ライフサイエンスコーパス: oxime

1 n synthase kinase 3beta (6-bromoindirubin-3'-oxime).

2 ysed Beckmann rearrangement of the zerumbone oxime.

3 ed lethality in 6/11 animals without amidine-oxime.

4 lsulfonyl)-1,3-butadiene with an appropriate oxime.

5 gh reaction with an appropriate nucleophilic oxime.

6 a hydroxylamine to provide the corresponding oximes.

7 -nitroso derivative to the corresponding E/Z-oximes.

8 nnulations of alkynes with readily available oximes.

9 l-mediated and metal-catalyzed) reactions of oximes.

10 allyl oximes enables rapid access to O-vinyl oximes.

11 followed by conversion to ketohydrazones or oximes.

12 h respect to both the iodoalkynes and chloro-oximes.

13 e from 3-phenylpropanones via their O-phenyl oximes.

14 th only, which is virtually the same for all oximes.

15 ve generation of iminyl radicals from simple oximes.

16 the design of a new class of reactive O-aryl oximes.

17 e (20a) was obtained from ent-beyeran-16-one oxime (17) by Beckmann fragmentation, hydrolysis, and Cu

18 itized reactions of a series of benzaldehyde oximes (1a-o) were studied by steady-state (product stud

19 The addition of the neutral oxime 2,3-butanedione monoxime increases the rate of rea

20 condensation of hydrazonophenylacetaldehyde oxime (2), obtained from 2-isonitrosoacetophenone (1), w

21 fic isolation of a diastereo and enantiopure oxime, 2-phenylpropanaldehyde oxime, from prior multidim

22 h RS41A and the standard peripherally active oxime, 2-pyridinealdoxime methiodide.

23 lohexan-1-ones 1a-1c, 4-silacyclohexan-1-one oximes 2a-2c, 1,4-azasilepan-7-ones 3a-3c, 1,4-azasilepa

24 xybenzylidene)hydrazono-2-phenylacetaldehyde oxime (5) and (4-methylbenzylidene)hydrazono-2-phenylace

25 ylbenzylidene)hydrazono-2-phenylacetaldehyde oxime (6), respectively.

26 he indirubin derivative 6-bromo-indirubin-3'-oxime (6BIO) as a promising antimetastatic agent.

27 f JAK/STAT3 signaling in 6-bromoindirubin-3'-oxime (6BIO)-mediated growth inhibition of human melanom

28 iptional inhibitor named 6-bromoindirubin-3'-oxime (6BIO).

29 yl-2-(propan-2-ylidenehydrazono)acetaldehyde oxime (7).

30 5 min after OP exposure, i.p,) with amidine oximes 7a-c and 12a, 12c, 12e, 12f, and 15b (145 mumol/k

31 ith (99m)Tc-labeled hexamethylpropyleneamine oxime ((99m)Tc-HMPAO) or PET with (15)O-water.

32 yl)ethynyl]-2-cyclohexen-1-one-O-(methyl-11C)oxime, a negative allosteric modulator of the metabotrop

33 isomers of 2-hydrazono-2-phenylacetaldehyde oxime, a reagent in the synthetic route, reveal existenc

34 hiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime] activators of human CAR.

35 Alcohols, oximes, aldehydes, and ketones are known to react under

36 oduct via a previously uncharacterized retro oxime-aldol reaction.

37 an NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime), an unselective but hitherto the most potent K(Ca

38 We identify 7-bromoindirubin-3'-oxime, an indirubin oxime derivative that induces necros

39 igands on ITO and characterize the resulting oxime and amide linkages by electrochemistry, X-ray phot

40 lood-brain barrier, the pH dependence of the oxime and amine ionizing groups of the compounds and the

41 bstrates for PFTase and as reactants in both oxime and hydrazone formation.

42 ntramolecular hydrogen bond formation in the oxime and hydroxy derivatives was confirmed by IR and (1

43 of salicylaldoxime or 2-hydroxybenzaldeyhyde oxime and L = MeOH, EtOH) via the use of derivatized oxi

44 y alcohol are converted to pentafluorobenzyl oxime and pentafluorobenzoyl ester derivatives, which ar

45 beta-elimination and formation of pyridine-4-oxime and phenyl vinyl ketone and ends with the formatio

46 f reactions starting from a bis(cyanoalkenyl)oxime and proceeding via nitrone cycloadditions have bee

47 2,3-dioxoporphyrin can be converted, via the oxime and using the acid- or oxidant-induced reaction pa

48 of highly substituted pyrroles directly from oximes and alkynes was developed via independent optimiz

49 prepared by Rh(III)-catalyzed cyclization of oximes and diazo compounds via aryl and vinylic C-H acti

50 vel electron donor-acceptor complexes of the oximes and Et3N was proposed as a key step of this proce

51 The formation of oximes and hydrazones is employed in numerous scientific

52 The formation of oximes and hydrazones is widely used in chemistry and bi

53 ing ethers, esters, carbazates, ketones, and oximes and measured their affinity for Hsp90 and their a

54 hlorophosphite-mediated Beckmann ligation of oximes and p-toluenesulfonyl azide gives access to N-sul

55 of isomeric bicyclo[2.2.1]heptane-7- and -8-oximes and their corresponding C-nitroso derivatives, wh

56 Et-sao2- (Et-saoH2 = 2-hydroxypropiophenone oxime) and Me3CCO2- (pivalate), produces the complex [Mn

57 S-11 (6-bromo-5-methyl-1H-indole-2,3-dione-3-oxime) and SKS-14 (7-fluoro-3-(hydroxyimino)indolin-2-on

58 PTP inhibitors TRO-19622 (cholest-4-en-3-one oxime) and TAT-Bcl-X(L)-BH4.

59 elective PIFA mediated dehydrogenation of an oxime, and a subsequent Lossen rearrangement which occur

60 base in DMSO-d6 to afford the corresponding oxime, and no reverse isomerization from the oxime to th

61 with technetium 99m-hexamethylpropyleneamine oxime, and then reinfused intravenously.

62 dition to methods reported by us, hydrazone, oxime, and thioether linkages between gammaDPGA and seve

63 tively modified with biotin, dyes, aliphatic oximes, and hydroxylamines.

64 alpha,beta-Unsaturated O-pivaloyl oximes are coupled to alkenes by Rh(III) catalysis to af

65 such as alcohols, amides, carboxylates, and oximes are discussed.

66 Reactivation capacities of novel oximes are rank ordered by their relative reactivation r

67 method to prepare phenols with benzaldehyde oxime as a hydroxide surrogate.

68 present work, we achieved this goal by using oxime-based chemical conjugation to synthesize dimers of

69 We report the compatibility of various oxime-based compounds with the use of the Ugi multicompo

70 tion discusses miscellaneous applications of oxime-based glycoconjugates, such as enantioselective ca

71 The described oxime-based library protocol provides detailed procedure

72 forms; (ii) tethering with aldehydes to form oxime-based linkages with sufficient purity; and (iii) d

73 ture and have been employed for syntheses of oxime-based metal complexes and cage-compounds, oxime fu

74 ery and reuse, we have developed a fluorous, oxime-based palladacycle 1 and demonstrated that it is a

75 res of SNO-OCTs can be employed to modify an oxime-bearing styrene copolymer and introduce an array o

76 te a GSK3beta inhibitor (6-bromoindirubin-3'-oxime BIO) for amelioration of bone destruction in a mur

77 the GSK3beta inhibitor 6-bromo-indirubin-3'-oxime (BIO) and the PPARgamma inhibitor GW9662 (GW) enha

78 by GSK-3beta antagonist 6-bromoindirubin-30-oxime (BIO) for Wnt signaling activation during embryoni

79 ffects of GSK3 inhibitor 6-bromoindirubin-3'-oxime (BIO) predicted unstable TERT repression dependent

80 Wnt signaling activator (6-bromoindirubin-3'-oxime [BIO]) or inhibitor (JW74), in the presence or abs

81 a set of well-defined conjugates bearing an oxime bond between the chain and the substrate.

82 dy drug conjugates (NDCs) were produced, via oxime bond formation between ketones on the side chain o

83 D) peptide to modify the O-hydroxylamines by oxime bond formation.

84 The resulting oxime bond was found to rapidly hydrolyze at pH2 releasi

85 (+)(pyridinium) cleavage and ether C(beta)-O(oxime) bond formation in aqueous media has been presente

86 The advantages of the oxime-bonded, site-specific NDCs were even more apparent

87 After a brief introduction to oxime bonds and their relative stabilities compared to r

88 agen model peptides that are cross-linked by oxime bonds between 4-aminooxyproline (Aop) and 4-oxoace

89 -BSA-FITC [beta-estradiol-6-(O-carboxymethyl)oxime-bovine serum albumin conjugated with fluorescein i

90 olecular, beta-estradiol 6-(O-carboxy-methyl)oxime-BSA, was covalently immobilized onto the optical f

91 azole-5-carbaldehyde-O-(3,4-dichlorobenzy l) oxime, but not by the indirect hCAR activator, phenobarb

92 ng has occurred, common therapeutics such as oximes cannot reactivate the cholinesterase enzyme and r

93 Above room temperature, both types of oxime carbamate acted as selective new precursors for am

94 Oxime carbamates derived from the volatile diethylamine

95 A set of oxime carbamates having N-alkyl and N,N-dialkyl substitu

96 radicals were generated by UV irradiation of oxime carbonate precursors.

97 In most cases, arenes with oximes, carboxylic acids, and amines as directing groups

98 A simple reaction scheme utilizing oxime chemistry was identified as a means to efficiently

99 reactions based on Huisgen cycloaddition and oxime chemistry, where the oxime linkage is redox active

100 ical yield (13%-18%) by use of site-specific oxime chemistry.

101 ction behavior of N-benzoylethylpyridinium-4-oxime chloride in aqueous media under mild reaction cond

102 hiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime (CITCO).

103 hiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime (CITCO).

104 iazole-5-carbaldehyde-O-(3,4-dichlorobenz yl)oxime (CITCO)], pregnane X receptor (PXR) [rifampicin],

105 (C7-R)-nitroso compound to the corresponding oximes compared with that of the (C8-S)-nitroso derivati

106 The best oxime-conjugated knottin dimer achieved an unprecedented

107 ne-bearing reagents were used to form stable oxime conjugates with latent aldehyde functionality pres

108 roles were made in good yields from O-phenyl oximes containing pent-4-ene acceptors.

109 substrates by pinacolborane (pinBH) affords oxime-containing chiral tertiary boronic esters with yie

110 yed a key role in both the ease by which the oxime could be reduced and the subsequent reactivity of

111 The application of an oxime cross-linked hydrogel system is demonstrated.

112 e to promote cascade, tandem condensation to oximes, cyclization to nitrones, and 1,3-dipolar cycload

113 volves the reversible generation of unstable oxime cyclotrimers, which are readily intercepted by bor

114 tify 7-bromoindirubin-3'-oxime, an indirubin oxime derivative that induces necrosis, as a potent indu

115 lated hydroxylamine derivative that forms an oxime derivative with the aldehyde/keto group found in o

116 the APCI positive ion mass spectra of PFBHA oxime derivatives and is observed in four of the five ex

117 go a smooth reaction to produce 1,3-oxazol-2-oxime derivatives in good yields.

118 n and subsequent separation and detection of oxime derivatives of 2-alkylcyclobutanones by high perfo

119 The released oxime-derivatives of the carbonylated-OxPLs are subseque

120 Reaction of the oxime derived from 2-(oxo-cyclopentyl)acetic acid ethyl

121 Acyl oximes derived from a variety of indolylalkanones underw

122 ry photocycloaddition reaction involving the oxime did not provide the intended polyheterocyclic fene

123 We now report that the oxime-directed CAHB of alkyl-substituted methylidene and

124 Oxime-directed catalytic asymmetric hydroboration is div

125 zed isomerization of easily prepared O-allyl oximes enables rapid access to O-vinyl oximes.

126 step, excitation of 2 causes cleavage of the oxime ester (Phi = 0.56) followed by base generation aft

127 In this process, an oxime ester function reacts with an aromatic C-H bond un

128 ft of the palladacycle-ligated methyl ketone oxime ester to enable the C-C bond formation by reductiv

129 other C-H functionalization reactions using oxime esters and potentially other carbonyl derivatives

130 st into the N-O bond of O-pentafluorobenzoyl oxime esters generates imino-Pd(II) intermediates, which

131 Methyl ketone oxime esters have been found to be excellent coupling pa

132 nts for the efficacy of O-pentafluorobenzoyl oxime esters in aza-Heck reactions of this type.

133 that end, latent PBGs were designed that are oxime esters of aliphatic acids, which undergo Norrish t

134 h undergo Norrish type II reactions to yield oxime esters of aromatic acids that are efficient PBGs.

135 Unlike UV light promoted reactions of oxime esters, the mechanism is almost certainly not medi

136 ational design of thioaryl naphthylmethanone oxime ether analogs containing functional properties of

137 iments with a deuterium-labeled benzaldehyde oxime ether.

138 ck of the aryl ring onto the nitrogen of the oxime ether.

139 s with the formation of O-alkylated pyridine oxime ether.

140 Axially chiral cyclohexylidene oxime ethers exhibit unique chirality because of the res

141 ord single geometric isomers of aryl alkynyl oxime ethers has also been developed.

142 epared by the reduction of pure (Z)-ethanone oxime ethers in up to 99% ee using 15% of catalyst.

143 pha-oximino ketenes derived from alpha-diazo oxime ethers provides 2H-azirines bearing quaternary cen

144 eening molecular targets of water-soluble 3'-oxime ethers revealed 6ha as preferential inhibitor of i

145 thesis of single geometric isomers of diaryl oxime ethers through Suzuki coupling of N-alkoxyimidoyl

146 A series of 2'-arylbenzaldehyde oxime ethers were synthesized and shown to generate the

147 atalyzed ortho-C-H arylation of acetophenone oxime ethers with aryl pinacol boronic esters, leading t

148 try to give single E- or Z-isomers of diaryl oxime ethers.

149 esults obtained for a series of acetophenone oxime ethers.

150 tein scaffolds [(18)F-N-(4-fluorobenzylidene)oxime (FBO)-Z(HER2:477) and (18)F-FBO-(Z(HER2:477))(2)]

151 xaldehyde (Fc-1) and ferrocenecarboxaldehyde oxime (Fc-2).

152 t ambient temperature include methoxy-phenyl oxime, followed by n-hexanol and 3Z-hexenal, which gives

153 rs of the intermediates as well as different oximes (formaldehyde and acetone oxime) were considered.

154 f N-terminal Gln was resistant to subsequent oxime formation attempts.

155 -imine intermediates, allows rapid hydrazone/oxime formation even with relatively low concentrations

156 act as superior catalysts for hydrazone and oxime formation, speeding the reaction considerably over

157 ABAO and aldehydes is kinetically similar to oxime formations performed under stoichiometric aniline

158 position of the phenyl group adjacent to the oxime, forming a quinoline moiety.

159 We used oxime-forming chemical ligation to introduce a temporary

160 nd enantiopure oxime, 2-phenylpropanaldehyde oxime, from prior multidimensional separation, is descri

161 f 2-bromo-2-cyclohexen-1-ol, formation of an oxime function, conversion to an oximoyl chloride, intra

162 Steric hindrance near the oxime functional group played a key role in both the eas

163 ealed a number of features, most notably the oxime functionality to be important to this selectivity.

164 me-based metal complexes and cage-compounds, oxime functionalizations, and the preparation of new cla

165 (h) AChE mutants that, when coupled with an oxime, give rise to catalytic reactivation and aging res

166 A two-methylene linker between the oxime group and the N-1-piperazine ring displayed the be

167 nge of substrates, the C-H bonds beta to the oxime group are selectively oxidized.

168 Derivatives with an oxime group at the 6-position exhibited the greatest bac

169 in conferring nucleophilic reactivity of the oxime group.

170 A new pentadentate oxime has been designed to drive the preferential coordi

171 While formation of hydrazone and oxime has been traditionally regarded as being limited b

172 esis of novel axially chiral cyclohexylidene oximes has been developed by catalytic desymmetrization

173 -ylacetate and N-tosyl-4-chloro-3-piperidone oxime have been used to construct the tetracyclic skelet

174 ctionally substituted 2-alkyn-1-one O-methyl oximes have been cyclized under mild reaction conditions

175 ulky side chains GF, GD, and VR, by H-series oximes HLo-7, HI-6, and ICD-585.

176 g uptake of (99m)Tc-hexamethylpropyleneamine oxime (HMPAO) is reported to be partially dependent on t

177 leukocytes ((99m)Tc-hexamethylpropyleneamine oxime [HMPAO]-labeled white blood cells [WBC]).

178 ophenone oxime, Me-saoH2 = 2-hydroxyethanone oxime, HO2CCPh3 = triphenylacetic acid, HO2CCMe3 = pival

179 ith 2-PAM, the most promising cyclic amidine-oxime (i.e., 12e) showed comparable or greater reactivat

180 Even at 25% of the initial dose of amidine-oxime (i.e., a dose of 36 mumol/kg, i.p.), 7b and 12e pr

181 ta-catenin activity with 6-bromoindirubin-3'-oxime improved cardiac contractility and ameliorated int

182 synthesized by Beckmann rearrangement of its oxime in the presence of ZnCl2.

183 byproduct formation and high selectivity for oximes in good yield and purity.

184 by reacting dicarboxylic acid chlorides with oximes in the presence of excess triethylamine.

185 mpound, as well as IQ-1 and three additional oxime indenoquinoxalines, were found to be high-affinity

186 glutathione adducts derived from the quinone oxime intermediates of dronedarone and NDBD.

187 diastereomeric (E,Z) and enantiomeric (R,S) oxime into a third reactor column where isomerization oc

188 The surface chemistry product oxime is also redox active but at a different potential

189 We showed that (E)-O-benzoylethylpyridine-4-oxime is formed in aqueous solution by a base-induced ta

190 ent-inhibited acetylcholinesterase (AChE) by oxime is the most important step in the treatment of ner

191 Optimization and scope of the O-allyl oxime isomerization and subsequent pyrrole formation are

192 d optical spectrum from that of the starting oxime (lambdamax = 667 nm).

193 The replacement of the carbonyl group with oxime leads to a reduction of the difference in the phot

194 ddition, we interrogated an 840-member novel oxime library for reactivation of Y337A/F338A hAChE-OP c

195 d L = MeOH, EtOH) via the use of derivatized oxime ligands and bulky carboxylates leads to a family o

196 Via the use of derivatized oxime ligands and bulky carboxylates we show that it is

197 tically modified with compound 1 followed by oxime ligation and click reaction to simultaneously inco

198 zontal lineN functions, synthetic aspects of oxime ligation and methodologies for introducing the ami

199 uential click approach with a combination of oxime ligation and strain promoted alkyne-azide cycloadd

200 lusters and glycodendrimers obtained through oxime ligation are described in terms of synthetic desig

201 effect comparable to fluorine and introduce oxime ligation as a tool for the functionalization of sy

202 8)F-radiolabeled polyamides were prepared by oxime ligation between 4-[(18)F]-fluorobenzaldehyde and

203 The oxime ligation demonstrates tunable reaction kinetics wi

204 s was demonstrated by an intercellular photo-oxime ligation that could be remotely cleaved and disass

205 n this system and selectively conjugated via oxime ligation to a therapeutic peptide mimetic containi

206 sialic acids, followed by aniline-catalyzed oxime ligation with a suitable tag.

207 Aniline catalysis dramatically accelerates oxime ligation, allowing use of low concentrations of am

208 ermed OPRAH) by total chemical synthesis and oxime ligation, with an acceleration of the final ligati

209 ural polyethylenglycol (PEG) linker by using oxime ligation.

210 ns of cells for subsequent cell assembly via oxime ligation.

211 n be modified with diverse molecular tags by oxime ligation.

212 A photodeprotection-oxime-ligation sequence permits user-defined quantities

213 The use of an oxime linkage between the polyamide and an aromatic func

214 cycloaddition and oxime chemistry, where the oxime linkage is redox active and switchable.

215 n auristatin through a stable, non-cleavable oxime linkage to afford a chemically homogeneous ADC.

216 25285/NCTC 9343 via a physiologically stable oxime linkage to furnish the first semisynthetic bacteri

217 h was then site-selectively modified through oxime linkage with benzylalkoxyamine or 5 kDa-poly(ethyl

218 to an auristatin derivative through a stable oxime linkage.

219 The O-SPC conjugates used oxime linkages between the terminal Kdo residues at the

220 ycans to recombinantly produced proteins via oxime linkages.

221 Directed by an oxime-masked alcohol, annulation chemoselectively occurs

222 O)2] (12) (Et-saoH2 = 2-hydroxypropiophenone oxime, Me-saoH2 = 2-hydroxyethanone oxime, HO2CCPh3 = tr

223 halen-1-yl)methanone O-2-(diethylamino)ethyl oxime (MND) exhibited the best safety profile.

224 evidenced by an increased "twisting" of the oxime moiety (Mn-N-O-Mn) and a change in carboxylate lig

225 The presence of an oxime moiety in the aromatic photosubstrate allowed the

226 h (3)) compounds and methyl 2-pyridyl ketone oxime (mpkoH) affords a new family of Mn/carboxylato/oxi

227 P conjugates to delineate the most efficient oxime-mutant enzyme pairs for catalytic bio-scavenging.

228 r catalyst, which would initially reduce the oxime N-O bond to generate a nucleophilic copper(II) ena

229 The oxime N-O bond undergoes oxidative addition to Pd(0)(PCy

230 (SKA-31), 6,7-dichloro-1H-indole-2,3-dione 3-oxime (NS309), and 1-ethylbenzimidazolin-2-one (EBIO), a

231 was developed by the covalent linkage of an oxime nucleophile and a peripheral site ligand.

232 lidine arises from conjugate addition of the oxime onto the diene to afford a transient nitrone that

233 in one location through the formation of an oxime or a hydrazone linkage.

234 Oxime or hydrazone formation was then employed to immobi

235 sent on the benzene ring of the benzaldehyde oximes or when the hydroxyl hydrogen atom is unavailable

236 sights into the chemistry of nitrile oxides, oximes, oxazete, and nitroso compounds as well as S(N)Vi

237 Initial gold-promoted addition of the oxime oxygen to the activated alkyne afforded the O-viny

238 alpha,beta-Unsaturated oxime pivalates are proposed to undergo reversible C(sp(

239 s to the monocarbam linker, siderophore, and oxime portion of the molecules were examined.

240 The 10 best reactivating oximes, predominantly hydroxyimino acetamide derivatives

241 ns have demonstrated that the efficacy of an oxime primarily depends on its ability to reactivate ner

242 activated transport path opens upon retinal oxime production, instead of or in addition to the natur

243 ii) direct in vitro biological evaluation of oxime products without purification.

244 Our results suggest that the oximes provide a novel structural linker for 4-arylpiper

245 If the in vitro oxime reactivation of nerve agent-inhibited animal AChE

246 mono- and bis-pyridinium oximes showed that oxime reactivation of nerve agent-inhibited human AChE i

247 Amidine-oxime reactivation rates for OP-inactivated acetylcholin

248 t therapy to combat OP poisoning involves an oxime reactivator (2-PAM, obidoxime, TMB4, or HI-6) comb

249 he synthesis and activity of a new series of oxime reactivators of cholinesterases (ChEs) that contai

250 A new class of amidine-oxime reactivators of organophosphate (OP)-inhibited cho

251 g azide-alkyne, tetrazine-trans-cyclooctene, oxime, reductive amination, native chemical ligation, Su

252 and alkoxyamines, to generate hydrazones and oximes, respectively.

253 [1,3] sigmatropic rearrangements of O-vinyl oximes, respectively.

254 enzyl (3), and O-tert-butyl (4) benzaldehyde oximes result in the formation of the corresponding radi

255 eplacement of the N,N-dioxide moiety with an oxime, ring-opening of the central diketopiperazine, and

256 Starting with the initial lead oxime RS41A identified in our earlier study and extendin

257 High conversion (100%) with >90% oxime selectivity is achieved at room temperature under

258 e; typically, the oxidation potential of the oxime should be below 2.0 V.

259 c studies with five mono- and bis-pyridinium oximes showed that oxime reactivation of nerve agent-inh

260 potential of metal-involving conversions of oxime species for application in various fields of chemi

261 PET or blood flow (hexamethylpropyleneamine oxime) SPECT is widely used for the differential diagnos

262 inase inhibitor from a novel aminopyrimidine oxime structural class that blocks the proliferation of

263 earrangement product with beta-ester O-allyl oxime substrates.

264 ound-induced mechanochemical scission of the oxime sulfonate mechanophore also generates a ketone fun

265 Here we demonstrate that oxime sulfonates-known photoacid generators-are also aci

266 Technetium- Tc 99 m Hexamethylpropyleneamine Oxime (Tc-99 m HMPAO) during ictal and interictal state

267 this is the first report of a nonquaternary oxime that has, comparable to 2-PAM, in vitro potency fo

268 of salicylaldoxime or 2-hydroxybenzaldeyhyde oxime) that display analogous structural cores but remar

269 photolysis of acetophenone O-allylcarbamoyl oxime, the corresponding oxazolidin-2-onylmethyl radical

270 e animal model for the in vivo evaluation of oxime therapy.

271 f an alphaC-lithiated O-silyl ethyl pyruvate oxime to benzoquinone, which is followed by an oxa-Micha

272 oxime, and no reverse isomerization from the oxime to the C-nitroso compound was observed.

273 Phthaloyl chlorides reacted with acetone oxime to yield 3-(1-methylethenyl)-1H-2,3-benzoxazine-1,

274 catalysis of the intermolecular addition of oximes to activated alkynes and thermal rearrangement of

275 arrangement of the in situ generated O-vinyl oximes to form pyrroles that contain a functional group

276 pling with alpha,beta-unsaturated O-pivaloyl oximes to provide substituted pyridines in good yield.

277 efficient than or as efficient as pyridinium oximes to reactivate VX-, tabun- and ethyl paraoxon-inhi

278 on of cyclohexenone and tetralone O-pivaloyl oximes to the corresponding primary anilines and 1-amino

279 o assess the mechanism of the intramolecular oxime transfer reaction that leads to the formation of i

280 orotitanium enolate with O-methyl or -benzyl oximes under optimized conditions to gain improved acces

281 mines were synthesized from their respective oximes using a pulsed addition of excess NaBH(3)CN at pH

282 pid oxidation of various aliphatic amines to oximes using m-CPBA as an oxidant in ethyl acetate is de

283 products can be subsequently converted into oximes using SnCl2.2H2O in high yields.

284 omethanes and pyrrole to afford two isomeric oximes via conjugate addition followed by rearomatizatio

285 The oxime was employed as both a directing group (DG) and an

286 on of the (C8-S)-nitroso compound to the E/Z-oximes was approximately 8 times faster (at 40 degrees C

287 A small set of 2-aminoaryl alkanone O-phenyl oximes was prepared and shown to produce dihydroquinazol

288 und IQ-1 (11H-indeno[1,2-b]quinoxalin-11-one oxime) was found to be a potent, noncytotoxic inhibitor

289 H-indeno[1,2-b]quinoxalin-11-one-O-(2-furoyl)oxime]was a specific inhibitor of the c-Jun N-terminal k

290 O-Phenyl oximes were found to be excellent precursors for iminyl

291 Amidine-oximes were tested in vitro, and reactivation rates for

292 Amidine-oximes were tested in vivo for protection against the to

293 s different oximes (formaldehyde and acetone oxime) were considered.

294 size an unprecedented type of Baylis-Hillman oxime, which underwent N-O coupling to produce new isoxa

295 studies have shown that the reaction of the oxime with triplet chloranil ((3)CA) proceeds via an ele

296 reaction of O-methyl alpha,beta-unsaturated oximes with aldehydes and N-tosyl imines affords seconda

297 on microwave-promoted reactions of O-phenyl oximes with aldehydes.

298 Condensation of oximes with boronic acids RB(OH)2 or B(OH)3 affords rema

299 Substituted benzaldehyde oximes with oxidation potentials greater than 2.0 V quen

300 eased accessibility of the Y337A mutation to oximes within the space-impacted active center gorge wit