ライフサイエンスコーパス: oxylipin

1 polyunsaturated fatty acids to corresponding oxylipins.

2 difying or eliminating the function of these oxylipins.

3 tems and the other to form novel NAE-derived oxylipins.

4 e tissue specific synthesis of divinyl ether oxylipins.

5 uces physiologically important lipids called oxylipins.

6 in diet-induced obesity-C18 epoxide and diol oxylipins.

7 carotenoids, flavonoids, glucosinolates and oxylipins.

8 ic cascade responsible for the regulation of oxylipins.

9 lism of PU-NAEs through the formation of NAE-oxylipins.

10 poA is responsible for the production of the oxylipins 8R-hydroperoxyoctadecadienoic acid and 5S,8R-d

11 and pathogen defense (volatile aldehydes and oxylipins), a mechanism of unmolested nitrogen and carbo

12 The oxylipins, a large family of oxygenated lipid derivative

13 d oxygenation, resulting in the formation of oxylipins activating plant defense against hemibiotrophi

14 We additionally explored whether A. nidulans oxylipins affect seed LOX gene expression during Aspergi

15 Here, we show that oxylipins also facilitate infestation of Arabidopsis tha

16 n UHPLC run enables the quantification of 43 oxylipins and 5 PUFAs, covering pro and anti-inflammator

17 the infection became stronger an increase of oxylipins and diacylglycerols was revealed.

18 Oxylipins and endocannabinoids are classes of bioactive

19 Moreover, increased levels of oxylipins and salicylic acid favored closure of stomata

20 ss spectrometry (UHPLC-MS) assay to quantify oxylipins and their PUFA precursors in 100 muL of human

21 wledge of the involvement of FAs, FA-derived oxylipins, and enzymes catalyzing FA metabolism in plant

22 high levels of polyunsaturated fatty acids, oxylipins, and glutathione.

23 OF MS for semi-polar metabolites, LC-MRM for oxylipins, and headspace GC-MS for volatile compounds.

24 cluding genes related to halogen metabolism, oxylipins, and multicellularity (microRNA processing and

25 Among the microbial oxylipins, the fungal oxylipins are best characterized and function as hormone

26 e fatty acids, recent evidence suggests that oxylipins are components of plastid-localized polar comp

27 ive to drought, indicating that LOX6-derived oxylipins are important for the responses to abiotic and

28 Cyclooxygenase (COX)-derived oxylipins are important mediators of inflammation.

29 result provides genetic evidence that fungal oxylipins are involved in plant LOX gene expression chan

30 Plant oxylipins are structural analogs of animal prostaglandin

31 In Aspergillus nidulans, oxylipins are synthesized by the dioxygenase enzymes Ppo

32 Structurally similar oxylipins are synthesized in seeds via the action of lip

33 cific signatures of ox-lipids, like those of oxylipins, are indicative of their functions.

34 Several recent studies have implicated oxylipins as a novel class of host-microbe signalling mo

35 Lipid and oxylipin biomarker screening through adduct hierarchy se

36 identification of lipid, oxidized lipid, and oxylipin biomarkers in high-mass-accuracy HPLC-MS data.

37 (PLA2) plays an important role in regulating oxylipin biosynthesis in mammals, but the molecular and

38 operoxides in roots, and that this branch of oxylipin biosynthesis is regulated by the jasmonate sign

39 pids being the primary products of plastidic oxylipin biosynthesis.

40 Herein, we explored whether a plant oxylipin biosynthetic gene (ZmLOX3) could substitute fun

41 These results indicate that oxylipin biosynthetic genes were present in the last com

42 links sequential catalytic activities in an oxylipin biosynthetic pathway.

43 ic acid and methyl jasmonate, as well as the oxylipin-biosynthetic intermediates 13-hydroperoxylinole

44 (teleomorph: Emericella nidulans) endogenous oxylipins, called psi factor, serve as hormone-like sign

45 Although oxylipins can be synthesized from free fatty acids, rece

46 and OPDA-18:3 DGDG, each containing a single oxylipin chain, rose 2- to 9-fold.

47 GDG, and OPDA-OPDA DGDG, each containing two oxylipin chains, increased 200- to 1,000-fold.

48 Oxylipins comprise a family of oxygenated fatty acid-der

49 oAC strain that was reduced in production of oxylipins, conidia and the mycotoxin sterigmatocystin.

50 In unwounded leaves, the levels of these oxylipin-containing complex lipid species were low, betw

51 e complex polar lipid species, 17 species of oxylipin-containing phosphatidylglycerols, monogalactosy

52 es the first genetic evidence for reciprocal oxylipin cross-talk in the Aspergillus-seed pathosystem.

53 (Ephx2)(-/-) mice, which have elevated epoxy-oxylipins, demonstrated opposing effects to epoxI-treate

54 Here we show that oxylipins derived from this activity inhibit flagellum-d

55 nvolvement of EPHX2-associated lipidomic and oxylipin dysregulations in AN, and reveal their potentia

56 enase, lipoxygenase, and epoxygenase derived oxylipins, especially eicosanoids, play important roles

57 In Candida albicans, exposure to the oxylipin farnesol causes the regulation of specific gene

58 Some of these oxylipins, for example jasmonic acid (JA), are important

59 Cytochrome P450 pathway oxylipins from arachidonic acid, linoleic acid, alpha-li

60 Oxylipins function as signaling molecules in plant growt

61 f an increase in JA levels and expression of oxylipin genes during leaf senescence, and indicates tha

62 ion of P450s in phenylpropanoid, carotenoid, oxylipin, glucosinolate, and brassinosteroid biosynthese

63 These findings demonstrate that epoxy-oxylipins have a critical role in monocyte lineage recru

64 The biological roles of oxylipins have been extensively studied in animals, plan

65 n plant photoprotection and the synthesis of oxylipin hormones as regulators of development and defen

66 ion, enzyme elaboration, and a sophisticated oxylipin host crosstalk associated with a quorum-like de

67 roles of cytochrome P450 (CYP)-derived epoxy-oxylipins in a well-characterized model of sterile resol

68 To investigate the role of these oxylipins in anther and pollen development, we character

69 demonstrating the importance of root-derived oxylipins in colonization of aboveground organs by an in

70 These data support an important role for oxylipins in integrating mitotic and meiotic spore devel

71 These experiments implicate oxylipins in pathogen development and suggest that Delta

72 her studies that implicate a role for fungal oxylipins in pathogenesis by Aspergillus and Candida spp

73 r study thus uncovers a role for prokaryotic oxylipins in the physiology and pathogenicity of bacteri

74 th elevated levels of JAs, suggest a role of oxylipins in tomato flower/seed development.

75 s accurate measurement of several esterified oxylipins--in particular hydro(pero)xyeicosatetraenoic a

76 Phospholipid-esterified oxylipins include newly described families of bioactive

77 Oxylipins including jasmonates are signaling compounds i

78 Mammalian oxylipins, including the prostaglandins (PGs), mediate m

79 In parallel, levels of LOX5-derived oxylipins increased in roots and in petiole exudates of

80 nes of evidence indicated that 9-LOX-derived oxylipins induce BR synthesis and signaling to activate

81 cks 9-LOX activity, and noxy2-2, which shows oxylipin insensitivity and mitochondrial dysfunction.

82 biosynthesis of the cyclopentanone class of oxylipins is catalyzed by allene oxide cyclase (AOC) tha

83 One possible explanation for the elevated oxylipins is that frataxin deficiency results in increas

84 that plays a key role in the biosynthesis of oxylipin jasmonates, which are involved in signal and de

85 We measured oxylipin levels using tandem mass spectrometry and ELISA

86 PUFA and oxylipin markers were tested as potential biomarkers for

87 propose that Ppo products, PG, and/or other oxylipins may serve as activators of mammalian immune re

88 ed, hormone-like lipogenic molecules, called oxylipins, mediate the balance of asexual to sexual spor

89 hytodienoic acid (OPDA), both members of the oxylipin messenger family.

90 patial organization of these two branches of oxylipin metabolism.

91 acid hydroperoxides to different branches of oxylipin metabolism.

92 identify a specific, bioactive ethanolamide oxylipin metabolite of NAE18:2, different from those of

93 Quantification of oxylipin metabolites in lox mutants demonstrated altered

94 Here, we identify and quantify endogenous oxylipin metabolites of N-linolenoylethanolamine (NAE 18

95 correlation between obesity and hepatic C18 oxylipin metabolites of omega-6 (omega6) and omega-3 (om

96 Changes in several novel oxylipin metabolites were detected, including arabidopsi

97 Detectable levels of endogenous NAE-oxylipin metabolites were identified in FAAH fatty acid

98 hese results suggest that host and microbial oxylipins might interfere with the metabolism, perceptio

99 catrienoic acid-insensitive nonresponding to oxylipins (noxy) mutants showed the importance of the ce

100 Previous studies using nonresponding to oxylipins (noxy), a series of Arabidopsis (Arabidopsis t

101 xo-phytodienoic acid (OPDA) was the dominant oxylipin occurring nearly exclusively in the seed coat t

102 We suggest that NAE oxylipins of linolenic acid represent a newly identified

103 turated cyclopropane- and lactone-containing oxylipins of marine origin has been designed and applied

104 The oxylipins of these polar complex lipid species include o

105 tectable increase in JA may indicate that an oxylipin other than JA regulates basal resistance and sy

106 ulation are governed, in part, by endogenous oxylipins (oxygenated, polyunsaturated fatty acids and m

107 on of regulatory and structural genes of the oxylipin pathway and by studying nonlinearities in gene-

108 The oxylipin pathway generates not only prostaglandin-like j

109 induced systemic resistance, showed that the oxylipin pathway is differentially regulated.

110 Two members of the 9-lipoxygenase (9-LOX) oxylipin pathway, 9-hydroxyoctadecatrienoic acid and 9-k

111 arly the allene oxide synthase branch of the oxylipin pathway, responsible for production of jasmonic

112 ith the induction of the first enzyme of the oxylipin pathway, the lipoxygenase (LOX), leading to a f

113 insect suppression of the HPL branch of the oxylipin pathway.

114 further investigated the stimulation of the oxylipin pathway: metabolites and enzymes of the pathway

115 Large differential increases in oxylipin-pathway lipoxygenases and auxin-responsive tran

116 eased from membranes and is converted to the oxylipins phytodienoic acid and jasmonic acid through th

117 In this work, six new bioactive oxylipins -phytoprostanes - were detected in gulupa shel

118 Oxygenated fatty acids, or oxylipins, play an essential role in physiological signa

119 root) and radial (cell-to-cell) transport of oxylipins plays a major role in the wound response.

120 ication of 9-hydroxyoctadecadienoic acid (an oxylipin produced by the LOX5 enzyme) to roots restored

121 We also demonstrate that oxylipins produced by P. aeruginosa promote virulence in

122 S)-lipoxygenase (12-LOX), a highly expressed oxylipin-producing enzyme in the human platelet, is an e

123 dicate that pPLAIIalpha negatively regulates oxylipin production and suggest a role in the removal of

124 xpression, biofluid oxylipin profile, tissue oxylipin production capacity, and blood pressure.

125 Oxylipin production in this fungus is dependent on devel

126 These results indicate that oxylipin production is important for host colonization a

127 We further provide evidence of H(2)O(2) and oxylipin production that, as in plants and animals, may

128 The expression of genes involved in oxylipin production was also higher in the pPLAIIalpha-d

129 somes, whereas LOX, responsible for NAE 18:2-oxylipin production, was distributed in cytosol-enriched

130 type evaluating protein expression, biofluid oxylipin profile, tissue oxylipin production capacity, a

131 dividuals undergoing a fasting intervention; oxylipin profiles highlighted significantly altered PUFA

132 y, the validated method was used to evaluate oxylipin profiles in lipopolysaccharide-exposed mice, an

133 hat chewing insects differentially alter the oxylipin profiles produced by the two main and competing

134 at wounding and drought differentially alter oxylipin profiles, particularly the allene oxide synthas

135 Comprehensive oxylipin profiling together with genetic and pharmacolog

136 Consequently, these oxylipins promote bacterial organization in microcolonie

137 plants, thus confirming that a LOX5-derived oxylipin promotes infestation of the foliage by GPAs.

138 he biosynthesis of the linoleic acid derived oxylipin psiBalpha.

139 Oxylipin ratios were calculated as proxy markers of in v

140 In plants, oxylipins regulate developmental processes and defense r

141 nctions and the biosynthesis of hydroxylated oxylipins remains scarce.

142 Oxylipins represent a vast and diverse family of seconda

143 ool for the evaluation of complex regulatory oxylipin responses in in vitro or in vivo studies.

144 Hormone measurements showed that the oxylipin signal must precede subsequent increases in eth

145 Jasmonates are oxylipin signals that play important roles in the develo

146 rabidopsis thaliana) ecotypes to examine the oxylipin signature in response to specific stresses and

147 Oxylipin signatures of wounded opr3 leaves revealed the

148 a PN biosynthetic gene, thus suggesting that oxylipin species regulate secondary metabolites at the t

149 dentification of endogenous amide-conjugated oxylipins suggests potential significance of these metab

150 f the genes involved in the initial steps of oxylipin synthesis revealed that abrogation of the PLDal

151 frataxin leads to elevation of COX2-mediated oxylipin synthesis stimulated by increases in transcript

152 S), the cytochrome P450 that initiates plant oxylipin synthesis.

153 ethods offer a comprehensive coverage of the oxylipin synthetic cascade applicable to a wide range of

154 f solandelactones is proposed for these C 22 oxylipins that parallels a hypothesis put forward previo

155 olized by CYP74 cytochrome P-450s to various oxylipins that play important roles in plant growth and

156 Jasmonates are oxygenated lipids (oxylipins) that control defense gene expression in respo

157 Among the microbial oxylipins, the fungal oxylipins are best characterized a

158 ave shown that exogenous application of seed oxylipins to Aspergillus cultures alters sporulation and

159 JA-deficient mutants confirmed shoot-to-root oxylipin transport.

160 Jasmonates, oxylipin-type plant hormones, are implicated in diverse

161 of oxygenated polyunsaturated fatty acids, "oxylipins." We employed three Arabidopsis (Arabidopsis t

162 Epoxide substrates of sEH and associated oxylipins were measured in ill AN, recovered AN and gend

163 Epoxy-oxylipins were produced in a biphasic manner during the

164 In 21 min, 39 oxylipins were quantified along with eight corresponding

165 f lipoxygenase- and cyclooxygenase-dependent oxylipins were unchanged.

166 with 5-, 12-, and 15-lipoxygenases produced oxylipins, which were identified and characterized by li

167 ids (LComega3PUFAs), which are substrate for oxylipins with anti-inflammatory and antiangiogenic prop

168 substrate to different classes of bioactive oxylipins within chloroplasts.