ライフサイエンスコーパス: oxidized LDL

1 d that the peptides isolated from the Cu(2+)-oxidized LDL all contained kynurenine residues in place

2 peptides with absorbance at 365 nm in Cu(2+)-oxidized LDL not treated with DNPH.

3 The product profile we observed in Cu(2+)-oxidized LDL was remarkably different from the profiles

4 as human plasma, MDA-modified LDL and Cu(2+)-oxidized LDL.

5 llular cholesterol accumulation in humans 3) oxidized LDL, LDL, and cholesterol, but not high-density

6 (IL23A), adrenergic beta-2 receptor (ADRB2), oxidized LDL (lectin-like) receptor 1 (OLR1), and IL-8 r

7 oprostanes (p = 0.065), they failed to alter oxidized LDL or autoantibodies to oxidized LDL.

8 Although oxidized LDL (OxLDL) is thought to contribute to lesion

9 lerotic lesion size ( approximately 40%) and oxidized LDL and macrophage content of the plaques.

10 lpha, tumor necrosis factor [TNF]-alpha, and oxidized LDL [ox-LDL]) by use of Northern blot and ribon

11 w-density lipoprotein (LDL) cholesterol, and oxidized LDL cholesterol decreased significantly, wherea

12 opolysaccharide, native LDL cholesterol, and oxidized LDL-cholesterol stimulation.

13 addition to hyperglycemia, extravasated and oxidized LDL is an important insult to the diabetic reti

14 e proliferator-activated receptor gamma, and oxidized LDL receptors were elevated in the livers of do

15 aATP correlated negatively with glycemia and oxidized LDL.

16 cells were also found to internalize LDL and oxidized LDL (oxLDL) readily.

17 of total cholesterol, and especially LDL and oxidized LDL, improves coronary endothelial function bot

18 t deprivation, free cholesterol loading, and oxidized LDL.

19 observed in APOE4 macrophages after LPS and oxidized LDL activation.

20 phagocytic capacity in response to LPS, and oxidized LDL-induced expression of ApoE and Abca1.

21 density lipoprotein [LDL]), macrophages, and oxidized LDL was performed in retinal sections from four

22 AD decreased malondialdehyde and oxidized LDL at 7 d (35% and 11%, respectively; P < 0.01

23 fect on increasing the binding of native and oxidized LDL to biglycan than versican.

24 tran, and, most importantly, both native and oxidized LDL, resulting in intracellular lipid accumulat

25 wth factors, heavy metals, nitric oxide, and oxidized LDL.

26 FAH), which mediates inactivation of PAF and oxidized LDL.

27 he lipid hydroperoxide-modified proteins and oxidized LDL was confirmed.

28 ipids associated with LDL, HDL (CE, TG), and oxidized LDL (lysophosphatidylcholine, lysoPC).

29 chment of triglyceride-rich lipoproteins and oxidized LDLs, HDL cholesterol fall, adipokine imbalance

30 of large triglyceride-rich lipoproteins and oxidized LDLs, lower HDL cholesterol and adiponectin con

31 increased levels of oxidized lipids (such as oxidized LDL and pro-inflammatory HDL), upregulation of

32 Atherogenic lipoproteins such as oxidized LDL are implicated in the pathogenesis of ather

33 by favoring the formation of pro-atherogenic oxidized LDL.

34 Because oxidized LDL (ox-LDL) is implicated in many proatherogen

35 Because oxidized LDL (oxLDL) is thought to promote atherogenesis

36 Cross talk between oxidized LDL (ox-LDL) and angiotensin II (Ang II) may be

37 lso found on the cell surface where it binds oxidized LDL, an important factor in atherogenesis.

38 o- to threefold higher plasma levels of both oxidized LDL (oxLDL) and cLDL compared with control mice

39 e enhanced tissue factor pathway activity by oxidized LDL, but not the increased mRNA or protein indu

40 vascular plaque buildup is mainly caused by oxidized LDL (ox-LDL) rather than native-LDL.

41 Promoter activity was enhanced by oxidized LDL, and LPS was inhibited by DETA-NO.

42 e factor messenger RNA (mRNA) was induced by oxidized LDL or native LDL; however, native LDL did not

43 within an atherogenic lesion are induced by oxidized LDL.

44 of calcium flux suppressed SR-A induction by oxidized LDL.

45 ver, upregulation of TLR-4 in macrophages by oxidized LDL suggests that TLR-4 may provide a potential

46 Activation of monocyte/macrophages (M/Ms) by oxidized LDL further increased ALP activity in coculture

47 re induced by lipopolysaccharide (LPS) or by oxidized LDL but not native LDL.

48 phore greatly enhanced SR-A up-regulation by oxidized LDL or other treatments that promote intracellu

49 Many cell functions are altered in vitro by oxidized LDL, but few have been examined in vivo.

50 oxidative stress indexes (protein carbonyls, oxidized LDLs, and 8-iso-prostaglandin-F(2alpha)) were m

51 ased SR-A gene transcription induced by cell-oxidized LDL up-regulated SR-A mRNA and increased by 30-

52 In THP-1 cells, oxidized LDL induced monocyte-to-macrophage differentiat

53 Cholesterol (oxidized LDL) uptake and accumulation were markedly incr

54 d NAD(P)H oxidase expression and circulating oxidized LDL, suggesting a potential for increased oxida

55 ma was due to a 260% increase of circulating oxidized LDL (oxLDL) binding to its receptor, LOX-1, and

56 min E levels (P<0.0001), reduced circulating oxidized LDL (P=0.03), and reduced LDL oxidative suscept

57 d human subjects, they show that circulating oxidized LDL and circulating monocyte-derived tissue fac

58 In conclusion, oxidized LDL-mediated PGIS nitration and associated thro

59 In contrast, oxidized LDL (OxLDL), which is mainly formed in the aort

60 o malondialdehyde-LDL also recognized copper oxidized LDL, acrolein-LDL, or LDL modified by arachidon

61 Copper-oxidized LDL (Cu-OxLDL) was able to compete with 125I-Mo

62 Copper-oxidized LDL also increased SR-A receptor expression.

63 Levels of IgG antibodies against copper-oxidized LDL were lower in sIgM.Ldlr(-/-) mice fed a hig

64 low-density lipoprotein (MDA-LDL) and copper-oxidized LDL (Cu-OxLDL) were measured in 765 subjects in

65 dies to malondialdehyde (MDA)-LDL and copper-oxidized LDL (Cu-OxLDL), and apolipoprotein B-100-immune

66 centrations of native LDL (n-LDL) and copper-oxidized LDL.

67 r ERK activation than that induced by copper-oxidized LDL +/- glycation (P < 0.05).

68 d and internalized more than 60% less copper-oxidized LDL and LDL modified by monocyte-generated reac

69 EC) uptake of experimentally prepared copper-oxidized LDL (oxLDL).

70 IgG and IgM autoantibodies binding to copper-oxidized LDL, 4-hydroxynonenal-LDL, acrolein-LDL, and LD

71 HAECs were incubated with copper-oxidized LDL, and the supernatant was subsequently purif

72 Compared with copper-oxidized LDL, L5 was only mildly oxidized, although its

73 DL had little effect, incubation with either oxidized LDL or LPS/TNF-alpha significantly increased su

74 HL does, however, enhance oxidized LDL uptake by peritoneal macrophages.

75 In contrast, extensively oxidized LDL and acetyl-LDL, which are more electronegat

76 elative effect on the binding of extensively oxidized LDL to proteoglycans compared with native LDL.

77 isms of OxLDL were obtained with extensively oxidized LDL unlikely to occur in early stages of athero

78 heat-denatured enzymes, oxidized fibrinogen, oxidized LDL, and native or oxidized amyloid beta-peptid

79 at acidic pH, displays binding activity for oxidized LDL (ox-LDL).

80 t least some of the macrophage receptors for oxidized LDL can recognize both the lipid and the protei

81 Data support a proatherogenic role for oxidized LDL in atherosclerosis and several studies show

82 present in oxidized LDL, lipid extracts from oxidized LDL were fractionated by normal phase HPLC.

83 ively fragmented phospholipids isolated from oxidized LDL, a synthetic oxidized alkylphospholipid (az

84 fractions containing lysophospholipids from oxidized LDL or phospholipase A2-treated native LDL stim

85 However, neither conditioned medium from oxidized-LDL-activated M/Ms or transwell coculture had t

86 Glucose-oxidized LDL resulted in phosphorylation of extracellula

87 The mitogenic effect of glucose-oxidized LDL was mediated by CD36 and by extracellular s

88 Hence, oxidized LDL administered in vivo can injure the endothe

89 in monocytes in vitro in response to highly oxidized LDL but not minimally modified LDL.

90 In ARPE19 cells and HMVECs, oxidized LDL and 7kCh induced VEGF 8- to 10-fold above c

91 Consonant with this hypothesis, HOCl oxidized LDL cholesterol in the presence of Cl- and at a

92 sults of recent studies that demonstrate how oxidized LDL affects cellular function, and highlights k

93 Extensively copper- and hypochlorite-oxidized LDL bound poorly to versican and biglycan.

94 sed HLA II and CD11c expression and impaired oxidized LDL uptake.

95 lysoPC was consistent with its abundance in oxidized LDL.

96 )-PAF analogs were 100-fold more abundant in oxidized LDL than PAF.

97 re the likely source of PAF-like activity in oxidized LDL.

98 them to previously undetectable agonists in oxidized LDL.

99 cero-3-phosphocholines (C(4)-PAF analogs) in oxidized LDL that comigrated with PAF-like activity.

100 usive precursors for PAF-like bioactivity in oxidized LDL.

101 an atherogenic lysophospholipid contained in oxidized LDL, rapidly induces P-selectin expression in b

102 e present review is that oxysterols found in oxidized LDL (oxLDL) play a role in atherogenesis.

103 These studies demonstrate that lysoPC in oxidized LDL limit EC wound healing responses in vitro,

104 We identified mediators in oxidized LDL that induced an inflammatory reaction in vi

105 lipid) was a major antimigratory molecule in oxidized LDL.

106 r the formation of modified phospholipids in oxidized LDL remain poorly understood.

107 lude oxidatively fragmented phospholipids in oxidized LDL.

108 ocholesterol, the major oxysterol present in oxidized LDL and atherosclerotic lesions, in Abcg1(+/+),

109 antimigratory activity of lysoPC present in oxidized LDL, lipid extracts from oxidized LDL were frac

110 hese proteins can play a significant role in oxidized LDL uptake by activated macrophages in vitro an

111 of low-density lipoprotein (LDL), including oxidized LDL and acetylated LDL, but not native LDL.

112 esponse to oxidized phospholipids, including oxidized LDL.

113 o a number of immobilized proteins including oxidized LDL, IgG, amyloid beta peptide 1-42, C4b-bindin

114 ls specific for lesional antigens, including oxidized LDLs and heat shock protein 60 (HSP60), may pro

115 bility to macromolecules in vivo, we infused oxidized LDL, native LDL, or their solvent intravenously

116 with native LDL or solvent control infusion, oxidized LDL infusion increased (1) the number of injure

117 n monocyte-derived macrophages that ingested oxidized LDL, while enhancing high-density lipoprotein-s

118 kinase C activity by phorbol ester inhibited oxidized LDL- and lysoPC-induced DNA synthesis.

119 last growth factor-2 significantly inhibited oxidized LDL and lysoPC-induced DNA synthesis in SMC; ir

120 Interestingly, oxidized LDL induced more ABCA1 in wild type macrophages

121 Intraretinal oxidized LDL was absent in nondiabetic subjects but pres

122 a superoxide scavenger, reduced intraretinal oxidized LDL and glycated LDL levels, PGIS nitration, an

123 bited EC movement to the same extent as iron-oxidized LDL and antimigratory activity correlated with

124 C and uptake at 37 degrees C of 125I-labeled oxidized LDL by activated THP-1 cells was inhibited by 3

125 P, but not by low-density lipoprotein (LDL), oxidized LDL, VLDL, apoC-I, apoC-III, or heparin.

126 ncluding fasting apoB, LDL, small dense LDL, oxidized LDL, and postprandial concentrations of remnant

127 (DKO) were treated with control LDL, GV-LDL, oxidized LDL (ox-LDL) or LDL aggregated by vortexing (vx

128 They took-up less oxidized LDL, whereas CD11c expression, interaction with

129 itive inhibition with the SR-binding ligands oxidized LDL and malondialdehyde-acetaldehyde-modified L

130 Like oxidized LDL, LGE2-LDL, but not native LDL, undergoes re

131 ardiomyocytes in relation to the lectin-like oxidized LDL receptor (LOX-1).

132 The lectin-like oxidized LDL receptor LOX-1 mediates endothelial cell (E

133 vate platelets via its receptor, lectin-like oxidized LDL receptor-1 (LOX-1), and alphabeta amyloid p

134 iation of 3 polymorphisms in the lectin-like oxidized LDL receptor-1 (LOX1 or OLR1) gene with coronar

135 t-activating factor receptor and lectin-like oxidized LDL receptor-1 to attenuate Akt activation and

136 including TLR9, pentraxin-3, and lectin-like oxidized LDL receptor-1, was regulated, in part, via a M

137 human DCs via DC-ASGPR, but not lectin-like oxidized-LDL receptor, Dectin-1, or DC-specific ICAM-3-g

138 her total antioxidant status (TAS) and lower oxidized LDL as expected.

139 Therefore, we measured oxidized LDL (oxLDL), advanced glycation end products-mo

140 clustering-responsive receptor that mediates oxidized LDL uptake by macrophages.

141 ociated phospholipase A2 (Lp-PLA2), Mercodia oxidized LDL (OxLDL) with antibody 4E6, oxidized phospho

142 Mildly oxidized LDL also activated MAP and Jun kinases and incr

143 Mildly oxidized LDL and methyl-LDL, which have an electrophoret

144 We conclude that: (a) mildly oxidized LDL can induce an increased apoJ/PON ratio, and

145 results suggest that HO-1 induced by mildly oxidized LDL may protect against the induction of inflam

146 isoform of HO, was highly induced by mildly oxidized LDL, and augmented induction was observed with

147 dicate that a highly electronegative, mildly oxidized LDL subfraction present in human hypercholester

148 important, they demonstrate that even mildly oxidized LDL formed in atherosclerotic lesions may activ

149 These findings support a role for mildly oxidized LDL in the redox regulation of macrophage diffe

150 Injection of mildly oxidized LDL (but not native LDL) into BL/6 mice (but no

151 roxidation, reverses the oxidation of mildly oxidized LDL (MM-LDL), and inhibits the ability of MM-LD

152 l nature, the mitogenic components of mildly oxidized LDL (moxLDL) remain unclear.

153 We have examined the effects of mildly oxidized LDL and atherosclerosis on the levels of two pr

154 We now demonstrate that mildly oxidized LDL generated by incubation with oxygen radical

155 Oxidized phospholipids in the mildly oxidized LDL appear to be responsible for HO-1 induction

156 atment of HepG2 cells in culture with mildly oxidized LDL (but not native LDL) resulted in reduced mR

157 here it was induced by treatment with mildly oxidized LDL (moxLDL) and IFN-gamma.

158 al lipopolysaccharide (LPS) and by minimally oxidized LDL (mmLDL), as a model for subclinical endotox

159 inding was effectively competed by minimally oxidized LDL but not by native LDL.

160 (IL)-1beta and IL-6 as well as by minimally oxidized LDL.

161 e ability of the cells to generate minimally oxidized LDL.

162 dentical to those present in human minimally oxidized LDL and in murine atherosclerotic lesions.

163 We have developed a model of minimally oxidized LDL (mmLDL) in which native LDL is modified by

164 h of treatment with as little as 5 microg/ml oxidized LDL.

165 ncubated with native LDL (50 micrograms/mL), oxidized LDL (30 micrograms/mL), or lipopolysaccharide (

166 Except where noted, 125I-labeled moderately oxidized LDL (ModOxLDL) was prepared by long term storag

167 PC), a major component of minimally modified/oxidized-LDL (MM-LDL) mimics the biological activities a

168 ssociated phospholipase A2, myeloperoxidase, oxidized LDL, lipoprotein (a), isoprostanes, and small,

169 C. pneumoniae in the presence or absence of oxidized LDL, then measured foam cell formation.

170 Scavenger receptor-mediated accumulation of oxidized LDL (OxLDL)-derived cholesteryl ester is consid

171 arteries from the pro-inflammatory action of oxidized LDL.

172 beta(2)GP1 as well as to delipidated apoB of oxidized LDL but not to native apoB.

173 ry wall might increase the atherogenicity of oxidized LDL, since it enables its binding to vascular b

174 lipoprotein regulation given its binding of oxidized LDL in vitro and its colocalization to a region

175 e data suggest that the increased binding of oxidized LDL to LPL-ECM may be due to the exposure of no

176 correlates with increased negative charge of oxidized LDL and with a moderate increase in thioflavin

177 atidylcholine (lysoPC), a lipid component of oxidized LDL, has an important role in the antimigratory

178 ic acid metabolites, which are components of oxidized LDL found in large amounts in atherosclerotic p

179 dylcholine (lyso-PC), abundant components of oxidized LDL, mediate the effects of atherogenic lipids.

180 (pravastatin) therapy reduced the content of oxidized LDL, inflammatory cells (macrophage, T cells) i

181 Accordingly, we studied the effects of oxidized LDL (oxLDL) or tumor necrosis factor-alpha (TNF

182 Thus, C. pneumoniae augments the effects of oxidized LDL on cell death independent of a sustained in

183 on, protect against the cytotoxic effects of oxidized LDL, and inhibit platelet activation.

184 monoclonal antibodies to various epitopes of oxidized LDL ("E0 antibodies").

185 dative stress (autoantibodies to epitopes of oxidized LDL, F2-isoprostanes, 8-hydroxy-2'-deoxyguanosi

186 rs to various oxidation-specific epitopes of oxidized LDL, including OxPLs containing phosphorylcholi

187 We separated total lipid extracts of oxidized LDL using high-performance liquid chromatograph

188 hological sequence leading from formation of oxidized LDL in the artery wall to cellular dysfunction

189 ipoproteins, particularly different forms of oxidized LDL (ox-LDL), have been reported to elicit humo

190 One proposed mechanism involves fusion of oxidized LDL in the arterial wall; another involves oxid

191 arterial proteoglycans, facilitate fusion of oxidized LDL in vivo.

192 orescence (NIRF) approach for the imaging of oxidized LDL in atherosclerosis.

193 -60, and a change in T-dependent isotypes of oxidized LDL-specific antibodies.

194 rcholesterolemia leads to elevated levels of oxidized LDL (oxLDL) in plasma and that this induces exp

195 expression could link the elevated levels of oxidized LDL and fibrin deposition known to precede CAV.

196 s, diabetes increased intraretinal levels of oxidized LDL and glycated LDL, induced PGIS nitration, e

197 Levels of oxidized LDL and Lp(a) lipoprotein were measured in a to

198 Levels of oxidized LDL are reported as the oxidized phospholipid c

199 Circulating levels of oxidized LDL are strongly associated with angiographical

200 the constituents and molecular mechanisms of oxidized LDL-mediated HO-1 induction, human renal epithe

201 The moiety of oxidized LDL that stimulates DNA synthesis and the cellu

202 In monocytes cultured in the presence of oxidized LDL, strong induction and colocalization of TF

203 fected with C. pneumoniae in the presence of oxidized LDL.

204 A range of oxidized LDL species is thus generated, ultimately resul

205 his was evidenced by the cross-reactivity of oxidized LDL with antibodies against hemoglobin that was

206 inflammation is triggered by recognition of oxidized LDL (oxLDL) by Kupffer cells (KCs).

207 due to its ability to block the retention of oxidized LDL in vivo.

208 Hypoxic lipid accumulation and storage of oxidized LDL, cholesteryl esters and triglycerides were

209 Accordingly, treatment of oxidized LDL with phospholipase A(1) greatly reduced pho

210 ation that occurs depends upon the uptake of oxidized LDL (Ox-LDL), a process in which the scavenger

211 oxidized phospholipids, blocks the uptake of oxidized LDL (OxLDL) by macrophages.

212 lso discovered that CD36-dependent uptake of oxidized LDL (oxLDL) in vitro and foam cell formation in

213 TZDs markedly stimulate the uptake of oxidized LDL (oxLDL) into adipocytes, and this requires

214 of CD36 expression and macrophage uptake of oxidized LDL (oxLDL).

215 PPARalpha(-/-) mice had increased uptake of oxidized LDL and decreased cholesterol efflux.

216 er receptor (MSR), involved in the uptake of oxidized LDL, binds a variety of polyanionic ligands, an

217 b) mice have increased binding and uptake of oxidized LDL, in part due to a post-transcriptional incr

218 and atherogenesis by mediating the uptake of oxidized LDL.

219 Generation of oxidized LDLs and reduced nitric oxide (NO) availability

220 xamined the tissue-specific effects of AT on oxidized LDL (ox-LDL)-mediated endothelial dysfunction i

221 tudy evaluated the impact of atorvastatin on oxidized LDL (OxLDL) in patients with acute coronary syn

222 xidation-specific epitopes (OSE), present on oxidized LDL (OxLDL), apoptotic cells, cell debris and m

223 we determined the effect of rosiglitazone on oxidized LDL (oxLDL)-induced apoptosis.

224 sis when challenged with free cholesterol or oxidized LDL loading.

225 induced by loading with free cholesterol or oxidized LDL.

226 n in the RPE, induced by vitamin A dimers or oxidized LDL, inhibits these defense mechanisms by activ

227 ae, human heat-shock protein 60 (hHSP60), or oxidized LDL (ox-LDL).

228 There was no difference in hsCRP or oxidized LDL concentrations after egg doses.

229 xposed to LPS (10 microg/mL), native LDL, or oxidized LDL (30 microg/mL) for 6 hours.

230 POE4 macrophages when stimulated with LPS or oxidized LDL.

231 rated by platelet-activating factor (PAF) or oxidized LDL that acts as a PAF mimetic.

232 to platelet-derived growth factor (PDGF) or oxidized LDL (oxLDL) (p < 0.0001).

233 se and 24-h postdose serum hsCRP, and plasma oxidized LDL were measured.

234 Previously oxidized LDL aggregated rapidly and spontaneously at pH

235 et of fluid flow, atherogenic flow profiles, oxidized LDL, and proatherosclerotic cytokines all stimu

236 erogenic lipoprotein that, unlike profoundly oxidized LDL (OxLDL), is not recognized by scavenger rec

237 expression by small-interfering RNA promoted oxidized-LDL-mediated monocyte adhesion to ECs, EC migra

238 eptide, high-sensitivity C-reactive protein, oxidized LDL antibody, soluble receptor tumor necrosis f

239 or CD36, has been shown previously to reduce oxidized LDL uptake in vitro and atherosclerotic lesions

240 We also observed reduced oxidized LDL uptake and increased cholesterol efflux by

241 20 mumol/liter of rosiglitazone reduced oxidized LDL-induced apoptosis by 40% and neutralizing a

242 muli, including shear stress, cyclic strain, oxidized LDL, hyperglycemia, and cell growth, modulate e

243 Plasma markers of oxidant stress (oxidized LDL and autoantibodies) were also measured.

244 ghly analogous to acetylated LDL rather than oxidized LDL.

245 However, direct evidence that oxidized LDL causes atherosclerosis is lacking.

246 and in vitro migration assays, we found that oxidized LDL (oxLDL), but not native LDL, inhibited migr

247 It is hypothesized that oxidized LDL exposes similar molecular patterns recogniz

248 We hypothesized that oxidized LDL mediated the activation of the tissue facto

249 Although there is the possibility that oxidized LDL activates the NLRP3 inflammasome in vivo, o

250 Here we show that oxidized LDL and amyloid-beta trigger inflammatory signa

251 We previously showed that oxidized LDL (oxLDL) formed in the setting of hyperlipid

252 e evidence has been accumulated showing that oxidized LDL promotes pro-atherogenic events.

253 These results suggest that oxidized LDL and its lysoPC moiety stimulate SMC to ente

254 gether with biglycan or versican allowed the oxidized LDL to bind the proteoglycans in an LPL dose-de

255 atory transcription factor NFkappaB, and the oxidized LDL receptor LOX-1.

256 ion of molecular mechanisms that involve the oxidized LDL receptor (LOX-1), endothelial localized nit

257 rosclerotic lesions, where MafB mediates the oxidized LDL-activated LXR/RXR-induced expression of apo

258 rkers of LDL oxidation such as antibodies to oxidized LDL (Ab-OxLDL) and LDL-containing immune comple

259 ical role in the production of antibodies to oxidized LDL and consequently in the formation of LDL-co

260 Monoclonal antibodies to oxidized LDL, cloned from the apo E-deficient mice, also

261 (PK) of a human recombinant IgG1 antibody to oxidized LDL (anti-oxLDL) in cynomolgus monkey.

262 B cells and significantly higher antibody to oxidized LDL and cardiolipin.

263 rate diminished plasma IgG autoantibodies to oxidized LDL epitopes in 12/15-lipoxygenase knockout mic

264 d to alter oxidized LDL or autoantibodies to oxidized LDL.

265 lower titers of plasma IgG autoantibodies to oxidized LDL.

266 6 modulates platelet function via binding to oxidized LDL (oxLDL), cell-derived microparticles, and t

267 CD36 binding to oxidized LDL triggers signaling cascades that are requir

268 We now report that CRP binds to oxidized LDL (OxLDL) and oxidized PtC (OxPtC), but does

269 ester accumulation in macrophages exposed to oxidized LDL and that mice with deletions of either rece

270 alternatively stimulated and then exposed to oxidized LDL.

271 tent of LDL; however, the addition of LPL to oxidized LDL together with biglycan or versican allowed

272 The immune response to oxidized LDL (OxLDL) may play an important role in ather

273 ipate in macrophage signaling in response to oxidized LDL.

274 did not affect endothelial cell responses to oxidized LDL, but lesion formation was partially reduced

275 Here, we show that the single-transmembrane oxidized LDL (oxLDL) receptor (LOX-1) resides in proximi

276 stress or pathways involved in transmitting oxidized LDL-mediated signals in circulating platelets a

277 outcomes including plasma triacylglycerols, oxidized LDL, and LDL cholesterol.

278 rs including 15-lipoxygenase and lectin-type oxidized LDL receptor-1 both in vitro and in vivo.

279 However, unlike oxidized LDL, C. pneumoniae infection does not activate

280 r receptor PPARgamma dramatically upregulate oxidized LDL receptor 1 (OLR1) in adipocytes by facilita

281 ), by AT(1) receptor activation, upregulates oxidized LDL (ox-LDL) endothelial receptor LOX-1 gene ex

282 Using oxidized LDL as a representative protein ligand for H2O2

283 udy assesses whether oxidative stress, using oxidized LDL (ox-LDL) as a proxy, is associated with met

284 in cultured DRG neurons from adult rat using oxidized LDLs (oxLDLs).

285 same products are also detected in in vitro oxidized LDL.

286 cells express cyclooxygenase-2, but the way oxidized LDL stimulates cyclooxygenase-2 transcription i

287 ify the specific oxidative modifications, we oxidized LDL in the presence of Cu(2+), treated with DNP

288 To test whether oxidized LDL could injure endothelial cells and alter en

289 gress in delineating the mechanisms by which oxidized LDL effects changes in gene expression will be

290 lipoprotein (LDL) is non-atherogenic, while oxidized LDL (ox-LDL) is critical to atherosclerosis.

291 Incubation of endothelial cells with oxidized LDL (OxLDL) or lysolecithin resulted in decreas

292 68) fractions were inversely correlated with oxidized LDL, IL-10, IL-6, and C-reactive protein.

293 estigated whether maternal immunization with oxidized LDL (OxLDL) before pregnancy protects the fetus

294 assessed in bovine aortic ECs incubated with oxidized LDL (ox-LDL).

295 context of their potential interactions with oxidized LDL and atherogenesis.

296 ) macrophages, especially after loading with oxidized LDL.

297 Moreover, stimulation with oxidized LDL induced dramatically greater gene expressio

298 appaB binding to DNA by prior treatment with oxidized LDL.

299 ntibodies, which bind the PC of OxPLs within oxidized LDL (OxLDL), also reduces atherogenesis.