ライフサイエンスコーパス: oxygenase

1 noid products of Synechocystis apocarotenoid oxygenase.

2 of Sudestada1 (Sud1), a Drosophila ribosomal oxygenase.

3 cal roles for a widely distributed ribosomal oxygenase.

4 oxidative bicyclization mediated by a Rieske oxygenase.

5 on-carbon bond cleaving enzyme, myo-inositol-oxygenase.

6 in requires oxygen for its synthesis by heme oxygenase.

7 mum basilicum L.) trichomes as a Rieske-type oxygenase.

8 atophagous) mites, lack a gene encoding haem oxygenase.

9 iffer from those generated by canonical heme oxygenases.

10 bsequent induction of CYP1-metabolizing mono-oxygenases.

11 minals, but resistant to inhibition of cyclo-oxygenases.

12 istorically problematic cytochrome P450 mono-oxygenases.

13 s achieved by cytochrome P450-dependent mono-oxygenases.

14 ormer group of CCOs functions as mono- or di-oxygenases.

15 porting in vitro catalysis by 2-oxoglutarate oxygenases.

16 Ms) are 2-oxoglutarate- and Fe(II)-dependent oxygenases.

17 a new structural subfamily of 2OG-dependent oxygenases.

18 y oxoglutarate- or cytochrome P450-dependent oxygenases.

19 of Fe(II) and 2-oxoglutarate (2OG) dependent oxygenases.

20 tile oxidants formed by nature's most potent oxygenases.

21 common intermediate with the canonical heme oxygenases.

22 beta,beta-Carotene 15-15' mono-oxygenase 1 (BCMO1) is a key enzyme in vitamin A (VitA)

23 duced progesterone levels and placental heme oxygenase 1 (Hmox1) expression and increased methylation

24 KEY POINTS: Haem oxygenase 1 (Hmox1) is a cytoprotective enzyme with anti

25 ulates the expression of genes encoding heme oxygenase 1 (Hmox1), glutamate-cysteine ligase catalytic

26 rf2-regulated genes/proteins, including heme oxygenase 1 (Hmox1).

27 xpression and a delayed upregulation of heme oxygenase 1 (HO-1) expression.

28 erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) gene proteins in retinal tissues (P <

29 tigated whether up-regulation of DAF by heme oxygenase 1 (HO-1) is an underlying mechanism by using H

30 To assess intracellular heme oxygenase 1 (HO-1) isolated PBMCs were used.

31 10R) by cmvIL-10 led to upregulation of heme oxygenase 1 (HO-1), an enzyme linked with suppression of

32 ression of the major antioxidant enzyme heme oxygenase 1 (HO-1).

33 mulated MMP-1 expression via activating heme oxygenase 1 (HO-1).

34 (matrix metalloproteinase 1 [MMP-1] and heme oxygenase 1 [HO-1]), and proinflammatory cytokines (inte

35 miR-24 also regulated heme oxygenase 1 and H2A histone family, member X, in vivo.

36 hypoxia-inducible factor 1alpha-induced heme oxygenase 1 expression resulting in improved survival of

37 sed inducible nitric oxide synthase and heme-oxygenase 1 expression, and increased MDA and plasma cre

38 sed inducible nitric oxide synthase and heme-oxygenase 1 expression, and increased plasma creatinine

39 of hypoxia-inducible factor 1alpha and heme oxygenase 1 in the hippocampus was increased in the argo

40 GP5 (glycoprotein 5), as well as HMOX1 (haem oxygenase 1) and BCL2L1 (BCL2-like 1) which are involved

41 for hypoxia-inducible factor 1alpha and heme oxygenase 1, and 4) immunohistochemistry of hippocampal

42 iron in liver despite up-regulation of heme oxygenase 1, ferroportin, and ferritins.

43 robustly increased genes and proteins, heme oxygenase 1, NADPH-quinone oxidoreductase 1, and growth

44 on of H2A histone family, member X, and heme oxygenase 1, which were experimentally validated as dire

45 oassociated virus (rAAV)-encoding human heme oxygenase-1 (hHO-1) in attenuating post-ischemic inflamm

46 CX3CR1 receptor induced upregulation of heme-oxygenase-1 (HMOX-1), an antioxidant and anti-inflammato

47 ), cluster of differentiation (CD) 163, heme oxygenase-1 (HMOX1), and biliverdin reductase A (BLVRA)

48 l downregulation of the redox regulator heme oxygenase-1 (HO-1 or HMOX1).

49 Although heme oxygenase-1 (HO-1) acts downstream of vascular endotheli

50 AD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1) and a high ratio of Bcl-2/Bax.

51 s by the regulations of novel molecules heme oxygenase-1 (HO-1) and programmed death-1 ligand 1 (PD-L

52 Despite recent data identifying heme oxygenase-1 (HO-1) as a putative autophagy inducer, its

53 toprotective and antiapoptotic molecule heme oxygenase-1 (HO-1) at the transcriptional level.

54 The Nrf2/heme oxygenase-1 (HO-1) axis affords significant protection a

55 Heme oxygenase-1 (HO-1) catalyzes the degradation of heme, wh

56 The enzyme heme oxygenase-1 (HO-1) degrades heme and protects against is

57 We tested the hypothesis that heme oxygenase-1 (HO-1) expression, which is protective in is

58 ioxidative and anti-inflammatory enzyme heme oxygenase-1 (HO-1) in the brains of individuals with HAN

59 Heme oxygenase-1 (HO-1) is a stress-inducible, anti-inflammat

60 Heme oxygenase-1 (HO-1) is a ubiquitously expressed inducible

61 Heme oxygenase-1 (HO-1) is an inducible enzyme that exhibits

62 Heme oxygenase-1 (HO-1) is an inducible stress-responsive enz

63 Heme oxygenase-1 (HO-1) is an inducible, detoxifying enzyme t

64 Expression of the cytoprotective enzyme heme oxygenase-1 (HO-1) is significantly reduced in the brain

65 Heme oxygenase-1 (HO-1) levels were previously shown to disti

66 nducing the activity of the host enzyme heme oxygenase-1 (HO-1) on hRSV replication and pathogenesis

67 expression of the cytoprotective enzyme heme oxygenase-1 (HO-1) play a critical role in the growth an

68 Heme oxygenase-1 (HO-1) protein is an antioxidant enzyme usua

69 nly overexpression of the gene encoding heme oxygenase-1 (HO-1) significantly correlated with increas

70 mutant induced the anti-oxidant enzyme heme-oxygenase-1 (HO-1) through activation of NRF2.

71 egulation of the cytoprotective protein heme oxygenase-1 (HO-1) which is capable of mitigating acute

72 fication with pNaKtide and induction of heme oxygenase-1 (HO-1) with cobalt protoporphyrin (CoPP) mar

73 Heme oxygenase-1 (HO-1), a pivotal cytoprotective enzyme, has

74 t PRRSV downregulates the expression of heme oxygenase-1 (HO-1), a pivotal cytoprotective enzyme, pos

75 ntioxidant transcription factor, and of heme oxygenase-1 (HO-1), one of its main target genes, in OA

76 olid tumors and myeloid leukemia cells, heme oxygenase-1 (HO-1), the anti-oxidant, anti-inflammatory,

77 tion as a master protective sentinel is heme oxygenase-1 (HO-1), the rate-limiting step in the catabo

78 The wound mRNA levels of heme oxygenase-1 (HO-1), TNF-alpha, the receptor for advanced

79 racellular heme levels are regulated by heme oxygenase-1 (HO-1), which catalyzes the degradation of h

80 We therefore investigated the role of heme oxygenase-1 (HO-1), which catalyzes the degradation of h

81 pression of the stress response protein heme oxygenase-1 (HO-1), which interacts with and thereby inh

82 ulation of the stress-responsive enzyme heme oxygenase-1 (HO-1).

83 animals, and exhibited upregulation of heme oxygenase-1 (HO-1).

84 s by upregulating the stress-responsive heme-oxygenase-1 (HO-1).

85 Heme oxygenase-1 (HO-1, Hmox1) regulates viability, prolifera

86 in displayed synergistic lethality with heme oxygenase-1 and glutamate-cysteine ligase inhibitors aga

87 Nrf2 pathway, enhancing GSH/GSSG ratio, heme oxygenase-1 and glyoxalase 1 in liver tissue.

88 cuss here new insights into the role of heme oxygenase-1 and heme on cardiovascular health, and impor

89 ctility rather than passive stretch via heme oxygenase-1 and histone deacetylase signalling.

90 Nrf2-binding sites on the promoters of heme oxygenase-1 and NADPH quinone oxidoreductase 1.

91 r DJ-1 attenuated Cu((II))ATSM-mediated heme oxygenase-1 and NADPH quinone oxidoreductase-1 induction

92 le cardioprotective effects ascribed to heme oxygenase-1 are best evidenced by its ability to regulat

93 ing expression of the IL-10 target gene heme oxygenase-1 by mechanisms dependent on p38 MAPK activity

94 a and FAS concentrations, and increased heme oxygenase-1 concentration.

95 nces its paracine effects on RIII via a heme oxygenase-1 dependent mechanism, which may help us to ma

96 -1beta and nitric oxide partially via a heme oxygenase-1 dependent mechanism.

97 e thymidine dinucleotide repeats in the heme oxygenase-1 gene promoter in 386 patients with coronary

98 e thymidine dinucleotide repeats in the heme oxygenase-1 gene promoter is associated with cardiovascu

99 e thymidine dinucleotide repeats in the heme oxygenase-1 gene promoter is associated with higher risk

100 The Heme Oxygenase-1 in renal Transplantation study was a randomi

101 expression of the Nrf2 target protein, heme oxygenase-1 in the skin and protected against UVB-induce

102 proteomics screen, we identified HO-1 (heme oxygenase-1), the rate-limiting enzyme in the degradatio

103 idant systems such as peroxiredoxins-1, heme oxygenase-1, and anti-apoptotic factors, including BCL2,

104 ti-inflammatory factors interleukin-10, heme oxygenase-1, and Hsp70 in macrophages stimulated or not

105 hemokine (C-C motif) ligand 22 (CCL22), heme oxygenase-1, and TSG6.

106 n of the oxidative stress response gene heme oxygenase-1, and we demonstrated that NF-kappaB inhibiti

107 of the CBS inhibitor, CO, a product of heme oxygenase-1, flip the operating preference of CSE from c

108 ession of Nrf2-dependent genes, such as heme oxygenase-1, glutamate-cysteine ligase catalytic subunit

109 appaB, hypoxia-inducible factor-1alpha, heme oxygenase-1, inducible nitric oxide synthase, B-cell lym

110 ulation of key Nrf2 target genes (i.e., heme oxygenase-1, NAD(P)H dehydrogenase, quinone 1, glutathio

111 ntly upregulates Nrf2-responsive genes, heme oxygenase-1, NAD(P)H quinone oxidoreductase 1, and gluta

112 at impair liver regeneration, including heme oxygenase-1, programmed cell death 4, and the cyclin-dep

113 ocytes expressed higher basal levels of heme oxygenase-1.

114 of NF-erythroid 2-related factor 2 and heme oxygenase-1.

115 beta-carotene oxygenase 2 (BCO2) is a carotenoid cleavage enzyme locat

116 ed integration site (Wnt), and beta-carotene oxygenase 2 (BCO2).

117 Here, we report that mice deficient in heme oxygenase-2 (HO-2), which generates the gaseous molecule

118 itres of lentiviral vectors expressing Cyclo-oxygenase-2 by 600-fold, and adenoviral vectors expressi

119 inding site within the cellular protein heme oxygenase-2 that acts as a trap to inhibit N-myristoylat

120 Cyclo-oxygenase-2(-/-) mice had increased plasma levels of ADM

121 Ala for Thr at position 136 of apocarotenoid oxygenase, a site predicted to govern the mono- versus d

122 2,4-dioxygenase (HOD) belongs to a class of oxygenases able to catalyze this energetically unfavorab

123 e site residues in an apocarotenoid-cleaving oxygenase (ACO) from Synechocystis Most active site subs

124 It possesses unique bi-functional oxygenase activities, acting as both an arginine demethy

125 t, when normalized to their arachidonic acid oxygenase activities, the lipoxin synthase activities of

126 Owing to the wasteful oxygenase activity and slow turnover of Rubisco, the enz

127 Finally, a third oxygenase activity encoded in the biosynthetic gene clus

128 c cluster, which demonstrate that functional oxygenase activity is critical for antibiotic production

129 The counterproductive oxygenase activity of RuBisCO has persisted over billion

130 Aldehyde-deformylating oxygenase (ADO) is a ferritin-like nonheme-diiron enzyme

131 2OG oxygenases also catalyze prolyl and asparaginyl hydroxyl

132 duct may support IsdG's dual role as both an oxygenase and a sensor of heme availability in S. aureus

133 zymes ribulose 1,5-bisphosphate carboxylase/ oxygenase and carbonic anhydrase to facilitate carbon fi

134 nit of ribulose-1,5-bisphosphate carboxylase/oxygenase and its reverse peptide with a series of unrel

135 S was found to rebalance homeostasis between oxygenases and anti-oxidative enzymes by decreasing cycl

136 n the catalytic cycle of both enzymes (e.g., oxygenases) and synthetic oxidation catalysts.

137 oding for scavenger receptors, beta-carotene oxygenases, and ketolases.

138 AO, we considered membrane-bound Rieske-type oxygenases as potential candidates.

139 high frequency of lytic polysaccharide mono-oxygenases, as well as other physiological adaptation su

140 In mammalian tissues, beta-carotene 15,15'-oxygenase (BCO1) converts beta-carotene to retinaldehyde

141 r carotenoid oxygenase, beta-carotene 9',10'-oxygenase (BCO2) catalyzes the oxidative cleavage of car

142 can also be cleaved by beta-carotene 9',10'-oxygenase (BCO2) to form beta-apo-10'-carotenal, a precu

143 f mutants of the two Arabidopsis Rieske-type oxygenases (besides PAO) uncovered that phyllobilin hydr

144 Another carotenoid oxygenase, beta-carotene 9',10'-oxygenase (BCO2) catalyz

145 Cyanobacterial aldehyde-deformylating oxygenase (cADO) converts long-chain fatty aldehydes to

146 The anti-Markovnikov oxygenase can be combined with other catalysts in synthe

147 The results reveal a direct link between oxygenase catalysis and the regulation of gene expressio

148 II)- and 2-(oxo)glutarate-dependent (Fe/2OG) oxygenases catalyze an array of challenging transformati

149 Iron(II)- and 2-(oxo)-glutarate-dependent oxygenases catalyze diverse oxidative transformations th

150 ydroxylation is emerging as an important 2OG oxygenase catalyzed pathway, but its biological function

151 jd4), a 2-oxoglutarate- and Fe(II)-dependent oxygenase, catalyzes carbon 4 (C4) lysyl hydroxylation o

152 Carotenoid cleavage oxygenases (CCOs) are non-heme, Fe(II)-dependent enzymes

153 describe a new family of carotenoid cleavage oxygenases (CCOs) in metazoans, the BCO2-like (BCOL) cla

154 to an aryl-nitro product catalyzed by the N-oxygenase CmlI in three two-electron steps.

155 ed by the non-heme diiron cluster-containing oxygenase CmlI.

156 te the mechanism of oxygen activation in the oxygenase component (C2) of p-hydroxyphenylacetate 3-hyd

157 e Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenases comprise a large family of enzymes that utili

158 odilatation with nitric oxide (NO) and cyclo-oxygenase (COX) signalling pathways, microdialysis fibre

159 Increased generation of cyclo-oxygenase (COX-1 and COX-2)-derived vasoconstrictor fact

160 eek high-salt (HS) diet on the role of cyclo-oxygenases (COX-1 and COX-2) and the vasoconstrictor pro

161 sign of cross-linked artificial nonheme iron oxygenase crystals, we filled this gap by developing bio

162 tion of the gene encoding cytochrome P450 3A oxygenase (CYP3A) causes a prominent class of dangerous

163 In addition, nitric oxide and cyclo-oxygenase-derived byproducts are required for full expre

164 d away from the NADPH-FAD center, toward the oxygenase dimer.

165 th genetically disrupted carotenoid cleavage oxygenases displayed adipose tissue rather than eye-spec

166 chain, bacterial NOS is only composed of an oxygenase domain and must rely on separate redox partner

167 rough the FAD and FMN cofactors, to the heme oxygenase domain, the site of NO generation.

168 2-Oxoglutarate (2OG) and Fe(II)-dependent oxygenase domain-containing protein 1 (OGFOD1) is predic

169 odulin (CaM) binds between the reductase and oxygenase domains to activate NO synthesis.

170 me which is a key component of the P450 mono-oxygenase drug-metabolizing system.

171 acterial effects while CO, generated by heme oxygenases, enhances phagocytosis of macrophages.

172 ydroxylation reaction taking place at Rieske oxygenase enzymes and is regarded as a difficult problem

173 Predictions indicated hydrolase or oxygenase enzymes catalyzed the initial reactions.

174 remarkable chemistry of the family of Rieske oxygenase enzymes, nonheme iron complexes of tetradentat

175 hondrion-localized, GSH-dependent persulfide oxygenase ETHE1, suggesting that the physiological subst

176 s are complemented by gene disruption of the oxygenases evdO1 and evdMO1 from the everninomicin biosy

177 s, identifies branch points in 2OG-dependent oxygenase evolution and distinguishes between JmjC-conta

178 as observed in other 2OG and iron-dependent oxygenase family members.

179 in the ribulose-1,5-bisphosphate carboxylase/oxygenase family of enzymes.

180 ew of protein hydroxylation catalyzed by 2OG oxygenases, focusing on recent discoveries.

181 e oxygen rebound step typically used by most oxygenases for forming C-O bonds.

182 The apocarotenoid oxygenase from Synechocystis has been hypothesized to re

183 identification and characterization of three oxygenases from the fumagillin biosynthetic pathway, inc

184 c model of ribulose bisphosphate carboxylase/oxygenase function.

185 utbreak isolates were found to harbor a heme oxygenase gene (hemO)-containing gene cluster.

186 we showed that heterologous expression of an oxygenase gene (oxyBAC) present in this gene array in E.

187 on and ribulose 1,5-bisphosphate carboxylase/oxygenase gene clusters, underscoring its ability to den

188 eviously shown the catalytic actions of heme oxygenase (HemO) along with the cytoplasmic heme transpo

189 infections, such as the iron-regulated heme oxygenase (HemO) of Pseudomonas aeruginosa, due to links

190 for interaction with the iron-regulated heme oxygenase (HemO).

191 We hypothesize that in beta-thalassemia heme oxygenase (HO) 1 could play a pathogenic role in the dev

192 Heme oxygenase (HO) catalyzes the rate-limiting step in the O

193 o biliverdin (BV) through the action of haem oxygenase (HO) is a critical step in haem metabolism.

194 Free heme is metabolized by heme oxygenase (HO), resulting in the generation of carbon mo

195 Heme oxygenase (HO)-1 overexpression or induction has been sh

196 xpression of antioxidant genes, such as heme oxygenase (HO)-1, that protect parasites from oxidative

197 Heme oxygenase (HO)-2 deficiency impairs wound healing and ex

198 ne potential and increases in cytosolic heme oxygenase (HO-1) expression and mitochondrial colocaliza

199 t interact with HIV-1 MA, we found that heme oxygenase (HO-2) specifically binds the myristate moiety

200 s expression of the CO-producing enzyme heme oxygenase (HO1) and that CO is sensed by M. tuberculosis

201 cal mechanism of heme degradation is by heme oxygenases (HOs).

202 recently discovered mononuclear nonheme iron oxygenases: hydroxyethylphosphonate dioxygenase (HEPD) a

203 tions and is the major linalool metabolizing oxygenase in Arabidopsis flowers.

204 Carbon monoxide (CO)--produced by haem oxygenase in cardiomyocytes--has been reported to preven

205 r paralogous 2-oxoglutarate/Fe(II)-dependent oxygenases in Arabidopsis thaliana as JA hydroxylases an

206 s review we discuss the emerging role of 2OG oxygenases in gene expression control, examine the regul

207 Recent work has identified roles for 2OG oxygenases in the modification of translation-associated

208 KDM4A-C with selectivity over other KDMs/2OG oxygenases, including closely related KDM4D/E isoforms.

209 utarate-enabled activation of 2-oxoglutarate oxygenases, including prolyl hydroxylase domain 2, the m

210 trificans, a beta-proteobacterium, adopts an oxygenase-independent pathway to degrade cholesterol.

211 will be useful in designing new types of 2OG oxygenase inhibitors based on various conformational sta

212 n chelators, which make up most reported 2OG oxygenase inhibitors.

213 lectively referred to as carotenoid cleavage oxygenases is responsible for oxidative conversion of ca

214 f 2OG to ethylene, atypical among Fe(II)/2OG oxygenases, is facilitated by the binding of l-Arg which

215 The Fe(II) and 2-oxoglutarate dependent oxygenase Jmjd6 has been shown to hydroxylate lysine res

216 nduced by JA we named them JASMONATE-INDUCED OXYGENASES (JOXs).

217 n the mouse identified the kynurenine 3-mono-oxygenase (KMO) gene (Kmo) as a candidate gene associate

218 se, or ribulose 1,5-bisphosphate carboxylase/oxygenase, large subunit (RuBisCO) superfamily.

219 ive carbocyclization catalyzed by the Rieske oxygenase-like enzyme RedG.

220 ns catalyzed by other nonheme iron-dependent oxygenase-like enzymes, such as isopenicillin N synthase

221 nonheme iron, alpha-ketoglutarate-dependent oxygenases likely responsible for this chemistry.

222 ydrate polymers by lytic polysaccharide mono-oxygenases (LPMOs).

223 ied lipid A dependent on the PhoPQ-regulated oxygenase LpxO.

224 We demonstrated a novel Rieske oxygenase MarG catalyzed stereoselective bicyclization o

225 varying flux ratio of RubisCO carboxylase to oxygenase may contribute to the adaptive stress response

226 which H2 S, reactive oxygen species and haem oxygenase may integrate to provide a rapid oxygen sensin

227 substrate-free KshA, suggesting that Rieske oxygenases may have a dynamic nature similar to cytochro

228 discovery of ObF8H suggests that Rieske-type oxygenases may represent overlooked candidate catalysts

229 nced flux between haem biosynthesis and haem oxygenase-mediated degradation.

230 of the proximal tubular enzyme myo-inositol oxygenase (MIOX) induces oxidant stress in vitro However

231 The catabolic enzyme myo-inositol oxygenase (MIOX) is expressed in proximal tubules and up

232 Myo-inositol oxygenase (MIOX), a tubular-specific enzyme, modulates r

233 by the massive induction by arsenite of heme oxygenase mRNA (HMOX1; 68-fold increase), the rate-limit

234 2OG) and ferrous iron-dependent nucleic acid oxygenase (NAOX) that catalyzes the demethylation of N(6

235 e reported the structure of a TET-like (5m)C oxygenase (NgTET1) from Naegleria gruberi, a single-cell

236 ses of everninomicin biosynthesis, the AviO1 oxygenase of avilamycin biosynthesis, and HygX of hygrom

237 on crystal structures of the EvdO1 and EvdO2 oxygenases of everninomicin biosynthesis, the AviO1 oxyg

238 ed mutants affecting either chlorophyllide a oxygenase or the chloroplastic lipocalin, now renamed pl

239 ase (OsGGP) by 80%, while KO of myo-inositol oxygenase (OsMIOX) did not affect foliar AsA levels.

240 y revealing Tet2 as an iterative, de novo mC oxygenase, our study provides insight into how features

241 is catalyzed by two enzymes: pheophorbide a oxygenase (PaO) and red chl catabolite reductase (RCCR).

242 G1 (NYC1), PHEOPHYTINASE (PPH), and PHEIDE a OXYGENASE (PaO), and higher chlorophyll retention than t

243 by the Rieske-type oxygenase PHEOPHORBIDE a OXYGENASE (PAO), are the end products of chlorophyll deg

244 of the chlorin macrocycle by the Rieske-type oxygenase PHEOPHORBIDE a OXYGENASE (PAO), are the end pr

245 Active demethylation of 5mC by TET oxygenases produces 5-formylcytosine (fC) and 5-carboxyl

246 Cofactor-free oxidases and oxygenases promote and control the reactivity of O2 with

247 o increase yields by suppressing the Rubisco oxygenase reaction and, in turn, photorespiration.

248 branch, an apparently typical 2-oxoglutarate oxygenase reaction to give succinate, carbon dioxide, an

249 ptide scaffold, the differential oxidase and oxygenase reactivities of two 4A-->4G variants, one with

250 al that the kinetic properties of individual oxygenases reflect their biological capacity to act as h

251 Characterized 2OG oxygenases regulate fundamental cellular processes by ca

252 main containing protein (PPHD) contain a 2OG oxygenase related in structure and function to the anima

253 ere we engineered cells to express the haeme oxygenase responsible for BV biosynthesis and a brighter

254 of extracellular heme through the HemO heme oxygenase, resulting in more-efficient heme utilization.

255 oA2, encoding an aromatic ring-hydroxylating oxygenase (RHO).

256 phylogenetically classified as a Rieske-type oxygenase (RO) and belongs to a group which catalyzes th

257 The finding that ribosomal oxygenases (ROXs) occur in organisms ranging from prokar

258 zymes, ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and carbonic anhydrase (CA), in an e

259 rating ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and its substrate CO2 within a prote

260 ribulose-1,5-bisphosphate (RuBP) carboxylase/oxygenase (Rubisco) catalyzes primary carbon dioxide ass

261 enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) in a paracrystalline lattice, making

262 Ribulose 1,5-bisphosphate carboxylase/oxygenase (RubisCO) is a critical yet severely inefficie

263 enzyme ribulose 1,5-bisphosphate carboxylase/oxygenase (rubisco) is inhibited by nonproductive bindin

264 Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) is the key enzyme involved in photos

265 sms, D-ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) is the major enzyme assimilating atm

266 Ribulose-1,5-biphosphate carboxylase/oxygenase (Rubisco) is the most abundant enzyme in plant

267 enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) often limit plant productivity.

268 Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) plays a critical role in sustaining

269 enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) with carbonic anhydrase.

270 ion of ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco) with O2 instead of CO2 , leading to

271 ite of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco), simultaneously enhancing carbon fix

272 ing enzyme ribulose bisphosphate carboxylase/oxygenase (RuBisCO).

273 nzyme, Ribulose 1,5 bisphosphate carboxylase oxygenase (Rubisco).

274 enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco).

275 Stilbene cleavage oxygenases (SCOs) cleave the central double bond of stil

276 lancelet, nematode, and molluscan carotenoid oxygenase sequences.

277 These "2OG oxygenases" sit at the intersection of nutrient availabi

278 re Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenases, some of which are associated with cancer.

279 -ordinated-5H3 (unc5H3), doublecortin, cyclo-oxygenase, sonic hedgehog and Disrupted in schizophrenia

280 captures, for the first time, the reductase-oxygenase structural arrangement and the CaM-dependent r

281 coding ribulose-1,5 bisphosphate carboxylase-oxygenase subunit proteins of the Calvin cycle and AMP s

282 celet) suggests that the carotenoid cleavage oxygenase superfamily has evolved in the "extremely high

283 e Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenase superfamily.

284 The cytochrome P450-dependent mono-oxygenase system is responsible for the metabolism and d

285 a cytochrome P450 [CYP71D1V2; tabersonine 3-oxygenase (T3O)] and an alcohol dehydrogenase [ADHL1; ta

286 ide hydrolases and lytic polysaccharide mono-oxygenases targeting cellulose, xylan, and chitin, were

287 oxylase (BBOX) is a 2-oxoglutarate dependent oxygenase that catalyzes the final hydroxylation step in

288 Here we delete in a moss the P450 oxygenase that defines the entry point in angiosperm lig

289 phosphonate synthase (MPnS) are nonheme iron oxygenases that both catalyze the carbon-carbon bond cle

290 Nonheme iron oxygenases that carry out four-electron oxidations of su

291 Recently, 2OG-dependent oxygenases that catalyse hydroxylation of transfer RNA a

292 (OGFOD1) is predicted to be a conserved 2OG oxygenase, the catalytic domain of which is related to h

293 l as a model system, we use nature's favored oxygenase, the cytochrome P450, to perform high-level ox

294 implicated in the mechanisms of nonheme iron oxygenases, their C-H bond cleaving properties being att

295 amily of Fe(II) and 2-oxoglutarate dependent oxygenases; their catalytic domain is closely related to

296 (II) and 2-(oxo)glutarate (Fe/2OG)-dependent oxygenase, then inverts the C5 configuration.

297 Unlike heme oxygenases, this intermediate does not form with added H

298 catalyzed by 2-oxoglutarate (2OG)-dependent oxygenases, was first identified in collagen biosynthesi

299 kidneys, whereas high levels of C3 and heme oxygenase were identified in pancreas biopsies.

300 we show that NgTET1 is a 5-methylpyrimidine oxygenase, with activity on both (5m)C (major activity)