ライフサイエンスコーパス: oxygen tension

1 lly damaging stimuli (e.g. sunlight and high oxygen tension).

2 tously expressed, regardless of the level of oxygen tension.

3 ble factor (HIF) activity in response to low oxygen tension.

4 nse of all mammalian cells to alterations in oxygen tension.

5 a single threshold for harm from supranormal oxygen tension.

6 ) mutants, of PDO300 were isolated under low oxygen tension.

7 a redox signal even in the presence of high oxygen tension.

8 microRNAs, which fine-tune adaptation to low oxygen tension.

9 egulated in cardiac myocytes on a decline in oxygen tension.

10 tically with decreasing pH or with decreased oxygen tension.

11 pendent degradation irrespective of cellular oxygen tension.

12 bient (20% O(2)) and physiological (5% O(2)) oxygen tension.

13 elative to iPs, under conditions of elevated oxygen tension.

14 is despite normal serum Epo levels and blood oxygen tension.

15 endothelium-specific response to increasing oxygen tension.

16 ressing fibrinolysis under conditions of low oxygen tension.

17 n of cyclic mechanical strain and controlled oxygen tension.

18 t neonatal cardiomyocytes are exposed to low oxygen tension.

19 ong-term persistence under conditions of low oxygen tension.

20 s one source of the underlying variations in oxygen tension.

21 ced a 65% to 70% reduction in blood flow and oxygen tension.

22 selective for L-DHA, and up-regulated by low oxygen tension.

23 and constitutively expressed irrespective of oxygen tension.

24 converted back to reduced holo-mNT under low oxygen tension.

25 hemic tissue in direct proportion to reduced oxygen tension.

26 nzyme activation in response to increases in oxygen tension.

27 -mediated nitrite reduction as a function of oxygen tension.

28 elopment in response to tissue mechanics and oxygen tension.

29 nt of protein degradation but depends on the oxygen tension.

30 asis by upregulating various genes under low oxygen tension.

31 n of RAMPs 1, 2, and 3 was unaffected by low oxygen tension.

32 r their physiology in response to changes in oxygen tension.

33 pha, which is tightly controlled by cellular oxygen tension.

34 ment in the first trimester occurs under low oxygen tension.

35 onsive genes to facilitate adaptation to low oxygen tension.

36 ked contrast, this effect was lost under low oxygen tension.

37 A-MB-468 cells with time and with increasing oxygen tension.

38 chondria and a reduction of the interstitial oxygen tension.

39 liferative capacity of adult cells under low oxygen tension.

40 gulating the cellular response to changes in oxygen tension.

41 stream signals composed of TGF-beta1, RA and oxygen tension.

42 eobacteria to sense environmental changes in oxygen tension.

43 and recovery following starvation under high oxygen tensions.

44 s hypoxia-inducible factors (HIFs) at normal oxygen tensions.

45 activity over a wide range of physiological oxygen tensions.

46 ectly mediate cellular adaptation to reduced oxygen tensions.

47 levels in the cell increase with decreasing oxygen tensions.

48 onmetal-binding hypoxia mimetics and reduced oxygen tensions.

49 oth are used for respiration under different oxygen tensions.

50 atory conditions are primarily controlled by oxygen tensions.

51 during placentation, which occurs under low oxygen tensions.

52 behaves as a nitric oxide (NO) donor at low oxygen tensions.

53 tivity under constant, rather than changing, oxygen tensions.

54 es its RNA-binding activity at physiological oxygen tensions.

55 has an important metabolic function at high oxygen tensions.

56 responsiveness to nitrosovasodilators at low oxygen tensions.

57 potential strategy to rapidly raise arterial oxygen tensions.

58 d of niches that house cells across variable oxygen tensions.

59 ns, and the subsequent 6 at near-physiologic oxygen tensions.

60 ates for efficient catalysis under different oxygen tensions.

61 ) and previously reported electrode-measured oxygen tension (22 +/- 1 mm Hg).

62 ween the droplet-derived preretinal vitreous oxygen tension (24 +/- 2 mm Hg, mean +/- SEM, n = 18) an

63 Culturing cells under low oxygen tension (3%) largely prevented the shMTH1-depende

64 nse of vascular endothelial cells at reduced oxygen tension (5% and 2%), in particular the effect of

65 is approximately 100 nmol/L at physiological oxygen tensions (5 to 10 mumol/L); we tested whether the

66 tively independent of oxygen tension at high oxygen tensions (5-21%), where they were approximately 1

67 Depending on the oxygen tension, a concerted action of the three transcri

68 phile that has to survive high environmental oxygen tensions, adapt to oxygen limitation in the intes

69 How oxygen tension affects IRSs and their functions is poorl

70 Current guidelines limit the use of high oxygen tension after return of spontaneous circulation a

71 Three-dimensional mapping of chorioretinal oxygen tension allowed quantitative P(O2) measurements i

72 in sensitivity of SNOHb vasodilation at low oxygen tensions also was observed.

73 hat GC light zones are hypoxic, and that low oxygen tension () alters B cell physiology and function.

74 ygen intermediates, and increased or reduced oxygen tension), although the mutant was more sensitive

75 -growing tumors of regions with gradients of oxygen tension and acute hypoxia (less than 1.4% oxygen)

76 iators of the cellular response to decreased oxygen tension and are overexpressed in a number of tumo

77 lieved to play vital roles in the YRO (e.g., oxygen tension and ATP levels), we tested oxygen's role

78 ry lung volume, but did not improve arterial oxygen tension and caused a reduction in cardiac output.

79 with the hypothesis that increased arterial oxygen tension and consequently increased CSF Po(2) resu

80 ng a strong association between brain tissue oxygen tension and diffusion of dissolved plasma oxygen

81 racting node for microenvironment sensing of oxygen tension and glucocorticoid action in foci of infl

82 rs that affect a homeostatic response to low oxygen tension and have been identified as key mediators

83 ECs) are exposed to profound fluctuations in oxygen tension and have evolved adaptive transcriptional

84 Increases in oxygen tension and in H(2)O(2) both induce activation of

85 immune response genes in the setting of low oxygen tension and inflammation.

86 This transition is governed by oxygen tension and involves the large-scale production o

87 gulating the cellular response to changes in oxygen tension and is essential for normal development.

88 P. aeruginosa is known to grow under reduced oxygen tension and is even capable of respiring anaerobi

89 th the unique advantages of exceptional high oxygen tension and local anti-inflammatory and immunosup

90 , B. burgdorferi experiences fluctuations in oxygen tension and may encounter reactive oxygen species

91 ccurred in the setting of preserved arterial oxygen tension and myocardial perfusion.

92 Reduced oxygen tension and nitric oxide exposure are two conditi

93 define the relationship between supranormal oxygen tension and outcome in postresuscitation patients

94 Thus, a combination of low oxygen tension and overexpression of EGFR within the pri

95 of a pathway that confers resistance to high oxygen tension and protects cells from undergoing ferrop

96 ceptors in the carotid bodies sense arterial oxygen tension and regulate respiration.

97 blasts are ideally situated in bone to sense oxygen tension and respond to hypoxia by activating the

98 se-dependent association between supranormal oxygen tension and risk of in-hospital death.

99 l hydroxylases (PHDs) perceive intracellular oxygen tension and signal hypoxia-inducible factors (HIF

100 plastic phenotype that could be modulated by oxygen tension and that when injected into the renal cor

101 erial blood pressure, cardiac output, tissue oxygen tension and the circulating pool of NO metabolite

102 e relationship was observed between arterial oxygen tension and the magnitude of hyperleukocytosis.

103 re, myocardial blood flow, myocardial tissue oxygen tension, and ejection fraction before and after i

104 ic infection leads to a considerably reduced oxygen tension, and it is believed that some bacteria gr

105 kle brachial index, increased transcutaneous oxygen tension, and reduced rest pain.

106 s, effects more apparent at 5%, than at 20%, oxygen tension, and these progenitors survived less well

107 e, many solid tumors are associated with low oxygen tension, and when NSCLC cells were cultured with

108 rst 6 livers were perfused at high perfusate oxygen tensions, and the subsequent 6 at near-physiologi

109 ty cytochrome bd oxidase, which is used when oxygen tensions are low, also failed to colonize.

110 hESCs cultured at low oxygen tensions are more pluripotent and display an incr

111 even in the acute infection phase, where low oxygen tensions are not expected.

112 sculature coincide with drastic increases in oxygen tension as placental blood flow is initiated.

113 pids and in particular cholesterol under low oxygen tension as revealed by TOF-SIMS coupled to princi

114 ce of these results became evident under low oxygen tensions, as hypoxia enhanced ECAR in M-MO via HI

115 umption rates were relatively independent of oxygen tension at high oxygen tensions (5-21%), where th

116 Hypoxic inflammation (decreased oxygen tension at sites of inflammation) is a feature of

117 ral artery development, leading to decreased oxygen tension at the placentation site, stabilized hypo

118 g/kg) caused a dose-related increase in the oxygen tension at which Hb is 50% saturated (p50), with

119 The apparent P50 (oxygen tension at which hemoglobin is 50% saturated) val

120 is, however, unaffected by copper under high oxygen tension because of the aerobic coproporphyrinogen

121 ed MLH1 and PMS2 levels, in keeping with low oxygen tension being the stress signal that provokes the

122 Reduction of maternal arterial oxygen tension by 50% over 30 min resulted in a subseiue

123 In response to a low oxygen tension, C. jejuni increases the transcription an

124 2) indicating that physiological changes in oxygen tension can influence cotransport function.

125 Collectively, TGF-beta1, RA and oxygen tension can modulate the dynamic change in AKAP12

126 tively, by treatment with CoCl2, whereas low oxygen tension caused increases in expression of 3-, 4-,

127 taPsim and mitochondrial ROS production from oxygen tension changes, provides an immune-metabolic bas

128 xide anions via quinone reduction under high oxygen tensions, contributes to the unique microaerobic

129 Using this sensor, changes in oxygen tension could be monitored in real-time as attach

130 A) released from the meninges, together with oxygen tension, could constitute the mechanism for rapid

131 Gene expression of XOR is regulated by oxygen tension, cytokines and glucocorticoids.

132 n oxygen concentration of 3%, whereas higher oxygen tensions decreased GSNO and increased GSSG format

133 When oxygen tension decreases, the response regulator PrrA of

134 Indeed, under normal oxygen tension, delivery of active Lck into L929 cells a

135 Below 5% oxygen, the rate fell in an oxygen tension-dependent manner.

136 setting of up-regulated DHA transport at low oxygen tensions, DHA would contribute 26% of the total i

137 he product of CBF and cerebral arteriovenous oxygen tension difference (AVTO2), suggesting a strong a

138 monoxide (DL(CO)), and the alveolar-arterial oxygen tension difference P(A-a)O(2) were measured and a

139 prove that metabolic programming of MSCs by oxygen tension directs chondrogenesis into either perman

140 At high levels of cardiac work, tissue oxygen tension dropped significantly along with ejection

141 Cellular response to changes in oxygen tension during normal development or pathologic p

142 Most patients maintain an adequate arterial oxygen tension during single-lung ventilation.

143 e of conditions encountered in vivo, such as oxygen tension, environmental pH and nutrient availabili

144 tly, slowing blood flow velocity at arterial oxygen tension even without additional contributions fro

145 High oxygen tension, exposure to light, and the biochemical e

146 MPhi activated under these oxygen tensions failed to produce sufficient amounts of

147 When oxygen tension falls, HIF-alpha subunits translocate to

148 hypothesis was that key factors relating to oxygen tension fluctuations would vary between the two t

149 lpha is highly conserved and that changes in oxygen tensions following cartilage loss from injury or

150 to broaden the permissible range of arterial oxygen tensions for pulmonary/tissue oxygen transport.

151 Low oxygen tension growth of mucoid variants readily selects

152 oading following independent manipulation of oxygen tension, Hb conformation, and glycolytic pathway

153 assured oxidative loading was not altered by oxygen tension, heme ligation, or the inhibitors employe

154 Under normal oxygen tension, HIF-1 activity is usually suppressed due

155 Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to t

156 Adaptation to low oxygen tension (hypoxia) is a critical event during deve

157 Low oxygen tension (hypoxia) is commonly thought to be a sha

158 Recent evidence suggests that low oxygen tension (hypoxia) may control fetal development a

159 Low oxygen tension (hypoxia) promotes the upregulation of se

160 Low oxygen tension (hypoxia) regulates chondrocyte different

161 on point under stress conditions such as low oxygen tension (hypoxia).

162 s) has been proposed to be influenced by low oxygen tension (hypoxia).

163 l tissue-protecting mechanism, driven by low oxygen tension (i.e. hypoxia) in inflamed or cancerous t

164 otopic endochondral ossification by lowering oxygen tension in adjacent tissue, creating the correct

165 receptors in vascular smooth muscle, by low oxygen tension in erythrocytes and neurons, by high extr

166 dazole staining also showed that TM elevates oxygen tension in hypoxic cells.

167 Oxygen tension in mammalian cell culture can profoundly

168 Since a major determinant of oxygen tension in mammalian embryos after implantation i

169 The oxygen tension in normal cartilage is not likely to fall

170 Variations in oxygen tension in particular have been correlated with c

171 and EtrA (FNR), which respond to changes in oxygen tension in S. oneidensis MR-1.

172 clear whether the reduced cabin pressure and oxygen tension in the airplane cabin create an increased

173 on the epithelial surface, establishing low oxygen tension in the lumen, and interacting with gut-co

174 nduction of reporter transcription under low oxygen tension in the presence of either endogenous huma

175 intervals from 4 to 28 days, blood flow and oxygen tension in the proximal adductor muscles were mea

176 concentration gradient of oxygen, with lower oxygen tension in the region destined to become articula

177 Administration of 50% oxygen increased oxygen tension in the subcutaneous site to 140 mm Hg, co

178 ood flow does not necessarily mean increased oxygen tension in the tissue.

179 ned to become articular cartilage and higher oxygen tension in transient hypertrophic cartilage.

180 We employed this probe to evaluate the oxygen tension in tuberculous granulomas in four animal

181 allows wireless measurement of renal tissue oxygen tension in unrestrained rats.

182 The oxygen tension in vivo is significantly lower than that

183 es but only fell to approximately 1% for low oxygen tensions in synovial fluid, with no supply from t

184 With fluctuating oxygen tensions in tumors, arrested hypoxic cells may un

185 These results suggest that low oxygen tension increases endothelial cell capacity to pr

186 pregestational diabetic pregnancies when the oxygen tension increases.

187 cardiovascular circulation and in the eye as oxygen tension increases.

188 sociation between rectal luminal lactate and oxygen tension indicates that luminal lactate is a marke

189 We show that low oxygen tension induces molting at smaller body size, con

190 ypertension, we studied the acute effects of oxygen tension, inhaled nitric oxide (iNO), and calcium

191 Recent findings indicate that local oxygen tension is a critical determinant for the progres

192 Low oxygen tension is a major host factor inducing bacterios

193 Low oxygen tension is a metabolic hallmark of chronic infect

194 cytochrome bo(3) oxidase, which is used when oxygen tension is high, was found not to be necessary fo

195 presence of melanin in combination with low oxygen tension is known to compromise PDT.

196 dium flow revealed that a sudden decrease in oxygen tension is the predominant trigger for initiating

197 Mechanical ventilation using high oxygen tensions is often necessary to treat patients wit

198 e presence of multiple areas of hypoxia (low oxygen tension) is a hallmark feature of human and exper

199 Hypoxia, or low oxygen tension, is a major regulator of tumor developmen

200 ctivator of some photosynthesis genes at low oxygen tension, is involved in redox-dependent expressio

201 lar hypoxia response pathways despite normal oxygen tension-is considered to be a likely mechanism un

202 We tested whether environmental shifts in oxygen tension lead to events in the adult newt brain th

203 is only prominent in axenic Mtb cultures at oxygen tensions </=1%.

204 m and homeostasis is sensitive to changes in oxygen tension manifest in ischemia.

205 level such as sulfide exposure and possibly oxygen tension may inhibit the heterocystous types in su

206 In rapidly growing tumors, reduction in oxygen tension may occur with increased distance from bl

207 ons, suggesting that adaptation to different oxygen tensions may influence colonization potential.

208 Here, we show that oxygen tension, mediated by OPC-encoded hypoxia-inducibl

209 Low oxygen tension-mediated transcription by hypoxia-inducib

210 However, oxygen tension monitored by the peripheral (arterial) ch

211 nditions, with this process regulated by pH, oxygen tension, nitrite concentration, and the redox sta

212 uction, and this process is regulated by pH, oxygen tension, nitrite, and reducing substrate concentr

213 pH 5.8, and nonreplicating persisters at low oxygen tension of </= 10 parts per billion.

214 in the carotid body respond to decreases in oxygen tension of the blood and transmit this sensory in

215 activity of AphB is influenced by the pH and oxygen tension of the environment.

216 change in glutamate levels was seen when the oxygen tension of the medium was lowered from 150 mm Hg

217 el directed at addressing the role of tissue oxygen tension on cutaneous wound healing.

218 Nevertheless, the effects of low oxygen tension on osteogenic precursors remain to be ful

219 uate the effects of physiologically relevant oxygen tensions on L-14C-DHA transport.

220 n the wild-type strain grown at high and low oxygen tensions, on the strain overproducing PpsR, and o

221 tion from a high oxygen level (10% dissolved oxygen tension or DOT) to a low oxygen level (0.2% DOT)

222 that is reversed by culturing under reduced oxygen tension or the addition of antioxidants.

223 a threshold effect at a specific supranormal oxygen tension, or is a dose-dependent association.

224 This work defines the oxygen tensions over which hypoxic damage occurs in C. e

225 inversely correlated with wake-time arterial oxygen tension (P = 0.0007) and oxygen saturation (P < 0

226 he specific determinants of low brain tissue oxygen tension (P(bt)O2) following severe traumatic brai

227 s developed for three-dimensional mapping of oxygen tension (P(O2)) in chorioretinal vasculatures.

228 nstructing for explicit targets for arterial oxygen tension (PaO2, 55-86 mm Hg) and oxyhemoglobin sat

229 tility are carried out at a nonphysiological oxygen tension [partial pressure of oxygen (pO2)] that c

230 n untreated ischemic muscle, muscle flow and oxygen tension partially recovered by days 14 to 28.

231 ject to frequent, pronounced fluctuations in oxygen tension, particularly during inflammation.

232 Cerebral cortical carbon dioxide and oxygen tensions (Pbco2 and Pbo2) were concurrently measu

233 Cerebral cortical tissue carbon dioxide and oxygen tensions (Pbco2 and Pbo2) were measured concurren

234 evolution of microvascular blood flow, brain oxygen tension (PbO2), and metabolism in a clinically re

235 f electrical TNS for improving CBF and brain oxygen tension (PbrO2), with the goal of decreasing seco

236 obes to measure intracranial pressure, brain oxygen tension (PbtO2), and brain microdialysis, and ele

237 under aerobic conditions and is regulated by oxygen tension, pH, nitrite, and reducing substrate conc

238 Changes in cellular oxygen tension play important roles in physiological pro

239 ygen saturation (StO2) and calculated muscle oxygen tension (PmO2) to standard hemodynamic variables

240 output; and quadriceps muscle blood flow and oxygen tension (PMo2).

241 hich couple the conformation of Hb to tissue oxygen tension (Po(2)) and thereby provide a basis for t

242 under normoxia and hypoxia based on vascular oxygen tension (PO(2)) imaging.

243 Oxygen tension (PO(2)) was measured noninvasively in the

244 lism is directly related to retinal vascular oxygen tension (PO2) and inner retinal oxygen extraction

245 d continuous measurements of cortical tissue oxygen tension (PO2) for more than 2 weeks and can repro

246 orescence-based imaging technology, that low oxygen tension (pO2) impairs NO-mediated anti-leishmania

247 perform direct in vivo measurements of local oxygen tension (pO2) in the bone marrow of live mice.

248 S-Oxidation of RyR1 is coupled to muscle oxygen tension (pO2) through O2-dependent production of

249 Myocardial oxygen tension (Po2) was monitored by electron paramagne

250 promote macrophage lipid storage: low tissue oxygen tension (pO2), low extracellular pH (pHo), and ex

251 Differences in oxygen tension (Po2)cause variations in response to radi

252 Antioxidants and low oxygen tension prevented SA IL-1alpha expression and res

253 ed human macrophages cultured at physiologic oxygen tensions produced copious nitrite.

254 The oxygen tension profile across articular cartilage was pr

255 of oxygen and used these rates to calculate oxygen tension profiles across articular cartilage.

256 conclusion, metabolic programming of MSCs by oxygen tension provides a simple yet effective mechanism

257 l oxygen content (CaO2), jugular bulb venous oxygen tension (PVO2), venous oxygen content (CVO2), art

258 ependent decrease in hydroxylation at higher oxygen tensions relative to proline 564 hydroxylation.

259 Average inner retinal oxygen tension remained within normal limits at all dise

260 vironmental cues, such as changes in ambient oxygen tension, remains poorly understood.

261 r transplants, with livers perfused at lower oxygen tensions, reperfused uneventfully.

262 The treatment of low-blood oxygen tensions requires restoration of functional airwa

263 nges in ankle brachial index, transcutaneous oxygen tension, rest pain, and walking capacity after ce

264 ermine how and when changes in environmental oxygen tension result in an appropriate cellular respons

265 stingly, gene network analysis revealed that oxygen tension resulted in metabolic programming of the

266 During the first trimester of gestation, oxygen tension rises steeply, leading to excessive produ

267 a, which may be operative at the physiologic oxygen tensions seen in solid lymphoid organs.

268 Because low oxygen tension stabilizes hypoxia-inducible factor alpha

269 Oxygen tension, substrate, and pH levels were important

270 reful consideration of nutrient delivery and oxygen tension suggested that these factors could not so

271 f viability was partially rescued by lowered oxygen tension, suggesting that the high sensitivity of

272 ssue perfusion as measured by transcutaneous oxygen tension (TcPo(2)) in patients with critical limb

273 ne (TrHBMEC) to a much greater extent at low oxygen tension than in room air.

274 odilation is a physiological response to low oxygen tension that increases blood supply to match meta

275 cription factor complex stabilized under low oxygen tension to mediate cellular responses, including

276 ells in vitro were treated with CoCl2 or low oxygen tension to mimic hypoxia.

277 , CBF by laser Doppler flowmetry, and tissue oxygen tension (tpO(2)) using polarographic microelectro

278 horoid and is contingent upon retinal tissue oxygen tension (tPO2) gradients across the retinal depth

279 ardiac index, pulse oximetry, transcutaneous oxygen tension, transcutaneous carbon dioxide tension, a

280 elegans males sense external environment and oxygen tension, triggering long-lasting downstream signa

281 ch allows eukaryotic cells to respond to low oxygen tension via the formation of a heterodimeric comp

282 ting TSCs induce HIF activity independent of oxygen tension via unclear mechanisms.

283 The oxygen tension was found to decrease due to oxygen consu

284 Oxygen tension was measured in retinal vessels using pho

285 zed; as a pair of master regulators when low oxygen tension was sensed, they coordinated the critical

286 Over ascending ranges of oxygen tension, we found significant linear trends of in

287 or cell survival probability under differing oxygen tensions, we calculate average radiation effect o

288 At limiting oxygen tensions, we found that proline 402 exhibits an o

289 Spatial profiles of oxygen tension were obtained in the cat retina, in vivo,

290 Tissue oxygen tensions were lower on day 10 of infection when t

291 in Beas-2B nuclear extracts because ambient oxygen tensions were required for the demethylation reac

292 LSCs home in bone marrow areas at low oxygen tension, where HSCs are physiologically hosted.

293 chestrators of chondrogenesis in response to oxygen tension which is, at least in part, mediated thro

294 hether this effect was caused by the reduced oxygen tension, which affects mainly peripheral chemorec

295 mechanisms, from transcriptional networks to oxygen tension, which control trophoblast differentiatio

296 bacter sphaeroides is induced upon a drop of oxygen tension with similar kinetics to those of genes f

297 d for quantitative mapping of retinal tissue oxygen tension with the potential to enable sequential m

298 Oxygen tensions within cartilage are strongly affected b

299 ed conditions under which supplementation of oxygen tension would serve to benefit cellular viability

300 bit abundant macrophage infiltration and low oxygen tension, yet how hypoxic conditions may affect in