ライフサイエンスコーパス: oxidized glutathione

1 against either gamma-glutamyl amino acids or oxidized glutathione.

2 y measures the total GSH pool, including the oxidized glutathione.

3 g can be further promoted by the presence of oxidized glutathione.

4 n assembly required microsomal membranes and oxidized glutathione.

5 nor NOC12, with no effect in the presence of oxidized glutathione.

6 rodes (GCE) for the detection of reduced and oxidized glutathione.

7 d via treatment of organotypic cultures with oxidized glutathione.

8 ncentrations, compared to in the presence of oxidized glutathione.

9 peroxidase, and higher ratios of reduced to oxidized glutathione.

10 edox balance to a higher ratio of reduced to oxidized glutathione.

11 higher concentrations of SAH, adenosine, and oxidized glutathione.

12 P fused to sensor domains to measure H2O2 or oxidized glutathione.

13 related with a decreased ratio of reduced to oxidized glutathione.

14 he production of reactive oxygen species and oxidized glutathione.

15 by elevations in lung lipid peroxidation and oxidized glutathione.

16 ontrol, 15.75+/-4.33 micromol/g, P<0.0005; % oxidized glutathione, 4.49+/- 1.87% versus control, 22.8

17 In agreement, the ratio of reduced:oxidized glutathione, a major antioxidant and indicator

18 o our mimetic peptide with its reactivity to oxidized glutathione, a nonspecific substrate.

19 for 24 h) resulted in marked GSH depletion, oxidized glutathione accumulation, hydroxyl radical gene

20 The oxidized glutathione-activated TRPC5-like current result

21 Decreasing the ratio of reduced to oxidized glutathione also promoted select disulfide bond

22 Decyl-GS, metolachlor-GS, and oxidized glutathione, although competitive with DNP-GS,

23 3-fold greater steady state concentration of oxidized glutathione and a 3-fold increase in pro-oxidan

24 , and there was an increase in mitochondrial oxidized glutathione and a decrease in mitochondrial red

25 For two reagents with net charges, oxidized glutathione and cystamine, however, the apparen

26 d generation of both reduced glutathione and oxidized glutathione and enhanced production of reactive

27 was refolded in the presence of reduced and oxidized glutathione and further purified by using two i

28 ctase (glr1 delta) accumulate high levels of oxidized glutathione and have a twofold increase in tota

29 was conducted on p21ras S-glutathiolated by oxidized glutathione and identified C118 as the major si

30 lfide bond reduction using dithiothreitol on oxidized glutathione and insulin show reactive-ELDI to b

31 CT elevated tissue levels of oxidized glutathione and lipid peroxides and elicited sm

32 12 dissociation; however, in the presence of oxidized glutathione and NOC12, FKBP12 dissociation was

33 The levels of reduced and oxidized glutathione and pyridine nucleotides in rods we

34 eline levels of tissue AGER1 and glutathione/oxidized glutathione and reduced plasma 8-isoprostanes a

35 indicative of oxidative stress, including % oxidized glutathione and steady-state levels of pro-oxid

36 ted into a denaturant-free buffer containing oxidized glutathione and the nonionic detergent octyl gl

37 nidine HCl, 20% glycerol, 2.5 mM reduced and oxidized glutathione, and 5 mM CaCl2, followed by buffer

38 thione (gamma-L-glutamyl-cysteinyl-glycine), oxidized glutathione, and glutathione S-conjugates.

39 ss in roots, as indicated by accumulation of oxidized glutathione, and induced expression of a gene e

40 s of total glutathione, reduced glutathione, oxidized glutathione, and intracellular reactive oxygen

41 lutathione analog azidophenacyl-glutathione, oxidized glutathione, and the LTD4 antagonist MK571 were

42 n, decreased ratio of reduced glutathione to oxidized glutathione, and up-regulation of superoxide di

43 High levels of oxidized glutathione are also observed in a trx1 delta,

44 carbonyls, protein methionine sulfoxide, and oxidized glutathione as well as reduced levels of free a

45 Oxidized glutathione, as a sole source of cysteine, also

46 The ratio of reduced to oxidized glutathione, as well as the level of free thiol

47 rather than changes in reduced glutathione, oxidized glutathione, ascorbate and dehydroascorbate con

48 e find that, in contrast, the maintenance of oxidized glutathione at low concentrations is the main f

49 show that restoring the ratio of reduced to oxidized glutathione blocks the glucocorticoid effects o

50 ted in the active site of both enzymes using oxidized glutathione bound to GR as a template.

51 or), and high-energy phosphates, reduced and oxidized glutathione (chromatography), and I/R injury we

52 reduced glutathione and increased levels of oxidized glutathione compared with normal CD34(+) cells.

53 rease in the ratio of reduced glutathione to oxidized glutathione consistent with a 1.6-fold increase

54 rease in dihydrofluorescein fluorescence and oxidized glutathione content between 0 and 8 h after rel

55 idative stress response gene expression, and oxidized glutathione content.

56 xidase and isomerase activity of reduced and oxidized glutathione, Cys, Cys-Cys, and reduced and oxid

57 es several nitrogen-containing compounds and oxidized glutathione derivatives.

58 TR/GR-null livers cannot reduce oxidized glutathione disulfide using NADPH but still req

59 ternal reducing agent, or in the presence of oxidized glutathione, DTNB-reactive thiols of the plasma

60 Hepatic ratios of reduced:oxidized glutathione, established regulators of gluconeo

61 ial cells, and increased reduced glutathione/oxidized glutathione following Cl2 exposure whereas CysL

62 nes with the concomitant oxidation of GSH to oxidized glutathione (GS-SG).

63 -related decrease in the ratio of reduced to oxidized glutathione (GSH/GSSG) as well as a pro-oxidizi

64 marker profiles, tissue-reduced glutathione/oxidized glutathione (GSH/GSSG) ratio and oxidative dama

65 creased GSH content, the ratio of reduced to oxidized glutathione (GSH/GSSG), chlorophyll content, ph

66 of oxidative stress, the ratio of reduced to oxidized glutathione (GSH/GSSG), in a well-controlled st

67 obe, in concert with measurements of reduced/oxidized glutathione (GSH/GSSG), to assess cytosolic red

68 rease in the ratio of reduced glutathione-to-oxidized glutathione (GSH/GSSG), which preceded DNA frag

69 tial due to an increased ratio of reduced to oxidized glutathione (GSH/GSSG).

70 ecrosis factor (TNF)-alpha after 4 hours and oxidized glutathione (GSSG) after 8 hours indicated deve

71 in lung epithelium as well as the amount of oxidized glutathione (GSSG) and 4-hydroxynonenal (4-HNE)

72 Diamide caused a rapid increase in oxidized glutathione (GSSG) and a loss of mitochondrial

73 = 27 microM, Kii = 48 microM with respect to oxidized glutathione (GSSG) and Kis = 144 microM, Kii =

74 Determinations of oxidized glutathione (GSSG) and reduced glutathione (GSH

75 protein thiols) and intracellularly [altered oxidized glutathione (GSSG) and reduced glutathione leve

76 Similar channel inhibition was seen with oxidized glutathione (GSSG) and thiol-modulating reagent

77 Import of oxidized glutathione (GSSG) by S. mutans 33402 in 7H9 me

78 ges in endothelial cell glutathione (GSH) or oxidized glutathione (GSSG) can alter neutrophil adhesiv

79 Glutathione (GSH) and oxidized glutathione (GSSG) control cellular function an

80 , one possible mechanism being inhibition of oxidized glutathione (GSSG) export from the infected hum

81 lfide bonds by thiol/disulfide exchange with oxidized glutathione (GSSG) has been characterized.

82 cubation of (67)Zn(7)-MT-2 with an excess of oxidized glutathione (GSSG) increased metal donation fou

83 reversed translational inhibition caused by oxidized glutathione (GSSG) or heat shock.

84 0 micromol/L) and cysteinyl-glycine, but not oxidized glutathione (GSSG) or OTC, blunted the LPS-indu

85 Exposure of the Na,K-ATPase to oxidized glutathione (GSSG) resulted in an increase in t

86 ), an enzyme that catalyzes the reduction of oxidized glutathione (GSSG) to GSH in the presence of be

87 idative stress cells show an increase in the oxidized glutathione (GSSG) to reduced glutathione (GSH)

88 pathic hearts show an increased recycling of oxidized glutathione (GSSG) to reduced glutathione (GSH)

89 responses for reduced glutathione (GSH) and oxidized glutathione (GSSG) were linear over more than f

90 ular levels of reduced glutathione (GSH) and oxidized glutathione (GSSG) were measured by HPLC.

91 During chilling stress, levels of oxidized glutathione (GSSG) were significantly higher in

92 sicular entry has come from the formation of oxidized glutathione (GSSG) within the interior of the v

93 l and channel activity with those induced by oxidized glutathione (GSSG), a cytosolic product of oxid

94 mine the concentrations of reduced (GSH) and oxidized glutathione (GSSG), and it enables the calculat

95 re assayed for reduced glutathione (GSH) and oxidized glutathione (GSSG), by the sensitive enzymatic

96 GSH, oxidized glutathione (GSSG), cysteine, GSH efflux, DNA s

97 f glucose, sorbitol, fructose, myo-inositol, oxidized glutathione (GSSG), glycolytic intermediates, m

98 nstrated that high ROS levels, via increased oxidized glutathione (GSSG), induce isoform-specific S-g

99 Increasing the flux of O-2 yielded oxidized glutathione (GSSG), peaking when the flux of NO

100 eumoniae-exposed mice had elevated levels of oxidized glutathione (GSSG), resulting in a dramatic cha

101 lfhydryl group, S-hexylglutathione (SHG) and oxidized glutathione (GSSG), were inactive per se but at

102 PC), and to react with entrapped GSH to form oxidized glutathione (GSSG).

103 also as a by-product of increased levels of oxidized glutathione (GSSG).

104 ion (thiolation) promoted by the presence of oxidized glutathione (GSSG).

105 ase activity could be fully reactivated with oxidized glutathione (GSSG).

106 ress because they had significantly elevated oxidized glutathione (GSSG).

107 tathione (GSx) within 8 h, without change in oxidized glutathione (GSSG); no effect was seen in pure

108 n value for the [reduced glutathione (GSH)]/[oxidized glutathione (GSSG)] ratio was significantly dec

109 Oxidized glutathione(GSSG) was a much less effective inh

110 Oxidized glutathione, (GSSG) has also been found to inhi

111 utathione in the liver and lowered levels of oxidized glutathione in both liver and blood.

112 levels and an increased ratio of reduced-to-oxidized glutathione in mitochondria.

113 ) and could therefore be oxidized rapidly by oxidized glutathione in the cytosol.

114 hiols and the relative levels of reduced and oxidized glutathione in the ER to control Ero1p activity

115 equently the equilibrium between reduced and oxidized glutathione in the lumen of these compartments.

116 tion in GLR1 drastically increases levels of oxidized glutathione in these two subcellular compartmen

117 lower redox ratio of reduced glutathione to oxidized glutathione) in children with autism.

118 eous increases in the levels of cysteine and oxidized glutathione, in addition to reduced glutathione

119 SSG redox ratio was decreased and percentage oxidized glutathione increased in both cytosol and mitoc

120 ge glutathione levels or ratio of reduced to oxidized glutathione (indicative of oxidative stress) in

121 fide couple of reduced glutathione (GSH) and oxidized glutathione is a key regulator of major transcr

122 e, in protection against chlorine compounds, oxidized glutathione is almost as effective as reduced g

123 ta provides in vivo evidence suggesting that oxidized glutathione is present in the E. coli periplasm

124 ed glutathione as is its drug transport, and oxidized glutathione, itself a substrate for transport,

125 Intracellular oxidized glutathione leads to TRPC5 activation via TRPC5

126 lung lavage fluid, and increased (P < 0.05) oxidized glutathione levels in the lung lavage fluid.

127 between study groups were observed in either oxidized glutathione levels or redox index (P > 0.05, F

128 young human alphaL-crystallin fractions with oxidized glutathione, levels of PSSG were determined by

129 -10 mM) in phosphate buffer (pH 7.4) yielded oxidized glutathione, nitrite, nitrous oxide, and ammoni

130 Relative to oxidized glutathione, NOV-002 was an equivalent substrat

131 other oxidants such as hydrogen peroxide and oxidized glutathione on the oxidation of this protein in

132 M, one to two orders of magnitude less than oxidized glutathione or any other glutathione derivative

133 xymethylated bovine serum albumin, RCM-BSA), oxidized glutathione or Hg2+.

134 Treatment of A. thaliana seedlings with oxidized glutathione or paraquat induces APS reductase a

135 ccurs through thiol-disulphide exchange with oxidized glutathione or reaction of oxidant-induced prot

136 on to all GS conjugates and not simulated by oxidized glutathione or reduced glutathione.

137 activity against other disulphides, such as oxidized glutathione or thioredoxin.

138 after incubation with the oxidants diamide, oxidized glutathione, or hydrogen peroxide or with nitri

139 centrations of homocysteine (P < 0.0001) and oxidized glutathione (P < 0.0001) than did controls.

140 r glutathione, which reduces the Cys-SeOH of oxidized glutathione peroxidase, was able to reduce the

141 rotein oxidation and a decreased glutathione/oxidized glutathione ratio were observed, but the opposi

142 ated in HKCs, while arginine and glutathione/oxidized glutathione ratio were reduced.

143 s was evidenced by a decrease in the reduced oxidized/glutathione ratio, imbalance of cellular antiox

144 decreased cellular NADPH/NADP(+) and reduced/oxidized glutathione ratios (GSH/GSSG) and increased cel

145 In addition, higher glutathione/oxidized glutathione ratios suggested that microprobed c

146 s, smt15-1 cells had an increased reduced-to-oxidized glutathione redox ratio throughout the cell cyc

147 es that of cysteine, whereas the spectrum of oxidized glutathione resembles that of cystine.

148 wed that incubation of alpha-crystallin with oxidized glutathione results in significant loss of its

149 Using oxidized glutathione S-transferase as a model substrate,

150 ice had less pulmonary neutrophil influx and oxidized glutathione than wild-type littermates at 7 day

151 Oxidized glutathione, the drug-glutathione S-conjugate D

152 t was competitively inhibited by reduced and oxidized glutathione, the glutathione conjugates S-(p-az

153 city, the drug glutathione conjugate APA-SG, oxidized glutathione, the LTD4 antagonist MK571, arsenat

154 ione, formed by disulfide rearrangement with oxidized glutathione to inhibit and stabilize the enzyme

155 on; reduced Trx reacts nonenzymatically with oxidized glutathione to maintain a high glutathione/glut

156 ne reductase (GR) catalyzes the reduction of oxidized glutathione to reduced glutathione.

157 Plasma concentrations of reduced and oxidized glutathione, vitamin B-6, homocysteine, cystein

158 However, the K(m) values for oxidized glutathione were 9muM for GGT1 and 43muM for GG

159 ELF and the concentration of glutathione and oxidized glutathione were determined.

160 Renal levels of oxidized glutathione were significantly higher in cy/+ t

161 t noted and the levels of total, reduced and oxidized glutathione were similar in transgene (+) and (

162 isulfide bond when s-COMT was incubated with oxidized glutathione, whereas cysteines 69, 95, 157, and

163 ably, alterations in the ratio of reduced to oxidized glutathione, which is the primary determinant o