ライフサイエンスコーパス: oxirane

1 ct to the spontaneous addition of GSH to the oxirane.

2 vinyl-substituted oxiranes, or hydroxymethyl oxiranes.

3 idation to yield a series of A2E epoxides or oxiranes.

4 w insights into the Lewis acid activation of oxiranes.

5 via regioselective ring-opening reactions of oxirane 12 and cyclic sulfamidate 22 with lithium dialky

6 Oxirane 12 was formed in eight steps from 4, and cyclic

7 tB(+/+) mice with L-3-trans-(propylcarbamoyl)oxirane-2-carbonyl-L-isoleucyl-L-proline (CA-074 Me) als

8 hether an ethyl-2-[6-(4-chlorophenoxy)hexyl]-oxirane-2-carboxylate (etomoxir)-induced inhibition of f

9 ( R)- and ( S)-oxirane-2-carboxylate were determined to be active site-

10 se mechanism for these enzymes, (R)- and (S)-oxirane-2-carboxylate were investigated as potential irr

11 rreversible inactivation of cis-CaaD by ( R)-oxirane-2-carboxylate with two important distinctions: t

12 ent manner and only by the (R)-enantiomer of oxirane-2-carboxylate.

13 A six-step conversion of oxirane 3 to oxetane 9 is reported.

14 Epoxidation of 29a and 29b afforded oxiranes 36a and 36b which were used in alkylation of ad

15 NP-poly(A) molecule at one end covalently to oxirane acrylic beads, an affinity column was prepared f

16 enylsulfonyl)methylthiirane (SB-3CT) and its oxirane analogue is investigated computationally.

17 ion of SB-3CT is 1.6 kcal/mol lower than its oxirane analogue, and the ring-opening reaction energy o

18 .0 kcal/mol more exothermic than that of its oxirane analogue.

19 Although reactions such as oxirane and lactide polymerizations are fairly well-know

20 gioselective epoxide ring-opening of alkynyl oxiranes and a stereoselective aza-Cope-Mannich reaction

21 lent oxygen and nitrogen in the formation of oxiranes and aziridines; however, such reactivity is not

22 Cu(I) catalyst and a pyridine oxide, alkynyl oxiranes and oxetanes can be converted into functionaliz

23 With the oxiranes and oxetanes, the chloro derivative gave a diff

24 Unlike the synthetically exploited oxiranes and thiiranes, aziridines that lack electron-wi

25 he biosynthesis of A2E and its conversion to oxiranes are accelerated by light.

26 on, and cationic polymerization of epoxides (oxiranes), are briefly reviewed.

27 This permits the use of readily available oxiranes as alternatives to aldehydes that are difficult

28 d ocular tissues from abcr(-/-) mice for A2E oxiranes by mass spectrometry.

29 ides or related quaternary carbon-containing oxiranes can be troublesome and difficult to achieve.

30 with exclusive attack at the least hindered oxirane carbon.

31 the POC-isomer leads to the formation of an oxirane derivative with an unexpectedly high stereoselec

32 en developed that effectively utilize chiral oxiranes derived from Katsuki-Sharpless epoxidation of a

33 followed by stereocontrolled, regioreversed oxirane formation and reductive transposition of this in

34 Thus, the gem-dimethyl acceleration of oxirane formation for 1-3 is found to be predominantly a

35 derived from the hydroxyl group of HPP, this oxirane formation reaction is effectively a dehydrogenat

36 an was developed by employing donor-acceptor oxiranes in a new reaction with gamma-hydroxyenones.

37 ve alpha-oxazolidinonylallenylstannanes with oxiranes in the presence of BF3.OEt2 produced beta-hydro

38 onal study of the rearrangement reactions of oxiranes initiated by lithium dialkylamides is presented

39 lving rate-limiting formation of a transient oxirane intermediate that opens in water to give alpha-d

40 e-limiting formation of a 1,2-anhydro sugar (oxirane) intermediate.

41 Finally, we showed that the formation of A2E oxiranes is strongly suppressed by treating the abcr(-/-

42 ide the intrinsic anti tendency of the vinyl oxirane moiety and forces the cuprate to undergo syn add

43 et pathway consists of a dissociation of the oxirane moiety to give a triplet carbene and aldehyde, w

44 Oxirane opening enables A-ring proton exchange, as does

45 are within hydrogen bonding distance to the oxirane or phosphonate oxygens of fosfomycin resulted in

46 y either epoxy-methoximes, vinyl-substituted oxiranes, or hydroxymethyl oxiranes.

47 five atoms inclusively, the combinations of oxirane, oxetane, and tetrahydrofuran are rather extensi

48 The relative rates of attack of ammonia on oxirane, oxetane, thiirane, and thietane were determined

49 e reaction involves Mn(II) activation of the oxirane oxygen and E44 acting as a general base.

50 ing the negative charge that develops on the oxirane oxygen in the transition state.

51 ylative 1,5-substitution of conjugated enyne oxiranes provides a diastereoselective route to (E)-conf

52 uggested as the exclusive mechanism by which oxiranes react in the presence of organolithium bases.

53 These oxiranes react with DNA in vitro, suggesting a potential

54 ynthesis of isopeptide analogues in which an oxirane replaces the scissile peptide bond.

55 etones are formed through the opening of the oxirane ring after alpha-substitution.

56 d radical-stabilizing groups adjacent to the oxirane ring for the deoxygenation reaction to occur.

57 hed by treatment of mCPBA, and the resulting oxirane ring in resin 9 was opened with various nucleoph

58 with an initial attack of phosphorane at the oxirane ring of epichlorohydrin.

59 zes the addition of glutathione (GSH) to the oxirane ring of the antibiotic, rendering it inactive.

60 N-methylamine with subsequent intramolecular oxirane ring opening and (b) a carbene insertion reactio

61 168 Hz; and when this hydrogen is cis to the oxirane ring, ((1)J[C(1)-H(1)] = 171-174 Hz.

62 catalyzes the addition of glutathione to the oxirane ring, rendering the antibiotic inactive.

63 olyl azido alcohols from terminal alkyne via oxirane ring-opening of epichlorohydrin, followed by cli

64 stereoselective epoxide formation/reductive oxirane ring-opening strategy is presented.

65 hodology, developed by Miyashita, allowed an oxirane-ring-opening reaction with a double inversion of

66 ent at the C-2 position, and the presence of oxirane rings.

67 The oxirane synthon is obtained with an anti configuration f

68 favorable for the alkoxide obtained from the oxirane than for the thiolate obtained from the thiirane

69 attack of an active site carboxylate on the oxirane to give an ester intermediate followed by hydrol

70 al Lewis-acid-catalyzed rearrangement of the oxirane to the corresponding aldehyde via an alkyl, aryl

71 Alternatively, the oxirane undergoes a nucleophilic substitution reaction w

72 In one mechanism, the oxirane undergoes acid-catalyzed ring opening followed b

73 Both (E)-cinnamyl acetate and vinyl oxirane were efficiently used to form the anti-branched

74 Unlike A2E, the oxiranes were more abundant in albino vs. pigmented abcr