ライフサイエンスコーパス: oxoglutarate

1 c acid, N-acetylglucosamine, and decreased 2-oxoglutarate.

2 mall effectors, most notably glutamine and 2-oxoglutarate.

3 es not prevent the binding of the cofactor 2-oxoglutarate.

4 trimethylamine N-oxide (TMAO), citrate and 2-oxoglutarate.

5 hylase activity dependent on both iron and 2-oxoglutarate.

6 carbon/nitrogen and depleted in starch and 2-oxoglutarate.

7 the oxidative deamination of glutamate to 2-oxoglutarate.

8 ino-terminal GAF domain of NifA that binds 2-oxoglutarate.

9 the release of 14CO2 from labeled [1-14C]-2-oxoglutarate.

10 le oxidative deamination of L-glutamate to 2-oxoglutarate.

11 ate, Ala:glyoxylate, Glu:pyruvate, and Ala:2-oxoglutarate.

12 he oxidative deamination of l-glutamate to 2-oxoglutarate.

13 ve succinylation by E1o in the presence of 2-oxoglutarate.

14 NIFL-NIFA system is directly responsive to 2-oxoglutarate.

15 gar phosphate levels, and lower content of 2-oxoglutarate.

16 xy-d-GlcNAc to form UDP-4-amino-FucNAc and 2-oxoglutarate.

17 nteractions are modulated by ADP, ATP, and 2-oxoglutarate.

18 oxylases via enzyme-catalysed oxidation to 2-oxoglutarate.

19 eir ability to bind the effector molecules 2-oxoglutarate (2-OG) and ATP or ADP.

20 These 2-oxoglutarate (2-OG) and non-heme iron-dependent oxygenas

21 co-regulated cancer genes associated with 2-oxoglutarate (2-OG) and succinate metabolism, including

22 lytic domain in complex with the substrate 2-oxoglutarate (2-OG) and the inhibitor N-oxalylglycine (N

23 thetase/glutamate synthase system requires 2-oxoglutarate (2-OG) as a carbon precursor.

24 Levels of 2-oxoglutarate (2-OG) reflect nitrogen status in many bact

25 Recently, members of the 2-oxoglutarate (2-OG)-dependent dioxygenase family have be

26 s (JBP1 and JBP2) homologous to the Fe(2+)/2-oxoglutarate (2-OG)-dependent dioxygenase superfamily wh

27 Iron (II)/2-oxoglutarate (2-OG)-dependent oxygenases catalyse oxidat

28 sigE and that this binding is enhanced by 2-oxoglutarate (2-OG).

29 ch was corrected by provision of exogenous 2-oxoglutarate (2-OG).

30 f the enzyme in complex with the substrate 2-oxoglutarate (2-OG).

31 2-Oxoglutarate (2OG) and Fe(II)-dependent oxygenase domain

32 ALKBH5 is a 2-oxoglutarate (2OG) and ferrous iron-dependent nucleic ac

33 nge of Bacteria and Archaea sense cellular 2-oxoglutarate (2OG) as an indicator of nitrogen limitatio

34 NrpR, nifOR(1), nifOR(2), and the effector 2-oxoglutarate (2OG) combine to regulate nif expression, l

35 human homologues belong to a subfamily of 2-oxoglutarate (2OG) dependent oxygenases (2OG oxygenases

36 The human 2-oxoglutarate (2OG) dependent oxygenases belong to a fami

37 mber of the Jumonji C family of Fe(II) and 2-oxoglutarate (2OG) dependent oxygenases.

38 presence of NifI(1) and NifI(2), and that 2-oxoglutarate (2OG), a potential signal of nitrogen limit

39 e MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that cat

40 anslocation (TET) proteins are Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenases that successiv

41 cherichia coli DNA repair enzyme AlkB is a 2-oxoglutarate (2OG)-dependent Fe(2+) binding dioxygenase

42 FTO is a 2-oxoglutarate (2OG)-dependent N-methyl nucleic acid demet

43 ber of the mononuclear nonheme Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenase superfamily.

44 Mononuclear non-heme Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenases comprise a large

45 2-Oxoglutarate (2OG)-dependent oxygenases have important r

46 ome sequences predict the presence of many 2-oxoglutarate (2OG)-dependent oxygenases of unknown bioch

47 The JmjC KDMs are Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenases, some of which a

48 prolyl and lysyl residues, as catalyzed by 2-oxoglutarate (2OG)-dependent oxygenases, was first ident

49 on hydroxylation as catalyzed by iron- and 2-oxoglutarate (2OG)-dependent prolyl and asparaginyl hydr

50 The roles of 2-oxoglutarate (2OG)-dependent prolyl-hydroxylases in euka

51 lyze the interconversion of isocitrate and 2-oxoglutarate (2OG).

52 tosolic alpha-ketoglutarate, also known as 2-oxoglutarate (2OG).

53 corbate, and the Kreb's cycle intermediate 2-oxoglutarate (2OG).

54 ression increased levels of the metabolite 2-oxoglutarate (2OG).

55 PLOD2 (procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2) hydroxylates lysine residu

56 nhibition is antagonised by the binding of 2-oxoglutarate, a key metabolic signal of the carbon statu

57 The electron acceptor for 2-oxoglutarate:acceptor oxidoreductase was determined to b

58 rate respiration is mediated by the enzyme 2-oxoglutarate:acceptor oxidoreductase; mutagenesis of thi

59 lly vulnerable, as it employs pyruvate and 2-oxoglutarate:acceptor oxidoreductases (Por and Oor), whi

60 One such enzyme is the 2-oxoglutarate (alpha-ketoglutarate) oxidoreductase (OOR),

61 e deficient in glutamate synthase (glutamate-oxoglutarate amidotransferase [GOGAT]) activity have dif

62 Mutation of gltB (encoding glutamate oxoglutarate amidotransferase or GOGAT) in RU2307 increa

63 ss experienced by enzymes, such as glutamine oxoglutarate amidotransferase, that contain redox active

64 gical role of the NADH-dependent glutamine-2-oxoglutarate aminotransferase (NADH-GOGAT) enzyme was ad

65 he urea and glutamine synthetase/glutamine 2-oxoglutarate aminotransferase pathways and redirected to

66 in phosphotransferase, and diaminobutyrate-2-oxoglutarate aminotransferase.

67 , nitrate/nitrite reductases and glutamine:2-oxoglutarate aminotransferase.

68 4S-containing ferredoxin-dependent glutamine oxoglutarate aminotransferases declined significantly in

69 With the carbon skeleton provided by 2-oxoglutarate, ammonia/ammonium (NH(4)(+)) is assimilated

70 n using the isoquinolone Roxadustat or the 2-oxoglutarate analog dimethyloxalylglycine (DMOG).

71 olyl hydroxylase inhibitors are lipophilic 2-oxoglutarate analogues (2OGAs) that are widely taken up

72 A set of human 2-oxoglutarate analogues were screened using a unified ass

73 n mitochondria) after conversion to 2-[U-13C]oxoglutarate and [U-(13)C]aspartate is formed from [U-(1

74 an evolutionarily conserved superfamily of 2-oxoglutarate and Fe(II)-dependent dioxygenases that medi

75 shunt is a major contributor to flux from 2-oxoglutarate and glutamate to succinate in Synechocystis

76 rs (HIFs) are principally regulated by the 2-oxoglutarate and Iron(II) prolyl hydroxylase (PHD) enzym

77 Unlike classical 2-oxoglutarate and iron-dependent dioxygenases, which incl

78 asmic reticulum and belong to the group of 2-oxoglutarate and iron-dependent dioxygenases.

79 5Q and R275W mutants were assayed for both 2-oxoglutarate and phytanoyl-CoA oxidation.

80 of ADP-stimulated (State 3) and uncoupled 2-oxoglutarate and succinate oxidation increased in parall

81 nguish between the C5-carboxylate group of 2-oxoglutarate and the epsilon-ammonium group of l-lysine.

82 ounds (iron, ascorbate, hydrogen peroxide, 2-oxoglutarate, and succinate) influenced by cellular oxid

83 ta-Phe, (R)-3-amino-5-methylhexanoic acid, 2-oxoglutarate, and the inhibitor 2-aminooxyacetic acid, w

84 form that contained iron, the co-substrate 2-oxoglutarate, and the reaction product of EctD, 5-hydrox

85 tudies, including galN, N-acetylglucosamine, oxoglutarate, and urocanic acid, enhancing metabolome co

86 hat Jumonji domain-containing 4 (Jmjd4), a 2-oxoglutarate- and Fe(II)-dependent oxygenase, catalyzes

87 roxymethyl-cytosine (hmC) by the action of 2-oxoglutarate- and Fe(ii)-dependent oxygenases of the TET

88 e Jumonji C lysine demethylases (KDMs) are 2-oxoglutarate- and Fe(II)-dependent oxygenases.

89 boxyl-terminal domain corresponding to the 2-oxoglutarate- and iron-dependent dioxygenase domains sim

90 (the flavin-dependent KDM1 enzymes and the 2-oxoglutarate- and oxygen-dependent JmjC KDMs, respective

91 Our data suggest that an Fe(II)-, oxoglutarate-, and oxygen-dependent enzyme may directly

92 ishes AmtB/GlnK association, and sites for 2-oxoglutarate are evaluated.

93 s depends on iron as the activating metal, 2-oxoglutarate as a co-substrate, and ascorbic acid as a c

94 equirement for iron(II) as a co-factor and 2-oxoglutarate as a co-substrate.

95 adipate and pyruvate substitute poorly for 2-oxoglutarate as a cosubstrate.

96 sing flavin (amine oxidases) or Fe(II) and 2-oxoglutarate as cofactors (2OG oxygenases) has changed t

97 alpha-ketoglutarate (alternatively termed 2-oxoglutarate) as a co-substrate in so many oxidation rea

98 Mutation of Arg-275 resulted in impaired 2-oxoglutarate binding.

99 AML-associated mutations in the Fe(2+) and 2-oxoglutarate-binding residues increased the Km values fo

100 dependent dioxygenases, putative iron- and 2-oxoglutarate-binding residues, typical of such enzymes,

101 core with both Fe(II) and the cosubstrate 2-oxoglutarate bound in the active site.

102 ids, AOX1A and AOX1D are both activated by 2-oxoglutarate, but only AOX1A is additionally activated b

103 had been blocked by the deletions and that 2-oxoglutarate can be converted to succinate in vivo in th

104 mitochondrial transport of 2OG through the 2-oxoglutarate carrier (OGC) participates in control of nu

105 nicotinamide, methionine, acetylcarnitine, 2-oxoglutarate, choline, and creatine.

106 tic iron center is exposed to solvent, the 2-oxoglutarate co-substrate likely adopts an inactive conf

107 These enzymes use an Fe(II) cofactor and 2-oxoglutarate co-substrate to oxidize organic substrates.

108 e 8 or 5-carboxy-8-hydroxyquinoline 9, two 2-oxoglutarate competitive templates developed for JmjC in

109 -42041935, was a potent (pK(I) = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhi

110 For the Fe(II) in the DAOCS-2-oxoglutarate complex the EXAFS spectrum was successfully

111 strand core and residues binding iron and 2-oxoglutarate, consistent with divergent evolution within

112 s should be amenable to the assay of other 2-oxoglutarate-consuming enzymes and to the discovery of i

113 Severe decreases were also seen in 2-oxoglutarate content, a key indicator of cellular carbon

114 69H mutations caused partial uncoupling of 2-oxoglutarate conversion from phytanoyl-CoA oxidation.

115 r primary substrates while decomposing the 2-oxoglutarate cosubstrate to form succinate and CO(2).

116 tive interaction occurs with the analogous 2-oxoglutarate decarboxylase (E1o) of the 2-oxoglutarate d

117 022 and combinations thereof, deficient in 2-oxoglutarate decarboxylase (Sll1981), succinate semialde

118 Genes encoding a novel 2-oxoglutarate decarboxylase and succinic semialdehyde deh

119 Independent of the 2-oxoglutarate decarboxylase bypass, the gamma-aminobutyra

120 The Deltasll1981 strain, lacking 2-oxoglutarate decarboxylase, exhibited a succinate level

121 ite flux to succinate than the pathway via 2-oxoglutarate decarboxylase.

122 ccinyltransferase (Dlst), a subunit of the 2-oxoglutarate dehydrogenase (alpha-KGDH) complex.

123 (a) Functionally competent 2-oxoglutarate dehydrogenase (E1o-h) and dihydrolipoyl suc

124 ogenase E1 component subunit beta (PDHB) and oxoglutarate dehydrogenase (OGDH) required dual phosphor

125 ived from alpha-ketoglutarate dehydrogenase (oxoglutarate dehydrogenase (OGDH)), a ubiquitous intrace

126 However, the 2-oxoglutarate dehydrogenase (OGDH), branched-chain 2-oxoa

127 ire the expression of the TCA cycle enzyme 2-oxoglutarate dehydrogenase (OGDH).

128 mplete in many other anaerobes (absence of 2-oxoglutarate dehydrogenase activity), isotopic labeling

129 cid as a cofactor (pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and glycine decarboxylase).

130 to succinate and thus functionally replace 2-oxoglutarate dehydrogenase and succinyl-CoA synthetase.

131 boxylic acid (TCA) cycle because they lack 2-oxoglutarate dehydrogenase and thus cannot convert 2-oxo

132 The 2-oxoglutarate dehydrogenase complex (OGHDC) (also known a

133 ependent E1o component (EC 1.2.4.2) of the 2-oxoglutarate dehydrogenase complex catalyses a rate-limi

134 (BCOADC-E2) in 4 of 49 (8%), to PDC-E2 and 2-oxoglutarate dehydrogenase complex E2 (OGDC-E2) in 9 of

135 of the gene encoding the E1 subunit of the 2-oxoglutarate dehydrogenase complex in the antisense orie

136 A traditional 2-oxoglutarate dehydrogenase complex is missing in the cya

137 e enzymes, pyruvate dehydrogenase complex, 2-oxoglutarate dehydrogenase complex, NAD-malic enzyme, an

138 -oxo-acid dehydrogenase, and E2 subunit of 2-oxoglutarate dehydrogenase complex.

139 2-oxoglutarate decarboxylase (E1o) of the 2-oxoglutarate dehydrogenase complex.

140 We report that the intact pyruvate and 2-oxoglutarate dehydrogenase complexes specifically copuri

141 yl CoA ligase, aconitase, and pyruvate and 2-oxoglutarate dehydrogenase complexes.

142 h engineered variants of the E2 subunit of 2-oxoglutarate dehydrogenase indicate that binding sites f

143 n this organism, even though a traditional 2-oxoglutarate dehydrogenase is lacking.

144 re reported unique properties of the human 2-oxoglutarate dehydrogenase multienzyme complex (OGDHc),

145 nit binding domain from Escherichia coli's 2-oxoglutarate dehydrogenase multienzyme complex (termed B

146 interactions with other components of the 2-oxoglutarate dehydrogenase multienzyme complex.

147 (E2p, E2o) components of the pyruvate and 2-oxoglutarate dehydrogenase multienzyme complexes are spe

148 to enzymes of the tricarboxylic acid cycle (oxoglutarate dehydrogenase, isocitrate dehydrogenase) an

149 s and thus upregulates ATP citrate lyase and oxoglutarate dehydrogenase, two key enzymes that determi

150 ine diphosphate-dependent Escherichia coli 2-oxoglutarate dehydrogenase, which is a key component of

151 ing domain of a large multienzyme complex, 2-oxoglutarate dehydrogenase.

152 Pyruvate and 2-oxoglutarate dehydrogenases are substituted by 'ancient'

153 Feruloyl-CoA 6'-hydroxylase (F6'H), a 2-oxoglutarate dependent dioxygenase (2OGD), catalyzes a p

154 The Fe(II) and 2-oxoglutarate dependent oxygenase Jmjd6 has been shown to

155 amma-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate dependent oxygenase that catalyzes the fina

156 nserved eukaryotic subfamily of Fe(II) and 2-oxoglutarate dependent oxygenases; their catalytic domai

157 d gene (FTO) is a member of the Fe (II)- and oxoglutarate-dependent AlkB dioxygenase family and is li

158 d heterologous expression, we identified a 2-oxoglutarate-dependent dioxygenase (BX13) that catalyzes

159 The protein level of a probable 2-oxoglutarate-dependent dioxygenase 2-ODD2, involved in g

160 The Fe(II) and 2-oxoglutarate-dependent dioxygenase deacetoxycephalospori

161 ioxygenase (HtxA) is a novel member of the 2-oxoglutarate-dependent dioxygenase enzyme family.

162 The TET enzymes are members of the 2-oxoglutarate-dependent dioxygenase family and comprise t

163 s, homozygous mutations in the Fe(II)- and 2-oxoglutarate-dependent dioxygenase family gene F6'H1 and

164 Tpa1 is a member of the Fe(II) and 2-oxoglutarate-dependent dioxygenase family, and we show t

165 In a mutant screening, we identified 2-oxoglutarate-dependent dioxygenase Feruloyl-CoA 6'-Hydro

166 -hydroxylation catalyzed by the Fe(II) and 2-oxoglutarate-dependent dioxygenase Jumonji domain-6 prot

167 er of the non-heme-containing iron(II) and 2-oxoglutarate-dependent dioxygenase superfamily and is ev

168 xidase cluster of the Arabidopsis thaliana 2-oxoglutarate-dependent dioxygenase superfamily tree.

169 nalysis revealed it to be a member of the Fe-oxoglutarate-dependent dioxygenase superfamily.

170 identified six pathway enzymes, including an oxoglutarate-dependent dioxygenase that closes the core

171 ein (JMJD6) is a JmjC-containing iron- and 2-oxoglutarate-dependent dioxygenase that demethylates his

172 lso known as Egl nine homolog 1 (EGLN1), a 2-oxoglutarate-dependent dioxygenase that hydroxylates HIF

173 bacterial DNA repair enzyme AlkB, an iron/2-oxoglutarate-dependent dioxygenase that reverses alkylat

174 coli that DES has the characteristics of a 2-oxoglutarate-dependent dioxygenase.

175 -hydroxylase isoform 1 (PHD1), an iron and 2-oxoglutarate-dependent dioxygenase.

176 oxalylglycine, an inhibitor of Fe(II)- and 2-oxoglutarate-dependent dioxygenases also inhibited AhR-d

177 The Fe(II)/2-oxoglutarate-dependent dioxygenases are a catalytically

178 Iron- and 2-oxoglutarate-dependent dioxygenases are a diverse family

179 ription factor alpha subunit by oxygen and 2-oxoglutarate-dependent dioxygenases promotes decay of th

180 erated by a series of non-haem Fe(II)- and 2-oxoglutarate-dependent dioxygenases that catalyse the po

181 ignal is generated by a series of iron and 2-oxoglutarate-dependent dioxygenases that catalyze post-t

182 l 4-hydroxylases are a family of iron- and 2-oxoglutarate-dependent dioxygenases that negatively regu

183 Like other iron/2-oxoglutarate-dependent dioxygenases, AlkB employs a two-

184 The FNSI class comprises soluble Fe(2+)/2-oxoglutarate-dependent dioxygenases, and FNSII enzymes a

185 Gibberellin (GA) 3-oxidase, a class of 2-oxoglutarate-dependent dioxygenases, catalyzes the conve

186 ometabolites and competitive inhibition of 2-oxoglutarate-dependent dioxygenases, particularly, hypox

187 ow amino acid sequence homology with known 2-oxoglutarate-dependent dioxygenases, putative iron- and

188 kinetic parameters of two bacterial Fe(II)/2-oxoglutarate-dependent dioxygenases.

189 it will be a valuable tool to study Fe(II)/2-oxoglutarate-dependent dioxygenases.

190 hese levels of R-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases.

191 The TET family of FE(II) and 2-oxoglutarate-dependent enzymes (Tet1/2/3) promote DNA de

192 generated by the TET family of Fe(II) and 2-oxoglutarate-dependent enzymes through oxidation of 5-me

193 uctural characteristics of non-heme Fe(II) 2-oxoglutarate-dependent enzymes, although key enzymatic r

194 bstantiated by the pioneering discovery of 2-oxoglutarate-dependent flavone demethylase activity in b

195 umors accumulate succinate, which inhibits 2-oxoglutarate-dependent histone and DNA demethylase enzym

196 irectly decreased the activity of a Fe(II)-2-oxoglutarate-dependent histone H3K9 demethylase in nucle

197 TH domain related to the family of Fe(2+)/2-oxoglutarate-dependent hydroxylases.

198 JMJD6 catalyses the iron- and 2-oxoglutarate-dependent hydroxylation of lysyl residues i

199 The 2-oxoglutarate-dependent iron enzyme ALKBH3 is an antitumo

200 ort that recombinant PHF8 is an Fe(II) and 2-oxoglutarate-dependent N(epsilon)-methyl lysine demethyl

201 2-Oxoglutarate-dependent nucleic acid demethylases are of

202 C synthase (DAOC/DACS) is an iron(II) and 2-oxoglutarate-dependent oxygenase involved in the biosynt

203 tallographic data for other members of the 2-oxoglutarate-dependent oxygenase super-family led to sec

204 orin C synthase (DAOCS) is an iron(II) and 2-oxoglutarate-dependent oxygenase that catalyzes the conv

205 A widely used generic assay for 2-oxoglutarate-dependent oxygenases relies upon monitoring

206 f the HIF system is provided by Fe(II) and 2-oxoglutarate-dependent oxygenases that catalyse the post

207 iron binding residues that are present in 2-oxoglutarate-dependent oxygenases.

208 TO shares sequence motifs with Fe(II)- and 2-oxoglutarate-dependent oxygenases.

209 cocontrolled by PHD2 and PHD3, oxygen- and 2-oxoglutarate-dependent prolyl-4-hydroxylases that regula

210 ed by using wild-type and variant forms of 2-oxoglutarate-dependent taurine dioxygenase.

211 2-Oxoglutarate-dependent versions appear to have further e

212 ly, Grob-type oxidative fragmentation of a 2-oxoglutarate-derived intermediate occurs to give ethylen

213 2-Oxoglutarate did not affect activity in DeltanifI(1)nifI

214 2-Oxoglutarate diminishes AmtB/GlnK association, and sites

215 nce comparisons suggest that hypophosphite:2-oxoglutarate dioxygenase (HtxA) is a novel member of the

216 DEFGHIJKLMN operon encodes a hypophosphite-2-oxoglutarate dioxygenase (HtxA), whereas the predicted a

217 Whereas the Fe-2-oxoglutarate dioxygenase core matches that in other supe

218 vitamin C, a potential cofactor for Fe(II) 2-oxoglutarate dioxygenase enzymes such as Tet enzymes.

219 hondrial poison cyanide or the nonspecific 2-oxoglutarate dioxygenase inhibitor dimethyloxalylglycine

220 er the tested conditions, a broad-spectrum 2-oxoglutarate dioxygenase inhibitor is a better mimic of

221 Ofd1, a prolyl 4-hydroxylase-like 2-oxoglutarate dioxygenase, controls the oxygen-dependent

222 ion of ATF3 under anoxia is independent of 2-oxoglutarate dioxygenase, HIF-1 and p53, presumably invo

223 also striking enrichment for the family of 2-oxoglutarate dioxygenases, including the jumonji-domain

224 uncharacterized prolyl 4-hydroxylase-like 2-oxoglutarate-Fe(II) dioxygenase, accelerates Sre1N degra

225 ese findings further highlight the role of 2-oxoglutarate/Fe(II) oxygenases in fundamental cellular p

226 morphine biosynthesis are catalyzed by the 2-oxoglutarate/Fe(II)-dependent dioxygenases, thebaine 6-O

227 DhpJ, a 2-oxoglutarate/Fe(II)-dependent enzyme, introduces the vin

228 port the identification of four paralogous 2-oxoglutarate/Fe(II)-dependent oxygenases in Arabidopsis

229 icarboxylic acid cycle, ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and pyruvate:fer

230 osphite in a process strictly dependent on 2-oxoglutarate, ferrous ions, and oxygen.

231 acid directly competes with the substrate 2-oxoglutarate for binding within the active site of HCS.

232 logical function of NADH-GDH is to provide 2-oxoglutarate for the tricarboxylic acid cycle.

233 ti-correlation between 2-hydroxyglutarate, 2-oxoglutarate, fructose, hexadecanoic acid, hypotaurine,

234 a two-step mechanism in which oxidation of 2-oxoglutarate generates a highly reactive enzyme-bound ox

235 tate and reintroduced in the TCA cycle via 2-oxoglutarate/glutamate.

236 xykynurenine:xanthurenic acid ratio, and the oxoglutarate:glutamate ratio.

237 l the carbon status through the binding of 2-oxoglutarate, have been implicated in the regulation of

238 inine in a nonoxidized conformation and of 2-oxoglutarate in an unprecedented high-energy conformatio

239 ganisms includes demonstrating the role of 2-oxoglutarate in regulating the activity of the transcrip

240 The P(II) effector 2-oxoglutarate, in the presence of Mg-ATP, inhibited DraT-

241 Extraction and quantification of 2-oxoglutarate indicated concentrations 10-fold higher in

242 , glutamate, and the anaplerotic substrate 2-oxoglutarate, inhibiting MM cell growth.

243 To determine pathways that convert 2-oxoglutarate into succinate in the cyanobacterium Synech

244 an alternative assay in which depletion of 2-oxoglutarate is monitored by its postincubation derivati

245 The iron and 2-oxoglutarate ligands are bound within the EctD active si

246 ion of another membrane carrier protein, the oxoglutarate malate carrier had no effect.

247 yruvate, orthophosphate dikinase, and the 2'-oxoglutarate/malate transporter are expressed in oat and

248 l as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic

249 eal that 2-hydroxyglutarate is oxidized to 2-oxoglutarate non-enzymatically, likely via iron-mediated

250 Deficiency in 2-oxoglutarate occurred despite increased citrate and mala

251 resonance upon reaction of the E1o-h with 2-oxoglutarate (OG) by itself or when assembled from indiv

252 However, the dicarboxylate (DIC) and 2-oxoglutarate (OGC) carriers localized to the inner mitoc

253 ial for function of the pyruvate (PDH) and 2-oxoglutarate (OGDH) dehydrogenases and thus for aerobic

254 ility to override the allosteric effect of 2-oxoglutarate on NifA activity.

255 ne, histidine, and ferrous iron but not by 2-oxoglutarate or oxygen.

256 hould not solely rely upon PAHX assays for 2-oxoglutarate or phytanoyl-CoA oxidation.

257 plant secondary metabolism are catalyzed by oxoglutarate- or cytochrome P450-dependent oxygenases.

258 ndria also inhibited State 3 succinate and 2-oxoglutarate oxidation by 30 %, but not that of palmitoy

259 on rather than activation of succinate and 2-oxoglutarate oxidation.

260 In one branch, an apparently typical 2-oxoglutarate oxygenase reaction to give succinate, carbo

261 f 2-hydroxyglutarate-enabled activation of 2-oxoglutarate oxygenases, including prolyl hydroxylase do

262 at levels supporting in vitro catalysis by 2-oxoglutarate oxygenases.

263 ic flux using (13)C labelling; acetate and 2-oxoglutarate production was reduced in the light.

264 stimulated and inhibited, respectively, by 2-oxoglutarate, providing a mechanistic link between PII s

265 lizing the typical keto-acid cosubstrates, 2-oxoglutarate, pyruvate, and oxaloacetate, Ab-ArAT4 posse

266 GPR99, previously described as an oxoglutarate receptor (Oxgr1), showed both a functional

267 variety of nitrogen assimilation genes by 2-oxoglutarate-reversible binding to conserved palindromic

268 Pyruvate and oxaloacetate bind to the 2-oxoglutarate site of HIF-1alpha prolyl hydroxylases, but

269 cycle intermediates (citrate, isocitrate, 2-oxoglutarate, succinate, fumarate, malate, and oxaloacet

270 annotation implicates a ferredoxin-dependent oxoglutarate synthase, isotopic evidence does not suppor

271 r yields slow but substantial oxidation of 2-oxoglutarate that is inefficiently coupled to nucleotide

272 ing for activity both molecular oxygen and 2-oxoglutarate that, under normoxia, selectively hydroxyla

273 f a novel enzymatic activity that converts 2-oxoglutarate to D-2-hydroxyglutarate.

274 fungi by condensing acetyl-coenzyme A and 2-oxoglutarate to form 3R-homocitrate and coenzyme A.

275 ersible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate, and thereby

276 on, but via the four-electron oxidation of 2-oxoglutarate to give ethylene in an arginine-dependent r

277 Pyl is also able to ligate 2-oxoglutarate to other 4-amino-sugar derivatives to form

278 Together, these two enzymes convert 2-oxoglutarate to succinate and thus functionally replace

279 rate dehydrogenase and thus cannot convert 2-oxoglutarate to succinyl-coenzyme A (CoA).

280 t, in the presence of ATP and Mg(II), adds 2-oxoglutarate to the 4-amino moiety of UDP-4-amino-FucNAc

281 tes that this mutation prevents binding of 2-oxoglutarate to the GAF domain.

282 Addition of 2-oxoglutarate to the growth media of the double mutant st

283 Addition of 2-oxoglutarate to wild-type extracts enhanced activity up

284 ltaR306 mutant complexed with iron(II) and 2-oxoglutarate (to 2.10 A) and the DeltaR306A mutant compl

285 samination enzymes, namely 4-aminobutyrate-2-oxoglutarate transaminase (GABA-T) and alanine-glyoxylat

286 ian transaminating enzymes 4-aminobutyrate-2-oxoglutarate transaminase and alanine-glyoxylate transam

287 ture quenching by solvent, which uncouples 2-oxoglutarate turnover from nucleobase oxidation.

288 d in the synthesis of UDP-FucNAc-4-amido-(2)-oxoglutarate (UDP-Yelosamine), a modified UDP-sugar not

289 e in counteracting the response of NifA to 2-oxoglutarate, under conditions that are inappropriate fo

290 le oxidative deamination of l-glutamate to 2-oxoglutarate using NAD(P)(+) as coenzyme.

291 DAOCS was crystallized +/-Fe(II) and/or 2-oxoglutarate using the hanging drop method.

292 Oxidation of 2-oxoglutarate was significantly uncoupled from oxidation

293 apparent K(m) values for hypophosphite and 2-oxoglutarate were 0.58 +/- 0.04 mm and 10.6 +/- 1.4 micr

294 1.2 and 7121.4 eV for DAOCS alone and with 2-oxoglutarate were both consistent with the presence of F

295 of NIFL is relieved by elevated levels of 2-oxoglutarate when PII is uridylylated under conditions o

296 ity that is counteracted by high levels of 2-oxoglutarate, which acts as a signal of nitrogen limitat

297 amination activity of GDH might regenerate 2-oxoglutarate, which is a cosubstrate that facilitates th

298 oxidative decarboxylation of isocitrate to 2-oxoglutarate with a specific activity of 22.5 units/mg a

299 the oxidative deamination of glutamate to 2-oxoglutarate with concomitant reduction of NAD(P)(+), an

300 N at 1.99 A), a bidentate O,O-co-ordinated 2-oxoglutarate with Fe-O distances of 2.08 A, another O at