ライフサイエンスコーパス: oxidative damage

1 glycation, is quantitatively as important as oxidative damage.

2 ase, most probably through the generation of oxidative damage.

3 d Purple Haze cultivars against H2O2-induced oxidative damage.

4 induced obesity at the cost of moderate skin oxidative damage.

5 ating pathological conditions resulting from oxidative damage.

6 ation, and the latter a mimic of age-related oxidative damage.

7 , causing in consequence the accumulation of oxidative damage.

8 l lesions of Nrf2(-/-) mice, indicating high oxidative damage.

9 sponse in the hippocampus, which counteracts oxidative damage.

10 permeability and salt passage as a result of oxidative damage.

11 ration is a prerequisite to the CM15-induced oxidative damage.

12 m Miracle Fruit leaves (AML) on mutation and oxidative damage.

13 ng of mycothiol and accumulation of cellular oxidative damage.

14 on to suppress ROS and to protect cells from oxidative damage.

15 tance of maintaining telomere integrity upon oxidative damage.

16 n species (ROS) and protects the genome from oxidative damage.

17 rved mitochondrial morphology, and decreased oxidative damage.

18 iated with increased lactate and evidence of oxidative damage.

19 oxidant defense response may protect against oxidative damage.

20 to many diseases in which cells suffer from oxidative damage.

21 n be applied to antimutation as well as anti-oxidative damage.

22 o-2, SHSY-5Y and K562) against t-BHP-induced oxidative damage.

23 ain injury via proinflammatory mediators and oxidative damage.

24 reactive oxygen species production and photo-oxidative damage.

25 RCA1(5382insC) impact the cell's response to oxidative damage.

26 n a NF-kappaB-independent manner by reducing oxidative damage.

27 ucleotide pools are especially vulnerable to oxidative damage.

28 are particularly vulnerable to metabolic and oxidative damage.

29 and might help protect against free-radical oxidative damage.

30 differentiated cells, even in the absence of oxidative damage.

31 antioxidants that protect the plant against oxidative damage.

32 important therapeutic targets, are prone to oxidative damage.

33 cribed to counteract neuronal ROS to prevent oxidative damage.

34 ither DNA repair or the cellular response to oxidative damage.

35 circumstances, with regenerative stress and oxidative damage.

36 on of cellular membranes from stress-induced oxidative damage.

37 dification that protects the protein against oxidative damage.

38 ve diseases and brain injury associated with oxidative damage.

39 defence system to cope with salinity induced-oxidative damage.

40 , which leads to endothelial dysfunction and oxidative damage.

41 potential requirement for AI-2 in evasion of oxidative damage.

42 chemia-induced inflammatory response and DNA oxidative damage.

43 pensatory response contributes to additional oxidative damage.

44 een widely considered as a biomarker for DNA oxidative damage.

45 helating activity as well as decreased lipid oxidative damage.

46 the cream cowpea type in protecting DNA from oxidative damage.

47 evelopment, or as toxic compounds leading to oxidative damage.

48 well as sensitive enzymes from intracellular oxidative damage.

49 dicating a role of TAG in protection against oxidative damage.

50 ogenase mutants with increased resistance to oxidative damage.

51 telomeres highly susceptible to ROS-induced oxidative damage.

52 s from undergoing ferroptosis in response to oxidative damage.

53 ST-derived H2S protects chromosomal DNA from oxidative damage.

54 uces intracellular ROS formation, leading to oxidative damage.

55 xposure to oxygen compared to other forms of oxidative damage.

56 translocation, epithelial inflammation, and oxidative damage.

57 tial to embed mutations during the repair of oxidative damage.

58 uman oocytes is caused, at least in part, by oxidative damage.

59 within a protein shell to protect cells from oxidative damage.

60 correct nucleotide excision repair following oxidative damage.

61 to (although slightly affected retention at) oxidative damage.

62 nce of the enzyme in protecting tissues from oxidative damage.

63 s MT, the primary site and primary target of oxidative damage.

64 water comes along with its vulnerability to oxidative damage.

65 g consistent with replication errors and not oxidative damage.

66 lating with female sex and microvascular and oxidative damages.

67 y influenced their protective effect against oxidative damages.

68 Indeed, products of oxidative damage accumulate in skeletal muscle during ag

69 cid synthesis and structure, protection from oxidative damage, activity of ion channels, cell prolife

70 It protects hearts from oxidative damage after ischaemia-reperfusion or hypoxia-

71 to counteract peroxide stress, but not other oxidative damaging agents.

72 ts of their consumption on the prevention of oxidative damage along the gut.

73 targeting genes related to drug metabolism, oxidative damage, altered neurotransmission, neuroinflam

74 ively low, associated with increased protein oxidative damage and a spontaneous fibrotic-like pulmona

75 Fe(III) sequestration by transferrin reduces oxidative damage and Abeta aggregation, it is not clear

76 In addition, increased oxidative damage and adaptations in stress responses obs

77 EPA significantly attenuated IND-induced oxidative damage and apoptosis.

78 quantify the association of iron status with oxidative damage and bone loss.

79 tential of this compound against UVA-induced oxidative damage and cell death was evaluated in culture

80 Photo-induced oxidative damage and cell death were drastically reduced

81 ta and Tau accumulation through increases in oxidative damage and cellular energy deficits; these, in

82 ssion of SODA also resulted in mitochondrial oxidative damage and failure of SODA/DeltasodA promastig

83 Oxidative damage and inflammation are both implicated in

84 ce, and this was associated with hippocampal oxidative damage and inflammation despite an enhanced ex

85 ulted in a significant prevention of cardiac oxidative damage and inflammation.

86 ice that lack beta cell autophagy, increased oxidative damage and loss of an antioxidant-protective p

87 Considerable evidence indicates that oxidative damage and mitochondrial dysfunction contribut

88 SS31 is associated with some improvements in oxidative damage and mitophagy in muscles of old mice.

89 of reactive oxygen species (ROS), leading to oxidative damage and neuronal cell death, plays an impor

90 e in mice do not appreciably protect against oxidative damage and neurotoxicity in the PQ+MB model of

91 consumption were evaluated on biomarkers of oxidative damage and on aging-associated reductions in m

92 en species accumulation, limiting downstream oxidative damage and preserving mitochondrial function.

93 PPP to supply cytosolic NADPH to counteract oxidative damage and protect mouse erythrocytes.

94 SOD2 defense, making RPE more susceptible to oxidative damage and thereby contributing to AMD pathoge

95 c tissue, thereby decreasing ROS production, oxidative damage and tissue necrosis.

96 ve developed strategies to protect PSII from oxidative damage and to repair damaged PSII.

97 ss, as well as intrinsic stress factors like oxidative damage and unfolded protein accumulation.

98 onents of salinity stress along with reduced oxidative damage and upregulation of stress-responsive g

99 uptake in the protection of nitrogenase from oxidative damage and, thus, in an efficient provision of

100 Complement activation, oxidative damage, and activation of the NLRP3 inflammaso

101 late higher levels of ROS, exhibit increased oxidative damage, and display reduced germination on soi

102 hemodynamic changes, reducing inflammation, oxidative damage, and fibrosis in the experimental model

103 of ongoing complement activation, markers of oxidative damage, and host surface-specific polyanions.

104 f antioxidant genes in their skin, more skin oxidative damage, and increased epidermal thickness and

105 xpression, loss of ATF4 resulted in enhanced oxidative damage, and increased free cholesterol in live

106 ht increased adenosine triphosphate, reduced oxidative damage, and increased median life spans, witho

107 l protein complexes, studies of the onset of oxidative damage, and more recent advances that enable h

108 espiratory capacity, increased mitochondrial oxidative damage, and reduced viability in the presence

109 ccating and germinating seeds from excessive oxidative damage, and suggested that APX6 modulate the R

110 ates employ distinct mechanisms to remediate oxidative damage, and that carbon source affected the is

111 Many organisms seem to tolerate oxidative damage, and the extension of health span and l

112 enesis, the mutation spectrum shifted toward oxidative damage, and the mutation rate increased.

113 o decreased intracellular superoxide levels, oxidative damage, apoptosis, and DNAJC3 (a marker for en

114 Mitochondrial dysfunction and oxidative damage are commonly associated with early stag

115 acid oxidation in mitochondria and increased oxidative damage are features of non-alcoholic fatty liv

116 acid oxidation in mitochondria and increased oxidative damage are features of non-alcoholic fatty liv

117 fully known, recent evidence has implicated oxidative damage as a major cause of tissue injury in MS

118 y of JAK2-deficient livers, which diminished oxidative damage as compared to GH(tg)STAT5(Deltahep) mi

119 ession markedly sensitizes cells to telomere oxidative damage as well as XRCC1 inhibition.

120 ses in PPARG coactivator 1beta could prevent oxidative damage associated with complete loss of PGC1A

121 plantation, and autoimmunity, and preventing oxidative damage associated with inflammation.

122 ized role for mitochondrial cyclin B1 in the oxidative damage associated with neurological disorders.

123 tein carbonylation as an indicator of severe oxidative damage because it is irreversible and results

124 ne levels, total reactive oxygen species and oxidative damage biomarker levels, and of serum IgE leve

125 ssed for total and differential cell counts, oxidative damage biomarkers, and cytokine levels.

126 ly, PS significantly decreased the levels of oxidative damage biomarkers, malondialdehyde (MDA), 4-hy

127 ase can affect the mutability of a purine by oxidative damage by as much as eightfold.

128 ing a mechanism for protection against photo-oxidative damage by minimizing the tissue exposure to de

129 ly increased Caco-2 cells resistance towards oxidative damage by recovering the cell viability and in

130 (FFA) levels (P < 0.001) and ameliorated the oxidative damage by reducing malondialdehyde (MDA) conce

131 w other proteins with only mild or localized oxidative damage can be targeted for degradation without

132 e, loss of estrogen signaling contributes to oxidative damage caused by low levels of PGC1A in liver,

133 ne hallmark of aging cells is an increase in oxidative damage caused by reactive oxygen species (ROS)

134 Oxidative damage caused by reactive oxygen species has b

135 ectarivores use nectar sugar to mitigate the oxidative damage caused by the muscular demands of fligh

136 The labile iron-mediated oxidative damage caused by UVA to mitochondria leads to

137 The effect of apple phenolics on the oxidative damage caused to myofibrillar proteins by an i

138 on of TRIM21 in mice confers protection from oxidative damages caused by arsenic-induced liver insult

139 is essential for survival, it also initiates oxidative damage, cell death and aberrant immune respons

140 the malondialdehyde serum levels and protein oxidative damage, compared to the CC group.

141 PrimPol to study lesion bypass synthesis on oxidative damage-containing DNA templates.

142 Inflammation and oxidative damage contribute to the pathogenesis of asthm

143 data are consistent with the hypothesis that oxidative damage contributes to chemotherapy-associated

144 nescence in vitro and accumulate products of oxidative damage, despite activation of the redox respon

145 ural progenitors exhibit increased levels of oxidative damage, DNA double-strand breaks, increased DN

146 note, despite the expectation of exacerbated oxidative damage due to the reduction in urate, protein

147 chlorophyll synthesis genes to prevent photo-oxidative damage during de-etiolation.

148 n complexes in biological fluids that resist oxidative damage during heme-driven inflammation.

149 in the gelation media allowed decreasing the oxidative damage during storage in comparison to the fre

150 valuable tool for the quantification of ROS oxidative damage during winemaking.

151 results suggest that, with the exception of oxidative damage, endogenously induced DNA damage does n

152 xercise appear to be a transient increase in oxidative damage followed by redox-sensitive adaptations

153 olony health and productivity, and levels of oxidative damage for individual bees.

154 Oxidative damage from elevated production of reactive ox

155 al and fungal pathogens against H2O2-induced oxidative damage from host immune responses.

156 , suggesting that ALT activation may prevent oxidative damage from reaching levels that threaten cell

157 oxidative challenge, but the analysis of DNA oxidative damage gave conflicting results.

158 key roles in metabolism and defense against oxidative damage have led to thousands of studies over s

159 u and the ability of TERT to protect against oxidative damage in an in vitro model of tau pathology.

160 ythrocyte and mononuclear cell resistance to oxidative damage in apparently healthy volunteers.

161 rganic pollutants (POPs) in the induction of oxidative damage in cell structures, this issue has been

162 injury by inhibiting NAPDH oxidase-mediated oxidative damage in diabetic mice.

163 dynamics, immune defences, antioxidants and oxidative damage in different tissues vary along the urb

164 long period and was paralleled by decreased oxidative damage in fat and liver.

165 of expression of genes that protect against oxidative damage in females may contribute to their lowe

166 The reduced oxidative damage in JAK2-deficient livers was linked to

167 ngs showed reduced body size, high levels of oxidative damage in lipids and proteins, and a fragile j

168 High aerobic performance is linked to oxidative damage in muscles.

169 absence of TERT increases ROS generation and oxidative damage in neurons induced by pathological tau.

170 eight gain, prevents neuronal death, reduces oxidative damage in neurons, suppresses the decline of m

171 Therefore, increased oxidative damage in older oocytes may be one of the fact

172 ry eicosanoids and may account for increased oxidative damage in pericentral regions in NASH.

173 de (MDA) suggests that Ga stress could cause oxidative damage in plants.

174 ble intermediates that can further propagate oxidative damage in proteins.

175 ministration failed to attenuate age-related oxidative damage in skeletal muscle of old mice or provi

176 collaborate to protect M. smegmatis against oxidative damage in stationary phase.

177 tection to avoid, minimize, and repair photo-oxidative damage in stressful light conditions, allowing

178 mpair the translation apparatus or may cause oxidative damage in the cell.

179 hat ETC dysfunction, impaired energetics and oxidative damage in the hearts of rats exposed to chroni

180 /-) mice had increased inflammation-mediated oxidative damage in the ipsilateral foot and ankle joint

181 ), the mammalian 8-oxodGTPase that sanitizes oxidative damage in the nucleotide pool, is important fo

182 and reduced tau pathology, inflammation and oxidative damage in the P301S mice.

183 of double-strand breaks in the DNA, and (2) oxidative damage in the sperm DNA.

184 dentified as a unique approach in preventing oxidative damage in these molecules, which had been link

185 ls and clearly indicate the role of cellular oxidative damage in this process.

186 g1 heterozygous mice also showed evidence of oxidative damage in tissues.

187 rmation, we incubated nucleosomes containing oxidative damages in opposing DNA strands with selected

188 ddition, rearing conditions affect levels of oxidative damage incurred as adults.

189 alase antioxidant activity and decreased DNA oxidative damage indicate improved cellular redox status

190 ecapitulate the bioenergetic dysfunction and oxidative damage induced by exposure to cerebrospinal fl

191 em II (PSII) are highly susceptible to photo-oxidative damage induced by high-fluence or fluctuating

192 Besides protecting against the oxidative damage induced by paraquat treatment, our data

193 y caused by malfunction of photosystem I and oxidative damage induced by reactive oxygen species gene

194 ect on human cell lymphocytes in response to oxidative damage induced by X radiation and their antiox

195 Overexpression of TWINKLE rescued the oxidative damage induced replication stalling of mtDNA,

196 Taken together, our results demonstrate that oxidative damage induces telomere dysfunction and underl

197 We assessed behavior, tau pathology, oxidative damage, inflammation and numbers of mitochondr

198 and berries is associated with reduction in oxidative damage, inflammation, vascular reactivity, and

199 nsequence of ischemia-reperfusion injury and oxidative damage is a leading cause of permanent disabil

200 oli, a non-coded amino acid produced through oxidative damage is a significant threat to the accuracy

201 Our work shows that (i) blood lipid oxidative damage is associated with observable clinical

202 Oxidative damage is considered to play a central role in

203 The accumulation of oxidative damage is strongly linked to age-dependent dec

204 As free heme is a potent inducer of oxidative damage, its levels within cellular compartment

205 tores and radiation, both of which can cause oxidative damage leading to negative health effects.

206 acilitates fatty acid oxidation, counteracts oxidative damage, maintains mitochondrial sirtuin activi

207 r acellular capillaries and were stained for oxidative damage markers using nitrotyrosine immunohisto

208 on of ATP synthase activity causes complex I oxidative damage, mitochondrial inner membrane depolariz

209 In diabetes, oxidative damage occurs when there is an imbalance betwe

210 CS reasonably reduced oxidative damage of DNA, protein and RBC by inhibiting H

211 phils expressing membrane PR3 may potentiate oxidative damage of endothelial cells and promote the sy

212 Our results show that oxidative damage of even single residues at the interfac

213 Here, we present the first study on oxidative damage of human telomere G-quadruplexes withou

214 esent in tobacco smoke not only cause direct oxidative damage of lung proteins, contributing to the m

215 free ferrous iron in mitochondria caused by oxidative damage of mitochondrial aconitase, ultimately

216 t from external invaders or amyloid but from oxidative damage of our own genes.

217 metabolites and produced in large amounts by oxidative damage of the CO2 acceptor molecule ribulose 1

218 cteria by binding to the membrane, promoting oxidative damage of the lipids, which then disrupts the

219 the previously made notion that HoxR avoids oxidative damage of the metal centers of the MBH, in par

220 low density lipoprotein (LDL) oxidation and oxidative damage of vector DNA.

221 imuli, but if left unchecked, it can inflict oxidative damage on all types of biological macromolecul

222 these organelles particularly susceptible to oxidative damage on exposure to ultraviolet A (UVA, 320-

223 ssue, which switches on the early process of oxidative damages on heart rapidly through a ROS-p38 MAP

224 whether nestlings with either low levels of oxidative damage or high levels of antioxidant protectio

225 none mesylate fails to attenuate age-related oxidative damage or rescue the loss of muscle mass and f

226 dac can also protect RPE cells from chemical oxidative damage or UV light by initiating a protective

227 of reactive oxygen species (ROS), markers of oxidative damage, or antioxidant defenses.

228 ROS can cause oxidative damage particularly to proteins.

229 ed concern about the risk of excess iron and oxidative damage, particularly in bone.

230 in itself at Lys(11) and Lys(48) rather than oxidative damage per se.

231 se severe oxidative stress, and although the oxidative damage potential decreased concomitantly with

232 subset of toxic metalloporphyrins elicit the oxidative damage previously shown to be a significant co

233 Here, we measured oxidative damage (protein carbonyls, 8-OHdG) and antioxi

234 The thousands of mutations caused by oxidative damage recovered across the entire genome reve

235 le of 8-oxo-dG and 8-oxo-dA in AMD and other oxidative damage-related diseases in humans.

236 ent cells, mitochondrial common deletion and oxidative damage repair capacity in U2OS cells were foun

237 significantly elevated, whereas capacity for oxidative damage repair of mtDNA was markedly reduced in

238 ncreased insulin production and protect from oxidative damage, respectively.

239 echanism is insufficient to prevent neuronal oxidative damage, resulting in chronic deficits in worki

240 Among these factors, oxidative damage seems to initiate the injury.

241 stingly, deletion of CSB's UBD gives rise to oxidative damage sensitivity as well, while CSB DeltaUBD

242 rategies to enhance respiration and initiate oxidative damage should improve tuberculosis chemotherap

243 conclude that mitochondrial alterations and oxidative damage significantly contribute to CTX-mediate

244 to become sensitized to agents that increase oxidative damage such as ionizing radiation.

245 1 provides protection against H2 O2 -induced oxidative damage, suggesting potential future applicatio

246 dox balance and increases RPE sensitivity to oxidative damage, suggesting that deficiencies of reduct

247 fatty acid accumulated in NAFLD, causes more oxidative damage than other free fatty acids such as pal

248 pa, which could influence the sensitivity to oxidative damage that has previously been observed for W

249 prime suspects for involvement in the early oxidative damage that is evident in this disease.

250 asthmatic lungs displayed three hallmarks of oxidative damage that render it NO-insensitive, and iden

251 ve burst and to protect Caco-2 cells against oxidative damage, the peel extract being the most effici

252 enadione and plumbagin, which cause indirect oxidative damage through mitochondrial dysfunction, poli

253 s unprotected peptides from Cu(II) -mediated oxidative damage through the formation of an insoluble C

254 hypoxic zones within the SGZ might result in oxidative damage, thus triggering cell death.

255 apparatus to the client proteins preventing oxidative damage to [4Fe-4S] clusters.

256 In contrast, differentiated cells require oxidative damage to activate Nrf2.

257 lyacrylamide gel electrophoresis (SDS-PAGE), oxidative damage to amino acids, and changes in the prop

258 elationship between myeloperoxidase-mediated oxidative damage to apolipoprotein A-I, the major HDL pr

259 of a lipid-soluble antioxidant that prevents oxidative damage to biological components.

260 essive reactive oxygen species (ROS) induces oxidative damage to cellular constituents, ultimately le

261 Oxidative damage to DNA and hole transport between nucle

262 These results suggest that the ROS-induced oxidative damage to DNA and protein carbonylation are in

263 Lymphocytes exposed to oxidative damage to DNA at 8:00 AM display lower accumul

264 Oxidative damage to DNA is mainly repaired via base exci

265 s the main system involved in the removal of oxidative damage to DNA such as 8-Oxoguanine (8-oxoG) pr

266 ective than the HRGS system in promoting the oxidative damage to food proteins.

267 ited by the excision repair protein OGG1 for oxidative damage to interact with the damage-induced bas

268 tioxidant defense enzyme active in repairing oxidative damage to lipids, is a key inhibitor of ferrop

269 ular disease through direct and irreversible oxidative damage to macromolecules, as well as disruptio

270 Oxidative damage to mitochondria (MT) is a major mechani

271 Oxidative damage to mitochondrial DNA (mtDNA) in the ret

272 Increased ROS would result in oxidative damage to mitochondrial proteins, lipids, and

273 es in cell function, but the contribution of oxidative damage to morbidity is still debated.

274 This is crucial to prevent photo-oxidative damage to photosystem II (PSII) and is control

275 HDM challenge increased lung levels of oxidative damage to proteins (3-nitrotyrosine), lipids (

276 Such oxidative damage to proteins may lead to the formation o

277 Oxidative damage to renal tubular epithelial cells is a

278 w here that RPA is limiting for NER and that oxidative damage to RPA compromises NER capability.

279 Photoactivation causes oxidative damage to specific histidine residues in the k

280 However, a direct connection between oxidative damage to telomeric DNA, comprising <1% of the

281 UV-A exposed PG caused oxidative damage to the cell and significantly higher da

282 To minimize oxidative damage to the cell, malfunctioning mitochondri

283 (VI) and Fe(III) has been shown to result in oxidative damage to the DNA and change in the electroche

284 e pathway (PPP), resulting in a reduction in oxidative damage to the flight muscles.

285 Oxidative damage to the genome can yield the base 8-oxo-

286 sorption of too much light can lead to photo-oxidative damage to the photosynthetic apparatus and sus

287 ed oxygen or oxygen metabolites may increase oxidative damage to the trabecular meshwork cells, resul

288 We found that sugar-fed moths had lower oxidative damage to their flight muscle membranes than u

289 During assembly of PSII, oxidative damage to vulnerable assembly intermediate com

290 ory effects on the oil metabolisms to avoide oxidative damages to the imbibed seeds, and the seed she

291 ormalities with repressed fuel oxidation and oxidative damage upon high fat diet (HFD).

292 of enzymes and in response to environmental oxidative damage was also demonstrated.

293 Oxidative stress test indicated ZnO-induced oxidative damage was enhanced by thiram that finally res

294 Oxidative damage was observed in livers from Ppargc1a(f/

295 antioxidant treatment to sites of pathologic oxidative damage, we discuss promising therapeutic agent

296 Levels of oxidative damage were unchanged (liver) or reduced (brai

297 ges (hypertrophy, fibrosis, inflammation and oxidative damage) were assessed by echocardiography and

298 urate, protein carbonyl levels, a marker of oxidative damage, were actually reduced in the presence

299 nuclear DNA (nDNA), mtDNA is more exposed to oxidative damage, which may result in double-strand brea

300 Mitochondrial dysfunction and oxidative damage with age are hypothesized to increase r