ライフサイエンスコーパス: oxidosqualene

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1 -amyrin, a product of the cyclization of 2,3-oxidosqualene.

2 he suicide substrate (3S)-29-methylidene-2,3-oxidosqualene.

3 ith no stable intermediates between 2,3-( S)-oxidosqualene and friedelin.

4 2,3-( S)-Oxidosqualene (C 30H 50O) serves as a versatile starting

5 nthesis of cholesterol) from the acyclic 2,3-oxidosqualene catalyzed by oxidosqualene cyclase (OSC) h

6 cerevisiae led to the identification of one oxidosqualene cyclase (MlbAS) and two cytochrome P450s,

7 m the acyclic 2,3-oxidosqualene catalyzed by oxidosqualene cyclase (OSC) has stimulated the interest

8 Small-molecule oxidosqualene cyclase (OSC) inhibitors were found to be

9 e containing the ets2-1 allele show weakened oxidosqualene cyclase activity.

10 coenzyme A reductase but also inhibitors of oxidosqualene cyclase decrease tumor growth, suggesting

11 t the E. adriatica eudoraenol synthase is an oxidosqualene cyclase homologous to bacterial lanosterol

12 lioblastoma cells were also demonstrated for oxidosqualene cyclase inhibitors in combination with ato

13 Ten oxidosqualene cyclase inhibitors with high efficacy as c

14 and 12 protein gene sequences for eukaryotic oxidosqualene cyclase were compared with all available c

15 Two enzymes, squalene monooxygenase and oxidosqualene cyclase, are the minimum necessary for ini

16 ough transcriptome analysis of the roots, an oxidosqualene cyclase, OsONS1, was identified that produ

17 y program in which we combined CYP716Y1 with oxidosqualene cyclase, P450, and glycosyltransferase gen

18 Compounds were optimized against oxidosqualene cyclase-lanosterol synthase (OSC) inhibiti

19 Two MeJA-responsive oxidosqualene cyclases (ObAS1 and ObAS2) that encode for

20 Oxidosqualene cyclases (OSCs) positioned at a key metabo

21 model plant Arabidopsis thaliana encodes 13 oxidosqualene cyclases, 9 of which have been characteriz

22 uilding on proven methods for characterizing oxidosqualene cyclases, we heterologously expressed in y

23 e indispensable enzymatic cyclization of 2,3-oxidosqualene for varied triterpenoid biosynthesis.

24 zation of the linear 30 carbon precursor 2,3-oxidosqualene into different triterpene scaffolds.

25 Genetic manipulation of oxidosqualene-lanosterol cyclase did result in the build

26 genetic and pharmacological manipulation of oxidosqualene-lanosterol cyclase, that an oxysterol-deri

27 The effects of inhibitors of 2,3-oxidosqualene:lanosterol cyclase (cyclase) on cytochrome

28 A new orally active oxidosqualene:lanosterol cyclase (OSLC) inhibitor showed

29 ith a 1000-fold molar excess of 18-thia-2, 3-oxidosqualene or the nonterpenoid inhibitor BIBX79.

30 Five sulfur-containing analogues of 2,3-oxidosqualene (OS) were evaluated as inhibitors of squal

31 chair-chair-boat conformation of the (S)-2,3-oxidosqualene precursor during the cyclization process,

32 Squalene epoxidase converts squalene into oxidosqualene, the precursor of all known angiosperm cyc

33 st common intermediate in the cyclization of oxidosqualene to a diverse array of secondary triterpene

34 is a beta-amyrin synthase that converts 2,3-oxidosqualene to beta-amyrin in yeast, and its role in m

35 the isoprenoid pathway by cyclization of 2,3-oxidosqualene to cycloartenol.

36 teroid hormones is the conversion of (S)-2,3-oxidosqualene to lanosterol.

37 Plants also convert 2,3-oxidosqualene to other sterol-like cyclization products,

38 bstrate dioxidosqualene in preference to 2,3-oxidosqualene when expressed in yeast.

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