ライフサイエンスコーパス: oxysterol

1 he only macrophage-synthesized and -secreted oxysterol.

2 ication of ergosterol endoperoxide, a B-ring oxysterol.

3 icles in response to its endogenous ligands, oxysterols.

4 shown to lead to accumulation of neurotoxic oxysterols.

5 s C, i.e., rich in hydroperoxides but low in oxysterols.

6 Smoothened-/- mouse embryonic fibroblasts to oxysterols.

7 lining fluid, generating chemically reactive oxysterols.

8 homeostasis of cholesterol, bile acids, and oxysterols.

9 owed earlier that NPC1 binds cholesterol and oxysterols.

10 required for the known regulatory actions of oxysterols.

11 NPC2 bound cholesterol, but not oxysterols.

12 y lead to increased levels of LXR-activating oxysterols.

13 e pathways of metabolism that generate novel oxysterols.

14 inds 25-hydroxycholesterol (25-HC) and other oxysterols.

15 eversed by exogenous cholesterol or specific oxysterols.

16 reactive, giving rise to biologically active oxysterols.

17 Th1 cells, preferentially produce these two oxysterols.

18 n of the enzyme Cyp46a1, which generates the oxysterol 24-hydroxycholesterol (24S-HC) in a pancreatic

19 Binding of both sterols was competed by oxysterols (24-, 25-, and 27-HC).

20 with additive effects on serum levels of the oxysterol, 24S-hydroxycholesterol, a substrate of the en

21 e (Ch25h) and that are unable to produce the oxysterol 25-hydroxycholesterol (25-HC) overproduce infl

22 ere we report that in vitro additions of the oxysterol 25-hydroxycholesterol (25-HC), exogenous cytos

23 The oxysterol 25-hydroxycholesterol (25HC) plays multiple ro

24 Here, we report that the oxysterol 25-hydroxycholesterol and geranylgeraniol comb

25 These findings identify an oxysterol, 25-HC, as a critical mediator in the negative

26 LC) separation of a closely eluting isomeric oxysterol, 25-hydroxycholesterol.

27 more recent studies have indicated that the oxysterol 27-hydroxycholesterol (27HC), and not choleste

28 The oxysterol 27-hydroxycholesterol (27HC), synthesized by t

29 led to decreased levels of the 7-DHC-derived oxysterol, 3beta,5alpha-dihydroxycholest-7-en-6-one.

30 in ECs, and that these cells accumulated the oxysterol 7-ketocholesterol (7-KC) when Abcg1(-/-) mice

31 nction of RORalpha (NR1F1) in regulating the oxysterol 7alpha-hydroxylase (Cyp7b1), an enzyme critica

32 tion of LXRs a l so suppresses expression of oxysterol 7alpha-hydroxylase (Cyp7b1), which may lead to

33 Expression of liver oxysterol 7alpha-hydroxylase in the alternative bile aci

34 Conversely, inactivation of the CYP7B1 oxysterol 7alpha-hydroxylase, which degrades 25-hydroxyc

35 essive mutations in the gene CYP7B1 encoding oxysterol-7alpha-hydroxylase.

36 double blind interventional trial targeting oxysterol accumulation in serum of SPG5 patients.

37 Here, we show that oxysterols act by binding to Insigs, causing Insigs to b

38 ogical functions of sterol intermediates and oxysterols, acting through transcription factors such as

39 Liver X receptors (LXR) are oxysterol-activated nuclear receptors that play a centra

40 l site 1 and site 2 phosphomutants supported oxysterol activation of SM synthesis in OSBP-deficient C

41 um membrane phospholipid remodeling inhibits oxysterol activity.

42 The mechanism by which O3-derived oxysterols affect molecular function is unknown.

43 ) induce only HAS3 transcription, whereas 22,oxysterol affects both HAS2 and HAS3.

44 epatic cholesterol and accumulation of toxic oxysterols and bile acids.

45 protein-2 is responsive to both sterols and oxysterols and has been shown to mediate the transcripti

46 The ability of oxysterols and lipoprotein-containing serum to suppress

47 ice by promoting efflux of cholesterol and 7-oxysterols and preserving active eNOS dimer levels.

48 (LXR) are stimulated by cholesterol-derived oxysterols and serve as transcription factors to regulat

49 ydroxylates carbons 6 and 7 of the B ring of oxysterols and steroids.

50 d to account for the formation of all of the oxysterols and the reaction progress profile.

51 oduction of endogenous bioactive sterols and oxysterols and their mechanisms of action in the immune

52 activity is crucial for the inactivation of oxysterols and their subsequent conversion into bile sal

53 fourth are important for Insig's binding to oxysterols and to Scap.

54 relevant endogenous (e.g., cholestane 3,5,6 oxysterol) and exogenous (e.g., lipopolysaccharide) mole

55 eptors for oxidized cholesterol metabolites (oxysterols) and regulate several aspects of cholesterol

56 ivation of the UPR include oxidative stress, oxysterols, and high levels of intracellular cholesterol

57 ol homeostatic pathways is not duplicated by oxysterols, and some oxysterols are poor substrates for

58 ators of sterol metabolism, including serum, oxysterols, and synthetic liver X receptor (LXR) agonist

59 ous Smoothened activator is cholesterol, not oxysterols, and that vertebrate Hedgehog signaling contr

60 rol in breast cancer when the levels of this oxysterol are elevated.

61 EBI2; however, the cellular sources of this oxysterol are undefined.

62 procedure, the extraction and enrichment of oxysterols are combined in a unique step, reducing sampl

63 Side-chain oxysterols are enzymatically generated oxidation product

64 Oxysterols are increased in inflamed airways after aller

65 Certain oxysterols are known to have direct effects on membrane

66 Oxysterols are oxidized derivatives of cholesterol that

67 Oxysterols are oxygenated cholesterol derivates that are

68 ys is not duplicated by oxysterols, and some oxysterols are poor substrates for the pathways that det

69 port the contention that side chain-oxidized oxysterols are strong suppressors of cholesterol biosynt

70 The cytotoxic roles of oxysterols are, at least partly, due to a direct physica

71 Osteoinductive oxysterols are, therefore, novel activators of the hedge

72 Oxidation products of cholesterol, the oxysterols, are enzymatically produced molecules that pl

73 a previously unknown mechanism for selected oxysterols as immune modulators and a direct role for CY

74 t findings extend the biologic activities of oxysterols as ligands for nuclear receptors to a role in

75 viral entry and implicate membrane-modifying oxysterols as potential antiviral therapeutics.

76 dentification of several naturally occurring oxysterols as RORgammat agonists.

77 iochemical and cell biological properties of oxysterols based on their membrane biophysical propertie

78 ular pathways for the rapid equilibration of oxysterols between membranes, direct imaging of oxystero

79 Oxysterols, bile acids (BAs), and steroids work primaril

80 Oxysterols bind LXRs with high affinity in vitro and are

81 tion complex have been identified, including oxysterol binding protein (OSBP) and phosphatidylinosito

82 CV RNP complexes revealed the association of oxysterol binding protein (OSBP) as one of the component

83 Studies on oxysterol binding protein and oxysterol binding protein-

84 ls regulate cellular functions by binding to oxysterol binding protein and oxysterol binding protein-

85 The oxysterol binding protein homologue Kes1p has been impli

86 Oxysterol binding protein is a sterol-dependent scaffold

87 A homologue oxysterol binding protein of yeast (Osh4) peripherally b

88 Mesmin et al. show how a single molecule of oxysterol binding protein, which has a lipid binding dom

89 H-1 K289R mutation induced the expression of oxysterol binding protein-like 3 (OSBPL3), enhanced SREB

90 Two peptides matching to oxysterol binding protein-related protein 1L (ORP1L) and

91 g to a recently solved structure for a yeast oxysterol binding protein-related protein, Osh4, some me

92 Studies on oxysterol binding protein and oxysterol binding protein-related proteins should lead t

93 Oxysterol binding protein-related proteins, including th

94 by binding to oxysterol binding protein and oxysterol binding protein-related proteins.

95 sent the first molecular characterization of oxysterol binding to a 7TM receptor and identify positio

96 The sequence for the oxysterol-binding domain of PiORP1 was used to search th

97 late a range of cellular processes, only few oxysterol-binding effector proteins have been identified

98 The oxysterol-binding groove in the Smo CRD is analogous to

99 t Sac1-mediated PI4P metabolism requires the oxysterol-binding homology (Osh) proteins.

100 Oxysterol-binding protein (OSBP) and OSBP-related protei

101 Oxysterol-binding protein (OSBP) exchanges cholesterol a

102 Ceramide transfer protein (CERT) and oxysterol-binding protein (OSBP) play a crucial role in

103 rane-protein-associated protein A (VAPA) and oxysterol-binding protein (OSBP) regulate intracellular

104 culum (ER)-Golgi sterol transfer activity of oxysterol-binding protein (OSBP) regulates sphingomyelin

105 PI 4-kinase and oxysterol-binding protein (OSBP) were inhibited using RN

106 ynamin-1, kinesin, beta-tubulin, beta-actin, oxysterol-binding protein (OSBP)-related protein 2 (ORP2

107 t two similar ER integral membrane proteins, oxysterol-binding protein (OSBP)-related protein 5 (ORP5

108 We show that this transport requires oxysterol-binding protein (OSBP)-related proteins (ORPs)

109 er of the evolutionarily conserved family of oxysterol-binding protein (OSBP)-related proteins (ORPs)

110 -miR-885-5p levels correlated inversely with oxysterol-binding protein 2 (OSBPL2) expression (r = -0.

111 erto unknown relationship between members of oxysterol-binding protein and VAP33 families of plant pr

112 flip at the TGN appears to be to control the oxysterol-binding protein homologue Kes1/Osh4 and regula

113 ction between ER-localized VAP and endosomal oxysterol-binding protein ORP1L, and is required for the

114 re, the RIDalpha pathway is regulated by the oxysterol-binding protein ORP1L.

115 se PP2A, the tyrosine phosphatase HePTP, the oxysterol-binding protein OSBP and cholesterol.

116 y a novel substrate of PKD at the Golgi, the oxysterol-binding protein OSBP.

117 Kes1, and other oxysterol-binding protein superfamily members, are invol

118 ol-binding properties of a small Arabidopsis oxysterol-binding protein, ORP3a.

119 asome, and OSBPL1A, which encodes a presumed oxysterol-binding protein, were both preferentially expr

120 red JAK2 and tyrosine 394 phosphorylation of oxysterol-binding protein-1.

121 e studies identify a previously unrecognized oxysterol-binding protein-mediated mode of activation of

122 The oxysterol-binding protein-related protein (ORP) family i

123 ab7-interacting lysosomal protein (RILP) and oxysterol-binding protein-related protein 1L (ORP1L) are

124 Oxysterol-binding protein-related protein 8, which was r

125 Oxysterol-binding protein-related proteins (ORPs) have b

126 Oxysterol-binding proteins (OSBPs) and oxysterol-binding

127 In non-plant systems, oxysterol-binding proteins have been involved in sterol

128 There are at least twelve homologs of oxysterol-binding proteins in the Arabidopsis genome, bu

129 We show here that in yeast the oxysterol-binding proteins Osh1-Osh7 are collectively ne

130 These studies define Insigs as oxysterol-binding proteins, explaining the long-known ab

131 Oxysterol-binding proteins (OSBPs) and oxysterol-binding-protein related proteins (ORPs) are en

132 inery in the initial steps of steroid and/or oxysterol biosynthesis pathways are present and active i

133 SREBP)-dependent gene expression, side chain oxysterol biosynthesis, and cholesterol precursors in th

134 Cholesterol and oxysterols block COPII binding to MELADL by binding to d

135 Two classes of sterols, cholesterol and oxysterols, block export of sterol regulatory element-bi

136 nsport is inhibited by either cholesterol or oxysterols, blocking cholesterol synthesis.

137 response to loading with free cholesterol or oxysterol, but underlying mechanisms have not been eluci

138 We show that side chain oxysterols, but not steroid ring-modified oxysterols, ex

139 ol has allowed us to directly visualize this oxysterol by attaching an azide fluorophore through cycl

140 nification of the sample and purification of oxysterols by reversed phase C18-SPE followed by HPLC-MS

141 An empirical correlation ranking the oxysterols by their ability to modify membrane biophysic

142 We also show that certain oxysterols can maximally activate Shh target gene transc

143 h can be distinct from those of cholesterol, oxysterols can promote or inhibit the formation of membr

144 New studies now indicate that tumor-derived oxysterols can serve to subvert the immune system by rec

145 stent with experimental results showing that oxysterols can trigger cholesterol trafficking from the

146 ion of disease severity and progression with oxysterol concentrations, and demonstrate in a randomize

147 res and to investigate postmortem changes in oxysterol concentrations.

148 Then human specimens were analyzed for oxysterol concentrations.

149 Maximum oxysterols concentrations were achieved at 20 min in nea

150 acologic blockade or genetic inactivation of oxysterols controls pNET tumorigenesis by dampening the

151 fy an unanticipated protumor function of the oxysterol-CXCR2 axis and a possible target for cancer th

152 We demonstrate that interfering with the oxysterol-CXCR2 axis delays tumor growth and prolongs th

153 roteinase-14 cleavage site G-L prevented the oxysterol-dependent increase in arterial pressure and sE

154 th the SRE and nLXRE are required for normal oxysterol-dependent repression of this gene.

155 ch on sterol oxidation focuses mainly on the oxysterol derivatives formation to the exclusion of comp

156 in the cholesterol-biosynthetic pathway and oxysterol derivatives of cholesterol regulate diverse ce

157 Natural ligands that activate LXRs include oxysterol derivatives such as 25-hydroxycholesterol, 27-

158 est-7-en-6-one, a naturally occurring B-ring oxysterol derived from 7-DHC that also accumulates in Sm

159 Fifteen oxysterols derived from 7-DHC were isolated and characte

160 Furthermore, binding studies showed that oxysterols did not compete with fluorescently labeled cy

161 ss high baseline Gli activity, we found that oxysterols did not dramatically shift the IC50 concentra

162 ed U937, suggesting a functional role of the oxysterol/EBI2 pathway in these immune cells.

163 zed Gli-responsive element, 3) inhibition of oxysterol effects by the hedgehog pathway inhibitor, cyc

164 Oxysterols elicit profound effects on immune and inflamm

165 Oxysterols elicit profound effects on immune and inflamm

166 of vertebrate Smo and show that it binds to oxysterols, endogenous lipids that activate Hh signaling

167 lial cells to O3 results in the formation of oxysterols, epoxycholesterol-alpha and -beta and secoste

168 Side chain oxysterols exert cholesterol homeostatic effects by supp

169 in oxysterols, but not steroid ring-modified oxysterols, exhibit membrane expansion behavior in phosp

170 ith an LXR agonist that mimics activation by oxysterols, expression of these target genes was increas

171 to pregnant female mice led to a decrease in oxysterol formation in brain and liver tissues of the ne

172 of FAME delayed PS degradation and postponed oxysterols formation.

173 7-Ketocholesterol is a highly toxic oxysterol found in abundance in atherosclerotic plaques

174 body, the de novo production of steroids or oxysterols from cholesterol has not been examined.

175 ting efflux of 7-ketocholesterol and related oxysterols from macrophages onto HDL and in protecting t

176 CG1, which promote efflux of cholesterol and oxysterols from macrophages, has not been investigated.

177 Here we isolate oxysterols from porcine spleen extracts and show that th

178 se that the high reactivity of 7-DHC and the oxysterols generated from its peroxidation may play impo

179 cellular and molecular mechanisms governing oxysterol generation within tumor microenvironments rema

180 As expected, O3-derived oxysterols have a pro-inflammatory effect and increase N

181 Intriguingly, these oxysterols have also been detected in atherosclerotic pl

182 The biological effects of oxysterols have largely been credited to the activation

183 rall, these data demonstrate that O3-derived oxysterols have pro-inflammatory functions and form lipi

184 Oxysterols have recently been identified as natural liga

185 Tumor-derived oxysterols have recently been shown to favor tumor growt

186 Cholesterol-oxidized products, namely oxysterols, have been shown to favor tumor growth direct

187 in 24-hydroxycholesterol (24SOH), the major oxysterol in the brain.

188 use molecular dynamics simulations of these oxysterols in 1-palmitoyl 2-oleoyl phosphatidylcholine (

189 their potential to reduce formation of 7-DHC oxysterols in fibroblast from SLOS patients.

190 ies, studied dose-dependent neurotoxicity of oxysterols in human cortical neurons and performed a ran

191 trinsic, 'professional' role for sterols and oxysterols in macrophage and T-cell immunity.

192 idering the adverse effects of 7-DHC-derived oxysterols in neuronal and glial cultures and the positi

193 responsible for differential accumulation of oxysterols in organelle membranes.

194 A role for oxysterols in the effects of Sonic hedgehog protein focu

195 Oxysterols inactivated SREBP1 in wild type macrophages b

196 human NPC1 and confirmed its ability to bind oxysterols, including those with a hydroxyl group on the

197 ne cell function, and it was found that this oxysterol increases the number of polymorphonuclear-neut

198 Cholesterol or oxysterols induced ABCA1 expression in wild type macroph

199 The different oxysterols induced changes in membrane properties accord

200 of the Hh target genes Gli-1 and Patched, 2) oxysterol-induced activation of a luciferase reporter dr

201 lts suggest that an underlying mechanism for oxysterol-induced apoptosis in cells, e.g., monocyte/mac

202 to M1 polarization, decreased autophagy and oxysterol-induced cell death whereas overexpression of M

203 onto HDL and in protecting these cells from oxysterol-induced cytotoxicity.

204 This was demonstrated by 1) oxysterol-induced expression of the Hh target genes Gli-

205 mitochondria and its DNA may be targets for oxysterol-induced oxidative stress and may play a role i

206 Indeed, targeting of the Smo CRD by oxysterol-inspired small molecules can block signaling b

207 This oxysterol is an efficient suppressor of cholesterol synt

208 The function of this oxysterol is unknown.

209 Furthermore, the effect of oxysterols is abolished in Smoothened mutants that retai

210 e believe that preventing formation of 7-DHC oxysterols is critical for countering the detrimental ef

211 When cell cholesterol is lowered, or oxysterols is introduced, the complex disassembles and p

212 t direct membrane perturbation by side-chain oxysterols is significant and suggests that these membra

213 ) DCs highly express EBI2 and migrate to its oxysterol ligand, 7alpha,25-OHC.

214 regnanolone (ALLO) and T0901317, a synthetic oxysterol ligand, act in concert to delay onset of neuro

215 To determine whether oxysterol ligands for EBI2 are increased in asthma exace

216 for NOX4 in insulin-stimulated generation of oxysterol ligands for LXR, a key lipogenic factor.

217 analysis and studies of naturally occurring oxysterol ligands indicate that the transactivation and

218 f the UPR in response to free cholesterol or oxysterol loading in insulin-resistant macrophages.

219 programs upon their activation by endogenous oxysterols, LXRs have recently also been implicated in r

220 2) processing, and selectively attenuate the oxysterol-mediated repression of SREBP-2 processing.

221 To examine whether oxysterol-membrane interactions contribute to the regula

222 These studies implicate oxysterol-membrane interactions in acute regulation of s

223 etastatic effects of a high-fat diet via its oxysterol metabolite, 27-hydroxycholesterol.

224 , including roles for catechol estrogen- and oxysterol-metabolites of parasite origin as initiators o

225 T cell activation triggers induction of the oxysterol-metabolizing enzyme SULT2B1, consequent suppre

226 patients, indicating that elevated levels of oxysterols might be key pathogenic factors in SPG5.

227 In a cell viability test, the oxysterol mixture from 7-DHC peroxidation was found to b

228 genous modulator of NMDARs acting at a novel oxysterol modulatory site that also represents a target

229 GPR183) was shown to be activated by several oxysterols, most potently by 7alpha,25-dihydroxycholeste

230 also accounts for the formation of numerous oxysterol natural products isolated from fungal species,

231 ing cholesterol to 27-hydroxycholesterol, an oxysterol of multiple functions, including tissue-specif

232 les for metabolites of catechol estrogen and oxysterols of parasite origin as initiators of carcinoge

233 Whereas the effects of some oxysterols on membrane order, fluorescence probe microen

234 -rich domain (CRD) as the site of action for oxysterols on Smo, involving residues structurally analo

235 Using alkynyl surrogates of O3-derived oxysterols, our data demonstrate adduction of LXR with S

236 Oxysterols, oxidized metabolites of cholesterol, are end

237 se the intriguing possibility that targeting oxysterol pathways could serve as a novel therapeutic ap

238 BCG1 results in increased levels of specific oxysterols, phosphatidylcholines, and oxidized phospholi

239 osis induced by 7-ketocholesterol, the major oxysterol present in oxidized LDL and atherosclerotic le

240 esterol itself and other naturally occurring oxysterols present in brain do not modulate NMDARs at co

241 we report that specific, naturally occurring oxysterols, previously shown to direct pluripotent mesen

242 Using this unique oxysterol probe, we provide evidence that oxysterol regu

243 s CH25H, have essential roles in controlling oxysterol production in lymphoid tissues, and they sugge

244 SL-mediated steroidogenesis entails enhanced oxysterol production.

245 By comparing the oxysterol profile formed from 7-DHC and those formed fro

246 od hydrogen atom donor alpha-tocopherol, the oxysterol profile of 7-DHC peroxidation differed distinc

247 The oxysterol profile of the retina suggests that all known

248 Qualitatively, oxysterol profiles were similar in the bovine and human

249 responses is not mediated by enantiospecific oxysterol-protein interactions.

250 resent study demonstrates a key role for the oxysterol receptor liver X receptor beta (LXRbeta) in th

251 We recently showed that tumor-derived oxysterols recruit neutrophils endowed with protumoral a

252 We report that tumor-derived oxysterols recruit protumor neutrophils in a liver X rec

253 ew insights into the mechanism through which oxysterols regulate cellular cholesterol balance.

254 Oxysterols regulate cellular functions by binding to oxy

255 uggesting a possible mechanism for how these oxysterols regulate cholesterol homeostasis.

256 y further the understanding of ways in which oxysterols regulate intracellular lipid transport.

257 k inhibition where the levels of sterols and oxysterols regulate the expression of cholesterologenic

258 ological sensors of cholesterol metabolites (oxysterols), regulating key genes involved in cholestero

259 embrane perturbations may play a role in the oxysterol regulation of cholesterol homeostasis.

260 ue oxysterol probe, we provide evidence that oxysterol regulation of cholesterol homeostatic response

261 AT3 and relevant coregulatory factors to the oxysterol-responsive region of the profilin-1 promoter.

262 We show that these oxysterols reverse the inhibitory effect of an RORgammat

263 Unexpectedly, we found that this oxysterol selectively accumulates in the Golgi membrane

264 hat oxidative stress and the accumulation of oxysterols should be considered as two key factors in ch

265 in CYP27A1, a key enzyme in generating these oxysterols, showed significant reduction of IL-17-produc

266 geranylgeranyl pyrophosphate and a secondary oxysterol signal.

267 s) and hydroxylated cholesterol derivatives (oxysterols); Smo is also highly sensitive to cellular st

268 sed to O3 contained elevated levels of these oxysterol species.

269 These findings demonstrate that oxysterols stimulate hedgehog pathway activity by indire

270 ptional repression of rhotekin 2 (RTKN2), an oxysterol stress responder, to optimize cell survival.

271 Recent work has shown that side-chain oxysterols, such as 25-hydroxycholesterol (25-HC), alter

272 Related oxysterols, such as 5alpha,6alpha-epoxycholesterol (5,6-

273 nsively studied, fundamental questions about oxysterols, such as their subcellular distribution and t

274 sterols between membranes, direct imaging of oxysterols suggests that a vesicular pathway is responsi

275 ogenous regulator decreases lipogenesis, and oxysterol sulfation can be a key protective regulatory p

276 Oxysterol synergized with nonsteroid LXR ligand induced

277 m, 24(S)-hydroxycholesterol (24(S)-HC) is an oxysterol synthesized from cholesterol by cholesterol 24

278 Oxysterols that inhibit raft formation are cytotoxic.

279 and beta are nuclear receptors activated by oxysterols that originated from the oxidation of cholest

280 GPCR known to bind and to be activated by an oxysterol, the goal of this study was to understand the

281 e show that the nuclear hormone receptor for oxysterols, the liver X receptor alpha (LXRalpha), regul

282 d the known immunological effects of certain oxysterols, thus uncovering a previously unknown role fo

283 al state through the production of a natural oxysterol to inhibit viral entry and implicate membrane-

284 Recent data expand the functional roles of oxysterols to fetal development and to the detoxificatio

285 oteins, explaining the long-known ability of oxysterols to inhibit cholesterol synthesis in animal ce

286 acellular receptors, cholesterol to Scap and oxysterols to Insig.

287 with rapid chromatographic separation of the oxysterols to permit accurate determination of plasma 24

288 abolome profiling of all naturally occurring oxysterols upon infection or IFN-stimulation, we reveal

289 t, 5-cholestenoic acid, is the most abundant oxysterol, varying up to threefold in different persons.

290 In the brain, the predominant oxysterol was 24S-hydroxycholesterol.

291 lls, efflux of 7-ketocholesterol and related oxysterols was completely dependent on expression of ABC

292 ygen species are related to the formation of oxysterols, we assessed the effect of 22-(R)-hydroxychol

293 el membranes, cholesterol and eight selected oxysterols were compared by fluorescence probe technique

294 Oxysterols were found to impair metabolic activity and v

295 7-DHC-derived oxysterols were measured in fibroblasts from SLOS patien

296 erial properties of the bilayer when certain oxysterols were present in the bilayer.

297 used by the presence of the second dipole of oxysterols, which reduces the energetic barrier for Abet

298 atic cells involves metabolism to side-chain oxysterols, which serve as transport forms of cholestero

299 Given the association of some oxysterols with atherosclerosis, it is important to iden

300 cholesterol metabolites such as steroids or oxysterols within endocrine tissues are currently recogn