretion, and

131 elieved to be responsible for the apoplastic oxidative burst demonstrated by suspension-cultured cell

132 Reduction in the neutrophil oxidative burst, diminished formation of neutrophil extr

133 This oxidative burst drives crosslinking of the cell wall, in

134 a couple of seconds, while higher intensity oxidative bursts due to the emptying of vacuoles outside

135 mechanisms to evade or counter the phagocyte oxidative burst, effectively masking the impact of this

136 The first peak of the bimodal oxidative burst elicited by O3 in wild-type plants is al

137 nt rice exhibits increased susceptibility to oxidative bursts elicited by avirulent isolates.

138 quantitative PCR outlining the importance of oxidative burst for the induction of MDSC.

139 ts surface-expressed gp96 in PMNs to prevent oxidative burst for the onset of neonatal meningitis.

140 the plcHR operon induced a much more robust oxidative burst from neutrophils.

141 ition of an avirulent pathogen stimulates an oxidative burst generating O2- and H2O2, and these react

142 tput nitric oxide pathway (iNOS(-/-)) or the oxidative burst (gp91(phox-/-)) are more susceptible to

143 channel blockers prevented expression of the oxidative burst, (ii) introduction of exogenous Ca2+ int

144 n-kinase inhibitors, were found to block the oxidative burst in a concentration-dependent manner.

145 man neutrophil studies, ST94A stimulated the oxidative burst in and adhered to human neutrophils at l

146 We found that an oxidative burst in eosinophils could be triggered throug

147 Because Gsr has been implicated in the oxidative burst in human neutrophils and is abundantly e

148 Purified CP5 and CP8 stimulated a modest oxidative burst in human neutrophils but failed to activ

149 irulence by regulating the generation of the oxidative burst in human phagocytes.

150 ipid dynamics, membrane trafficking, and the oxidative burst in macrophages from SHIP-1-deficient and

151 hil migration, and Fcgamma receptor-mediated oxidative burst in macrophages were decreased in cells f

152 morphologic changes in Dictyostelium and the oxidative burst in mammalian neutrophils.

153 f TF as an important mediator of C5a-induced oxidative burst in neutrophils in aPL-induced fetal inju

154 of O2- and H2O2, which is reminiscent of the oxidative burst in neutrophils, is a central component o

155 is under study for its role in enhancing the oxidative burst in patients with chronic granulomatous d

156 se mutants to inhibit both apoptosis and the oxidative burst in polymorphonuclear leukocytes but were

157 ized that the small GTPase Rac1 mediates the oxidative burst in reperfused tissue and thereby contrib

158 (peroxidase 33 [PRX33] and PRX34), block the oxidative burst in response to a fungal elicitor, and ca

159 ed that patients with AgP exhibited a higher oxidative burst in response to E. coli (P = 0.002) and P

160 educed levels of neutrophil phagocytosis and oxidative burst in response to Escherichia coli stimulat

161 B 19-kDa lipoprotein enhanced the subsequent oxidative burst in response to fMLP as assessed by oxida

162 HS did not suppress oxidative burst in response to phorbol myristate acetate

163 ox) CYBA 242 T allele was associated with an oxidative burst in response to the challenge by two stra

164 We found that both MAMPs triggered a rapid oxidative burst in root border-like cells of both specie

165 A and okadaic acid) were found to induce the oxidative burst in the absence of any additional stimulu

166 a signal function for Ca2+ downstream of the oxidative burst in the activation of a physiological cel

167 Stimulation of the oxidative burst in the cell suspension was achieved by a

168 a highly specific TLR4 agonist, elicited an oxidative burst in the monocyte-like cell line THP-1 in

169 ntify cytokine production, phagocytosis, and oxidative burst in the presence or absence of blocking a

170 s the early role of the neutrophil and of an oxidative burst in this infection with an intracellular

171 crease adherence, migration, chemotaxis, and oxidative burst in vitro, and primes monocyte response t

172 hanced FcgammaRIIa-mediated phagocytosis and oxidative burst in vitro.

173 ulent Pseudomonas syringae induces secondary oxidative bursts in discrete cells in distant tissues, l

174 ytic activity was decreased, and spontaneous oxidative burst increased in all patients with acetamino

175 S and opsonized with the same sera using the oxidative burst indicator system dihydrorhodamine123/rho

176 inhibitor bisindolylmaleimide inhibited the oxidative burst induced by either PMA or intact pseudomo

177 The oxidative burst induced cell death within 6 h of IL-8 st

178 The primary oxidative burst induces these systemic responses, and bo

179 An endogenous oxidative burst induction by 4beta-phorbol 12beta-myrist

180 to those elicited by flagellin, including an oxidative burst, induction of defense-response genes, an

181 ious effect of cellular damage caused by the oxidative burst inside the macrophages, C. neoformans ha

182 Upon oxidative burst, interchange of oxidants between WT and

183 Because oxidative burst is a common defense response and reactiv

184 The oxidative burst is an early response to pathogen attack

185 The oxidative burst is an important effector mechanism, this

186 A sustained, intracellular oxidative burst is associated with PICD.

187 The oxidative burst is likely the most rapid defense respons

188 Therefore, absolute resistance to the oxidative burst is not a mechanism by which ExPEC surviv

189 activating Toll-like receptors (TLRs) induce oxidative burst is unknown.

190 f avirulent microbial pathogens activates an oxidative burst leading to the accumulation of reactive

191 GmMMP2 activation did not correlate with the oxidative burst leading to the hypersensitive response c

192 ERK-MAPK pathway, CREB, and generation of an oxidative burst, leading to downstream production of IL-

193 ether with ANCA-induced degranulation and an oxidative burst, leads to local tissue damage.

194 activity as measured by phagocytic activity, oxidative burst, lysozyme secretion, and ability to limi

195 production is one of the first indicators of oxidative burst, macrophage cells were exposed within th

196 ponse that should not require PPARgamma, the oxidative burst made by adherent human neutrophils.

197 The phagocyte oxidative burst, mediated by Nox2 NADPH oxidase-derived

198 ge pathogen-like Leishmania is inhibition of oxidative burst-mediated macrophage apoptosis to protect

199 in (thioredoxin reductase inhibitor) induces oxidative burst, mitochondrial damage, and necrotic cell

200 and tissue bacterial burdens, and neutrophil oxidative burst), morphologic (i.e., liver histology and

201 anate-labeled opsonized Escherichia coli and oxidative burst (OB) was determined by the percentage of

202 The oxidative burst occurring after challenge with avirulent

203 An oxidative burst occurs within 15 min of the root being i

204 xide were simultaneously detected during the oxidative burst of a zymosan-stimulated macrophage cell.

205 This species is also generated during the oxidative burst of activated human neutrophils and durin

206 Here, we report that the oxidative burst of BV-2 microglial cells leads to oxidat

207 um have been reported to protect against the oxidative burst of host innate immune cells using a fami

208 exogenous sources of superoxide, such as the oxidative burst of phagocytes.

209 dogenous H2O2 in cell culture to monitor the oxidative burst of promyelocytes and in vivo to image lu

210 ids pathogen compatibility by modulating the oxidative burst of the host plant.

211 arthritis in C57BL/10 mice and the effect of oxidative burst on disease.

212 on of these variants in cells either reduced oxidative burst or altered interactions among proteins i

213 mutant is lost upon inhibition of neutrophil oxidative burst or in human or murine nicotinamide adeni

214 abnormalities of the IL-12/IFN-gamma axis or oxidative burst pathways were identified.

215 ant goal and molecular identification of the oxidative burst peroxidase allows further exploration of

216 ignificant reduction in Fc receptor-mediated oxidative burst, phagocytosis of opsonised polystyrene b

217 Recent findings indicate that H2O2 from this oxidative burst plays a central role in the orchestratio

218 ta demonstrate that the peroxidase-dependent oxidative burst plays an important role in Arabidopsis b

219 Neutrophil functions, such as phagocytosis, oxidative burst, polarization, and chemotaxis, were augm

220 iva, Sinorhizobium meliloti must overcome an oxidative burst produced by the plant in order for prope

221 Furthermore, the NOX2-dependent oxidative burst, produced by macrophages recruited to th

222 toneal neutrophil recruitment with increased oxidative burst production, whereas the TLR7/8 agonist a

223 ated murine peritoneal macrophages producing oxidative burst products but is unaffected by macrophage

224 to the resistance of M. tuberculosis against oxidative burst products generated by activated macropha

225 so include those with a putative role in the oxidative burst, proteolysis, the hypersensitive respons

226 ic ingestion and initiation of intracellular oxidative burst (r(2) = 0.99) using polystyrene beads co

227 activate many defense responses including an oxidative burst, rapid changes in the expression of over

228 We measured the oxidative burst reaction in mammalian macrophages (NR838

229 after an immediate inhibitory effect on the oxidative burst reaction.

230 Major PMN effector mechanisms, including oxidative burst, release of secondary granule contents a

231 e, tissue damage-associated component of the oxidative burst requires only the Galpha protein and ari

232 MAPKAP kinase 2 in neutrophil function, the oxidative burst response after manipulation of endogenou

233 We demonstrate that the oxidative burst response can be employed as readout for

234 estingly, a stimulus-dependent defect in the oxidative burst response of LFKO neutrophils was observe

235 in does play an immunomodulatory role in the oxidative burst response of neutrophils.

236 Results show that the human PMN oxidative burst response to immobilized beta-glucan is s

237 estin, which is protection from an excessive oxidative burst, resulting from the sustained stimulatio

238 poptotic cells was dependent on an excessive oxidative burst secondary to enhanced assembly of NADPH

239 ioning in direct defense, defense signaling, oxidative burst, secondary metabolism, abiotic stress, c

240 NA damage response, like deficiencies in the oxidative burst seen in chronic granulomatous disease, c

241 quently, but not invariably, to transduce an oxidative burst signal.

242 abscisic acid, salicylic acid, ethylene, and oxidative burst signaling) and in reactive oxygen metabo

243 pulses are essential to transduction of the oxidative burst signals by their respective elicitors: (

244 t of the signal transduction pathway linking oxidative burst signals to diverse downstream responses.

245 potent at inhibiting the adhesion-dependent oxidative burst than several other PGs tested.

246 sis were significantly more resistant to the oxidative burst than wild-type bacteria in human blood o

247 cient neutrophils displayed a very transient oxidative burst that abruptly ceased shortly after stimu

248 e that plastid genome instability induces an oxidative burst that favors, through nuclear genetic rep

249 diphenylene iodonium-insensitive apoplastic oxidative burst that generates H(2)O(2) in response to a

250 symbiosis, S. meliloti is presented with an oxidative burst that must be overcome.

251 f the roots caused by harvesting triggers an oxidative burst that spreads throughout the cassava root

252 nk between cyanogenesis and the onset of the oxidative burst that triggers PPD.

253 ukocytes, G(vH+) are required to support the oxidative burst that underlies microbial killing by the

254 ctivate PKCdelta and induction of neutrophil oxidative burst, the current study shows that the potent

255 r own NO as a key defense against the immune oxidative burst, thereby establishing bNOS as an essenti

256 te that phagosomal SHIP-1 enhances the early oxidative burst through localized alteration of the memb

257 We have investigated the source of this oxidative burst to identify possible strategies to limit

258 nging from interfering with phagocytosis and oxidative burst to iron acquisition.

259 novel applications using blue light induced oxidative bursts to prime crop plants against the delete

260 Downstream responses include ion fluxes, an oxidative burst, transcriptional reprogramming, and, in

261 ottleneck step of the converging pathways of oxidative burst triggering.

262 ith P. syringae did not elicit the defensive oxidative burst typical of most plants.

263 ent neutrophils also exhibited an attenuated oxidative burst upon encountering E. coli.

264 -type neutrophils that exhibited a sustained oxidative burst upon stimulation with phorbol ester and

265 owever, monocyte phagocytosis was normal and oxidative burst was augmented, suggesting that their inn

266 This increased oxidative burst was dependent on Dectin-1, Syk, PI3K, ph

267 Strong engagement of the oxidative burst was dependent on the presence of functio

268 ylococcal killing was normal, and neutrophil oxidative burst was increased both basally and on stimul

269 ymorphonuclear neutrophils; induction of the oxidative burst was inhibited by antibodies to either CD

270 This oxidative burst was shown to be dependent on the presenc

271 ependent adhesion and the adhesion-dependent oxidative burst was tested using a specific inhibitor of

272 5-oxo-ETE, except ERK1/2 phosphorylation and oxidative burst, were likewise prevented by pertussis to

273 s to yield up to a 50-fold increase in their oxidative burst when elicited in vitro with phorbol myri

274 Forskolin potentiates the oxidative burst when elicitor is subsequently added whil

275 MDM were competent to produce an early oxidative burst when stimulated with phorbol myristate a

276 successful detection of sustained macrophage oxidative burst, which corresponds to an increase in the

277 nhibitor also blocked the adhesion-dependent oxidative burst with a half-maximal concentration simila

278 n early transient rise in SA potentiates the oxidative burst, with resultant effects on accumulation

279 against DNA damage experienced following the oxidative burst within macrophages.

280 ac1N17) partially suppressed the TNF-induced oxidative burst without affecting TNF-induced mitochondr